Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice

Place navigation impaired in rats with hippocampal lesions

Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

2016 Alzheimer's disease facts and figures

Alzheimer's Association (2016) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2016.03.001 · Cited by 5,069 · see citing works

Oxidative stress and neurodegeneration: where are we now?

Halliwell, B. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03907.x · Cited by 2,614 · see citing works

Inflammation as a central mechanism in Alzheimer's disease

Kinney, J. W., Bemiller, S. M., Murtishaw, A. S., Leisgang, A. M., Salazar, A. M., & Lamb, B. T. (2018) · Alzheimer's & Dementia: Translational Research & Clinical Interventions · doi:10.1016/j.trci.2018.06.014 · Cited by 2,253 · see citing works

2018 Alzheimer's disease facts and figures

Alzheimer's Association (2018) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2018.02.001 · Cited by 1,912 · see citing works

Glutamate-induced neuronal death: a succession of necrosis or apoptosis depending on mitochondrial function

Ankarcrona, M., Dypbukt, J. M., Bonfoco, E., Zhivotovsky, B., Orrenius, S., Lipton, S. A., & Nicotera, P. (1995) · Neuron · doi:10.1016/0896-6273(95)90186-8 · Cited by 1,884 · see citing works

A review on Alzheimer's disease pathophysiology and its management: an update

Kumar, A., Singh, A., & Ekavali (2015) · Pharmacological Reports · doi:10.1016/j.pharep.2014.09.004 · Cited by 1,578 · see citing works

The contribution of astrocytes and microglia to traumatic brain injury

Karve, I. P., Taylor, J. M., & Crack, P. J. (2015) · British Journal of Pharmacology · doi:10.1111/bph.13125 · Cited by 651 · see citing works

Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson’s disease and Alzheimer’s disease

Jiang, T., Sun, Q., & Chen, S. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.07.005 · Cited by 594 · see citing works

World Alzheimer Report 2018: The state of the art of dementia research: New frontiers

Patterson, C. (2018) · Cited by 586 · see citing works

Cholinesterases: Roles in the Brain During Health and Disease

Ballard, C. G., Greig, N. H., Guillozet-Bongaarts, A. L., Enz, A., & Darvesh, S. (2005) · Current Alzheimer Research · doi:10.2174/1567205054367838 · Cited by 351 · see citing works

Recent progress in the identification of selective butyrylcholinesterase inhibitors for Alzheimer's disease

Li, Q., Yang, H., Chen, Y., & Sun, H. (2017) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.03.062 · Cited by 331 · see citing works

Astrocytes are GABAergic cells that modulate microglial activity

Lee, M., Schwab, C., & McGeer, P. L. (2010) · Glia · doi:10.1002/glia.21087 · Cited by 321 · see citing works

The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival

Carson, M. J., Cameron Thrash, J., & Walter, B. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.004 · Cited by 299 · see citing works

Apoptosis in Alzheimer’s Disease: An Understanding of the Physiology, Pathology and Therapeutic Avenues

Obulesu, M., & Lakshmi, M. J. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1454-4 · Cited by 290 · see citing works

Monoaminergic neuropathology in Alzheimer’s disease

Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Milošević, N. J., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., et al. (2016) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2016.04.001 · Cited by 289 · see citing works

Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats

Wang, T., Hu, X., Liang, S., Li, W., Wu, X., Wang, L., & Jin, F. (2015) · Beneficial Microbes · doi:10.3920/bm2014.0177 · Cited by 233 · see citing works

Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease

Li, Q., He, S., Chen, Y., Feng, F., Qu, W., & Sun, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.031 · Cited by 217 · see citing works

Adhatoda vasica: a critical review of ethnopharmacological and toxicological data

Pongprayoon, U., Malmfors, T., Wikman, G., & Bruhn, J. G. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00225-7 · Cited by 207 · see citing works

Ladostigil: A Novel Multimodal Neuroprotective Drug with Cholinesterase and Brain-Selective Monoamine Oxidase Inhibitory Activities for Alzheimers Disease Treatment

Weinreb, O., Amit, T., Bar‐Am, O., & Youdim, M. B. H. (2012) · Current Drug Targets · doi:10.2174/138945012799499794 · Cited by 154 · see citing works

Recent progress in multifunctional metal chelators as potential drugs for Alzheimer's disease

