The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

Claytor, Renee; Lile, Joshua A.; Nader, Michael A.

doi:10.1016/j.pbb.2006.03.007

Cited by 20Neurotransmitter Receptor Influence on BehaviorSchizophrenia research and treatmentNeural and Behavioral Psychology Studies

The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

Claytor, Renee, Lile, Joshua A., Nader, Michael A.·2006·Pharmacology Biochemistry and Behavior

DOI 10.1016/j.pbb.2006.03.007

Open this paper in CoChat — free account

Abstract

The dopamine D3 receptor is mainly expressed in regions of the brain associated with the limbic system. D3 receptor blockade may antagonize cocaine reinforcement while producing less severe extrapyramidal side effects than blockade of D2 receptors. The purpose of the present studies was to evaluate the effects of a selective D3 receptor antagonist and a non-selective D2/D3 receptor antagonist on food- and cocaine-maintained responding under two schedules of cocaine self-administration. Adult male rhesus monkeys were trained to respond under multiple schedules of food (1.0 g pellets) and cocaine (0.01-0.3 mg/kg/injection) presentation. In one experiment (n=4), the schedule was a fixed-interval (FI) 3-min and a second study (n=6) was conducted using a second-order fixed-ratio 5 (FI 6-min:S) schedule. The D3 antagonist PNU 99194-A (0.3-3.0 mg/kg), which is 14-fold selective for D3 relative to D2 receptors, or the D2/D3 antagonist eticlopride (0.001-0.03 mg/kg) was administered immediately prior to the experimental session for at least 5 consecutive sessions. Under the multiple FI 3-min schedule of food and cocaine presentation, PNU 99194-A and eticlopride decreased food- and cocaine-maintained responding in a dose-dependent manner and irrespective of cocaine dose. Under the multiple second-order schedule of food and cocaine presentation, at least one dose of PNU 99194-A and eticlopride decreased cocaine- and food-maintained responding. These findings indicate that PNU 99194-A can decrease operant responding in monkeys, but not in a manner that would suggest selectivity of cocaine- over food-maintained responding. Future studies with more selective D3 antagonists are needed to better address the role of this receptor subtype in cocaine addiction.

Integrity signals

Registry

Crossref · 10.1016/j.pbb.2006.03.007

Cites

38 of 38 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

If cocaine is administered with D2R-like antagonists, it loses its reinforcing effects.
“Furthermore, if cocaine is administered with D2R-like antagonists, it loses its reinforcing effects (Woolverton and Virus 1989; Bachtell et al 2005; Claytor et al 2006; Peng et al 2009).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Claytor et al 2006

Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats.
Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733 · see citing works
Handbook of operant behavior
Turner, R. M. (1978) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(78)90073-3 · Cited by 2,269 · see citing works
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180 · see citing works
The dopamine hypothesis of the reinforcing properties of cocaine
Kuhar, M. J., Ritz, M. C., & Boja, J. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90141-g · Cited by 989 · see citing works
Handbook of Operant Behavior
Honig, W. K., & Staddon, J. E. R. (2022) · Routledge eBooks · doi:10.4324/9781003256670 · Cited by 970 · see citing works
Decreased dopamine D<sub>2</sub> receptor availability is associated with reduced frontal metabolism in cocaine abusers
Volkow, N. D., Fowler, J. S., Wang, G., Hitzemann, R., Logan, J., Schlyer, D. J., Dewey, S. L., & Wolf, A. P. (1993) · Synapse · doi:10.1002/syn.890140210 · Cited by 924 · see citing works
Selective inhibition of cocaine-seeking behaviour by a partial dopamine D3 receptor agonist
Pilla, M. A., Perachon, S., Sautel, F., Garrido, F., Mann, A., Wermuth, C. G., Schwartz, J.-C., Everitt, B. J., & Sokoloff, P. (1999) · Nature · doi:10.1038/22560 · Cited by 565 · see citing works
Goodman and Gillman's The Pharmacological Basis of Therapeutics
Bigby, J. A. (1992) · Archives of Dermatology · doi:10.1001/archderm.1992.01680110146030 · Cited by 507 · see citing works
Preclinical Evaluation of Pharmacotherapies for Treatment of Cocaine and Opioid Abuse Using Drug Self-Administration Procedures
Mello, N. K. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00274-h · Cited by 390 · see citing works
The D3 Dopamine Receptor: Neurobiology and Potential Clinical Relevance
Levant, B. (1997) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01327-9 · Cited by 385 · see citing works
Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.
Caine, S. B., & Koob, G. F. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22355-2 · Cited by 298 · see citing works
Pharmacological Actions of a Novel, High-Affinity, and Selective Human Dopamine D3 Receptor Antagonist, SB-277011-A
Reavill, C., Taylor, S. G., Wood, M. D., Ashmeade, T., Austin, N. E., Avenell, K. Y., Boyfield, I., Branch, C. L., Cilia, J., Coldwell, M. C., et al. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39184-0 · Cited by 287 · see citing works
Contemporary Research in Behavioral Pharmacology
(1978) · Springer eBooks · doi:10.1007/978-1-4613-3967-0 · Cited by 274 · see citing works
Role of dopamine D2-like receptors in cocaine self-administration: studies with D2 receptor mutant mice and novel D2 receptor antagonists
Caine, S. B., Negus, S. S., Mello, N. K., Patel, S., Bristow, L., Kulagowski, J., Vallone, D., Saiardi, A., & Borrelli, E. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-07-02977.2002 · Cited by 234 · see citing works
Intravenous self-administration of dopamine receptor agonists by rhesus monkeys.
Woolverton, W. L., Goldberg, L. I., & Ginos, J. Z. (1984) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)21719-0 · Cited by 204 · see citing works
Antagonism of cocaine self-administration by selective dopamine D1 and D2 antagonists
Bergman, J., Kamien, J. B., & Spealman, R. D. (1990) · Behavioural Pharmacology · doi:10.1097/00008877-199000140-00009 · Cited by 201 · see citing works
Dopamine D3 Receptor Partial Agonists and Antagonists as Potential Drug Abuse Therapeutic Agents
Newman, A. H., Grundt, P., & Nader, M. A. (2005) · Journal of Medicinal Chemistry · doi:10.1021/jm040190e · Cited by 191 · see citing works
Self-citation
Attenuation of Cue-Controlled Cocaine-Seeking by a Selective D3 Dopamine Receptor Antagonist SB-277011-A
Ciano, P. D., Underwood, R. J., Hagan, J. J., & Everitt, B. J. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300148 · Cited by 187 · see citing works
PET Imaging of Dopamine D2 Receptors in Monkey Models of Cocaine Abuse: Genetic Predisposition Versus Environmental Modulation
Nader, M. A., & Czoty, P. W. (2005) · American Journal of Psychiatry · doi:10.1176/appi.ajp.162.8.1473 · Cited by 177 · see citing works
Self-citation
Effects of Dopamine D1-like and D2-likeAgonists in Rats that Self-Administer Cocaine
Caine, S. B., Negus, S. S., Mello, N. K., & Bergman, J. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35108-0 · Cited by 153 · see citing works
Second-order schedules of drug self-administration in animals
