The DOI matches its Crossref record; 305 of the 306 references it cites were found in a registry or an index.
Cannabis and adolescent brain development.
Abstract
Heavy cannabis use has been frequently associated with increased rates of mental illness and cognitive impairment, particularly amongst adolescent users. However, the neurobiological processes that underlie these associations are still not well understood. In this review, we discuss the findings of studies examining the acute and chronic effects of cannabis use on the brain, with a particular focus on the impact of commencing use during adolescence. Accumulating evidence from both animal and human studies suggests that regular heavy use during this period is associated with more severe and persistent negative outcomes than use during adulthood, suggesting that the adolescent brain may be particularly vulnerable to the effects of cannabis exposure. As the endocannabinoid system plays an important role in brain development, it is plausible that prolonged use during adolescence results in a disruption in the normative neuromaturational processes that occur during this period. We identify synaptic pruning and white matter development as two processes that may be adversely impacted by cannabis exposure during adolescence. Potentially, alterations in these processes may underlie the cognitive and emotional deficits that have been associated with regular use commencing during adolescence.
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“Further, other longitudinal studies argue against the strength or persistence of deficits over shorter periods, 17,20 especially in studies where abstinence was carefully monitored.101”
From Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis (2018) · cites this paper as [20]
Citations
Cites
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Persistent cannabis users show neuropsychological decline from childhood to midlife
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“Of interest in this regard is a recent large-scale longitudinal study by Meier et al. (2012) that followed 1037 participants from birth to adult-hood, assessing neuropsychological functioning at multiple time points betweentheagesof7and13years(priortotheonsetofregularcannabis use) and again at age…”
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Effects of Cannabis Use on Human Behavior, Including Cognition, Motivation, and Psychosis: A Review
Volkow, N. D., Swanson, J. M., Evins, A. E., DeLisi, L. E., Meier, M. H., Gonzalez, R., Bloomfield, M. A. P., Curran, H. V., & Baler, R. (2016) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2015.3278 · Cited by 867
Acute and Chronic Effects of Cannabinoids on Human Cognition—A Systematic Review
Broyd, S. J., van Hell, H. H., Beale, C., Yücel, M., & Solowij, N. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.12.002 · Cited by 674
Cannabis use, attitudes, and legal status in the U.S.: A review
Carliner, H., Brown, Q. L., Sarvet, A. L., & Hasin, D. S. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.07.008 · Cited by 582
Scott, J. C., Slomiak, S. T., Jones, J. D., Rosen, A. F. G., Moore, T. M., & Gur, R. C. (2018) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2018.0335 · Cited by 391
Keep off the grass? Cannabis, cognition and addiction
Curran, H. V., Freeman, T. P., Mokrysz, C., Lewis, D. A., Morgan, C. J. A., & Parsons, L. H. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.28 · Cited by 389
Metadata
- Authors
- Lubman, D. I., Cheetham, A., & Yücel, M.
- Affiliations
- Eastern Health (AU)
- The University of Melbourne (AU)
- Corresponding author
- Lubman, Dan I.
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 148
- Pages
- 1-16
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W1985057601
- Cited by
- 360
- References
- 306
- Citations by year
- 2026: 11 · 2025: 33 · 2024: 28 · 2023: 33 · 2022: 46 · 2021: 29 · 2020: 42 · 2019: 37 · 2018: 36 · 2017: 26 · 2016: 27 · 2015: 11
- FWCI
- 2.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- NHMRC (1021973)
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- cannabis use, adolescent brain development, endocannabinoid system, synaptic pruning, white matter development, neuromaturation, cognitive impairment, mental illness, neurodevelopmental vulnerability
- MeSH terms
- Adolescent, Animals, Brain, Cannabinoids, Cannabis, Depression, Female, Humans, Learning Disabilities, Memory Disorders, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Endocannabinoids
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