Cited by 75Neurotransmitter Receptor Influence on BehaviorRegulation of Appetite and ObesityNeural and Behavioral Psychology Studies

Impairment of acquisition of cocaine self-administration in rats maintained on a high-fat diet

Open access
WELLMAN, P, NATION, J, DAVIS, K·2007·Pharmacology Biochemistry and Behavior

Abstract

Variations in dietary constituents such as carbohydrate are known to alter psychostimulant function in brain. Relatively few studies have examined the reinforcing effects of psychostimulants in subjects maintained on high-fat diets. The present experiment compared the rate of acquisition of an operant response for intravenous (i.v.) cocaine infusions (0.2 mg/kg) in rats fed either a chow-pellet diet or a 35.9% (by weight) high-fat diet for 45 days prior to cocaine self-administration testing. Rats maintained on a high-fat diet for 45 days exhibited diminished acquisition of cocaine self-administration, and this effect was not a function of dietary-induced obesity. The results suggest that prolonged exposure to a high-fat diet diminishes the efficacy of cocaine reinforcement.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.pbb.2007.07.008

Cites

28 of 28 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Animal models of obesity show attenuated responses to drug rewards.

    “findings of attenuated responses to drug rewards in animal models of obesity (33,34).”

    From Obesity and addiction: Neurobiological overlaps (2013) · cites this paper as [34]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Anonymous . Nutrient Requirements of Laboratory Animals. Institute foe Laboratory Animal Research; 1995. [Google Scholar]

Cited by

Sorted by citations

Authors
WELLMAN, P., NATION, J., & DAVIS, K.
Affiliations
Texas A&M University (US)
Corresponding author
WELLMAN, P
Venue
Pharmacology Biochemistry and Behavior
Publisher
Elsevier BV
Published
2007-11
Volume
88
Issue
1
Pages
89-93
ISSN
0091-3057 (ISSN-L)
OpenAlex
W2080823637
Cited by
75
References
28
Citations by year
2025: 3 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 4 · 2018: 2 · 2017: 7 · 2016: 4 · 2015: 6 · 2014: 5 · 2013: 9 · 2012: 4
FWCI
1.59
Type
journal article
Language
en
Open access
Locations
  • Pharmacology Biochemistry and Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institute of Mental Health (MH65728, T32MH065728)
  • National Institute on Drug Abuse (R21DA017230, DA017230, R01DA013188, DA 13188)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
cocaine self-administration, high-fat diet, acquisitions, cocaine reinforcement, psychostimulants, diet-induced obesity, dietary carbohydrates
MeSH terms
Animals, Conditioning, Operant, Diet, Dietary Fats, Male, Reinforcement, Psychology, Self Administration, Weight Gain, Substance Abuse, Intravenous, Rats, Sprague-Dawley, Cocaine-Related Disorders, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review