Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family

Vladimir-Knežević, Sanda; Blažeković, Biljana; Kindl, Marija; Vladić, Jelena; Lower-Nedza, Agnieszka; Brantner, Adelheid

doi:10.3390/molecules19010767

Cited by 238Cholinesterase and Neurodegenerative DiseasesPhytochemistry and Biological ActivitiesMedicinal Plants and Neuroprotection

Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family

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Vladimir-Knežević, Sanda, Blažeković, Biljana, Kindl, Marija, Vladić, Jelena, Lower-Nedza, Agnieszka, Brantner, Adelheid·2014·Molecules

DOI 10.3390/molecules19010767PMC PMC6271370

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Abstract

The present study aimed to evaluate acetylcholinesterase (AChE) inhibitory and antioxidant activities of Lamiaceae medicinal plants growing wild in Croatia. Using Ellman’s colorimetric assay all tested ethanolic extracts and their hydroxycinnamic acid constituents demonstrated in vitro AChE inhibitory properties in a dose dependent manner. The extracts of Mentha x piperita, M. longifolia, Salvia officinalis, Satureja montana, Teucrium arduini, T. chamaedrys, T. montanum, T. polium and Thymus vulgaris at 1 mg/mL showed strong inhibitory activity against AChE. The antioxidant potential of the investigated Lamiaceae species was assessed by DPPH• scavenging activity and total antioxidant capacity assays, in comparison with hydroxycinnamic acids and trolox. The extracts differed greatly in their total hydroxycinnamic derivatives content, determined spectrophotometrically. Rosmarinic acid was found to be the predominant constituent in most of the investigated medicinal plants (by RP-HPLC) and had a substantial influence on their AChE inhibitory and antioxidant properties, with the exception of Teucrium species. These findings indicate that Lamiaceae species are a rich source of various natural AChE inhibitors and antioxidants that could be useful in the prevention and treatment of Alzheimer’s and other related diseases.

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The FRAP assay is a well-known, reliable approach that measures ferric reducing ability in a redox-linked colorimetric reaction that reduces Fe3+ to Fe2+.
“The FRAP assay is a well-known, reliable approach that measures ferric reducing ability in a redox-linked colorimetric reaction that reduces Fe3+ to Fe2+ [78–81].”
From Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae) (2020) · cites this paper as [79]
Section 3.5 describes a phosphomolybdenum assay for total antioxidant capacity, and Section 3.4 describes a DPPH assay. Searches for FRAP, ferric reducing ability, and Fe3+-to-Fe2+ reduction found no passage in our copy addressing the claimed assay or its reliability. (LLM, conf=0.76)
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Screening for acetylcholinesterase inhibition of medicinal plants from Croatia
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Acetyl- and butyril- cholinesterase inhibitory activity of Lamiaceae plant extracts
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Screening for acetylcholinesterase inhibition and antioxidant activity of selected plants from Croatia
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Authors: Vladimir-Knežević, S., Blažeković, B., Kindl, M., Vladić, J., Lower-Nedza, A., & Brantner, A.
Affiliations: Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev trg 20, Zagreb 10000, Croatia
University of Zagreb (HR)
University of Novi Sad (RS)
University of Graz (AT)
Corresponding author: Blažeković, Biljana
ORCID: Blažeković, Biljana
Kindl, Marija
Vladić, Jelena
Brantner, Adelheid
Venue: Molecules
Publisher: MDPI AG
Published: 2014-01-09
Volume: 19
Issue: 1
Pages: 767-782
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules19010767
PMC: PMC6271370
OpenAlex: W2001061645
Semantic Scholar: 21b840d6afb1cdea263f86ce901c1178f8819a54
Cited by: 238
References: 58
Citations by year: 2026: 16 · 2025: 20 · 2024: 17 · 2023: 19 · 2022: 27 · 2021: 28 · 2020: 23 · 2019: 18 · 2018: 22 · 2017: 16 · 2016: 15 · 2015: 10 · 2014: 7
FWCI: 10.91
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: CEEPUS
Topics: Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: acetylcholinesterase inhibition, antioxidant activity, Lamiaceae, medicinal plants, hydroxycinnamic acids, rosmarinic acid, Mentha, Salvia officinalis, Satureja, Teucrium, thyme, ethanolic plant extract, DPPH radical scavenging, Alzheimer's disease
MeSH terms: Rosmarinic Acid, Acetylcholinesterase, Alzheimer Disease, Animals, Biphenyl Compounds, Cholinesterase Inhibitors, Chromans, Chromatography, High Pressure Liquid, Cinnamates, Coumaric Acids, Eels, Free Radicals, Humans, Picrates, Plant Extracts, Plants, Medicinal, Free Radical Scavengers, Lamiaceae, Fish Proteins, Depsides, Drug Discovery, Chromatography, Reverse-Phase

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Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family

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