The DOI matches its Crossref record; 322 of the 325 references it cites were found in a registry or an index.
Polyphenols and neuroprotection: Therapeutic implications for cognitive decline
Abstract
Dietary polyphenols have been the focus of major interest for their potential benefits on human health. Several preclinical studies have been conducted to provide a rationale for their potential use as therapeutic agents in preventing or ameliorating cognitive decline. However, results from human studies are scarce and poorly documented. The aim of this review was to discuss the potential mechanisms involved in age-related cognitive decline or early stage cognitive impairment and current evidence from clinical human studies conducted on polyphenols and the aforementioned outcomes. The evidence published so far is encouraging but contrasting findings are to be taken into account. Most studies on anthocyanins showed a consistent positive effect on various cognitive aspects related to aging or early stages of cognitive impairment. Studies on cocoa flavanols, resveratrol, and isoflavones provided substantial contrasting results and further research is needed to clarify the therapeutic potential of these compounds. Results from other studies on quercetin, green tea flavanols, hydroxycinnamic acids (such as chlorogenic acid), curcumin, and olive oil tyrosol and derivatives are rather promising but still too few to provide any real conclusions. Future translational studies are needed to address issues related to dosage, optimal formulations to improve bioavailability, as well as better control for the overall diet, and correct target population.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Polyphenols are a class of compounds composed of a variety of molecules; several studies in animal models of ALS have shown that these have neuroprotective effects (110).”
From Modulation of the gut–brain axis via the gut microbiota: a new era in treatment of amyotrophic lateral sclerosis (2023) · cites this paper as [110]
Citations
Cites
3 retracted
Casini, M. L., Marelli, G., Papaleo, E., Ferrari, A. G., D’Ambrosio, F., & Unfer, V. (2006) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.09.048 · Cited by 141
RetractedKhan, M. S., Ali, T., Kim, M. W., Jo, M. H., Chung, J. I., & Kim, M. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1101-1 · Cited by 129
RetractedBarhwal, K. K., Das, S. K., Kumar, A., Hota, S. K., & Srivastava, R. B. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13225 · Cited by 50
RetractedRoth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32203-7 · Cited by 8,600
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Plant Polyphenols as Dietary Antioxidants in Human Health and Disease
Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942
Genistein, a specific inhibitor of tyrosine-specific protein kinases.
Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., WATANABE, S.-I. I., Itoh, N., Shibuya, M., & Fukami, Y. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45614-1 · Cited by 3,723
Inflammaging: a new immune–metabolic viewpoint for age-related diseases
Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586
The biochemistry and medical significance of the flavonoids
Havsteen, B. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,702
Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601
Cited by
Sorted by citations
Oxidative stress and inflammation in diabetic nephropathy: role of polyphenols
Jin, Q., Liu, T., Qiao, Y., Liu, D., Yang, L., Mao, H., Ma, F., Wang, Y., Peng, L., & Zhan, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1185317 · Cited by 490
Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14061137 · Cited by 255
Self-citationCaruso, G., Godos, J., Privitera, A., Lanza, G., Castellano, S., Chillemi, A., Bruni, O., Ferri, R., Caraci, F., & Grosso, G. (2022) · Nutrients · doi:10.3390/nu14040819 · Cited by 214
Self-citationGoya, L., Kongor, J. E., & de Pascual‐Teresa, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214365 · Cited by 97
The Interaction of Polyphenols and the Gut Microbiota in Neurodegenerative Diseases
Zhang, Y., Yu, W., Zhang, L., Wang, M., & Chang, W. (2022) · Nutrients · doi:10.3390/nu14245373 · Cited by 101
Mediterranean Diet and Quality of Life in Adults: A Systematic Review
Godos, J., Guglielmetti, M., Ferraris, C., Frías-Toral, E., Azpíroz, I. D., Lipari, V., Mauro, A. D., Furnari, F., Castellano, S., Galvano, F., et al. (2025) · Nutrients · doi:10.3390/nu17030577 · Cited by 94
Self-citationGiacomo, S. D., Percaccio, E., Gullì, M., Romano, A., Vitalone, A., Mazzanti, G., Gaetani, S., & Sotto, A. D. (2022) · Nutrients · doi:10.3390/nu14183709 · Cited by 85
Mediterranean Diet and Sleep Features: A Systematic Review of Current Evidence
Godos, J., Ferri, R., Lanza, G., Caraci, F., Vistorte, A. O. R., Torres, V. Y., Grosso, G., & Castellano, S. (2024) · Nutrients · doi:10.3390/nu16020282 · Cited by 90
Self-citationWang, Y., Hu, H., Liu, X., & Guo, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1138499 · Cited by 68
Romero‐Márquez, J. M., Navarro‐Hortal, M. D., Jiménez-Trigo, V., Muñoz-Ollero, P., Forbes-Hernández, T. Y., Esteban-Muñoz, A., Giampieri, F., Noya, I. D., Bullón, P., Ramírez, L. V., et al. (2022) · Antioxidants · doi:10.3390/antiox11040629 · Cited by 65
Nemeș, S. A., Mitrea, L., Teleky, B., Dulf, E. H., Călinoiu, L. F., Ranga, F., Elekes, D.-G.-A., Diaconeasa, Z. M., Dulf, F. V., & Vodnar, D. C. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.141237 · Cited by 56
The therapeutic potential of carnosine: Focus on cellular and molecular mechanisms
Caruso, G., Pietro, L. D., Cardaci, V., Maugeri, S., & Caraci, F. (2023) · Current Research in Pharmacology and Drug Discovery · doi:10.1016/j.crphar.2023.100153 · Cited by 55
Self-citationAnthocyanins: What do we know until now?
Giampieri, F., Cianciosi, D., Álvarez-Suárez, J. M., Quiles, J. L., Forbes-Hernández, T. Y., Navarro‐Hortal, M. D., Machì, M., Casanova, R. D. J. P., Espinosa, J. C. M., Chen, X., et al. (2023) · Journal of Berry Research · doi:10.3233/jbr-220087 · Cited by 53
Romero‐Márquez, J. M., Navarro‐Hortal, M. D., Jiménez-Trigo, V., Ramírez, L. V., Forbes-Hernández, T. Y., Esteban-Muñoz, A., Giampieri, F., Bullón, P., Battino, M. A., Sánchez‐González, C., et al. (2022) · Food and Chemical Toxicology · doi:10.1016/j.fct.2022.112914 · Cited by 49
Godos, J., Micek, A., Mena, P. R., Rio, D. D., Galvano, F., Castellano, S., & Grosso, G. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300472 · Cited by 57
Self-citationRethinking the Role of Orexin in the Regulation of REM Sleep and Appetite
Mogavero, M. P., Godos, J., Grosso, G., Caraci, F., & Ferri, R. (2023) · Nutrients · doi:10.3390/nu15173679 · Cited by 47
Self-citationGodos, J., Grosso, G., Ferri, R., Caraci, F., Lanza, G., Al-Qahtani, W. H., Caruso, G., & Castellano, S. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112143 · Cited by 48
Self-citationTarget fishing and mechanistic insights of the natural anticancer drug candidate chlorogenic acid
Wang, Q., Du, T., Zhang, Z., Zhang, Q., Zhang, J., Li, W., Jiang, J., Chen, X., & Hu, H. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.07.005 · Cited by 47
