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The Role of Oxytocin in Psychiatric Disorders: A Review of Biological and Therapeutic Research Findings

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Cochran, David M., Fallon, Daniel, Hill, Michael, Frazier, Jean A.·2013·Harvard Review of Psychiatry
DOI 10.1097/hrp.0b013e3182a75b7dPMC PMC4120070
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Abstract

Learning Objectives: After participating in this educational activity, the physician should be better able to Oxytocin is a peptide hormone integral in parturition, milk letdown, and maternal behaviors that has been demonstrated in animal studies to be important in the formation of pair bonds and in social behaviors. This hormone is increasingly recognized as an important regulator of human social behaviors, including social decision making, evaluating and responding to social stimuli, mediating social interactions, and forming social memories. In addition, oxytocin is intricately involved in a broad array of neuropsychiatric functions and may be a common factor important in multiple psychiatric disorders such as autism, schizophrenia, and mood and anxiety disorders. This review article examines the extant literature on the evidence for oxytocin dysfunction in a variety of psychiatric disorders and highlights the need for further research to understand the complex role of the oxytocin system in psychiatric disease and thus pave the way for developing new therapeutic modalities. Articles were selected that involved human participants with various psychiatric disorders and that either compared oxytocin biology to healthy controls or examined the effects of exogenous oxytocin administration.

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  • OXT influences processes implicated in disorders characterized by social deficits, such as major depressive disorder, posttraumatic stress disorder, ADS, and schizophrenia.

    “Studies indicate that OXT influences processes implicated in disorders characterized by social deficits, such as major depressive disorder, posttraumatic stress disorder, ADS, and schizophrenia (Cochran et al., 2013; Sippel et al., 2017).”

    From Convergence of oxytocin and dopamine signalling in neuronal circuits: Insights into the neurobiology of social interactions across species (2024) · cites this paper as Cochran et al., 2013

    The Introduction and Clinical Implications and Limitations sections link oxytocin to social functioning in autism (ASD), schizophrenia, and depression. The Anxiety Disorders section also reports a preliminary oxytocin study in people with PTSD, but it measures responses to combat imagery rather than social deficits. The source therefore does not support characterizing PTSD as a disorder with social deficits in this context; it also uses “ASD,” not “ADS.” (LLM, conf=0.82)

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Authors
Cochran, D. M., Fallon, D., Hill, M., & Frazier, J. A.
Affiliations
University of Massachusetts Chan Medical School (US)
Corresponding author
Cochran, David M.
ORCID
Venue
Harvard Review of Psychiatry
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2013-09
Volume
21
Issue
5
Pages
219-247
ISSN
1067-3229 (ISSN-L)
DOI
10.1097/hrp.0b013e3182a75b7d
PMC
PMC4120070
OpenAlex
W2068471892
Cited by
267
References
34
Citations by year
2026: 10 · 2025: 12 · 2024: 20 · 2023: 20 · 2022: 26 · 2021: 32 · 2020: 23 · 2019: 24 · 2018: 28 · 2017: 23 · 2016: 21 · 2015: 23 · 2014: 4
FWCI
2.10
Type
journal article
Language
en
Open access
Locations
  • Harvard Review of Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • eScholarship@UMassChan (submittedVersion)
Funders
Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD004147)
Topics
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
oxytocin, mental illness, social behavior, pair bonding, attachment, autism spectrum disorder, schizophrenia, mood disorders, anxiety disorders, oxytocin therapy, social memory, social decision-making
MeSH terms
Mental Disorders, Humans, Interpersonal Relations, Oxytocics, Oxytocin, Psychopathology, Psychotropic Drugs, Social Behavior, Randomized Controlled Trials as Topic, Emotional Intelligence, Epigenomics

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