Schindler, C. W., Panlilio, L. V., & Goldberg, S. R. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1157-4 · Cited by 147 · see citing works
Control of Hepatitis C: A Medicinal Chemistry Perspective
Gordon, C. P., & Keller, P. A. (2004) · Journal of Medicinal Chemistry · doi:10.1021/jm0400101 · Cited by 143 · see citing works
Effects of dopamine indirect agonists and selective D1-like and D2-like agonists and antagonists on cocaine self-administration and food maintained responding in rats
Barrett, A. C., Miller, J. R., Dohrmann, J. M., & Caine, S. B. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.07.007 · Cited by 134 · see citing works
Selective dopamine D3 receptor antagonism by SB‐277011A attenuates cocaine reinforcement as assessed by progressive‐ratio and variable‐cost–variable‐payoff fixed‐ratio cocaine self‐administration in rats
Xi, Z., Gilbert, J. G., Pak, A. C., Ashby, C. R., Heidbreder, C. A., & Gardner, E. L. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04159.x · Cited by 134 · see citing works
D3 receptor test in vitro predicts decreased cocaine self-administration in rats
Caine, S. B., Koob, G. F., Parsons, L. H., Everitt, B. J., Schwartz, J.-C., & Sokoloff, P. (1997) · Neuroreport · doi:10.1097/00001756-199707070-00054 · Cited by 130 · see citing works
The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food
Woolverton, W. L., & Virus, R. M. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90019-1 · Cited by 129 · see citing works
A Comparative In Vitro and In Vivo Pharmacological Characterization of the Novel Dopamine D3Receptor Antagonists (+)-S 14297, Nafadotride, GR 103,691 and U 99194
Audinot, V., Newman‐Tancredi, A., Gobert, A., Rivet, J., Brocco, M., Lejeune, F., Gluck, L., Desposte, I., Bervoets, K., Dekeyne, A., et al. (1998) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37778-x · Cited by 128 · see citing works
S33084, a Novel, Potent, Selective, and Competitive Antagonist at Dopamine D3-Receptors: II. Functional and Behavioral Profile Compared with GR218,231 and L741,626
Millan, M. J., Dekeyne, A., Rivet, J., Dubuffet, T., Lavielle, G., & Brocco, M. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39333-4 · Cited by 119 · see citing works
Differential distribution of D3 dopamine receptors in the brains of several mammalian species
Levant, B. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00529-0 · Cited by 107 · see citing works
Drugs as Reinforcers
Johanson, C. E. (1978) · Springer eBooks · doi:10.1007/978-1-4613-3967-0_7 · Cited by 102 · see citing works
Self-administration of the dopamine D3 agonist 7-OH-DPAT in rhesus monkeys is modified by prior cocaine exposure
Nader, M. A., & Mach, R. H. (1996) · Psychopharmacology · doi:10.1007/bf02247388 · Cited by 93 · see citing works
Self-citation
The effects of chronic buprenorphine treatment on cocaine and food self-administration by rhesus monkeys.
Mello, N. K., Lukas, S. E., Kamien, J. B., Mendelson, J. H., Drieze, J. M., & Cone, E. J. (1992) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)11427-4 · Cited by 71 · see citing works
Tardive and Withdrawal Dyskinesia Associated with Haloperidol
JACOBSON, G., Baldessarini, R. J., & Manschreck, T. C. (1974) · American Journal of Psychiatry · doi:10.1176/ajp.131.8.910 · Cited by 64 · see citing works
Reinforcing, subject-rated, and physiological effects of intranasal methylphenidate in humans: a dose–response analysis
Stoops, W. W., Glaser, P. E. A., & Rush, C. R. (2003) · Drug and Alcohol Dependence · doi:10.1016/s0376-8716(03)00131-5 · Cited by 56 · see citing works
The effects of benzamide analogues on cocaine self-administration in rhesus monkeys
Nader, M. A., Green-Jordan, K., Luedtke, R. R., & Mach, R. H. (1999) · Psychopharmacology · doi:10.1007/s002130051154 · Cited by 35 · see citing works
Self-citation
Effects of Phentermine on Responding Maintained under Multiple Fixed-Ratio Schedules of Food and Cocaine Presentation in the Rhesus Monkey
Wojnicki, F. H. E., Rothman, R. B., Rice, K. C., & Glowa, J. R. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)37989-3 · Cited by 35 · see citing works
Cocaine- and food-maintained responding under a multiple schedule in rhesus monkeys: environmental context and the effects of a dopamine antagonist
Nader, M. A., Sinnott, R. S., Mach, R. H., & Morgan, D. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1202-3 · Cited by 13 · see citing works
Self-citation
Pharmacological actions of a novel and selective dopamine D3 receptor antagonist, KCH-1110
Park, W. (2003) · Pharmacological Research · doi:10.1016/s1043-6618(03)00242-1 · Cited by 12 · see citing works

