Polyphenols and neuroprotection: Therapeutic implications for cognitive decline

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017

Roth, G. A., Abate, D., Abate, K. H., Abay, S. M., Abbafati, C., Abbasi, N., Abbastabar, H., Abd-Allah, F., Abdela, J., Abdelalim, A., et al. (2018) · The Lancet · doi:10.1016/s0140-6736(18)32203-7 · Cited by 8,600

The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer

Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

Pandey, K. B., & Rizvi, S. I. (2009) · Oxidative Medicine and Cellular Longevity · doi:10.4161/oxim.2.5.9498 · Cited by 3,942

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

Akiyama, T., Ishida, J., Nakagawa, S., Ogawara, H., WATANABE, S.-I. I., Itoh, N., Shibuya, M., & Fukami, Y. (1987) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)45614-1 · Cited by 3,723

Inflammaging: a new immune–metabolic viewpoint for age-related diseases

Franceschi, C., Garagnani, P., Parini, P., Giuliani, C., & Santoro, A. (2018) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0059-4 · Cited by 3,586

The biochemistry and medical significance of the flavonoids

Havsteen, B. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00298-x · Cited by 2,702

Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases

Del Rio, D., Rodriguez-Mateos, A., Spencer, J. P. E., Tognolini, M., Borges, G., & Crozier, A. (2013) · Antioxidants & Redox Signaling · doi:10.1089/ars.2012.4581 · Cited by 2,601

Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo

Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336

Health effects of quercetin: From antioxidant to nutraceutical

Boots, A. W., Haenen, G. R. M. M., & Bast, A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.03.008 · Cited by 2,121

Dietary phenolics: chemistry, bioavailability and effects on health

Crozier, A., Jaganath, I. B., & Clifford, M. N. (2009) · Natural Product Reports · doi:10.1039/b802662a · Cited by 2,062

How neuroinflammation contributes to neurodegeneration

Ransohoff, R. M. (2016) · Science · doi:10.1126/science.aag2590 · Cited by 1,967

Antioxidant and radical scavenging properties of curcumin

Ak, T. P., & Gülçın, İ. (2008) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2008.05.003 · Cited by 1,942

CURCUMIN: THE INDIAN SOLID GOLD

Aggarwal, B. B., Sundaram, C., Malani, N., & Ichikawa, H. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_1 · Cited by 1,740

Overviews of biological importance of quercetin: A bioactive flavonoid

Parasuraman, S., David, A. A., & Arulmoli, R. (2016) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.194044 · Cited by 1,619

Flavonoids, a class of natural products of high pharmacological potency

Havsteen, B. (1983) · Biochemical Pharmacology · doi:10.1016/0006-2952(83)90262-9 · Cited by 1,616

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530

ANTIOXIDANT AND ANTI-INFLAMMATORY PROPERTIES OF CURCUMIN

Menon, V. P., & Sudheer, A. R. (2007) · Springer eBooks · doi:10.1007/978-0-387-46401-5_3 · Cited by 1,407

The specificities of protein kinase inhibitors: an update

BAIN, J., McLAUCHLAN, H., ELLIOTT, M., & COHEN, P. (2003) · Biochemical Journal · doi:10.1042/bj20021535 · Cited by 1,369

Interaction between Phenolics and Gut Microbiota: Role in Human Health

Selma, M. V., Espín, J. C., & Tomás-Barberán, F. A. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf902107d · Cited by 1,324

Anthocyanins: A Comprehensive Review of Their Chemical Properties and Health Effects on Cardiovascular and Neurodegenerative Diseases

Mattioli, R., Francioso, A., Mosca, L., & Silva, P. (2020) · Molecules · doi:10.3390/molecules25173809 · Cited by 1,145

BDNF and synaptic plasticity, cognitive function, and dysfunction

Lu, B., Nagappan, G., & Lu, Y. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-642-45106-5_9 · Cited by 1,043

Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safety Profiles for Food, Pharmaceutical, Biotechnological and Medicinal Applications

Sharifi‐Rad, J., Rayess, Y. E., Abi-Rizk, A., Sadaka, C., Zgheib, R., Zam, W., Sestito, S., Rapposelli, S., Neffe‐Skocińska, K., Zielińska, D., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01021 · Cited by 1,042

Regulation of inflammation and redox signaling by dietary polyphenols

Rahman, I., Biswas, S. K., & Kirkham, P. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.07.004 · Cited by 1,003

The role of brain vasculature in neurodegenerative disorders

Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0234-x · Cited by 998

Dementia and Cognitive Impairment

Hugo, J., & Ganguli, M. (2014) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2014.04.001 · Cited by 990

Role of neuroinflammation in neurodegenerative diseases (Review)

Chen, W., Zhang, X., & Huang, W. (2016) · Molecular Medicine Reports · doi:10.3892/mmr.2016.4948 · Cited by 961

Curcumin: Biological, Pharmaceutical, Nutraceutical, and Analytical Aspects

Kotha, R. R., & Luthria, D. L. (2019) · Molecules · doi:10.3390/molecules24162930 · Cited by 960

Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial

Valls-Pedret, C., Sala-Vila, A., Serra-Mir, M., Corella, D., de la Torre, R., Martínez-González, M. Á., Martínez-Lapiscina, E. H., Fitó, M., Pérez-Heras, A., Salas-Salvadó, J., et al. (2015) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2015.1668 · Cited by 952

Flavan‐3‐ols: Nature, occurrence and biological activity

Aron, P. M., & Kennedy, J. A. (2007) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200700137 · Cited by 805

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

Genin, E., Hannequin, D., Wallon, D., Sleegers, K., Hiltunen, M., Combarros, O., Bullido, M. J., Engelborghs, S., De Deyn, P., Berr, C., et al. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.52 · Cited by 714

Green tea Epigallocatechin-3-Gallate (EGCG) Modulates Amyloid Precursor Protein Cleavage and Reduces Cerebral Amyloidosis in Alzheimer Transgenic Mice

Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend, K., Zeng, J., Morgan, D., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1521-05.2005 · Cited by 713

Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer’s disease

Moussa, C., Hebron, M. L., Huang, X., Ahn, J., Rissman, R. A., Aisen, P. S. S., & Turner, R. S. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0779-0 · Cited by 712

The effects of aging in the hippocampus and cognitive decline

Bettio, L. E. B., Rajendran, L., & Gil‐Mohapel, J. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.030 · Cited by 700

Multitargeting by curcumin as revealed by molecular interaction studies

Gupta, S. C., Prasad, S., Kim, J. H., Patchva, S., Webb, L. J., Priyadarsini, K. I., & Aggarwal, B. B. (2011) · Natural Product Reports · doi:10.1039/c1np00051a · Cited by 683

Potential Health Benefits of Olive Oil and Plant Polyphenols

Gorzynik-Debicka, M., Przychodzeń, P., Cappello, F., Kuban‐Jankowska, A., Marino, A., Knap, N., Woźniak, M., & Górska‐Ponikowska, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19030686 · Cited by 656

Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

Kirova, A.-M., Bays, R. B., & Lagalwar, S. (2015) · BioMed Research International · doi:10.1155/2015/748212 · Cited by 649

Oleuropein in Olive and its Pharmacological Effects

Omar, S. H. (2010) · Scientia Pharmaceutica · doi:10.3797/scipharm.0912-18 · Cited by 648

Curcumin Structure-Function, Bioavailability, and Efficacy in Models of Neuroinflammation and Alzheimer’s Disease

Begum, A. N., Jones, M. R., Lim, G. P., Morihara, T., Kim, P., Heath, D. D., Rock, C. L., Pruitt, M. A., Yang, F., Hudspeth, B., et al. (2008) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.108.137455 · Cited by 604

Blueberry supplementation improves memory in older adults

Krikorian, R., Shidler, M. D., Nash, T. A., Kalt, W., Vinqvist-Tymchuk, M. R., Shukitt-Hale, B., & Joseph, J. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9029332 · Cited by 582

Occurrence and content of hydroxycinnamic and hydroxybenzoic acid compounds in foods

Herrmann, K., & NAGEL, C. W. (1989) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398909527504 · Cited by 578

Renoprotective effect of the antioxidant curcumin: Recent findings

Trujillo, J., Chirino, Y. I., Molina‐Jijón, E., Andérica‐Romero, A. C., Tapia, E., & Pedraza‐Chaverrí, J. (2013) · Redox Biology · doi:10.1016/j.redox.2013.09.003 · Cited by 568

Brain aging and neurodegeneration: from a mitochondrial point of view

Grimm, A., & Eckert, A. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14037 · Cited by 565

The neuroprotective potential of flavonoids: a multiplicity of effects

Vauzour, D., Vafeiadou, K., Rodriguez‐Mateos, A., Rendeiro, C., & Spencer, J. P. E. (2008) · Genes & Nutrition · doi:10.1007/s12263-008-0091-4 · Cited by 561

Mechanisms of Neuroprotection by Quercetin: Counteracting Oxidative Stress and More

Costa, L. G., Garrick, J. M., Roqué, P. J., & Pellacani, C. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/2986796 · Cited by 550

SIRT1 Is Essential for Normal Cognitive Function and Synaptic Plasticity

Michan, S., Li, Y., Chou, M. M.-H., Parrella, E., Ge, H., Long, J. M., Allard, J. S., Lewis, K., Miller, M., Xu, W., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0027-10.2010 · Cited by 541

Neuroprotective effects of curcumin

Cole, G. M., Teter, B., & Frautschy, S. A. (2007) · ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY · doi:10.1007/978-0-387-46401-5_8 · Cited by 516

Isoflavones: estrogenic activity, biological effect and bioavailability

Vitale, D. C., Piazza, C., Melilli, B., Drago, F., & Salomone, S. (2012) · European Journal of Drug Metabolism and Pharmacokinetics · doi:10.1007/s13318-012-0112-y · Cited by 500

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

Julien, C., Tremblay, C., Émond, V., Lebbadi, M., Salem, N., Bennett, D. A., & Calon, F. (2008) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181922348 · Cited by 475

Green tea epigallocatechin-3-gallate (EGCG) reduces β-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice

Rezai-Zadeh, K., Arendash, G. W., Hou, H., Fernandez, F., Jensen, M., Runfeldt, M., Shytle, R. D., & Tan, J. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.107 · Cited by 459

Effects of Resveratrol on Memory Performance, Hippocampal Functional Connectivity, and Glucose Metabolism in Healthy Older Adults

Witte, A. V., Kerti, L., Margulies, D. S., & Floel, A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0385-14.2014 · Cited by 455

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

Sabogal-Guáqueta, A. M., Muñoz‐Manco, J. I., Ramírez‐Pineda, J. R., Lamprea, M. R., Osorio, E., & Cardona‐Gómez, G. P. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.01.027 · Cited by 453

Phenolic Compounds of Cereals and Their Antioxidant Capacity

Hung, P. V. (2014) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.708909 · Cited by 451

Cerebral hypoperfusion and glucose hypometabolism: Key pathophysiological modulators promote neurodegeneration, cognitive impairment, and Alzheimer's disease

Daulatzai, M. A. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23777 · Cited by 440

Effect of Soy Protein Containing Isoflavones on Cognitive Function, Bone Mineral Density, and Plasma Lipids in Postmenopausal Women: A Randomized Controlled Trial

Kreijkamp-Kaspers, S., Kok, L., Grobbee, D. E., de Haan, E. H. F., Aleman, A., Lampe, J. W., & van der Schouw, Y. T. (2004) · JAMA · doi:10.1001/jama.292.1.65 · Cited by 438

Modulation of arachidonic acid metabolism by curcumin and related -diketone derivatives: effects on cytosolic phospholipase A2, cyclooxygenases and 5-lipoxygenase

Hong, J. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh165 · Cited by 434

Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials

Jantan, I., Ahmad, W., & Bukhari, S. N. A. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2015.00655 · Cited by 427

Resveratrol Mitigates Lipopolysaccharide- and Aβ-Mediated Microglial Inflammation by Inhibiting the TLR4/NF-Κb/STAT Signaling cascade

Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426

Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.

