The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Serum Anti-Nuclear Antibodies as a Marker of Autoimmunity in Egyptian Autistic Children
Abstract
Autism may involve an autoimmune pathogenesis in a subgroup of patients. The frequency of anti-nuclear antibodies in 80 autistic children and their relationship to a family history of autoimmunity were studied, compared with 80 healthy, matched children. Children with autism had a significantly higher percent seropositivity of anti-nuclear antibodies (20%) than healthy children (2.5%; P < 0.01). Fifty percent of anti-nuclear antibody-seropositive autistic children had an anti-nuclear antibody titer of > or =1:640 (very high positive); 25%, > or =1:160 (high positive); and the remaining 25%, 1:80. All anti-nuclear antibody-seropositive healthy children had anti-nuclear antibody titers of 1:80. A family history of autoimmunity was significantly higher in autistic children (47.5%) than healthy controls (8.8%; P < 0.001). Anti-nuclear antibody seropositivity was significantly higher in autistic children with a family history of autoimmunity than those without such history (36.8% and 5%, respectively; P < 0.001). Anti-nuclear antibody seropositivity had significant positive associations with disease severity, mental retardation and electroencephalogram abnormalities. Autoimmunity may play a role in a subgroup of children with autism. Further studies are warranted to assess anti-nuclear antibody seropositivity, other markers of autoimmunity (e.g., brain-specific autoantibodies), and the role of immunotherapy in children with autism.
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In the citing paper
“Mostafa and Al-Ayadi reported significantly higher proportion of children with ASD having anti-MAG antiautoantibodies, anti-ganglioside M1, anti-neuronal and anti-nuclear antibodies than typically developing controls, that positively correlated with the severity of autism symptoms (CARS scores) [109,165,166,167].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [166]
In the citing paper
“Family history of autoimmune diseases was reported to be higher in children with ASD than controls [166,168].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [166]
In the citing paper
“Mostafa and Al-Ayadi reported significantly higher proportion of children with ASD having anti-MAG antiautoantibodies, anti-ganglioside M1, anti-neuronal and anti-nuclear antibodies than typically developing controls, that positively correlated with the severity of autism symptoms (CARS scores) [109,165,166,167].”
From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [166]
Citations
Cites
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Range of antinuclear antibodies in “healthy” individuals
Tan, E. M., Feltkamp, T. E. W., Smolen, J. S., Butcher, B., Dawkins, R., Fritzler, M. J., Gordon, T., Hardin, J. A., Kalden, J. R., Lahita, R. G., et al. (1997) · Arthritis & Rheumatism · doi:10.1002/art.1780400909 · Cited by 702
Familial Clustering of Autoimmune Disorders and Evaluation of Medical Risk Factors in Autism
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Mostafa, G. A., & AL-Ayadhi, L. Y. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-201 · Cited by 168
Self-citationAutoantibodies to cerebellum in children with autism associate with behavior
Goines, P., Haapanen, L., Boyce, R., Duncanson, P., Braunschweig, D., Delwiche, L., Hansen, R., Hertz-Picciotto, I., Ashwood, P., & Van de Water, J. (2011) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2010.11.017 · Cited by 134
Mostafa, G. A., Al Shehab, A., & Fouad, N. R. (2010) · Journal of Child Neurology · doi:10.1177/0883073809339393 · Cited by 105
Self-citationVitamin D and Autism Spectrum Disorder: A Literature Review
Mazahery, H., Camargo, C., Conlon, C., Beck, K., Kruger, M., & Von Hurst, P. (2016) · Nutrients · doi:10.3390/nu8040236 · Cited by 110
Oxidative stress in egyptian children with autism: Relation to autoimmunity
Mostafa, G. A., El-Hadidi, E. S., Hewedi, D. H., & Abdou, M. M. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.12.003 · Cited by 101
Self-citationFrye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96
Mostafa, G. A., & AL-ayadhi, L. Y. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-39 · Cited by 85
Self-citationVogel Ciernia, A., Careaga, M., LaSalle, J. M., & Ashwood, P. (2018) · Glia · doi:10.1002/glia.23261 · Cited by 69
Intravenous immunoglobulin for the treatment of autoimmune encephalopathy in children with autism
Connery, K., Tippett, M., Delhey, L. M., Rose, S., Slattery, J. C., Kahler, S. G., Hahn, J., Kruger, U., Cunningham, M. W., Shimasaki, C., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0214-7 · Cited by 64
Mostafa, G. A., & Al-Ayadhi, L. Y. (2012) · European Journal of Paediatric Neurology · doi:10.1016/j.ejpn.2011.12.010 · Cited by 64
Self-citation
Metadata
- Authors
- Mostafa, G. A., & Kitchener, N.
- Affiliations
- Ain Shams University (EG)
- Corresponding author
- Mostafa, Gehan A.
- ORCID
- Kitchener, Nabil
- Venue
- Pediatric Neurology
- Publisher
- Elsevier BV
- Published
- 2009-02
- Volume
- 40
- Issue
- 2
- Pages
- 107-112
- ISSN
- 0887-8994 (ISSN-L)
- OpenAlex
- W2066187663
- Cited by
- 69
- References
- 34
- Citations by year
- 2024: 2 · 2023: 2 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 3 · 2015: 9 · 2014: 7 · 2013: 6 · 2012: 9
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pediatric Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Clinical Neurology › Autoimmune Neurological Disorders and Treatments
- Keywords
- autism spectrum disorder, antinuclear antibodies, autoimmunity, autoimmune disease pathogenesis, seroprevalence, disease severity, intellectual disability, EEG abnormalities, immunotherapy
- MeSH terms
- Antibodies, Antinuclear, Autistic Disorder, Child, Child, Preschool, Egypt, Electroencephalography, Family, Female, Humans, Male, Intellectual Disability, Biomarkers, Autoimmunity
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