Flagged first, then by citations

1 of the 39 references couldn’t be matched to a known paper.

Sorted by citations

The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307 · see citing works
“Furthermore, if cocaine is administered with D2Rlike antagonists, it loses its reinforcing effects (Woolverton and Virus 1989; Bachtell et al. 2005; Claytor et al. 2006; Peng et al. 2009).”
Effects of Two Novel D3-Selective Compounds, NGB 2904 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-9 H-fluorene-2-carboxamide] and CJB 090 [N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-4-(pyridin-2-yl)benzamide], on the Reinforcing and Discriminative Stimulus Effects of Cocaine in Rhesus Monkeys
Martelle, J. L., Claytor, R., Ross, J. T., Reboussin, B. A., Newman, A. H., & Nader, M. A. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.113571 · Cited by 63 · see citing works
Self-citation
Tranylcypromine Substituted cis -Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D3 Receptor Antagonists
Chen, J., Levant, B., Jiang, C., Keck, T. M., Newman, A. H., & Wang, S. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm401798r · Cited by 59 · see citing works
Dopaminergic mechanism of reward-related incentive learning: Focus on the dopamine d3 receptor
Beninger, R. J., & Banasikowski, T. J. (2008) · Neurotoxicity Research · doi:10.1007/bf03033575 · Cited by 52 · see citing works
Dopamine D1 and D3 receptor polypharmacology as a potential treatment approach for substance use disorder
Galaj, E., Ewing, S., & Ranaldi, R. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.03.020 · Cited by 47 · see citing works
Effects of Chronic Buspirone Treatment on Cocaine Self-Administration
Mello, N. K., Fivel, P. A., Kohut, S. J., & Bergman, J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.202 · Cited by 44 · see citing works
Effects of Oral and Intravenous Administration of Buspirone on Food–Cocaine Choice in Socially Housed Male Cynomolgus Monkeys
Czoty, P. W., & Nader, M. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.300 · Cited by 33 · see citing works
Self-citation
Reduction of Cocaine Self-Administration and D3 Receptor-Mediated Behavior by Two Novel Dopamine D3 Receptor-Selective Partial Agonists, OS-3-106 and WW-III-55
Cheung, T. H. C., Loriaux, A. L., Weber, S. M., Chandler, K. N., Lenz, J. D., Schaan, R. F., Mach, R. H., Luedtke, R. R., & Neisewander, J. L. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.112.202911 · Cited by 25 · see citing works
Effects of Acute and Chronic Treatments with Dopamine D2 and D3 Receptor Ligands on Cocaine versus Food Choice in Rats
Thomsen, M., Barrett, A. C., Butler, P., Negus, S. S., & Caine, S. B. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.241141 · Cited by 25 · see citing works
Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys
John, W. S., Newman, A. H., & Nader, M. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.024 · Cited by 22 · see citing works
Self-citation
Double Dissociation of the Effects of Haloperidol and the Dopamine D3 Receptor Antagonist ABT-127 on Acquisition vs. Expression of Cocaine-Conditioned Activity in Rats
Banasikowski, T. J., Bespalov, A., Drescher, K. U., Behl, B., Unger, L., Haupt, A., Schoemaker, H., Sullivan, J. P., Gross, G., & Beninger, R. J. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.171348 · Cited by 20 · see citing works
Nicotine and cocaine self-administration using a multiple schedule of intravenous drug and sucrose reinforcement in rats
Stairs, D. J., Neugebauer‎, N. M., & Bardo, M. T. (2010) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32833a5c9e · Cited by 17 · see citing works
Novel family of fused tricyclic [1,4]diazepines: Design, synthesis, crystal structures and molecular docking studies
Adamski, A., Kruszka, D., Dutkiewicz, Z., Kubicki, M., Gorczyński, A., & Patroniak, V. (2017) · Tetrahedron · doi:10.1016/j.tet.2017.05.015 · Cited by 16 · see citing works
Long-term cocaine self-administration under fixed–ratio and second-order schedules in monkeys
Czoty, P. W., Reboussin, B. A., Calhoun, T., Nader, S. H., & Nader, M. A. (2007) · Psychopharmacology · doi:10.1007/s00213-006-0665-z · Cited by 13 · see citing works
Self-citation
Molecular Docking Studies of Methamphetamine and Amphetamine- Related Derivatives as an Inhibitor against Dopamine Receptor
Foroughi, K., Khaksari, M., & Shayannia, A. (2018) · Current Computer - Aided Drug Design · doi:10.2174/1573409915666181204144411 · Cited by 5 · see citing works
Differential effects of the dopamine D 3 receptor antagonist PG01037 on cocaine and methamphetamine self‐administration in rhesus monkeys
John, W. S., Newman, A. H., & Nader, M. A. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.930.5 · Cited by 1 · see citing works
Self-citation
Dopamine D2 Receptor Priming Enhances Dopaminergic Response to Amphetamine in the Nucleus Accumbens: Role of the D1 and D2 Receptors.
Huggins, K. N. (2009) · Digital Commons - East Tennessee State University (East Tennessee State University)
The Role of Dopamine D3 Receptors in Cocaine-Related Behavior
Galaj, E., & Ranaldi, R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803750-8.00046-4
Mécanismes de compensation dans la maladie de Parkinson : approches comportementale, pharmacologique, de neuro-imagerie et immunohistochimique chez le singe intoxiqué au MPTP après récupération des symptômes moteurs
Neumane, S. (2011) · doi:10.70675/4cb9b747z6b13z46eazb3cbzb58a8bffabf2
BindingDB Entry 50044411: Tranylcypromine substituted cis-hydroxycyclobutylnaphthamides as potent and selective dopamine D3 receptor antagonists.
BindingDB (2015) · UC San Diego · doi:10.7270/q2bv7j5v