Insulin resistance in Alzheimer’s disease: The genetics and metabolomics links
Amin, A. M., Mostafa, H. M. A., & Khojah, H. M. J. (2022) · Clinica Chimica Acta · doi:10.1016/j.cca.2022.12.016 · Cited by 45
Gahtani, R. M., Shoaib, S., Hani, U., Pillai, J. R., Alomary, M. N., Chauhan, W., Jahan, R., Tufail, S., & Ansari, M. A. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105798 · Cited by 41
Hong, D., Zhang, C., Wu, W., Lu, X., & Zhang, L. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1133546 · Cited by 38
Wang, D., Gu, X. Q., Ma, X., Chen, J., Zhang, Q., Yu, Z., Li, J., Meng, H., Tan, X., Tang, Y., et al. (2022) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2022.07.014 · Cited by 35
Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases
Beura, S. K., Dhapola, R., Panigrahi, A. R., Yadav, P., Kumar, R., HariKrishnaReddy, D., & Singh, S. K. (2023) · Medicinal Research Reviews · doi:10.1002/med.21965 · Cited by 37
Suraweera, T. L., Merlin, J. P. J., Dellaire, G., Xu, Z., & Rupasinghe, H. P. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043676 · Cited by 35
Navarro‐Hortal, M. D., Romero‐Márquez, J. M., Jiménez-Trigo, V., Xiao, J., Giampieri, F., Forbes-Hernández, T. Y., Grosso, G., Battino, M. A., Sánchez‐González, C., & Quiles, J. L. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2098244 · Cited by 35
Self-citationPolyphenols as Potential Geroprotectors
Proshkina, E., Koval, L. A., Platonova, E. Y., Golubev, D., Ulyasheva, N. S., Babak, T. V., Shaposhnikov, M. V., & Moskalev, A. (2024) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0247 · Cited by 36
Molecular Mechanisms of the Protective Effects of Olive Leaf Polyphenols against Alzheimer’s Disease
Romero‐Márquez, J. M., Forbes-Hernández, T. Y., Navarro‐Hortal, M. D., Quirantes‐Piné, R., Grosso, G., Giampieri, F., Lipari, V., Sánchez‐González, C., Battino, M. A., & Quiles, J. L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054353 · Cited by 39
Self-citationUceda, S., Echeverry‐Alzate, V., Reiriz, M., Miguel, E. M., Pérez-Curiel, A., Gómez-Senent, S., & Beltrán-Velasco, A. I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713294 · Cited by 36
Caruso, G. (2022) · Molecules · doi:10.3390/molecules27103303 · Cited by 33
Self-citationFibre & fermented foods: differential effects on the microbiota-gut-brain axis
Schneider, E., Balasubramanian, R., Ferri, A., Cotter, P. D., Clarke, G. A., & Cryan, J. F. (2024) · Proceedings of The Nutrition Society · doi:10.1017/s0029665124004907 · Cited by 37
Caruso, G., Privitera, A., Antunes, B. M., Lazzarino, G., Lunte, S. M., Aldini, G., & Caraci, F. (2022) · Molecules · doi:10.3390/molecules27144452 · Cited by 34
Self-citationChen, S.-Y., Weng, M.-H., Li, Z., Wang, G., & Yen, G. (2022) · Food & Function · doi:10.1039/d1fo04418d · Cited by 31
Polyphenol-Rich Beverages and Mental Health Outcomes
Micek, A., Jurek, J. M., Owczarek, M., Guerrera, I., Torrisi, S. A., Castellano, S., Grosso, G., Alshatwi, A. A., & Godos, J. (2023) · Antioxidants · doi:10.3390/antiox12020272 · Cited by 32
Self-citationFarzan, M., Farzan, M., Amini-Khoei, H., Shahrani, M., Bijad, E., Anjomshoa, M., & Shabani, S. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110112 · Cited by 30
Lorenzi, E. D., Franceschini, D., Contardi, C., Martino, R. M. C. D., Seghetti, F., Serra, M., Bisceglia, F., Pagetta, A., Zusso, M., & Belluti, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084381 · Cited by 28
Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review
Chen, R., Huang, L., Wang, R., Fei, J., Wang, H., & Wang, J. (2024) · Brain Sciences · doi:10.3390/brainsci14040354 · Cited by 27
