Diagnosis and Treatment of Heart Disease: Are Women Different From Men?

Xhyheri, Borejda; Bugiardini, Raffaele

doi:10.1016/j.pcad.2010.07.004

Cited by 56Sex and Gender in HealthcareAcute Myocardial Infarction ResearchCoronary Interventions and Diagnostics

Diagnosis and Treatment of Heart Disease: Are Women Different From Men?

Xhyheri, Borejda, Bugiardini, Raffaele·2010·Progress in Cardiovascular Diseases

DOI 10.1016/j.pcad.2010.07.004

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Abstract

Key questions concerning strategies for diagnosis, prevention, and treatment of heart disease in women remain unanswered. Thrombolytic therapy has been shown to reduce mortality similarly in men and women. In addition, percutaneous coronary intervention for acute coronary syndromes is as effective in women as in men. However, after hospital discharge, medical treatment carries different benefits in men and women. Aspirin has not been definitively proven to prevent cardiovascular events in women. Men and women respond differently to statins. Men may experience a greater benefit than women from angiotensin-converting enzyme inhibitors. β-Blockers substantially improve survival in women, with possibly a greater benefit than in men. Clopidogrel appears to be equally effective in reducing cardiovascular events in both men and women. Our report will review current knowledge supporting sex differences in the diagnosis and treatment of ischemic heart disease. A clear definition of the state of the science, with recognition of the shortcomings of current data, is necessary to guide future research and move the field forward.

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Coronary heart disease is the leading cause of death among women.
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Authors: Xhyheri, B., & Bugiardini, R.
Affiliations: University of Bologna (IT)
Corresponding author: Bugiardini, Raffaele
ORCID: Bugiardini, Raffaele
Venue: Progress in Cardiovascular Diseases
Publisher: Elsevier BV
Published: 2010-11
Volume: 53
Issue: 3
Pages: 227-236
ISSN: 0033-0620 (ISSN-L)
DOI: 10.1016/j.pcad.2010.07.004
OpenAlex: W1978594384
Cited by: 56
References: 180
Citations by year: 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 6 · 2013: 8 · 2012: 8
FWCI: 0.97
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Cardiovascular Diseases (publishedVersion)
PubMed (publishedVersion)
Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion)
Topics: Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Sex and Gender in Healthcare
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Health Sciences › Medicine › Surgery › Coronary Interventions and Diagnostics
Keywords: sex differences, ischemic heart disease, women, thrombolysis, percutaneous coronary intervention, acute coronary syndrome, aspirin, statins, ACE inhibitors, beta-blockers, clopidogrel, cardiovascular disease prevention
MeSH terms: Adrenergic beta-Antagonists, Angiotensin-Converting Enzyme Inhibitors, Attitude of Health Personnel, Delivery of Health Care, Female, Heart Function Tests, Humans, Health Knowledge, Attitudes, Practice, Male, Platelet Aggregation Inhibitors, Predictive Value of Tests, Sex Factors, Women's Health, Myocardial Ischemia, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Evidence-Based Medicine, Health Status Disparities, Healthcare Disparities

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Diagnosis and Treatment of Heart Disease: Are Women Different From Men?

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