Cited by 64Peroxisome Proliferator-Activated ReceptorsAdipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

PPARs and the orchestration of metabolic fuel selection

Sugden, Mary C., Zariwala, M. Gulrez, Holness, Mark J.·2009·Pharmacological Research

Abstract

This contribution describes recent advances in our knowledge of the regulatory interactions between the two major oxidative fuels glucose and lipid. It also addresses how the metabolic abnormalities associated with insulin resistance and ischemic diseases impair the ability of skeletal muscle to switch between the use of alternative metabolic fuels and the ability of adipose tissue to function appropriately in relation to the body's requirements for triglyceride mobilisation or storage, as appropriate to nutritional status. We discuss how targeting PPARs might ameliorate metabolic inflexibility in muscle through altered expression of pyruvate dehydrogenase kinase (PDK) isoforms and impact the functions of the adipocyte in lipid buffering and energy homeostasis. Focus has been placed on the participation of the regulatory pyruvate dehydrogenase kinases, PPAR targets, both in the beneficial and the potentially adverse actions of the PPARs in metabolic control.

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Crossref · 10.1016/j.phrs.2009.03.014

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130 of 130 references verified0 citation errors · 0 not checkable

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  • Dysregulation of pyruvate metabolism contributes to the pathogenesis of numerous diseases, including diabetes and obesity, mitochondrial disorders, cardiac failure, neurodegenerative disorders, and cancer.

    “Dysregulation of these processes contributes to the pathogenesis of numerous diseases, including diabetes and obesity (DeFronzo and Tripathy, 2009; Sugden et al., 2009), mitochondrial disorders (Kerr, 2013), cardiac failure (Fillmore and Lopaschuk, 2013), neurodegenerative disorders (Cunnane et al., 2011; Yao et al., 2011), and cancer (Currie et al., 2013; Tennant et al., 2010).”

    From Regulation of Substrate Utilization by the Mitochondrial Pyruvate Carrier (2014) · cites this paper as Sugden et al., 2009

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Authors
Sugden, M. C., Zariwala, M. G., & Holness, M. J.
Affiliations
Queen Mary University of London (GB)
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2009-09
Volume
60
Issue
3
Pages
141-150
ISSN
1043-6618 (ISSN-L)
OpenAlex
W2090782359
Cited by
64
References
130
Citations by year
2025: 2 · 2024: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 10 · 2014: 6 · 2013: 7 · 2012: 6
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Diabetes UK
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
  • Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords
peroxisome proliferator-activated receptors, glycolipid metabolism, insulin resistance, adipose tissue, energy homeostasis, pyruvate dehydrogenase kinase, ischemic diseases
MeSH terms
Adipose Tissue, Animals, Energy Metabolism, Fatty Acids, Glucose, Humans, Insulin Resistance, Ischemia, Mitochondria, Muscle, Obesity, Stress, Physiological, Peroxisome Proliferator-Activated Receptors, Lipid Metabolism

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