Al-Regaiey, K. (2024) · Immunity & Ageing · doi:10.1186/s12979-024-00481-w · Cited by 29
Godos, J., Castellano, S., Ferri, R., Caraci, F., Lanza, G., Scazzina, F., Alanazi, A. M., Marx, W., Galvano, F., & Grosso, G. (2023) · Experimental Gerontology · doi:10.1016/j.exger.2023.112284 · Cited by 24
Self-citationLang, J., Gao, L., Wu, J., Meng, J., Gao, X., Ma, H., & Yan, D. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03695-w · Cited by 25
Dietary Fats and Cognitive Status in Italian Middle-Old Adults
Currenti, W., Godos, J., Alanazi, A. M., Lanza, G., Ferri, R., Caraci, F., Grosso, G., Galvano, F., & Castellano, S. (2023) · Nutrients · doi:10.3390/nu15061429 · Cited by 24
Self-citationRecent advances in nuclear receptors-mediated health benefits of blueberry
Zou, H., Ye, H., Zhang, J., & Ren, L. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154063 · Cited by 23
Anthocyanin-rich fruits and mental health outcomes in an Italian cohort
Micek, A., Owczarek, M., Jurek, J. M., Guerrera, I., Torrisi, S. A., Grosso, G., Alshatwi, A. A., & Godos, J. (2022) · Journal of Berry Research · doi:10.3233/jbr-220054 · Cited by 23
Self-citationCaruso, G., Pietro, L. D., & Caraci, F. (2023) · Biomolecules · doi:10.3390/biom13030505 · Cited by 24
Self-citationDietary Phytoestrogen Intake and Cognitive Status in Southern Italian Older Adults
Giampieri, F., Godos, J., Caruso, G., Owczarek, M., Jurek, J. M., Castellano, S., Ferri, R., Caraci, F., & Grosso, G. (2022) · Biomolecules · doi:10.3390/biom12060760 · Cited by 24
Self-citationCharacterization of Carnosine Effect on Human Microglial Cells under Basal Conditions
Caruso, G., Privitera, A., Saab, M. W., Musso, N., Maugeri, S., Fidilio, A., Privitera, A. P., Pittalà, A., Jolivet, R., Lanzanò, L. L., et al. (2023) · Biomedicines · doi:10.3390/biomedicines11020474 · Cited by 21
Self-citationAlhakamy, N. A., Caruso, G., Privitera, A., Ahmed, O. A. A., Fahmy, U. A., Md, S., Mohamed, G. A., Ibrahim, S. R. M., Eid, B. G., Abdel‐Naim, A. B., et al. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14061133 · Cited by 20
Self-citationRetractedTsai, M.-M., Chen, J.-L., Lee, T., Liu, H., Velayuthaprabhu, S., & Hsieh, H. (2022) · Biomedicines · doi:10.3390/biomedicines10061270 · Cited by 21
Modulation of microRNAs through Lifestyle Changes in Alzheimer’s Disease
Pinto-Hernandez, P., Castilla-Silgado, J., Coto-Vilcapoma, A., Fernández-Sanjurjo, M., Fernández-García, B., Tomás-Zapico, C., & Iglesias-Gutiérrez, E. (2023) · Nutrients · doi:10.3390/nu15173688 · Cited by 22
Dietary Fats and Depressive Symptoms in Italian Adults
Currenti, W., Godos, J., Alanazi, A. M., Lanza, G., Ferri, R., Caraci, F., Galvano, F., Castellano, S., & Grosso, G. (2023) · Nutrients · doi:10.3390/nu15030675 · Cited by 23
Self-citationHernando‐Redondo, J., Malcampo, M., Pérez‐Vega, K. A., Paz‐Graniel, I., Martínez‐González, M. Á., Corella, D., Estruch, R., Salas‐Salvadó, J., Pintó, X., Arós, F., et al. (2024) · Nutrients · doi:10.3390/nu16183147 · Cited by 19
Koh, H. J., & Joo, J. D. (2025) · Biomedicines · doi:10.3390/biomedicines13020506 · Cited by 18
Amentoflavone Promotes Cellular Uptake and Degradation of Amyloid-Beta in Neuronal Cells
Han, B. H., Cofell, B., Everhart, E., Humpal, C., Kang, S.-S., Lee, S. K., & Kim‐Han, J. S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23115885 · Cited by 20
Wang, L., Xian, X., Zhou, M., Xu, K., Cao, S., Cheng, J., Dai, W., Zhang, W., & Ye, M. (2024) · Nutrients · doi:10.3390/nu16091333 · Cited by 20
Dietary Antioxidants and Brain Health: Focus on Cognitive and Affective Disorders