Santos, M. A., Chand, K., & Chaves, S. (2016) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2016.04.013 · Cited by 149 · see citing works

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Activities of β‐Carboline and Quinoline Alkaloids Derivatives from the Plants of Genus Peganum

Zhao, T., Ding, K., Zhang, L., Cheng, X. M., Wang, C., & Wang, Z. (2013) · Journal of Chemistry · doi:10.1155/2013/717232 · Cited by 147 · see citing works

Features and outcomes of drugs for combination therapy as multi-targets strategy to combat Alzheimer's disease

Sahoo, A. K., Dandapat, J., Dash, U. C., & Kanhar, S. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.12.015 · Cited by 147 · see citing works

A review on traditional uses, phytochemistry, pharmacology, pharmacokinetics and toxicology of the genus Peganum

Li, S., Cheng, X. M., & Wang, C. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.03.049 · Cited by 141 · see citing works

Effects of curcumin on short-term spatial and recognition memory, adult neurogenesis and neuroinflammation in a streptozotocin-induced rat model of dementia of Alzheimer’s type

Bassani, T. B., Turnes, J. M., Moura, E. L. R., Bonato, J. M., Cóppola-Segovia, V., Zanata, S. M., Oliveira, R. M. M. W., & Vital, M. A. B. F. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.014 · Cited by 134 · see citing works

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

Li, S.-P., Wang, Y., Qi, S., Zhang, Y., Deng, G., Ding, W.-Z., Ma, C., Lin, Q., Guan, H., Liu, W., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00346 · Cited by 133 · see citing works

Adverse effects associated with the use of donepezil in general practice in England

Dunn, N. R., Pearce, G. L., & Shakir, S. (2000) · Journal of Psychopharmacology · doi:10.1177/026988110001400410 · Cited by 117 · see citing works

Effects of harmine, an acetylcholinesterase inhibitor, on spatial learning and memory of APP/PS1 transgenic mice and scopolamine-induced memory impairment mice

He, D., Wu, H., Wei, Y., Liu, W., Huang, F., Shi, H., Zhang, B., Wu, X., & Wang, C. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.10.037 · Cited by 105 · see citing works

Animal models of dementia and cognitive dysfunction

Neha, N., Sodhi, R. K., Jaggi, A. S., & Singh, N. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.05.017 · Cited by 100 · see citing works

A critical review of cholinesterase inhibitors as a treatment modality in Alzheimer's disease

Schneider, L. S. S. (2000) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2000.2.2/lschneider · Cited by 99 · see citing works

Recent trends in analytical approaches for detecting neurotransmitters in Alzheimer's disease

Sangubotla, R., & Kim, J. (2018) · TrAC Trends in Analytical Chemistry · doi:10.1016/j.trac.2018.05.014 · Cited by 95 · see citing works

Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease

Vermeiren, Y., Dam, D. V., Aerts, T., Engelborghs, S., & Deyn, P. P. D. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.05.031 · Cited by 82 · see citing works

Protective effects of linalool against amyloid beta-induced cognitive deficits and damages in mice

Xu, P., Wang, K., Lü, C., Dong, L., Gao, L., Yan, M., Aibai, S., Yang, Y., & Liu, X. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.010 · Cited by 77 · see citing works

Cerebrospinal fluid levels of angiotensin- converting enzyme, acetylcholinesterase, and dopamine metabolites in dementia associated with Alzheimer's disease and Parkinson's disease: A correlative study

Zubenko, G. S., Marquis, J. K., Volicer, L., Direnfeld, L. K., Langlais, P. J., & Nixon, R. A. (1986) · Biological Psychiatry · doi:10.1016/0006-3223(86)90328-8 · Cited by 71 · see citing works

Potent AChE and BChE inhibitors isolated from seeds of Peganum harmala Linn by a bioassay-guided fractionation

Yang, Y., Cheng, X. M., Liu, W., Chou, G., Wang, Z., & Wang, C. (2015) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2015.03.070 · Cited by 69 · see citing works

Peripheral administration of an anti-TNF-α receptor fusion protein counteracts the amyloid induced elevation of hippocampal TNF-α levels and memory deficits in mice

Detrait, E., Danis, B., Lamberty, Y., & Foerch, P. (2014) · Neurochemistry International · doi:10.1016/j.neuint.2014.04.001 · Cited by 69 · see citing works

