Physical exercise down-regulated locomotor side effects induced by haloperidol treatment in Wistar rats.
Abstract
Extra-pyramidal symptoms (EPS) such as akinesia, dystonia, gait alteration and tremors are observed when dopamine D2-receptors are blocked by pharmacological agents such as haloperidol. These alterations produce a Parkinson disease-like state (PLS). Physical exercise has been proven to improve gait and locomotor symptoms in Parkinson's disease; we sought to elucidate the effects of physical exercise on PLS induced by chronic administration of haloperidol in rats. We used 48 rats distributed into four groups: Control, Exercise, Haloperidol, and Hal+Exe. All the animals received a daily injection of saline or haloperidol for 30 days, and the exercise groups underwent a daily 30-minute exercise protocol for 20 days. The animals were subjected to the ink-paw test, bar test and open-field test throughout the training period. The haloperidol-induced akinesia increased throughout the days of injections, but exercise was shown to alleviate it. The assessment showed shortened stride length and increased stance width with the use of haloperidol, which were significantly alleviated by exercise. These results indicate that exercise could be an interesting approach towards reducing unwanted EPS caused by haloperidol.
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Recent animal studies have demonstrated that AE ameliorates the metabolic, lipid peroxidation and extrapyramidal side effects of antipsychotic medication.
“Some evidence of this can be drawn from recent animal studies that have demonstrated that AE ameliorates the metabolic, lipid peroxidation and extrapyramidal side effects of antipsychotic medication (Czéh et al., 2007; Teixeira et al., 2011; Baptista et al., 2013; Boyda et al., 2014).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Baptista et al., 2013
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- Authors
- Baptista, P. P. A., de Senna, P. N., Paim, M. F., Saur, L., Blank, M., do Nascimento, P., Ilha, J., Vianna, M. R. M., Mestriner, R. G., Achaval, M., & Xavier, L. L.
- Affiliations
- Pontifícia Universidade Católica do Rio Grande do Sul (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- Corresponding author
- Baptista, Pedro Porto Alegre
- ORCID
- Venue
- Pharmacology Biochemistry and Behavior
- Publisher
- Elsevier BV
- Published
- 2013-03
- Volume
- 104
- Pages
- 113-118
- ISSN
- 0091-3057 (ISSN-L)
- OpenAlex
- W2004520587
- Cited by
- 23
- References
- 42
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2021: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 3 · 2013: 2
- FWCI
- 2.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology Biochemistry and Behavior (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- physical activity, haloperidol, extrapyramidal symptoms, akinesia, dopamine D2 receptor blockade, gait, stride length, stance width, antipsychotic adverse effects
- MeSH terms
- Animals, Behavior, Animal, Disease Models, Animal, Exploratory Behavior, Haloperidol, Lameness, Animal, Locomotion, Male, Physical Conditioning, Animal, Rats, Wistar, Dopamine Antagonists, Rats
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