Romani, A., Ieri, F., Urciuoli, S., Noce, A., Marrone, G., Nediani, C., & Bernini, R. (2019) · Nutrients · doi:10.3390/nu11081776 · Cited by 425

Bioavailability of Quercetin: Problems and Promises

Cai, X., Fang, Z., Dou, J., Yu, A., & Zhai, G. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990120 · Cited by 423

Diet and Inflammation in Cognitive Ageing and Alzheimer’s Disease

McGrattan, A., McGuinness, B., McKinley, M. C., Kee, F., Passmore, P., Woodside, J. V., & McEvoy, C. T. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-0271-4 · Cited by 414

Phenolic Compounds Prevent Alzheimer’s Pathology through Different Effects on the Amyloid-β Aggregation Pathway

Hamaguchi, T., Ono, K., Murase, A., & Yamada, M. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.090417 · Cited by 403

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

Jang, J.-H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00062-5 · Cited by 391

Do glia drive synaptic and cognitive impairment in disease?

Chung, W.-S., Welsh, C. A., Barres, B. A., & Stevens, B. (2015) · Nature Neuroscience · doi:10.1038/nn.4142 · Cited by 385

Epigenetic changes induced by curcumin and other natural compounds

Reuter, S., Gupta, S. C., Park, B., Goel, A., & Aggarwal, B. B. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0222-1 · Cited by 370

Lifestyle Modulators of Neuroplasticity: How Physical Activity, Mental Engagement, and Diet Promote Cognitive Health during Aging

Phillips, C. (2017) · Neural Plasticity · doi:10.1155/2017/3589271 · Cited by 370

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Cox, K. H., Pipingas, A., & Scholey, A. B. (2015) · Journal of Psychopharmacology · doi:10.1177/0269881114552744 · Cited by 368

Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial

Small, G. W., Siddarth, P., Li, Z., Miller, K. J., Ercoli, L. M., Emerson, N. D., Martinez, J., Wong, K. P., Liu, J., Merrill, D. A., et al. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.10.010 · Cited by 368

Polyphenols and health: What compounds are involved?

Rio, D. D., Costa, L. G., Lean, M. E. J., & Crozier, A. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.05.015 · Cited by 367

Actions of Brain-Derived Neurotrophin Factor in the Neurogenesis and Neuronal Function, and Its Involvement in the Pathophysiology of Brain Diseases

Numakawa, T., Odaka, H., & Adachi, N. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113650 · Cited by 367

Curcumin Induces Glutathione Biosynthesis and Inhibits NF-κB Activation and Interleukin-8 Release in Alveolar Epithelial Cells: Mechanism of Free Radical Scavenging Activity

Biswas, S. K., McClure, D., Jimenez, L. A., Megson, I. L., & Rahman, I. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.32 · Cited by 364

Blueberry Supplementation Enhances Signaling and Prevents Behavioral Deficits in an Alzheimer Disease Model

Joseph, J. A., Arendash, G. W., Gordon, M. N., Diamond, D. M., Shukitt‐Hale, B., Morgan, D., & Denisova, N. A. (2003) · Nutritional Neuroscience · doi:10.1080/1028415031000111282 · Cited by 363

Cocoa flavanol consumption improves cognitive function, blood pressure control, and metabolic profile in elderly subjects: the Cocoa, Cognition, and Aging (CoCoA) Study—a randomized controlled trial

Mastroiacovo, D., Kwik-Uribe, C. L., Grassi, D., Necozione, S., Raffaele, A., Pistacchio, L., Righetti, R., Bocale, R., Lechiara, M. C., Marini, C., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092189 · Cited by 355

Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment

Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., & Joseph, J. A. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114509992364 · Cited by 353

Translational control in synaptic plasticity and cognitive dysfunction

Buffington, S. A., Huang, W., & Costa-Mattioli, M. (2014) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-071013-014100 · Cited by 348

Alzheimer's Disease and Mild Cognitive Impairment

Kelley, B. J., & Petersen, R. C. (2007) · Neurologic Clinics · doi:10.1016/j.ncl.2007.03.008 · Cited by 335

Curcumin: A Potential Neuroprotective Agent in Parkinson's Disease

Mythri, R. B., & Bharath, M. M. S. (2012) · Current Pharmaceutical Design · doi:10.2174/138161212798918995 · Cited by 332

Myelin plasticity: sculpting circuits in learning and memory

Xin, W., & Chan, J. R. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-00379-8 · Cited by 329

Benefits in Cognitive Function, Blood Pressure, and Insulin Resistance Through Cocoa Flavanol Consumption in Elderly Subjects With Mild Cognitive Impairment: The Cocoa, Cognition, and Aging (CoCoA) Study

Desideri, G., Kwik-Uribe, C., Grassi, D., Necozione, S., Ghiadoni, L., Mastroiacovo, D., Raffaele, A., Ferri, L., Bocale, R., Lechiara, M. C., et al. (2012) · Hypertension · doi:10.1161/hypertensionaha.112.193060 · Cited by 311

Epigallocatechin‐3‐gallate, a DYRK1A inhibitor, rescues cognitive deficits in D own syndrome mouse models and in humans

de la Torre, R., Sola, S. D., Pons‐Espinal, M., Duchon, A., de Lagrán, M. M., Farré, M., Fitó, M., Benejam, B., Langohr, K., Rodríguez, J. C., et al. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201300325 · Cited by 297