An update on huperzine A as a treatment for Alzheimer's disease

Little, J. T., Walsh, S. P., & Aisen, P. S. S. (2008) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.17.2.209 · Cited by 69 · see citing works

Antitussive, expectorant, and bronchodilating effects of quinazoline alkaloids (±)-vasicine, deoxyvasicine, and (±)-vasicinone from aerial parts of Peganum harmala L

Liu, W., Wang, Y., He, D.-D., Li, S., Zhu, Y., Jiang, B., Cheng, X. M., Wang, Z., & Wang, C. (2015) · Phytomedicine · doi:10.1016/j.phymed.2015.08.005 · Cited by 68 · see citing works

The anti-inflamm-aging and hepatoprotective effects of huperzine A in d-galactose-treated rats

Ruan, Q., Liu, F., Gao, Z., Kong, D., Hu, X., Shi, D., Bao, Z., & Yu, Z. (2013) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.12.005 · Cited by 65 · see citing works

Neuroprotective effects of polygalacic acid on scopolamine-induced memory deficits in mice

Guo, C.-R., Shen, J., Meng, Z., Yang, X., & Li, F. (2016) · Phytomedicine · doi:10.1016/j.phymed.2015.12.009 · Cited by 63 · see citing works

Negative Symptoms in Patients With Alzheimer's Disease

GALYNKER, I. I., Roane, D. M., Miner, C. R., Feinberg, T. E., & Watts, P. (1995) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199524310-00007 · Cited by 60 · see citing works

Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors

Jing, L., Wu, G., Kang, D., Zhou, Z., Song, Y., Liu, X., & Zhan, P. (2018) · Drug Discovery Today · doi:10.1016/j.drudis.2018.11.012 · Cited by 57 · see citing works

Ameliorative effects of Matricaria chamomilla L. hydroalcoholic extract on scopolamine-induced memory impairment in rats: A behavioral and molecular study

Ioniță, R., Postu, P. A., Mihăşan, M., Gorgan, L., Hăncianu, M., Cioancă, O., & Hriţcu, L. (2018) · Phytomedicine · doi:10.1016/j.phymed.2018.04.049 · Cited by 54 · see citing works

Facile Access to Ring-Fused Aminals via Direct α-Amination of Secondary Amines with ortho-Aminobenzaldehydes. Synthesis of Vasicine, Deoxyvasicine, Deoxyvasicinone, Mackinazolinone and Ruteacarpine.

Richers, M. T., Deb, I., Platonova, A. Y., Zhang, C., & Seidel, D. (2013) · PubMed · Cited by 52 · see citing works

Huperzine A: A promising anticonvulsant, disease modifying, and memory enhancing treatment option in Alzheimer’s disease

Damar, U., Gersner, R., Johnstone, J. T., Schachter, S. C., & Rotenberg, A. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.12.006 · Cited by 49 · see citing works

Chlorinated tacrine analogs: Design, synthesis and biological evaluation of their anti-cholinesterase activity as potential treatment for Alzheimer’s disease

Ragab, H. M., Teleb, M., Haidar, H. R., & Gouda, N. A. (2019) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2019.02.033 · Cited by 49 · see citing works

Vitamin D3 deficiency in puberty rats causes presynaptic malfunctioning through alterations in exocytotic release and uptake of glutamate/GABA and expression of EAAC-1/GAT-3 transporters

Krisanova, N. V., Pozdnyakova, N., Pastukhov, A. O., Dudarenko, M., Maksymchuk, O., Pk, P., Sivko, R., & Borisova, Т. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.10.054 · Cited by 48 · see citing works

Abnormal neurotransmitter metabolite levels in Alzheimer patients with a delirium

van der Cammen, T. J. M., Tiemeier, H. W., Engelhart, M. J., & Fekkes, D. (2006) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.1569 · Cited by 45 · see citing works

Altered neurochemical profile in the M cGill‐ R ‐ T hy1‐ APP rat model of A lzheimer's disease: a longitudinal in vivo 1 H MRS study

Nilsen, L. H., Melø, T. M., Sæther, O., Witter, M. P., & Sonnewald, U. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12003 · Cited by 43 · see citing works

Structural features and antitussive activity of water extracted polysaccharide from Adhatoda vasica

Chattopadhyay, N., Nosalova, G., Saha, S., Bandyopadhyay, S. S., Flešková, D., & Ray, B. (2010) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2010.11.002 · Cited by 43 · see citing works

Leptin, hsCRP, TNF-α and IL-6 levels from normal aging to dementia: Relationship with cognitive and functional status

Magalhaes, C. A., Ferreira, C. N., Loures, C. M. G., Fraga, V. G., Chaves, A. C., de Oliveira, A. C. R., de Souza, L. C., Resende, E. D. P. F., Carmona, K. C., Guimarães, H. C., et al. (2018) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2018.08.027 · Cited by 42 · see citing works

Peripheral cholinergic disturbances in Alzheimer's disease

Rakonczay, Z., Horváth, Z., Juhász, A., & Kalman, J. L. (2005) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.10.034 · Cited by 41 · see citing works

20(S)-protopanaxadiol (PPD) alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of Egr-1, c-Fos and c-Jun in mice

Lü, C., Dong, L., Lv, J., Wang, Y., Fan, B., Wang, F., & Liu, X. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.11.008 · Cited by 40 · see citing works

Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC–ESI-MS/MS

Liu, W., Yang, Y., Cheng, X. M., Gong, C., Li, S., He, D., Yang, L., Wang, Z., & Wang, C. (2014) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2014.02.004 · Cited by 38 · see citing works

N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice

Min, A. Y., Doo, C. N., Son, E. J., Sung, N. Y., Lee, K. J., Sok, D., & Kim, M. R. (2015) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2015.09.016 · Cited by 38 · see citing works

Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic property

Lee, H. E., Jeon, S. J., Ryu, B., Park, S. J., Ko, S. Y., Lee, Y., Kim, E., Lee, S. H., Kim, H., Jang, D. S., et al. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.03.030 · Cited by 38 · see citing works

Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice

Liu, W., Zhu, Y., Wang, Y., Qi, S., Wang, Y., Ma, C., Li, S., Jiang, B., Cheng, X. M., Wang, Z., et al. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.04.019 · Cited by 33 · see citing works

[Effects of huperzine A and B on skeletal muscle and the electroencephalogram].

Yan, X., Lu, W.-H., Lou, W.-J., & Tang, X. C. (1987) · PubMed · Cited by 28 · see citing works

Elevation of serum TNF-α levels in mild and moderate Alzheimer patients with daytime sleepiness

Chen, R., Yin, Y., Zhao, Z., Huang, L., Huang, S., Zhuang, J., Wu, H., Peng, H., & Li, P. (2012) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.12.015 · Cited by 26 · see citing works

Novel carbamate derivatives as selective butyrylcholinesterase inhibitors

Bajda, M., Łątka, K., Hebda, M., Jończyk, J., & Malawska, B. (2018) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2018.03.003 · Cited by 26 · see citing works

Reduction of voluntary ethanol consumption in alcohol-preferring Alko alcohol (AA) rats by desoxypeganine and galanthamine

Doetkotte, R., Opitz, K., Kiianmaa, K., & Winterhoff, H. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.08.038 · Cited by 22 · see citing works

In vitro and in vivo anticancer activity of 2-acetyl-benzylamine isolated from Adhatoda vasica L. leaves

Balachandran, C., Arun, Y., Sangeetha, B., Duraipandiyan, V., Awale, S., Emi, N., Savarimuthu Ignacimuthu, S. J., & Perumal, P. T. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.06.096 · Cited by 22 · see citing works

Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade

Cui, W., Hu, S., Chan, H. H. N., Luo, J., Li, W., Mak, S., Choi, T. C., Rong, J., Carlier, P. R., & Han, Y. (2012) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2012.10.003 · Cited by 20 · see citing works

Asparagus adscendens root extract enhances cognition and protects against scopolamine induced amnesia: An in-silico and in-vivo studies

Pahwa, P., & Goel, R. K. (2016) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2016.10.007 · Cited by 20 · see citing works

Vitis labruscana leaf extract ameliorates scopolamine-induced impairments with activation of Akt, ERK and CREB in mice

Pariyar, R., Yoon, C., Svay, T., Kim, D. S., Cho, H.-K., Kim, S. Y., Oh, H., Kim, Y., Kim, J.-H., Lee, H.-S., et al. (2017) · Phytomedicine · doi:10.1016/j.phymed.2017.09.008 · Cited by 20 · see citing works

Dynamin binding protein gene expression and memory performance in aged rats

Casoli, T., Stefano, G. D., Fattoretti, P., Giorgetti, B., Balietti, M., Lattanzio, F., Aicardi, G., & Platano, D. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.11.012 · Cited by 18 · see citing works

In vivo and in vitro metabolism and pharmacokinetics of cholinesterase inhibitor deoxyvasicine from aerial parts of Peganum harmala Linn in rats via UPLC-ESI-QTOF-MS and UPLC-ESI-MS/MS

Deng, G., Liu, W., Ma, C., Rong, X., Zhang, Y., Wang, Y., Wu, C., Cao, N., Ding, W., Guan, H., et al. (2019) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2019.03.020 · Cited by 17 · see citing works

An In Silico Approach for Identification of Potential Anti-Mycobacterial Targets of Vasicine and Related Chemical Compounds

Chaliha, A. K., Gogoi, D., Chetia, P., Sarma, D., & Buragohain, A. K. (2016) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207319666151203001708 · Cited by 13 · see citing works

Alkaloids of Nitraria komarovii. XIII. Nitramine N-oxide and the structure of dehydroschoberine

Tulyaganov, T. S. (1993) · Chemistry of Natural Compounds · doi:10.1007/bf00631009 · Cited by 11 · see citing works

[Pharmacological characteristics of desoxypeganine hydrochloride].

Tuliaganov, N., Sadritdinov, F. S., & Suleĭmanova, G. A. (1986) · PubMed · Cited by 11 · see citing works

Standardized extract ofLactuca sativaLinn. and its fractions abrogates scopolamine-induced amnesia in mice: A possible cholinergic and antioxidant mechanism

Malik, J., Kaur, J., & Choudhary, S. (2017) · Nutritional Neuroscience · doi:10.1080/1028415x.2017.1291166 · Cited by 11 · see citing works

Adverse Events With Sustained-Release Donepezil in Alzheimer Disease

Lee, C., Lee, K., Yu, H., Ryu, S., Moon, S. W., Han, C., Lee, J., Lee, Y. M., Kim, S. G., Kim, K. W., et al. (2017) · Journal of Clinical Psychopharmacology · doi:10.1097/jcp.0000000000000726 · Cited by 11 · see citing works

Negative symptoms in patients with Alzheimer's disease

GALYNKER, I. I., Roane, D. M., Miner, C., & Feinberg, T. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90705-6 · Cited by 7 · see citing works

Randomized, crossover, single-blind, placebo-controlled, human pharmacology clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: multiple-dose pharmacokinetics.

Algorta, J., Pena, M. Á., Alvarez, A., Maraschiello, C., Maruhn, D., Windisch, M., & Mucke, H. A. (2009) · PubMed · Cited by 7 · see citing works

Phase I clinical trial with desoxypeganine, a new cholinesterase and selective MAO-A inhibitor: Tolerance and pharmacokinetics study of escalating single oral doses

Algorta, J., Pena, M. Á., Maraschiello, C., Álvarez-González, A., Maruhn, D., Windisch, M., & Mucke, H. A. (2008) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2008.30.2.1159649 · Cited by 5 · see citing works

Attenuation of Nrf2/Keap1/ARE in Alzheimer’s Disease by Plant Secondary Metabolites: A Mechanistic Review

Fakhri, S., Pesce, M., Patruno, A., Moradi, S. Z., Iranpanah, A., Farzaei, M. H., & Sobarzo‐Sánchez, E. (2020) · Molecules · doi:10.3390/molecules25214926 · Cited by 96 · see citing works

Potential of Naturally Derived Alkaloids as Multi-Targeted Therapeutic Agents for Neurodegenerative Diseases

Kong, Y., Tay, K.-C., Su, Y.-X., Wong, C., Tan, W.-N., & Khaw, K. (2021) · Molecules · doi:10.3390/molecules26030728 · Cited by 62 · see citing works

Pharmaco-fUS: Quantification of pharmacologically-induced dynamic changes in brain perfusion and connectivity by functional ultrasound imaging in awake mice

Rabut, C., Ferrier, J., Bertolo, A., Osmanski, B.-F., Mousset, X., Pezet, S., Deffieux, T., Lenkei, Z., & Tanter, M. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2020.117231 · Cited by 56 · see citing works

Trimethoxyflavones from Ocimum basilicum L. leaves improve long term memory in mice by modulating multiple pathways

