The DOI matches its Crossref record; 243 of the 245 references it cites were found in a registry or an index.
Behavioral effects of neuropeptides in rodent models of depression and anxiety
Abstract
In recent years, studies have advocated neuropeptide systems as modulators for the behavioral states found in mood disorders such as depression and anxiety disorders. Neuropeptides have been tested in traditional animal models and screening procedures that have been validated by known antidepressants and anxiolytics. However, it has become clear that although these tests are very useful, neuropeptides have distinct behavioral effects and dose-dependent characteristics, and therefore, use of these tests with neuropeptides must be done with an understanding of their unique characteristics. This review will focus on the behavioral actions of neuropeptides and their synthetic analogs, particularly in studies utilizing various preclinical tests of depression and anxiety. Specifically, the following neuropeptide systems will be reviewed: corticotropin-releasing factor (CRF), urocortin (Ucn), teneurin C-terminal associated peptide (TCAP), neuropeptide Y (NPY), arginine vasopressin (AVP), oxytocin, the Tyr-MIF-1 family, cholecystokinin (CCK), galanin, and substance P. These neuropeptide systems each have a unique role in the regulation of stress-like behavior, and therefore provide intriguing therapeutic targets for mood disorder treatment.
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“Preclinical studies demonstrated that exogenous intravenous and intranasal oxytocin can influence fear related responses in rodents and monkeys respectively, reducing hiding behaviour during an open field test and attentional bias towards threatening facial expressions (Parr et al., 2013;Rotzinger et al., 2010).”
From Meta-analytic review of the effects of a single dose of intranasal oxytocin on threat processing in humans (2018) · cites this paper as Rotzinger et al., 2010
Citations
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The Effects of Psychological Stress on Depression
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Metadata
- Authors
- Rotzinger, S., Lovejoy, D. A., & Tan, L. A.
- Affiliations
- University of Toronto (CA)
- Corresponding author
- Tan, Laura A.
- Venue
- Peptides
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 31
- Issue
- 4
- Pages
- 736-756
- ISSN
- 0196-9781 (ISSN-L)
- OpenAlex
- W2087834131
- Cited by
- 211
- References
- 245
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 21 · 2013: 24 · 2012: 27
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Peptides (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (FRN 72027622)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- neuropeptides, depression, anxiety, mood disorders, corticotropin-releasing factor, urocortin, neuropeptide Y, vasopressin, oxytocin, cholecystokinin, galanin, substance P, antidepressant screening, rodent models, therapeutic target
- MeSH terms
- Animals, Anxiety, Arginine Vasopressin, Behavior, Animal, Cholecystokinin, Corticotropin-Releasing Hormone, Depression, Disease Models, Animal, Humans, MSH Release-Inhibiting Hormone, Neuropeptide Y, Neuropeptides, Neuropsychological Tests, Oxytocin, Social Behavior, Galanin, Urocortins
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