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Cited by 145Gut microbiota and healthGastrointestinal motility and disordersTryptophan and brain disorders

The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.

Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

Open access
de J.R. De-Paula, Vanessa, Forlenza, Andrea S., Forlenza, Orestes V.·2018·Pharmacological Research
DOI 10.1016/j.phrs.2018.07.007
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Abstract

Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions. Therefore, the integrity of gut microbiota be relevant to the pathophysiology and control of important medical diseases like diabetes mellitus, inflammatory and autoimmune diseases, and even neuropsychiatric disorders such as depression, autism spectrum disorder, Parkinson's and Alzheimer disease. Gut microbiota may affect brain function and behaviour through the microbiota-gut-brain axis, in bidirectional interplay with top-down and bottom-up regulations. Through metabolic activity of non- pathogenical microorganisms and secretion of functional by-products that increase the permeability of the intestinal mucosa, the gut microbiota influences both the production and absorption of neurotransmitters (e.g., serotonin and GABA), increasing their bioavailability to the CNS. It has been further shown some components of the gut microbiota - predominantly bacteria - synthesize and release amyloid peptides and lipopolysaccharides, which in turn activate inflammatory signalling through the release of cytokines, with potential effects on the pathophysiological cascade of Alzheimer disease.

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Research works printed but not linked: 3

  1. Li, 2016, Biotic/abiotic stress-driven Alzheimer’s disease, Front. Cell. Neurosci., 1, 10
  2. Hu, 2016, Alzheimer’s disease and gut microbiota, Sci. China Life Sci., 10, 1006, 10.1007/s11427-016-5083-9 · DOI · Paper page
  3. Al-muzafar, 2017, Probiotic mixture improves fatty liver disease by virtue of its action on lipid profiles, leptin, and Inflamm. Biomarkers, BMC Complement Altern. Med., 1, 17

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Metadata

Authors
de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V.
Affiliations
Universidade de São Paulo (BR)
Corresponding author
Forlenza, Orestes V.
ORCID
Forlenza, Orestes V.
Venue
Pharmacological Research
Publisher
Elsevier BV
Published
2018-10
Volume
136
Pages
29-34
ISSN
1043-6618 (ISSN-L)
DOI
10.1016/j.phrs.2018.07.007
OpenAlex
W2888024736
Cited by
145
References
82
Citations by year
2026: 5 · 2025: 16 · 2024: 13 · 2023: 26 · 2022: 22 · 2021: 22 · 2020: 26 · 2019: 15
FWCI
1.54
Type
journal article
Language
en
Open access
Licence
Locations
  • Pharmacological Research (publishedVersion)
  • PubMed (publishedVersion)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders
  • FAPESP (Fundação de Amparo à Pesquisa de São Paulo (2013/20695-3, 2009/52825-8, 2016/01302-9)
  • CNPq (Conselho Nacional de Pesquisa Científica
  • ABADHS (Associação Beneficente Alzira Denise Hertzog da Silva)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
gut microbiota, Alzheimer's disease, microbiota-gut-brain axis, cognition, behavior, neurotransmitter production, serotonin, GABA, intestinal permeability, amyloid peptides, lipopolysaccharide, neuroinflammation, cytokines, neuropsychiatric disorders, Parkinson's disease, depression, autism spectrum disorder
MeSH terms
Gastrointestinal Microbiome, Alzheimer Disease, Animals, Behavior, Brain, Cognition, Humans, Neurotransmitter Agents

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