Resveratrol and Estradiol Rapidly Activate MAPK Signaling through Estrogen Receptors α and β in Endothelial Cells

Klinge, C. M., Blankenship, K. A., Risinger, K. E., Bhatnagar, S., Noisin, E. L., Sumanasekera, W. K., Zhao, L., Brey, D. M., & Keynton, R. S. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411565200 · Cited by 296

Phenolic Acids of Plant Origin—A Review on Their Antioxidant Activity In Vitro (O/W Emulsion Systems) Along with Their in Vivo Health Biochemical Properties

Kiokias, S. N., Proestos, C., & Oreopoulou, V. (2020) · Foods · doi:10.3390/foods9040534 · Cited by 293

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

de la Torre, R., de Sola, S., Hernández, G., Farré, M., Pujol, J., Rodríguez, J. C., Espadaler, J. M., Langohr, K., Cuenca‐Royo, A., Príncipe, A., et al. (2016) · The Lancet Neurology · doi:10.1016/s1474-4422(16)30034-5 · Cited by 291

Anthocyanins Reversed D-Galactose-Induced Oxidative Stress and Neuroinflammation Mediated Cognitive Impairment in Adult Rats

Rehman, S. U., Shah, S. A., Ali, T., Chung, J. I., & Kim, M. O. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9604-5 · Cited by 290

Bioavailability of Ferulic Acid

Bourne, L., & Rice-Evans, C. A. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9681 · Cited by 276

Resveratrol inhibits nitric oxide and TNF-α production by lipopolysaccharide-activated microglia

Bi, X. L., Yang, J., Dong, Y. X., Wang, J., Cui, Y. H., Ikeshima, T., Zhao, Y. Q., & Wu, C. F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.08.008 · Cited by 274

Diet and Mental Health: Review of the Recent Updates on Molecular Mechanisms

Godos, J., Currenti, W., Angelino, D., Mena, P. R., Castellano, S., Caraci, F., Galvano, F., Rio, D. D., Ferri, R., & Grosso, G. (2020) · Antioxidants · doi:10.3390/antiox9040346 · Cited by 274

Virgin olive oil supplementation and long-term cognition: the Predimed-Navarra randomized, trial

Martínez‐Lapiscina, E. H., Clavero, P., Toledo, E., Julian, B. S., Sánchez‐Tainta, A., Corella, D., Lamuela-Raventós, R. M., Martínez, J. A., & Martínez‐González, M. Á. (2013) · The journal of nutrition health & aging · doi:10.1007/s12603-013-0027-6 · Cited by 267

A mechanistic hypothesis for the impairment of synaptic plasticity by soluble Aβ oligomers from Alzheimer’s brain

Li, S., & Selkoe, D. J. (2020) · Journal of Neurochemistry · doi:10.1111/jnc.15007 · Cited by 263

The neuroprotective effects of cocoa flavanol and its influence on cognitive performance

Nehlig, A. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04378.x · Cited by 258

Concord Grape Juice Supplementation and Neurocognitive Function in Human Aging

Krikorian, R., Boespflug, E. L., Fleck, D. E., Stein, A. L., Wightman, J. D., Shidler, M. D., & Sadat-Hossieny, S. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf300277g · Cited by 255

The Neuroprotective Effects of Phenolic Acids: Molecular Mechanism of Action

Szwajgier, D., Borowiec, K., & Pustelniak, K. (2017) · Nutrients · doi:10.3390/nu9050477 · Cited by 255

Mitochondrial Dysfunction as a Driver of Cognitive Impairment in Alzheimer’s Disease

Sharma, C., Kim, S., Nam, Y., Jung, U. J., & Kim, S. R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094850 · Cited by 253

Potential Role of Olive Oil Phenolic Compounds in the Prevention of Neurodegenerative Diseases

Rodríguez-Morató, J., Xicota, L., Fitó, M., Farré, M., Dierssen, M., & de la Torre, R. (2015) · Molecules · doi:10.3390/molecules20034655 · Cited by 249

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

Uemura, M. T., Maki, T., Ihara, M., Lee, V. M. ‐., & Trojanowski, J. Q. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00080 · Cited by 246

The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C. (2019) · Brain Research · doi:10.1016/j.brainres.2019.146476 · Cited by 243

Site-specific Inhibitory Mechanism for Amyloid β42 Aggregation by Catechol-type Flavonoids Targeting the Lys Residues

Sato, M., Murakami, K., Uno, M., Nakagawa, Y., Katayama, S., Akagi, K., Masuda, Y., Takegoshi, K., & Irie, K. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.464222 · Cited by 237

Review of the Pharmacological Effects of Vitis vinifera (Grape) and its Bioactive Constituents: An Update

Nassiri‐Asl, M., & Hosseinzadeh, H. (2016) · Phytotherapy Research · doi:10.1002/ptr.5644 · Cited by 235

Curcumin and cognition: a randomised, placebo-controlled, double-blind study of community-dwelling older adults

Rainey‐Smith, S. R., Brown, B. M., Sohrabi, H. R., Shah, T. M., Goozee, K. G., Gupta, V. B., & Martins, R. N. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516001203 · Cited by 232

The role of APOE in cerebrovascular dysfunction

Tai, L. M., Thomas, R., Marottoli, F. M., Koster, K. P., Kanekiyo, T., Morris, A. W. J., & Bu, G. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1547-z · Cited by 231

Green tea effects on cognition, mood and human brain function: A systematic review

Mancini, E., Beglinger, C., Drewe, J., Zanchi, D., Lang, U. E., & Borgwardt, S. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.07.008 · Cited by 229

Function of Green Tea Catechins in the Brain: Epigallocatechin Gallate and its Metabolites

Pervin, M., Unno, K., Takagaki, A., Isemura, M., & Nakamura, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153630 · Cited by 216

