Cited by 145Gut microbiota and healthGastrointestinal motility and disordersTryptophan and brain disorders

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Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

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de J.R. De-Paula, Vanessa, Forlenza, Andrea S., Forlenza, Orestes V.·2018·Pharmacological Research

DOI 10.1016/j.phrs.2018.07.007

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Abstract

Approximately 95% of the symbiotic microbes in human body are located in the gut. This microbioma is involved in important homeostatic processes, not only related to gastrointestinal function but also to several complex modulatory processes, such as glucose and bone metabolism, inflammation and immune response, peripheral (enteric) and central neurotransmission. For that reason, recent studies proposed that abnormalities in gut microbiota may play a role in systemic and central nervous system (CNS) conditions. Therefore, the integrity of gut microbiota be relevant to the pathophysiology and control of important medical diseases like diabetes mellitus, inflammatory and autoimmune diseases, and even neuropsychiatric disorders such as depression, autism spectrum disorder, Parkinson's and Alzheimer disease. Gut microbiota may affect brain function and behaviour through the microbiota-gut-brain axis, in bidirectional interplay with top-down and bottom-up regulations. Through metabolic activity of non- pathogenical microorganisms and secretion of functional by-products that increase the permeability of the intestinal mucosa, the gut microbiota influences both the production and absorption of neurotransmitters (e.g., serotonin and GABA), increasing their bioavailability to the CNS. It has been further shown some components of the gut microbiota - predominantly bacteria - synthesize and release amyloid peptides and lipopolysaccharides, which in turn activate inflammatory signalling through the release of cytokines, with potential effects on the pathophysiological cascade of Alzheimer disease.

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Authors: de J.R. De-Paula, V., Forlenza, A. S., & Forlenza, O. V.
Affiliations: Universidade de São Paulo (BR)
Corresponding author: Forlenza, Orestes V.
ORCID: Forlenza, Orestes V.
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2018-10
Volume: 136
Pages: 29-34
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2018.07.007
OpenAlex: W2888024736
Cited by: 145
References: 82
Citations by year: 2026: 5 · 2025: 16 · 2024: 13 · 2023: 26 · 2022: 22 · 2021: 22 · 2020: 26 · 2019: 15
FWCI: 1.54
Type: journal article
Language: en
Open access: green
observatorio.fm.usp.br
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: FAPESP (Fundação de Amparo à Pesquisa de São Paulo (2013/20695-3, 2009/52825-8, 2016/01302-9)
CNPq (Conselho Nacional de Pesquisa Científica
ABADHS (Associação Beneficente Alzira Denise Hertzog da Silva)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords: gut microbiota, Alzheimer's disease, microbiota-gut-brain axis, cognition, behavior, neurotransmitter production, serotonin, GABA, intestinal permeability, amyloid peptides, lipopolysaccharide, neuroinflammation, cytokines, neuropsychiatric disorders, Parkinson's disease, depression, autism spectrum disorder
MeSH terms: Gastrointestinal Microbiome, Alzheimer Disease, Animals, Behavior, Brain, Cognition, Humans, Neurotransmitter Agents

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Relevance of gutmicrobiota in cognition, behaviour and Alzheimer’s disease

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