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Cited by 69Autism Spectrum Disorder ResearchSystemic Lupus Erythematosus ResearchAutoimmune Neurological Disorders and Treatments

The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.

Serum Anti-Nuclear Antibodies as a Marker of Autoimmunity in Egyptian Autistic Children

Mostafa, Gehan A., Kitchener, Nabil·2009·Pediatric Neurology
DOI 10.1016/j.pediatrneurol.2008.10.017
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Abstract

Autism may involve an autoimmune pathogenesis in a subgroup of patients. The frequency of anti-nuclear antibodies in 80 autistic children and their relationship to a family history of autoimmunity were studied, compared with 80 healthy, matched children. Children with autism had a significantly higher percent seropositivity of anti-nuclear antibodies (20%) than healthy children (2.5%; P < 0.01). Fifty percent of anti-nuclear antibody-seropositive autistic children had an anti-nuclear antibody titer of > or =1:640 (very high positive); 25%, > or =1:160 (high positive); and the remaining 25%, 1:80. All anti-nuclear antibody-seropositive healthy children had anti-nuclear antibody titers of 1:80. A family history of autoimmunity was significantly higher in autistic children (47.5%) than healthy controls (8.8%; P < 0.001). Anti-nuclear antibody seropositivity was significantly higher in autistic children with a family history of autoimmunity than those without such history (36.8% and 5%, respectively; P < 0.001). Anti-nuclear antibody seropositivity had significant positive associations with disease severity, mental retardation and electroencephalogram abnormalities. Autoimmunity may play a role in a subgroup of children with autism. Further studies are warranted to assess anti-nuclear antibody seropositivity, other markers of autoimmunity (e.g., brain-specific autoantibodies), and the role of immunotherapy in children with autism.

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Crossref · 10.1016/j.pediatrneurol.2008.10.017

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Metadata

Authors
Mostafa, G. A., & Kitchener, N.
Affiliations
Ain Shams University (EG)
Corresponding author
Mostafa, Gehan A.
ORCID
Kitchener, Nabil
Venue
Pediatric Neurology
Publisher
Elsevier BV
Published
2009-02
Volume
40
Issue
2
Pages
107-112
ISSN
0887-8994 (ISSN-L)
DOI
10.1016/j.pediatrneurol.2008.10.017
OpenAlex
W2066187663
Cited by
69
References
34
Citations by year
2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 9
FWCI
4.19
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Pediatric Neurology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
Keywords
autism spectrum disorder, antinuclear antibodies, autoimmunity, autoimmune disease pathogenesis, seroprevalence, disease severity, intellectual disability, EEG abnormalities, immunotherapy
MeSH terms
Antibodies, Antinuclear, Autistic Disorder, Child, Child, Preschool, Egypt, Electroencephalography, Family, Female, Humans, Male, Intellectual Disability, Biomarkers, Autoimmunity

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