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

Yang, T., Sun, Y., Lu, Z., Leak, R. K., & Zhang, F. (2016) · Ageing Research Reviews · doi:10.1016/j.arr.2016.09.007 · Cited by 214

Equol: Pharmacokinetics and Biological Actions ,

Setchell, K. D. R., & Clerici, C. (2010) · Journal of Nutrition · doi:10.3945/jn.109.119784 · Cited by 212

Isoflavones and cognitive function in older women: the SOy and Postmenopausal Health In Aging (SOPHIA) Study

Kritz‐Silverstein, D. C., hlen, D. V. M., Barrett-Connor, E. L., & Bressel, M. (2003) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200310030-00004 · Cited by 210

Coffee components and cardiovascular risk: beneficial and detrimental effects

Godos, J., Pluchinotta, F. R., Marventano, S., Buscemi, S., Li Volti, G., Galvano, F., & Grosso, G. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.940287 · Cited by 210

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

Morley, J. E., Armbrecht, H. J., Farr, S. A., & Kumar, V. B. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.11.015 · Cited by 205

Anthocyanin-rich Açai (Euterpe oleracea Mart.) Fruit Pulp Fractions Attenuate Inflammatory Stress Signaling in Mouse Brain BV-2 Microglial Cells

Poulose, S. M., Fisher, D. R., Larson, J., Bielinski, D. F., Rimando, A. M., Carey, A. N., Schauss, A. G., & Shukitt‐Hale, B. (2012) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf203989k · Cited by 204

Enhanced task-related brain activation and resting perfusion in healthy older adults after chronic blueberry supplementation

Bowtell, J. L., Bakkar, Z. A., Conway, M. E., Adlam, A., & Fulford, J. (2017) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0550 · Cited by 202

Dietary blueberry improves cognition among older adults in a randomized, double-blind, placebo-controlled trial

Miller, M. G., Hamilton, D. A., Joseph, J. A., & Shukitt‐Hale, B. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1400-8 · Cited by 200

Improved cognitive function in postmenopausal women after 12 weeks of consumption of a soya extract containing isoflavones

Duffy, R., Wiseman, H., & File, S. E. (2003) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(03)00116-3 · Cited by 197

Epigenetic regulation of astrocyte function in neuroinflammation and neurodegeneration

Neal, M. P., & Richardson, J. R. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.11.004 · Cited by 195

Synaptic Plasticity, Dementia and Alzheimer Disease

Skaper, S. D., Facci, L., Zusso, M., & Giusti, P. (2017) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527316666170113120853 · Cited by 192

Microbiota-gut-brain axis and cognitive function

Gareau, M. G. (2014) · Advances in Experimental Medicine and Biology · doi:10.1007/978-1-4939-0897-4_16 · Cited by 189

Curcumin Attenuates Amyloid-β Aggregate Toxicity and Modulates Amyloid-β Aggregation Pathway

Thapa, A., Jett, S. D., & Chi, E. Y. (2015) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.5b00214 · Cited by 188

Potential Mechanism by Which Resveratrol, a Red Wine Constituent, Protects Neurons

Zhuang, H., Kim, Y., Koehler, R. C., & Doré, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07534.x · Cited by 186

Oxidative Stress in Cognitive and Epigenetic Aging: A Retrospective Glance

Kandlur, A., Satyamoorthy, K., & Gangadharan, G. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00041 · Cited by 186

Curcumin protects PC12 cells against 1-methyl-4-phenylpyridinium ion-induced apoptosis by bcl-2-mitochondria-ROS-iNOS pathway

Chen, J., Tang, X., Zhi, J. L., Cui, Y., Yu, H., Tang, E. H., Sun, S. N., Feng, J. Q., & Chen, P. (2006) · APOPTOSIS · doi:10.1007/s10495-006-6715-5 · Cited by 185

Chocolate and the brain: Neurobiological impact of cocoa flavanols on cognition and behavior

Sokolov, A. N., Pavlova, M. A., Klosterhalfen, S., & Enck, P. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.06.013 · Cited by 181

Curcumin Enhances Neurogenesis and Cognition in Aged Rats: Implications for Transcriptional Interactions Related to Growth and Synaptic Plasticity

Dong, S., Zeng, Q., Mitchell, E. S., Xiu, J., Duan, Y., Li, C., Tiwari, J. K., Hu, Y., Cao, X., & Zhao, Z. Y. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031211 · Cited by 179

Green Tea Epigallocatechin 3-Gallate Accumulates in Mitochondria and Displays a Selective Antiapoptotic Effect Against Inducers of Mitochondrial Oxidative Stress in Neurons

Schroeder, E. K., Kelsey, N. A., Doyle, J., Breed, E. R., Bouchard, R. J., Loucks, F. A., Harbison, R. A., & Linseman, D. A. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2215 · Cited by 178

Enhanced neural activation with blueberry supplementation in mild cognitive impairment

Boespflug, E. L., Eliassen, J. C., Dudley, J. A., Shidler, M. D., Kalt, W., Summer, S. S., Stein, A. L., Stover, A. N., & Krikorian, R. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1287833 · Cited by 178

Estrogen and Bcl-2: Gene Induction and Effect of Transgene in Experimental Stroke

Alkayed, N. J., Goto, S., Sugo, N., Joh, H.-D., Klaus, J. A., Crain, B. J., Bernard, O., Traystman, R. J., & Hurn, P. D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07543.2001 · Cited by 177

Neurobiological links between depression and AD: the role of TGF-β1 signaling as a new pharmacological target

Caraci, F., Spampinato, S. F., Morgese, M. G., Tascedda, F., Salluzzo, M. G., Giambirtone, M. C., Caruso, G., Munafò, A., Torrisi, S. A., Leggio, G. M., et al. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.02.007 · Cited by 172

A double-blind, placebo-controlled, randomized trial of the effects of dark chocolate and cocoa on variables associated with neuropsychological functioning and cardiovascular health: clinical findings from a sample of healthy, cognitively intact older adults

