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Cited by 101Autism Spectrum Disorder ResearchAntioxidant Activity and Oxidative StressChild Nutrition and Feeding Issues

Oxidative stress in egyptian children with autism: Relation to autoimmunity

Mostafa, Gehan A., El-Hadidi, Eman S., Hewedi, Doaa H., Abdou, Mohammed M.·2010·Journal of Neuroimmunology
DOI 10.1016/j.jneuroim.2009.12.003
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Abstract

Unlabelled We are the first to study the relationship between oxidative stress (by measuring plasma F2-isoprostane, as a marker of lipid peroxidation, and glutathione peroxidase, as an antioxidant enzyme) and autoimmunity (as indicated by serum antineuronal antibodies) in a group of 44 Egyptian autistic children and 44 healthy matched-children. Our results showed that oxidative stress was found in 88.64% of autistic children. Oxidative stress, resulting from elevated plasma F2-isoprostane and/or reduced glutathione peroxidase, had significant risk for antineuronal positivity, which was found in 54.5% of autistic children, (odds ratio: 12.38 and 6.43, respectively, confidence interval: 1.37-112.10 and 1.21-34.19, respectively).Conclusions the strong association between oxidative stress and autoimmunity in autistic children may indicate the possible role of oxidative stress, through induction of autoimmunity, in some autistic patients. Therefore, studies considering the role of antioxidants and immunotherapy in amelioration of autistic manifestations are recommended.

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Crossref · 10.1016/j.jneuroim.2009.12.003

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  • Oxidative stress and reduced redox/antioxidant capacity in peripheral tissue are associated with anti-neuronal positivity.

    “Oxidative stress and reduced redox/antioxidant capacity in cerebellum and temporal cortex have been shown to have functional consequences for chronic inflammatory response, mitochondrial dysfunction and protein and DNA damage [3], and in peripheral tissue have been associated with anti-neuronal positivity [16] and clinical features of autism [15].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [16]

  • Children with ASD have lower levels of total glutathione and glutathione peroxidase than typically developing children.

    “Recent evidence shows that children with ASD have lower levels of total glutathion and glutathione peroxidase (an enzyme involved in antioxidant defense and detoxification), higher levels of oxidised glutathione and F2—isoprostane (a marker of oxidative stress and lipid peroxidation) and reduced capacity for methylation than typically developing children [16,153].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [16]

  • Children with ASD have higher levels of oxidised glutathione and F2-isoprostane than typically developing children.

    “Recent evidence shows that children with ASD have lower levels of total glutathion and glutathione peroxidase (an enzyme involved in antioxidant defense and detoxification), higher levels of oxidised glutathione and F2—isoprostane (a marker of oxidative stress and lipid peroxidation) and reduced capacity for methylation than typically developing children [16,153].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [16]

  • Several lines of evidence indicate oxidative stress and mitochondrial dysfunction are prevalent in individuals with ASD.

    “There are presently several lines of evidence indicating oxidative stress and mitochondrial dysfunction are prevalent in individuals with ASD [3,10,11,12,13,14,15,16].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [16]

  • Children with ASD have reduced capacity for methylation than typically developing children.

    “Recent evidence shows that children with ASD have lower levels of total glutathion and glutathione peroxidase (an enzyme involved in antioxidant defense and detoxification), higher levels of oxidised glutathione and F2—isoprostane (a marker of oxidative stress and lipid peroxidation) and reduced capacity for methylation than typically developing children [16,153].”

    From Vitamin D and Autism Spectrum Disorder: A Literature Review (2016) · cites this paper as [16]

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Authors
Mostafa, G. A., El-Hadidi, E. S., Hewedi, D. H., & Abdou, M. M.
Affiliations
Ain Shams University (EG)
Corresponding author
Mostafa, Gehan A.
ORCID
Abdou, Mohammed M.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2010-02
Volume
219
Issue
1-2
Pages
114-118
ISSN
0165-5728 (ISSN-L)
DOI
10.1016/j.jneuroim.2009.12.003
OpenAlex
W2008578046
Cited by
101
References
43
Citations by year
2025: 1 · 2024: 2 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 7 · 2019: 1 · 2018: 3 · 2017: 3 · 2016: 10 · 2015: 10 · 2014: 11 · 2013: 12 · 2012: 12
FWCI
5.10
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
  • Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
Keywords
oxidative stress, autism spectrum disorder, children, autoimmunity, F2-isoprostanes, lipid peroxidation, glutathione peroxidase, antineuronal antibodies, antioxidants, immunotherapy
MeSH terms
Antibodies, Autistic Disorder, Child, Child, Preschool, Egypt, Female, Glutathione, Glutathione Peroxidase, Humans, Male, Autoimmunity, Confidence Intervals, Case-Control Studies, Oxidative Stress, Statistics, Nonparametric, F2-Isoprostanes

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