Godos, J., & Grosso, G. (2021) · Antioxidants · doi:10.3390/antiox10111659 · Cited by 18
Self-citationAdherence to Mediterranean Diet Is Associated with Multiple Sclerosis Severity
Guglielmetti, M., Al-Qahtani, W. H., Ferraris, C., Grosso, G., Fiorini, S., Tavazzi, E., Greco, G., Malfa, A. L., Bergamaschi, R., & Tagliabue, A. (2023) · Nutrients · doi:10.3390/nu15184009 · Cited by 17
Self-citationJiménez, M. T. B., Rivas‐García, L., Sánchez‐González, C., Grosso, G., Lipari, V., Ramírez, L. V., Battino, M. A., Giampieri, F., Quiles, J. L., & Forbes-Hernández, T. Y. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110631 · Cited by 19
Self-citationSantos‐Terra, J., Deckmann, I., Carello‐Collar, G., Nunes, G. D., Bauer‐Negrini, G., Schwingel, G. B., Fontes‐Dutra, M., Riesgo, R. D. S., & Gottfried, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23084075 · Cited by 15
Effects of dietary polyphenols on maternal and fetal outcomes in maternal diabetes
Zhao, L., Chang, Q., Cong, Z., Zhang, Y., Liu, Z., & Zhao, Y. (2023) · Food & Function · doi:10.1039/d3fo02048g · Cited by 15
Zhao, W., Chen, Q., Zhang, Q., Li, S., Zhao, J., Chen, W., Yang, J., Xia, M., & Liu, Y. (2024) · GeroScience · doi:10.1007/s11357-024-01333-7 · Cited by 14
Caruso, G., Scalisi, E. M., Pecoraro, R., Cardaci, V., Privitera, A., Truglio, E., Capparucci, F., Jarošová, R., Salvaggio, A., Caraci, F., et al. (2023) · Frontiers in Veterinary Science · doi:10.3389/fvets.2023.1148766 · Cited by 14
Self-citationPrivitera, A., Cardaci, V., Weerasekara, D. B., Saab, M. W., Diolosà, L., Fidilio, A., Jolivet, R., Lazzarino, G., Amorini, A. M., Camarda, M., et al. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1161794 · Cited by 13
Self-citationMartínez-Ferri, E., Forbes-Hernández, T. Y., Cervantes, L., Soria, C., Battino, M. A., & Ariza, M. T. (2023) · Foods · doi:10.3390/foods13010110 · Cited by 13
Updates on Molecular and Biochemical Development and Progression of Prostate Cancer
Fahmy, O., Alhakamy, N. A., Rizg, W. Y., Bagalagel, A. A., Alamoudi, A. J., Aldawsari, H. M., Khateb, A. M., Eldakhakhny, B. M., Fahmy, U. A., Abdulaal, W. H., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10215127 · Cited by 13
Self-citationZafari, R., Goudarzi, N., Kamroo, A., Tafti, M. F., Ghorbani, A., Talebian, N., Najafi, S., Shahbazian, S., Rahmanian, M., Parvardeh, S., et al. (2025) · Nutrition & Metabolism · doi:10.1186/s12986-025-01022-y · Cited by 14
The association of dietary inflammatory index with sleep outcomes: A systematic review
Golmohammadi, M., Samadi, M., Salimi, Y., Nachvak, S. M., & Attari, V. E. (2024) · Health Promotion Perspectives · doi:10.34172/hpp.42595 · Cited by 12
Godos, J., Micek, A., Carota, G., Venuta, C. D., Mauro, A. D., Furnari, F., Balzano, R., Giorgio, J. D., Leonardi, A., Caruso, G., et al. (2025) · Mediterranean Journal of Nutrition and Metabolism · doi:10.1177/1973798x251360765 · Cited by 15
Self-citationMohamed, R. S., Fouda, K. A., Salama, A., & Akl, E. M. (2024) · Phytomedicine Plus · doi:10.1016/j.phyplu.2024.100588 · Cited by 11
Kong, H., Han, J., Meng, X., Wang, X., & Zhang, X.-A. (2025) · Nutrition Reviews · doi:10.1093/nutrit/nuaf227 · Cited by 14
Lee, T., Chen, J.-L., Tsai, M.-M., Wu, Y., Tseng, H., Cheng, L., Velayuthaprabhu, S., & Hsieh, H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010283 · Cited by 10
Proton-Coupled Electron Transfer and Hydrogen Tunneling in Olive Oil Phenol Reactions
Torić, J., Marković, A. K., Mustać, S., Pulitika, A., Brala, C. J., & Pilepić, V. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126341 · Cited by 12