Crews, W. D., Harrison, D. W., & Wright, J. W. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.4.872 · Cited by 169

Effects of Resveratrol on Cognitive Performance, Mood and Cerebrovascular Function in Post-Menopausal Women; A 14-Week Randomised Placebo-Controlled Intervention Trial

Evans, H. M., Howe, P. R. C., & Wong, R. H. X. (2017) · Nutrients · doi:10.3390/nu9010027 · Cited by 168

Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia

Jung, K. K., Lee, H. S., Cho, J. Y., Shin, W. C., Rhee, M. H., Kim, T., Kang, J. H., Kim, S. H., Hong, S., & Kang, S. Y. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.06.048 · Cited by 164

Cognitive-Enhancing Effect of Quercetin in a Rat Model of Parkinson's Disease Induced by 6-Hydroxydopamine

Sriraksa, N., Wattanathorn, J., Muchimapura, S., Tiamkao, S., Brown, K., & Chaisiwamongkol, K. (2011) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2012/823206 · Cited by 164

Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease

Caruana, M., Cauchi, R. J., & Vassallo, N. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00031 · Cited by 164

Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans

PhD, F. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s2310 · Cited by 162

Necdin Regulates p53 Acetylation via Sirtuin1 to Modulate DNA Damage Response in Cortical Neurons

Hasegawa, K., & Yoshikawa, K. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3052-08.2008 · Cited by 162

Resveratrol stimulates nitric oxide production by increasing estrogen receptor αa‐Src‐caveolin‐1 interaction and phosphorylation in human umbilical vein endothelial cells

Klinge, C. M., Wickramasinghe, N. S. M. D., Ivanova, M. M., & Dougherty, S. M. (2008) · The FASEB Journal · doi:10.1096/fj.07-103366 · Cited by 162

Resveratrol Inhibits β-Amyloid-Induced Neuronal Apoptosis through Regulation of SIRT1-ROCK1 Signaling Pathway

Feng, X., Liang, N., Zhu, D., Gao, Q., Peng, L., Dong, H., Yue, Q., Liu, H., Bao, L., Zhang, J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059888 · Cited by 160

Pharmacological effects of protocatechuic acid and its therapeutic potential in neurodegenerative diseases: Review on the basis of in vitro and in vivo studies in rodents and humans

Krzysztoforska, K., Mirowska-Guzel, D. M., & Widy‐Tyszkiewicz, E. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1354543 · Cited by 160

Cocoa polyphenols enhance positive mood states but not cognitive performance a randomized, placebo-controlled trial

Pase, M. P., Scholey, A. B., Pipingas, A., Kras, M., Nolidin, K., Gibbs, A., Wesnes, K., & Stough, C. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881112473791 · Cited by 154

Relationship between cognitive function and regulation of cerebral blood flow

Ogoh, S. (2017) · The Journal of Physiological Sciences · doi:10.1007/s12576-017-0525-0 · Cited by 150

Natural polyphenols effects on protein aggregates in Alzheimer's and Parkinson's prion-like diseases

Bilan, A. R., Freyssin, A., Page, G., & Fauconneau, B. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.233432 · Cited by 144

Oxidative stress predicts cognitive decline with aging in healthy adults: an observational study

Hajjar, I. M., Hayek, S. S., Goldstein, F. C., Martin, G. S., Jones, D. P., & Quyyumi, A. A. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-017-1026-z · Cited by 143

Amyloid‐beta ( A β1–42)‐induced paralysis in C aenorhabditis elegans is inhibited by the polyphenol quercetin through activation of protein degradation pathways

Regitz, C., Dußling, L. M., & Wenzel, U. (2014) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400014 · Cited by 142

Cognitive impairment and BDNF serum levels

Siuda, J. S., Patalong‐Ogiewa, M., Żmuda, W., Targosz-Gajniak, M., Niewiadomska, E., Matuszek, I., Jędrzejowska–Szypułka, H., & Rudzińska, M. (2016) · Neurologia i Neurochirurgia Polska · doi:10.1016/j.pjnns.2016.10.001 · Cited by 142

Cognitive response to fish oil, blueberry, and combined supplementation in older adults with subjective cognitive impairment

McNamara, R. K., Kalt, W., Shidler, M. D., McDonald, J. E., Summer, S. S., Stein, A. L., Stover, A. N., & Krikorian, R. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.12.003 · Cited by 142

Apolipoprotein E in Synaptic Plasticity and Alzheimer’s Disease: Potential Cellular and Molecular Mechanisms

Kim, J., Yoon, H., Basak, J., & Kim, J. (2014) · Molecules and Cells · doi:10.14348/molcells.2014.0248 · Cited by 141

Enhancing Human Cognition with Cocoa Flavonoids

Socci, V., Tempesta, D., Desideri, G., de Gennaro, L., & Ferrara, M. (2017) · Frontiers in Nutrition · doi:10.3389/fnut.2017.00019 · Cited by 141

Extra Virgin Olive Oil Improves Learning and Memory in SAMP8 Mice

Farr, S. A., Price, T. O., Dominguez, L. J., Motisi, A., Saiano, F., Niehoff, M. L., Morley, J. E., Banks, W. A., Nuran Ercal, A., & Barbagallo, M. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110662 · Cited by 139

Modulating effect of cytokines on mechanisms of synaptic plasticity in the brain

Levin, S. G., & Godukhin, O. V. (2017) · Biochemistry (Moscow) · doi:10.1134/s000629791703004x · Cited by 139

Natural Compounds as Inhibitors of Aβ Peptide Aggregation: Chemical Requirements and Molecular Mechanisms

Pagano, K., Tomaselli, S., Molinari, H., & Ragona, L. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.619667 · Cited by 139

Green tea EGCG, T cells, and T cell-mediated autoimmune diseases

Wu, D., Wang, J., Pae, M., & Meydani, S. N. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.001 · Cited by 138

