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Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease
Open accessAbstract
Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions. Therefore, the integrity of gut microbiota be relevant to the pathophysiology and control of important medical diseases like diabetes mellitus, inflammatory and autoimmune diseases, and even neuropsychiatric disorders such as depression, autism spectrum disorder, Parkinson's and Alzheimer disease. Gut microbiota may affect brain function and behaviour through the microbiota-gut-brain axis, in bidirectional interplay with top-down and bottom-up regulations. Through metabolic activity of non- pathogenical microorganisms and secretion of functional by-products that increase the permeability of the intestinal mucosa, the gut microbiota influences both the production and absorption of neurotransmitters (e.g., serotonin and GABA), increasing their bioavailability to the CNS. It has been further shown some components of the gut microbiota - predominantly bacteria - synthesize and release amyloid peptides and lipopolysaccharides, which in turn activate inflammatory signalling through the release of cytokines, with potential effects on the pathophysiological cascade of Alzheimer disease.
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Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease
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“Gut microbes influence the formation, absorption and transport of serotonin and GABA in the brain, moreover some bacterial species influence the formation of amyloid plaque which initiates the inflammatory cascade and hence susceptibility to AD [23].”
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The impact of the microbiota-gut-brain axis on Alzheimer’s disease pathophysiology
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Metadata
- Authors
- de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Forlenza, Orestes V.
- ORCID
- Forlenza, Orestes V.
- Venue
- Pharmacological Research
- Publisher
- Elsevier BV
- Published
- 2018-10
- Volume
- 136
- Pages
- 29-34
- ISSN
- 1043-6618 (ISSN-L)
- OpenAlex
- W2888024736
- Cited by
- 145
- References
- 82
- Citations by year
- 2026: 5 · 2025: 16 · 2024: 13 · 2023: 26 · 2022: 22 · 2021: 22 · 2020: 26 · 2019: 15
- FWCI
- 1.54
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Pharmacological Research (publishedVersion)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- FAPESP (Fundação de Amparo à Pesquisa de São Paulo (2013/20695-3, 2009/52825-8, 2016/01302-9)
- CNPq (Conselho Nacional de Pesquisa Científica
- ABADHS (Associação Beneficente Alzira Denise Hertzog da Silva)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- gut microbiota, Alzheimer's disease, microbiota-gut-brain axis, cognition, behavior, neurotransmitter production, serotonin, GABA, intestinal permeability, amyloid peptides, lipopolysaccharide, neuroinflammation, cytokines, neuropsychiatric disorders, Parkinson's disease, depression, autism spectrum disorder
- MeSH terms
- Gastrointestinal Microbiome, Alzheimer Disease, Animals, Behavior, Brain, Cognition, Humans, Neurotransmitter Agents
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