Zhu, R., Tong, X., Du, Y., Liu, J., Xu, X., He, Y., Wen, L., & Wang, Z. (2024) · Pesticide Biochemistry and Physiology · doi:10.1016/j.pestbp.2024.106172 · Cited by 10
Anthocyanin metabolites from gut microbiota and cognitive health
Godos, J., Micek, A., Caruso, G., Carota, G., Mauro, A. D., Furnari, F., Giorgio, J. D., D’Agostino, M., Leonardi, A., Balzano, R., et al. (2025) · Journal of Berry Research · doi:10.1177/18785093251364653 · Cited by 13
Self-citationRegulation of Host Defense Peptide Synthesis by Polyphenols
Tobin, I., & Zhang, G. (2023) · Antibiotics · doi:10.3390/antibiotics12040660 · Cited by 10
Suzukamo, C., Ochiai, R., Mitsui, Y., Osaki, N., & Ono, T. (2022) · Brain Sciences · doi:10.3390/brainsci12030370 · Cited by 9
Woodman, S. E., Antonopoulos, S. R., & Durham, P. L. (2022) · Frontiers in Pain Research · doi:10.3389/fpain.2022.809352 · Cited by 9
Cocoa Flavanols and the Aging Brain
Lalonde, R., & Strazielle, C. (2022) · Current Aging Science · doi:10.2174/1874609815666220819145845 · Cited by 9
Phytocompounds and lipid-based drug delivery system for neurodegenerative diseases
Özay, C., & Karpuz, M. (2024) · Asian Pacific Journal of Tropical Biomedicine · doi:10.4103/apjtb.apjtb_455_24 · Cited by 8
Yang, Q., Li, H., Zhang, H., Ma, L., Zhang, X., & Wu, J. (2025) · Frontiers in Medicine · doi:10.3389/fmed.2025.1582946 · Cited by 9
Microbial Phenolic Metabolites Are Associated with Improved Cognitive Health
Domínguez‐López, I., Galkina, P. А., Parilli‐Moser, I., Arancibia‐Riveros, C., Martínez‐González, M. Á., Salas‐Salvadó, J., Corella, D., Malcampo, M., Martínez, J. A., Tojal‐Sierra, L., et al. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300183 · Cited by 11
Yi, X., Bao, F., Fu, S., Yang, Y., & Xu, Y. (2024) · Medical Engineering & Physics · doi:10.1016/j.medengphy.2024.104160 · Cited by 8
Caruso, G., Fresta, C. G., Fidilio, A., Lazzara, F., Musso, N., Cardaci, V., Drago, F., Caraci, F., & Bucolo, C. (2023) · Molecules · doi:10.3390/molecules28083324 · Cited by 9
Self-citationRuiz, Z. V., Toledo, E., Vitelli‐Storelli, F., Bes‐Rastrollo, M., & Martínez‐González, M. Á. (2025) · European Journal of Nutrition · doi:10.1007/s00394-025-03581-5 · Cited by 7
García-Pérez, L., Padial-Ruz, R., Cepero-González, M., & Ubago-Jiménez, J. L. (2025) · Healthcare · doi:10.3390/healthcare13101197 · Cited by 10
Health effects of polyphenols combined with bacteria from the perspective of gut microbiota
Li, Y., Nie, X., Liu, C., Li, Q., Xie, M., & Xie, M. (2025) · Food Bioscience · doi:10.1016/j.fbio.2025.107930 · Cited by 7
Micek, A., Godos, J., Giampieri, F., Battino, M., Quiles, J. L., Rio, D. D., Mena, P. R., Caruso, G., Frías-Toral, E., Azpíroz, I. D., et al. (2025) · GeroScience · doi:10.1007/s11357-025-02008-7 · Cited by 7
Self-citationGodos, J., Lanza, G., Ferri, R., Caraci, F., Cano, S. S., Elío, I., Micek, A., Castellano, S., & Grosso, G. (2024) · Mediterranean Journal of Nutrition and Metabolism · doi:10.3233/mnm-240008 · Cited by 7
Self-citationSustainable Chemical Derivatization of Hydroxycinnamic Acids
Longobardo, L., Fabio, G. D., & Zarrelli, A. (2024) · ChemistrySelect · doi:10.1002/slct.202305046 · Cited by 7
Rossato, D. R., da Rosa, J. L. O., Fontoura, M. B., de Souza, L. E. M., de Almeida, T. M., Kudrna, K. B., Schaffazick, S. R., da Silva, C. B., Birk, L., Eller, S. C. W. D. S., et al. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04248-z · Cited by 9
Nut Consumption Is Associated with Cognitive Status in Southern Italian Adults