The effects of benzamide analogues on cocaine self-administration in rhesus monkeys
Nader, M. A., Green-Jordan, K., Luedtke, R. R., & Mach, R. H. (1999) · Psychopharmacology · doi:10.1007/s002130051154 · Cited by 35 · see citing works
Self-citation
Effects of drugs on food- and cocaine-maintained responding
Wojnicki, F. H. E., & Glowa, J. R. (1996) · Psychopharmacology · doi:10.1007/s002130050144 · Cited by 29 · see citing works
Dopamine D3 and D2 Receptor Mechanisms in the Abuse-Related Behavioral Effects of Cocaine: Studies with Preferential Antagonists in Squirrel Monkeys
Achat‐Mendes, C., Grundt, P., Cao, J., Platt, D. M., Newman, A. H., & Spealman, R. D. (2010) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.110.167619 · Cited by 54 · see citing works
The effects of a D1 and a D2 dopamine antagonist on behavior maintained by cocaine or food
Woolverton, W. L., & Virus, R. M. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90019-1 · Cited by 129 · see citing works
Differential effects of the dopamine D3 receptor antagonist PG01037 on cocaine and methamphetamine self-administration in rhesus monkeys
John, W. S., Newman, A. H., & Nader, M. A. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.024 · Cited by 22 · see citing works
Self-citation

Authors: Claytor, R., Lile, J. A., & Nader, M. A.
Affiliations: Wake Forest University Health Sciences (US)
ORCID: Lile, Joshua A.
Nader, Michael A.
Venue: Pharmacology Biochemistry and Behavior
Publisher: Elsevier BV
Published: 2006-03
Volume: 83
Issue: 3
Pages: 456-464
ISSN: 0091-3057 (ISSN-L)
DOI: 10.1016/j.pbb.2006.03.007
OpenAlex: W2020665253
Cited by: 19
References: 39
Citations by year: 2018: 2 · 2017: 3 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
FWCI: 0.51
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology Biochemistry and Behavior (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Drug Abuse (DA-12460, DA16455, R01DA016455, R01DA012460)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords: eticlopride, dopamine D3 receptor antagonist, cocaine self-administration, food reinforcement, cocaine reinforcement, fixed-interval schedules, second-order schedules, rhesus monkeys, cocaine dependence
MeSH terms: Animals, Behavior, Animal, Cocaine, Food, Indans, Macaca mulatta, Male, Reinforcement, Psychology, Reinforcement Schedule, Salicylamides, Self Administration, Dopamine Antagonists, Receptors, Dopamine D3, Dopamine D2 Receptor Antagonists

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The effects of eticlopride and the selective D3-antagonist PNU 99194-A on food- and cocaine-maintained responding in rhesus monkeys

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks