Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats
Abstract
The aim of the present investigation was to evaluate the anti-diabetic activity of 20-OH-ecdysone on glucose metabolic key enzymes in control and streptozotocin induced diabetic rats. On oral administration of 20-OH-ecdysone at a dose of 5mg/kg body weight per day to diabetic rats for 30 days resulted in a significant decrease in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and an increase in the levels of insulin and hemoglobin. Administration of 20-OH-ecdysone showed significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phosphate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. This study indicates that the administration of 20-OH-ecdysone to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels. A comparison was made between the action of 20-OH-ecdysone and antidiabetic drug-glibenclamide. The effects produced by the 20-OH-ecdysone were comparable to that of glibenclamide.
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In streptozotocin-induced type I diabetic rats, after 30 days of oral 20E administration, plasma glucose, glycated haemoglobin, and insulin were lowered.
“After 30 days of oral administration, the plasma levels of glucose, glycated haemoglobin (HbA1C), and insulin were lowered.”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [66]
The effect of 20E was comparable to the antidiabetic drug glibenclamide in streptozotocin-induced type I diabetic rats.
“The effect of 20E was comparable to the antidiabetic drug glibenclamide, known to promote insulin secretion of beta cells.”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [66]
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- Authors
- Sundaram, R., Naresh, R., Shanthi, P., & Sachdanandam, P.
- Affiliations
- University of Madras (IN)
- Corresponding author
- Sachdanandam, Panchanatham
- ORCID
- Sundaram, Ramalingam
- Venue
- Phytomedicine
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 19
- Issue
- 8-9
- Pages
- 725-729
- ISSN
- 0944-7113 (ISSN-L)
- OpenAlex
- W2070401870
- Cited by
- 27
- References
- 39
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 5 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 3.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytomedicine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- 20-hydroxyecdysone, ecdysteroids, streptozotocin-induced diabetes, type 2 diabetes, hepatic carbohydrate metabolism, glucose metabolism enzymes, hexokinase, glucose-6-phosphate dehydrogenase, glucose-6-phosphatase, fructose-1,6-bisphosphatase, glycolysis, gluconeogenesis, plasma glucose, HbA1c, insulin, glibenclamide, antidiabetic activity
- MeSH terms
- Administration, Oral, Animals, Blood Glucose, Body Weight, Diabetes Mellitus, Experimental, Drinking, Eating, Ecdysterone, Enzymes, Glucose-6-Phosphatase, Glucosephosphate Dehydrogenase, Glycogen, Glycated Hemoglobin, Hexokinase, Fructose-Bisphosphatase, Hypoglycemic Agents, Streptozocin, Vitex, Carbohydrate Metabolism, Rats
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