Cited by 182Diabetes Treatment and ManagementPharmacology and Obesity TreatmentDiabetes, Cardiovascular Risks, and Lipoproteins

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Anti-diabetic drugs and weight loss in patients with type 2 diabetes

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Lazzaroni, Elisa, Ben Nasr, Moufida, Loretelli, Cristian, Pastore, Ida, Plebani, Laura, Lunati, Maria Elena, Vallone, Luciana, Bolla, Andrea Mario, Rossi, Antonio, Montefusco, Laura, Ippolito, Elio, Berra, Cesare, D’Addio, Francesca, Zuccotti, Gian Vincenzo, Fiorina, Paolo·2021·Pharmacological Research

DOI 10.1016/j.phrs.2021.105782

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Abstract

Introduction Obesity is frequently a comorbidity of type 2 diabetes. Even modest weight loss can significantly improve glucose homeostasis and lessen cardiometabolic risk factors in patients with type 2 diabetes, but lifestyle-based weight loss strategies are not long-term effective. There is an increasing need to consider pharmacological approaches to assist weight loss in the so called diabesity syndrome. Aim of this review is to analyze the weight-loss effect of non-insulin glucose lowering drugs in patients with type 2 diabetes.Material and methods A systematic analysis of the literature on the effect of non-insulin glucose lowering drugs on weight loss in patients with type 2 diabetes was performed. For each class of drugs, the following parameters were analyzed: kilograms lost on average, effect on body mass index and body composition.Results Our results suggested that anti-diabetic drugs can be stratified into 3 groups based on their efficacy in weight loss: metformin, acarbose, empagliflozin and exenatide resulted in a in a mild weight loss (less than 3.2% of initial weight); canagliflozin, ertugliflozin, dapagliflozin and dulaglutide induces a moderate weight loss (between 3.2% and 5%); liraglutide, semaglutide and tirzepatide resulted in a strong weight loss (greater than 5%).Conclusions This study shows that new anti-diabetic drugs, particularly GLP1-RA and Tirzepatide, are the most effective in inducing weight loss in patients with type 2 diabetes. Interestingly, exenatide appears to be the only GLP1-RA that induces a mild weight loss.

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Authors: Lazzaroni, E., Ben Nasr, M., Loretelli, C., Pastore, I., Plebani, L., Lunati, M. E., Vallone, L., Bolla, A. M., Rossi, A., Montefusco, L., Ippolito, E., Berra, C., D’Addio, F., Zuccotti, G. V., & Fiorina, P.
Affiliations: ASST Fatebenefratelli Sacco (IT)
University of Milan (IT)
MultiMedica (IT)
Boston Children's Hospital (US)
Corresponding author: Fiorina, Paolo
ORCID: Loretelli, Cristian
Pastore, Ida
Lunati, Maria Elena
Bolla, Andrea Mario
Rossi, Antonio
Montefusco, Laura
Ippolito, Elio
Berra, Cesare
D’Addio, Francesca
Fiorina, Paolo
Venue: Pharmacological Research
Publisher: Elsevier BV
Published: 2021-09
Volume: 171
Pages: 105782
ISSN: 1043-6618 (ISSN-L)
DOI: 10.1016/j.phrs.2021.105782
OpenAlex: W3184250385
Cited by: 182
References: 75
Citations by year: 2026: 25 · 2025: 43 · 2024: 41 · 2023: 47 · 2022: 23 · 2021: 3
FWCI: 4.38
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Pharmacological Research (publishedVersion)
PubMed (publishedVersion)
Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: type 2 diabetes, weight loss, antidiabetic drugs, diabesity, obesity, GLP-1 receptor agonists, tirzepatide, exenatide, SGLT2 inhibitors, metformin, acarbose, body mass index, body composition
MeSH terms: Glucagon-Like Peptide-1 Receptor, Glucagon-Like Peptide-1 Receptor Agonists, Diabetes Mellitus, Type 2, Gastric Inhibitory Polypeptide, Humans, Hypoglycemic Agents, Obesity, Weight Loss, Glucagon-Like Peptide 1

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Anti-diabetic drugs and weight loss in patients with type 2 diabetes

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