Singh, V., Kaur, K., Kaur, S., Shri, R., Singh, T. G., & Singh, M. (2022) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2022.115438 · Cited by 40 · see citing works

Bergapten Improves Scopolamine-Induced Memory Impairment in Mice via Cholinergic and Antioxidative Mechanisms

Kowalczyk, J., Kurach, Ł., Boguszewska‐Czubara, A., Skalicka‐Woźniak, K., Kruk-Słomka, M., Kurzepa, J., Wydrzynska-Kuźma, M., Biała, G., Skiba, A., & Budzyńska, B. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00730 · Cited by 34 · see citing works

Bay Leaf (Laurus Nobilis L.) Incense Improved Scopolamine-Induced Amnesic Rats by Restoring Cholinergic Dysfunction and Brain Antioxidant Status

Brinza, I., Boiangiu, R. Ş., Hăncianu, M., Cioancă, O., Orhan, İ. E., & Hriţcu, L. (2021) · Antioxidants · doi:10.3390/antiox10020259 · Cited by 34 · see citing works

Cholinesterase Inhibitors from Plants and Their Potential in Alzheimer’s Treatment: Systematic Review

ALNasser, M. N., Alboraiy, G. M., Alsowig, E. M., & Alqattan, F. M. (2025) · Brain Sciences · doi:10.3390/brainsci15020215 · Cited by 35 · see citing works

Effects and mechanism of extracts rich in phenylpropanoids-polyacetylenes and polysaccharides from Codonopsis Radix on improving scopolamine-induced memory impairment of mice

Xie, Q., Hu, X., Zhao, X., Xiang, Z., Chen, Q., Xie, Z., Wang, H., Zhao, Y., Cheng, X. M., & Wang, C. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117106 · Cited by 26 · see citing works

Zexieyin formula alleviates Alzheimer's disease via post-synaptic CaMKII modulating AMPA receptor: Involved in promoting neurogenesis to strengthen synaptic plasticity in mice hippocampus.

Sun, Y., Zhang, H.-L., Liu, R.-Y., Wang, Y.-Q., Zhang, X.-R., Huang, R.-M., Zhu, B.-R., & Wu, H.-X. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155802 · Cited by 24 · see citing works

Alkaloids as neuroprotectors: targeting signaling pathways in neurodegenerative diseases

Utpal, B., Amin, M. A., Zehravi, M., Sweilam, S. H., Arjun, U. V. N. V., Madhuri, Y., Gupta, J. K., Yaidikar, L., Tummala, T., Suseela, R., et al. (2025) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-025-05258-3 · Cited by 19 · see citing works

Attenuation of Spatial Memory in 5xFAD Mice by Halting Cholinesterases, Oxidative Stress and Neuroinflammation Using a Cyclopentanone Derivative

Ullah, R., Ali, G., Ahmad, N., Akram, M., Kumari, G., Amin, M. U., & Umar, M. N. (2020) · Pharmaceuticals · doi:10.3390/ph13100318 · Cited by 24 · see citing works

Medicinal natural products—An introduction

Nahar, L., & Sarker, S. D. (2020) · Annual reports in medicinal chemistry · doi:10.1016/bs.armc.2020.02.008 · Cited by 21 · see citing works

Thymol inTrachyspermum ammiseed extract exhibits neuroprotection, learning, and memory enhancement in scopolamine‐induced Alzheimer's disease mouse model

Timalsina, B., Haque, M. N., Choi, H. J., Dash, R., & Moon, I. S. (2023) · Phytotherapy Research · doi:10.1002/ptr.7777 · Cited by 18 · see citing works

Attenuation of spatial memory in 5xFAD mice by targeting cholinesterases, oxidative stress and inflammatory signaling using 2-(hydroxyl-(2-nitrophenyl)methyl)cyclopentanone

Ullah, R., Ali, G., Subhan, F., Khan, A., Halim, S. A., Naveed, M., Kalsoom, S., & Al-Harrasi, A. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108083 · Cited by 17 · see citing works

Constituents, pharmacological activities, pharmacokinetic studies, clinical applications, and safety profile on the classical prescription Kaixinsan

Chen, L., Jiang, L., Shi, X., Yang, J., Wang, R., & Li, W. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1338024 · Cited by 14 · see citing works

