Cited by 809Cholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionBioactive natural compounds

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Acetylcholinesterase inhibitors from plants

Mukherjee, Pulok K., Kumar, Venkatesan, Mal, Mainak, Houghton, Peter J.·2007·Phytomedicine

DOI 10.1016/j.phymed.2007.02.002

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Abstract

Inhibition of acetylcholinesterase (AChE), the key enzyme in the breakdown of acetylcholine, is considered as a promising strategy for the treatment of neurological disorders such as Alzheimer's disease, senile dementia, ataxia and myasthenia gravis. A potential source of AChE inhibitors is certainly provided by the abundance of plants in nature. This article aims to provide a comprehensive literature survey of plants that have been tested for AChE inhibitory activity. Numerous phytoconstituents and promising plant species as AChE inhibitors are being reported in this communication.

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Authors: Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J.
Affiliations: Jadavpur University (IN)
King's College London (GB)
Corresponding author: Mukherjee, Pulok K.
ORCID: Mukherjee, Pulok K.
Mal, Mainak
Houghton, Peter J.
Venue: Phytomedicine
Publisher: Elsevier BV
Published: 2007-04
Volume: 14
Issue: 4
Pages: 289-300
ISSN: 0944-7113 (ISSN-L)
DOI: 10.1016/j.phymed.2007.02.002
OpenAlex: W2060288971
Cited by: 809
References: 62
Citations by year: 2026: 19 · 2025: 38 · 2024: 45 · 2023: 55 · 2022: 56 · 2021: 50 · 2020: 59 · 2019: 44 · 2018: 51 · 2017: 54 · 2016: 61 · 2015: 56 · 2014: 50 · 2013: 35 · 2012: 41
FWCI: 14.70
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Phytomedicine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Drug Discovery › Bioactive natural compounds
Keywords: acetylcholinesterase inhibitors, phytochemicals, phytochemical constituents, Alzheimer's disease, senile dementia, myasthenia gravis, ataxia, acetylcholine, plant species screening
MeSH terms: Alzheimer Disease, Cholinesterase Inhibitors, Humans, Phytotherapy, Plant Extracts, Plants, Medicinal

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Acetylcholinesterase inhibitors from plants

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