Blood Brain Barrier Permeability of (-)-epigallocatechin Gallate, its Proliferation-Enhancing Activity of Human Neuroblastoma SH-Sy5y Cells, and its Preventive Effect on Age-Related Cognitive Dysfunction in Mice

Pervin, M., Unno, K., Nakagawa, A., Takahashi, Y., Iguchi, K., Yamamoto, H., Hoshino, M., Hara, A., Takagaki, A., Nanjo, F., et al. (2017) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2016.12.012 · Cited by 137

Mitochondria at the interface between neurodegeneration and neuroinflammation

Bader, V., & Winklhofer, K. F. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.05.028 · Cited by 135

Effect of curcumin on brain insulin receptors and memory functions in STZ (ICV) induced dementia model of rat

Agrawal, R., Mishra, B., Tyagi, E., Nath, C., & Shukla, R. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2009.12.008 · Cited by 133

A Randomized, Double-Blinded, Placebo-Controlled Study to Compare the Safety and Efficacy of Low Dose Enhanced Wild Blueberry Powder and Wild Blueberry Extract (ThinkBlue™) in Maintenance of Episodic and Working Memory in Older Adults

Whyte, A. R., Cheng, N., Fromentin, E., & Williams, C. M. (2018) · Nutrients · doi:10.3390/nu10060660 · Cited by 132

Resveratrol decreases the insoluble Aβ1–42 level in hippocampus and protects the integrity of the blood–brain barrier in AD rats

Zhao, H., Li, N., Wang, Q.-N., Cheng, X., Li, X. M., & Liu, T. T. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.10.006 · Cited by 130

Polyphenols From Grape and Blueberry Improve Episodic Memory in Healthy Elderly with Lower Level of Memory Performance: A Bicentric Double-Blind, Randomized, Placebo-Controlled Clinical Study

Bensalem, J., Dudonné, S., Etchamendy, N., Pellay, H., Amadieu, C., Gaudout, D., Dubreuil, S., Paradis, M., Pomerleau, S., Capuron, L., et al. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly166 · Cited by 130

Green Tea Intake and Risks for Dementia, Alzheimer’s Disease, Mild Cognitive Impairment, and Cognitive Impairment: A Systematic Review

Kakutani, S., Watanabe, H., & Murayama, N. (2019) · Nutrients · doi:10.3390/nu11051165 · Cited by 130

High-flavonoid intake induces cognitive improvements linked to changes in serum brain-derived neurotrophic factor: Two randomised, controlled trials

Neshatdoust, S., Saunders, C., Castle, S. M., Vauzour, D., Williams, C. M., Butler, L. T., Lovegrove, J. A., & Spencer, J. P. E. (2016) · Nutrition and Healthy Aging · doi:10.3233/nha-1615 · Cited by 128

Aβ(1-42) Aggregates into Non-Toxic Amyloid Assemblies in the Presence of the Natural Polyphenol Oleuropein Aglycon

Rigacci, S., Guidotti, V., Bucciantini, M., Nichino, D., Relini, A., Berti, A., & Stefani, M. (2011) · Current Alzheimer Research · doi:10.2174/156720511798192682 · Cited by 127

The effect of flavanol-rich cocoa on cerebral perfusion in healthy older adults during conscious resting state: a placebo controlled, crossover, acute trial

Lamport, D. J., Pal, D., Moutsiana, C., Field, D. T., Williams, C. M., Spencer, J. P. E., & Butler, L. T. (2015) · Psychopharmacology · doi:10.1007/s00213-015-3972-4 · Cited by 126

Anthocyanins protect against LPS-induced oxidative stress-mediated neuroinflammation and neurodegeneration in the adult mouse cortex

Khan, M. S., Ali, T., Kim, M. W., Jo, M. H., Jo, M. G., Badshah, H., & Kim, M. O. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.005 · Cited by 126

Long-term soy isoflavone supplementation and cognition in women

Henderson, V. W., John, J. A. S., Hodis, H. N., Kono, N., McCleary, C. A., Franke, A. A., & Mack, W. J. (2012) · Neurology · doi:10.1212/wnl.0b013e318258f822 · Cited by 124

Gut microbiota modulation accounts for the neuroprotective properties of anthocyanins

Marques, C., Fernandes, I., Meireles, M., Faria, A., Spencer, J. P. E., Mateus, N. F. D. C. B., & Calhau, C. (2018) · Scientific Reports · doi:10.1038/s41598-018-29744-5 · Cited by 123

Effect of Estradiol and Soy Phytoestrogens on Choline Acetyltransferase and Nerve Growth Factor mRNAs in the Frontal Cortex and Hippocampus of Female Rats

Pan, Y., Anthony, M. S., & Clarkson, T. B. (1999) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.1999.d01-64.x · Cited by 122

Structure activity relationship of phenolic acid inhibitors of α-synuclein fibril formation and toxicity

Ardah, M. T., Paleologou, K. E., Lv, G., Khair, S. B. A., Kazim, A. S., Minhas, S. T., Al‐Tel, T. H., Al-Hayani, A. A., Haque, M. E., Eliezer, D., et al. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00197 · Cited by 120

Anthocyanins from Lycium ruthenicum Murr. Ameliorated d -Galactose-Induced Memory Impairment, Oxidative Stress, and Neuroinflammation in Adult Rats

Chen, S., Zhou, H., Zhang, G., Meng, J., Deng, K., Zhou, W., Wang, H., Wang, Z., Hu, N., & Suo, Y. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06402 · Cited by 120

An examination of the effects of the antioxidant Pycnogenol® on cognitive performance, serum lipid profile, endocrinological and oxidative stress biomarkers in an elderly population

Ryan, J. L., Croft, K. D., Mori, T. A., Wesnes, K. A., Spong, J., Downey, L. A., Kure, C., Lloyd, J., & Stough, C. K. K. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881108091584 · Cited by 119

