Protective role of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats
Abstract
Hyperlipidemia is an associated complication of diabetes mellitus. The association of hyperglycemia with an alteration of lipid parameters presents a major risk for cardiovascular complications in diabetes. The present study was designed to examine the antihyperlipidemic effect of 20-OH ecdysone on lipid profile and tissue fatty acid changes in streptozotocin induced diabetic rats. The levels of blood glucose, cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density lipoprotein, high density lipoprotein, lipoprotein lipase, lecithin cholesterol acyl transferase, 3-hydroxy 3-methylglutaryl coenzyme A reductase and fatty acid composition were estimated in plasma, liver and kidneys of control and experimental groups of rats. Oral administration of 20-OH ecdysone at a dose of 5mg/kg bodyweight per day to STZ-induced diabetic rats for a period of 30 days resulted in a significant reduction in fasting blood glucose, cholesterol, triglycerides, free fatty acids, phospholipids, low density lipoprotein, very low density lipoprotein, 3-hydroxy 3-methylglutaryl coenzyme A reductase and elevation of high density lipoprotein, lipoprotein lipase and lecithin cholesterol acyl transferasein comparison with diabetic untreated rats. Moreover, administration of 20-OH ecdysone to diabetic rats also decreased the concentrations of fatty acids, viz., palmitic, stearic (16:1) and oleic acid (18:1), whereas linolenic (18:3) and arachidonic acid (20:4) were elevated. The antihyperlipidemic effect of 20-OH ecdysone was compared with glibenclamide a well-known antihyperglycemic drug. The result of the present study indicates that 20-OH ecdysone showed an antihyperlipidemic effect in addition to its antidiabetic effect in experimental diabetes.
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Oral administration of 5 mg 20E/kg body weight per day to streptozotocin-induced type I diabetic rats for 30 days ameliorated unfavourable changes of lipid parameters.
“Oral administration of 5 mg 20E/kg body weight per day to STZ-induced (type I) diabetic rats for 30 days ameliorated the unfavourable changes of lipid parameters [67].”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [67]
In streptozotocin-induced type I diabetic rats, 20E reduced fasting blood glucose, cholesterol, free fatty acids, glycerol, phospholipids, low-density lipoproteins, very low-density lipoproteins, and 3-hydroxy-3-methylglutaryl CoA reductase in liver and kidney and elevated high-density lipoprotein, lipoprotein lipase, and lecithin cholesterol acyl transferase in plasma compared with diabetic控制.
“Namely, it reduced the fasting blood levels of glucose, cholesterol, free fatty acids, glycerol, phospholipids, low-density lipoproteins, very low-density lipoproteins, and 3-hydroxy-3-methylglutaryl CoA reductase in the liver and kidney and elevated the high-density lipoprotein, lipoprotein lipase, and lecithin cholesterol acyl transferase in the plasma compared with diabetic control rats.”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [67]
The lipid effect of 20E was like that of glibenclamide and can be explained by improved insulin level.
“This effect of 20E was like that of the antidiabetic drug glibenclamide and can be explained by the improved insulin level [58,67].”
From Molecular Targets of 20-Hydroxyecdysone in Mammals, Mechanism of Action: Is It a Calorie Restriction Mimetic and Anti-Aging Compound? (2025) · cites this paper as [67]
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- Authors
- Naresh Kumar, R., Sundaram, R., Shanthi, P., & Sachdanandam, P.
- Affiliations
- University of Madras (IN)
- Corresponding author
- Sachdanandam, Panchanatham
- ORCID
- Sundaram, Ramalingam
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2013-01
- Volume
- 698
- Issue
- 1-3
- Pages
- 489-498
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2026644336
- Cited by
- 21
- References
- 66
- Citations by year
- 2026: 2 · 2025: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Cholesterol and Lipid Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
- Keywords
- 20-hydroxyecdysone, streptozotocin-induced diabetes, hyperlipidemia, hypolipidemic effect, lipid profile, tissue fatty acid composition, cholesterol, triglycerides, lipoprotein lipase, lecithin:cholesterol acyltransferase, HMG-CoA reductase, glibenclamide, diabetes mellitus
- MeSH terms
- Animals, Blood Glucose, Diabetes Mellitus, Experimental, Ecdysterone, Fatty Acids, Kidney, Phosphatidylcholine-Sterol O-Acyltransferase, Lipids, Lipoprotein Lipase, Liver, Male, Pancreas, Rats, Wistar, Rats
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