Godos, J., Giampieri, F., Frías-Toral, E., Zambrano-Villacres, R., Vistorte, A. O. R., Torres, V. Y., Battino, M. A., Galvano, F., Castellano, S., & Grosso, G. (2025) · Nutrients · doi:10.3390/nu17030521 · Cited by 6
Self-citation(Poly)phenols and Multiple Sclerosis: Results from an Observational Cross-Sectional Study
Guglielmetti, M., Ferraris, C., Tagliabue, A., Frías-Toral, E., Tavazzi, E., Malfa, A. L., Greco, G., Bergamaschi, R., Zambrano-Villacres, R., Godos, J., et al. (2025) · Antioxidants · doi:10.3390/antiox14020188 · Cited by 6
Self-citationNew Insights on the Role of Bioactive Food Derivatives in Neurodegeneration and Neuroprotection
Fisette, A., Sergi, D., Breton-Morin, A., Descôteaux, S., & Martinoli, M. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220919085742 · Cited by 5
Nutraceuticals: A Complementary Approach in the Management of Alzheimer’s Disease
Bansal, K., Mishra, S., Singh, V., & Bajpai, M. (2023) · Neurochemical Journal · doi:10.1134/s1819712423030030 · Cited by 6
Micek, A., Alshatwi, A. A., Paladino, N., Guerrera, I., Grosso, G., Castellano, S., & Godos, J. (2023) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2023.2199182 · Cited by 7
Self-citationPharmacological mechanism of natural antidepressants: the role of epigenetic modifications
Lu, Y., Shang, R., Zhong, X., Shi, J., Zhang, G., Zhao, W., & Teng, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1616322 · Cited by 6
Nitric oxide: Potential therapeutic target in Heat Stress–induced Multiple Organ Dysfunction
Jaswal, P., Bansal, S., Chaudhary, R., Basu, J., Bansal, N., & Kumar, S. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03556-z · Cited by 5
Zhang, Y. F., Xu, Z., Wang, C., Li, J., Wu, M. Y., Yi, Y. Q., Wang, T., & Bian, P. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156845 · Cited by 5
Miao, X., Ye, H., Cui, X., Guo, X., & Su, F. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.09.006 · Cited by 5
Wu, Y., Chen, S.-Y., Yang, J.-Y., Chen, Y., & Yen, G. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105860 · Cited by 5
Stepaniak, U., Grosso, G., Polak, M., Gradowicz-Prajsnar, B., Kozela, M., Bobák, M., Niubo, A. S., Stefler, D., Haro, J. M., & Pająk, A. (2024) · GeroScience · doi:10.1007/s11357-024-01275-0 · Cited by 5
Self-citationParilli‐Moser, I., López-Solís, R., Domínguez‐López, I., Vallverdú‐Queralt, A., Hurtado‐Barroso, S., & Lamuela-Raventós, R. M. (2023) · Journal of Functional Foods · doi:10.1016/j.jff.2023.105746 · Cited by 5
Metadata
- Authors
- Caruso, G., Torrisi, S. A., Mogavero, M. P., Currenti, W., Castellano, S., Godos, J., Ferri, R., Galvano, F., Leggio, G. M., Grosso, G., & Caraci, F.
- Affiliations
- University of Catania (IT)
- Istituti Clinici Scientifici Maugeri (IT)
- I.R.C.C.S. Oasi Maria SS (IT)
- Corresponding author
- Grosso, Giuseppe
- ORCID
- Venue
- Pharmacology & Therapeutics
- Publisher
- Elsevier BV
- Published
- 2022-04
- Volume
- 232
- Pages
- 108013
- ISSN
- 0163-7258 (ISSN-L)
- OpenAlex
- W3204234964
- Cited by
- 140
- References
- 325
- Citations by year
- 2026: 19 · 2025: 29 · 2024: 27 · 2023: 35 · 2022: 28
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Pharmacology & Therapeutics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Catania
- Topics
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- dietary polyphenols, neuroprotection, cognitive decline, age-related cognitive impairment, anthocyanins, cocoa flavanols, resveratrol, isoflavones, quercetin, hydroxycinnamic acids, chlorogenic acid, curcumin, bioavailability, cognitive aging
- MeSH terms
- Neuroprotection, Anthocyanins, Humans, Tea, Polyphenols, Cognitive Dysfunction
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review