Quercetin protects the impairment of memory and anxiogenic-like behavior in rats exposed to cadmium: Possible involvement of the acetylcholinesterase and Na+,K+-ATPase activities

Abdalla, F. H., Schmatz, R., Cardoso, A. M., Carvalho, F. B., Baldissarelli, J., de Oliveira, J. S., da Rosa, M. M., Nunes, M. A. G., Rubin, M. A., da Cruz, I. B. M., et al. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.06.008 · Cited by 118

The human-microbiome superorganism and its modulation to restore health

Salvucci, E. (2019) · International Journal of Food Sciences and Nutrition · doi:10.1080/09637486.2019.1580682 · Cited by 118

Anthocyanins: From the Field to the Antioxidants in the Body

Bendokas, V., Stanys, V., Mažeikienė, I., Trumbeckaitė, S., Banienė, R., & Liobikas, J. (2020) · Antioxidants · doi:10.3390/antiox9090819 · Cited by 117

Loading into Nanoparticles Improves Quercetin's Efficacy in Preventing Neuroinflammation Induced by Oxysterols

Testa, G., Gamba, P., Badıllı, U., Gargiulo, S., Maina, M., Guina, T., Calfapietra, S., Biasi, F., Cavalli, R., Poli, G., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0096795 · Cited by 114

Effect of Quercetin on PC12 Alzheimer’s Disease Cell Model Induced by Aβ25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO‐1 Pathway

Yu, X., Li, Y., & Mu, X. (2020) · BioMed Research International · doi:10.1155/2020/8210578 · Cited by 113

Gene Differences between Caucasian, Negro, and Japanese Populations

Nei, M., & Roychoudhury, A. K. (1972) · Science · doi:10.1126/science.177.4047.434 · Cited by 112

Glial Cells - The Key Elements of Alzheimers Disease

Džamba, D., Harantová, L., Butenko, O., & Anděrová, M. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160129095924 · Cited by 112

Recent advances in the mechanisms of neuroinflammation and their roles in neurodegeneration

Niranjan, R. (2018) · Neurochemistry International · doi:10.1016/j.neuint.2018.07.003 · Cited by 112

Effects of Polyphenol-Rich Foods on Human Health

Grosso, G. (2018) · Nutrients · doi:10.3390/nu10081089 · Cited by 112

Cognitive improvement after 6 weeks of soy supplements in postmenopausal women is limited to frontal lobe function

File, S. E., Hartley, D. E., Elsabagh, S., Duffy, R., & Wiseman, H. (2005) · Menopause The Journal of The North American Menopause Society · doi:10.1097/00042192-200512020-00014 · Cited by 111

Impact of Resveratrol on Glucose Control, Hippocampal Structure and Connectivity, and Memory Performance in Patients with Mild Cognitive Impairment

Köbe, T., Witte, A. V., Schnelle, A., Tesky, V. A., Pantel, J., Schuchardt, J. P., Hahn, A., Bohlken, J., Grittner, U., & Flöel, A. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00105 · Cited by 111

Pivotal role of carnosine in the modulation of brain cells activity: Multimodal mechanism of action and therapeutic potential in neurodegenerative disorders

Caruso, G., Caraci, F., & Jolivet, R. B. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.004 · Cited by 110

Curcumin Prevents Dopaminergic Neuronal Death Through Inhibition of the c-Jun N-Terminal Kinase Pathway

Yu, S., Zheng, W., Xin, N., Chi, Z., Wang, N.-Q., Nie, Y.-X., Feng, W., & Wang, Z. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0908 · Cited by 109

Inflammation, mitochondria, and the inhibition of adult neurogenesis

Voloboueva, L. A., & Giffard, R. G. (2011) · Journal of Neuroscience Research · doi:10.1002/jnr.22768 · Cited by 109

Epigallocatechin‐3‐Gallate (EGCG) Promotes Autophagy‐Dependent Survival via Influencing the Balance of mTOR‐AMPK Pathways upon Endoplasmic Reticulum Stress

Holczer, M., Besze, B., Zámbó, V., Csala, M., Bánhegyi, G., & Kapuy, O. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6721530 · Cited by 109

Cerebral blood flow response to flavanol-rich cocoa in healthy elderly humans-1

Sorond, F. A., Lipsitz, L. A., Hollenberg, N. K., & Fisher, N. D. L. (2011) · Figshare · doi:10.6084/m9.figshare.87623 · Cited by 109

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Pan, Y., Anthony, M. S., & Clarkson, T. B. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00994-x · Cited by 105

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Park, S.-K., Jung, I.-C., Lee, W. K., Lee, Y. S., Park, H. K., Go, H. J., Kim, K., Lim, N. K., Hong, J. T., Ly, S. Y., et al. (2011) · Journal of Medicinal Food · doi:10.1089/jmf.2009.1374 · Cited by 105

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Becker, W., Soppa, U., & Tejedor, F. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/18715273113126660186 · Cited by 103

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Wang, X., Chen, S., Ma, G., Ye, M., & Lü, G. (2005) · Neuroreport · doi:10.1097/00001756-200502280-00013 · Cited by 99

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Hühn, S., Beyer, F., Zhang, R., Lampe, L., Grothe, J., Kratzsch, J., Willenberg, A., Breitfeld, J., Kovacs, P. L., Stümvoll, M., et al. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.03.023 · Cited by 99

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Ho, S. C., Chan, A. S.-Y., Ho, Y. P., So, E. K. F., Sham, A., Zee, B. C.-Y., & Woo, J. (2007) · Menopause The Journal of The North American Menopause Society · doi:10.1097/gme.0b013e31802c4f4f · Cited by 93

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Jin, Q., Liu, T., Qiao, Y., Liu, D., Yang, L., Mao, H., Ma, F., Wang, Y., Peng, L., & Zhan, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1185317 · Cited by 490

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