Insulin resistance, obesity, inflammation, and depression in polycystic ovary syndrome: biobehavioral mechanisms and interventions
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Objective To summarize physiological and psychological characteristics that are common among women diagnosed with polycystic ovary syndrome (PCOS) and provide evidence suggesting that addressing psychological disturbances can reduce or alleviate physical symptoms of PCOS through behavioral pathways and physiological pathways.Method(s) Empirical studies and expert consensuses pertaining to physiological, psychological, and medical management aspects of PCOS were identified and presented in this review. Articles were identified by searching Pubmed, PsycInfo, Medline ISI, CINAHL, or a Web browser (i.e., Google) using numerous combinations of terms pertaining to physiological, psychological, and medical management aspects of PCOS. An article was chosen to be included in this review if it reported findings and/or provided information that related to and helped support the main purpose(s) of this review article.Result(s) Available literature on the physiological (i.e., hyperandrogenism, central obesity, inflammation, insulin resistance) and psychological (i.e., depression, anxiety, eating disorders) factors among women with PCOS provides evidence that these various aspects of PCOS are strongly interrelated.Conclusion(s) The existence of these relationships among physiological and psychological factors strongly suggests that medical management of PCOS would greatly benefit from inclusion of psychological and behavioral approaches.
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The development of depression and depressive symptoms may be related to the presence of hyperandrogenism, hyperinsulinemia and elevated levels of inflammation in PCOS.
“The development of depression and depressive symptoms may also be related to the presence of hyperandrogenism, hyperinsulinemia and elevated levels of inflammation in PCOS [71].”
From Providing lifestyle advice to women with PCOS: an overview of practical issues affecting success (2021) · cites this paper as [71]
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- Authors
- Farrell, K., & Antoni, M. H.
- Affiliations
- University of Miami (US)
- Corresponding author
- Farrell, Kristen
- ORCID
- Antoni, Michael H.
- Venue
- Fertility and Sterility
- Publisher
- Elsevier BV
- Published
- 2010-10
- Volume
- 94
- Issue
- 5
- Pages
- 1565-1574
- ISSN
- 0015-0282 (ISSN-L)
- PMC
- PMC2941530
- OpenAlex
- W2019856053
- Cited by
- 209
- References
- 135
- Citations by year
- 2026: 15 · 2025: 16 · 2024: 16 · 2023: 18 · 2022: 9 · 2021: 18 · 2020: 21 · 2019: 13 · 2018: 13 · 2017: 8 · 2016: 5 · 2015: 12 · 2014: 17 · 2013: 9 · 2012: 10
- FWCI
- 1.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Fertility and Sterility (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (T32HL007426)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Health Sciences › Medicine › Reproductive Medicine › Endometriosis Research and Treatment
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- polycystic ovary syndrome, insulin resistance, obesity, inflammation, depression, hyperandrogenism, anxiety, eating disorders, psychological intervention, behavioral interventions, biobehavioral mechanisms
- MeSH terms
- Behavior Therapy, Depression, Female, Humans, Inflammation, Insulin Resistance, Life Style, Polycystic Ovary Syndrome, Obesity, Abdominal
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