Cited by 360Cannabis and Cannabinoid ResearchPrenatal Substance Exposure EffectsSubstance Abuse Treatment and Outcomes

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Cannabis and adolescent brain development.

Lubman, Dan I., Cheetham, Ali, Yücel, Murat·2015·Pharmacology & Therapeutics

DOI 10.1016/j.pharmthera.2014.11.009

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Abstract

Heavy cannabis use has been frequently associated with increased rates of mental illness and cognitive impairment, particularly amongst adolescent users. However, the neurobiological processes that underlie these associations are still not well understood. In this review, we discuss the findings of studies examining the acute and chronic effects of cannabis use on the brain, with a particular focus on the impact of commencing use during adolescence. Accumulating evidence from both animal and human studies suggests that regular heavy use during this period is associated with more severe and persistent negative outcomes than use during adulthood, suggesting that the adolescent brain may be particularly vulnerable to the effects of cannabis exposure. As the endocannabinoid system plays an important role in brain development, it is plausible that prolonged use during adolescence results in a disruption in the normative neuromaturational processes that occur during this period. We identify synaptic pruning and white matter development as two processes that may be adversely impacted by cannabis exposure during adolescence. Potentially, alterations in these processes may underlie the cognitive and emotional deficits that have been associated with regular use commencing during adolescence.

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Authors: Lubman, D. I., Cheetham, A., & Yücel, M.
Affiliations: Eastern Health (AU)
The University of Melbourne (AU)
Corresponding author: Lubman, Dan I.
ORCID: Lubman, Dan I.
Cheetham, Ali
Yücel, Murat
Venue: Pharmacology & Therapeutics
Publisher: Elsevier BV
Published: 2015-04
Volume: 148
Pages: 1-16
ISSN: 0163-7258 (ISSN-L)
DOI: 10.1016/j.pharmthera.2014.11.009
OpenAlex: W1985057601
Cited by: 360
References: 306
Citations by year: 2026: 11 · 2025: 33 · 2024: 28 · 2023: 33 · 2022: 46 · 2021: 29 · 2020: 42 · 2019: 37 · 2018: 36 · 2017: 26 · 2016: 27 · 2015: 11
FWCI: 2.72
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacology & Therapeutics (publishedVersion)
PubMed (publishedVersion)
Funders: NHMRC (1021973)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cannabis and Cannabinoid Research
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Prenatal Substance Exposure Effects
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cannabis use, adolescent brain development, endocannabinoid system, synaptic pruning, white matter development, neuromaturation, cognitive impairment, mental illness, neurodevelopmental vulnerability
MeSH terms: Adolescent, Animals, Brain, Cannabinoids, Cannabis, Depression, Female, Humans, Learning Disabilities, Memory Disorders, Pregnancy, Prenatal Exposure Delayed Effects, Schizophrenia, Endocannabinoids

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