Exploring Quinazoline as a Scaffold for Developing Novel Therapeutics in Alzheimer’s Disease

Abualassal, Q. I. A., Abudayeh, Z. H. M., Sirhan, A. Y., & Mkia, A. (2025) · Molecules · doi:10.3390/molecules30030555 · Cited by 14 · see citing works

A Comparative Study of the Impact of NO-Related Agents on MK-801- or Scopolamine-Induced Cognitive Impairments in the Morris Water Maze

Cieślik, P., Borska, M., & Wierońska, J. M. (2023) · Brain Sciences · doi:10.3390/brainsci13030410 · Cited by 13 · see citing works

Influence of Neostigmine on Early Postoperative Cognitive Dysfunction in Older Adult Patients Undergoing Noncardiac Surgery: A Double-Blind, Placebo-Controlled, Randomized Controlled Trial

Deng, C., Yang, L., Sun, D., Feng, Y., Sun, Z., & Li, J. (2023) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000006687 · Cited by 12 · see citing works

The PGC-1α/ERRα/ULK1 pathway contributes to Perioperative neurocognitive disorders by inducing mitochondrial dysfunction and activating NLRP3 inflammasome in aged mice

Zhang, W., Wu, C.-C., Ge, M.-M., Yuan, X.-M., Han, S.-Y., Zhao, F.-T., Zhang, X., Gao, F., Tian, Y.-K., Zhang, G., et al. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110119 · Cited by 12 · see citing works

Ameliorative effect of scopolamine-induced cognitive dysfunction by Fufangmuniziqi formula: The roles of alkaloids, saponins, and flavonoids

Zhao, X., Hu, X., Xie, Q., Qi, S., Xiang, Z., Sun, X., Xie, Z., Dang, R., Zhou, L., Liu, W., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116792 · Cited by 12 · see citing works

Phytochemical, Pharmacological, and Toxicological Studies on Peganum harmala L.: An Overview of the Last Decade

Gökkaya, İ., Renda, G., Subaş, T., & Özgen, U. (2023) · Clinical and Experimental Health Sciences · doi:10.33808/clinexphealthsci.1125345 · Cited by 8 · see citing works

Lancao decoction alleviates cognitive dysfunction: A new therapeutic drug and its therapeutic mechanism.

Sun, Y., Zhang, H.-L., Liu, R.-Y., Huang, R.-M., Gao, Z., Tian, L.-Y., Zhu, Y.-P., Liu, Y., Lu, C., & Wu, L. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155531 · Cited by 8 · see citing works

A multi-parameter evaluation of the neuroprotective and cognitive-enhancing effects of Origanum onites L. (Turkish Oregano) essential oil on scopolamine-induced amnestic rats

Aykaç, A., Teralı, K., Özbeyli, D., Pazarbaşı, S. E., Albayrak, Ö., Başer, K. H. C., & Şener, G. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00933-6 · Cited by 7 · see citing works

Effects of neostigmine on postoperative neurocognitive dysfunction: a systematic review and meta-analysis

Zhou, X., Chen, L., Zhao, L., Mao, W., Liu, X., Zhang, L., Xie, Y., & Li, L. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1464272 · Cited by 2 · see citing works

Crocin Mitigates Glutamate Excitotoxicity and Tau Hyperphosphorylation by Modulating EAAT2 and Akt/Tau Pathway in a Scopolamine-induced Rat Model of Alzheimer’s Disease

El-Baga, S. E., Hassan, M. H., Awadalla, E. A., & El-Kader, A. E.-K. M. A. (2026) · Neurochemical Research · doi:10.1007/s11064-026-04692-z · Cited by 2 · see citing works

Are operators describing b → sγ?

Dong, F.-L., Wang, W., & Xiong, Z. (2011) · Chinese Physics C · doi:10.1088/1674-1137/35/1/002 · Cited by 2 · see citing works

Neurocognitive effects of Prunus domestica fruit extract on scopolamine-induced amnesic mice

Chellammal, H. S. J., Mansor, M. M., Azil, A., Murugan, Y., Punitha, C., & Chandarasekaran, P. (2020) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2020.10118 · Cited by 2 · see citing works

Nanotherapeutics of Phytoantioxidants for CNS Disorders

Paul, A., Guha, N., & Zaman, K. (2022) · Wiley eBooks · doi:10.1002/9781119811794.ch20 · Cited by 2 · see citing works

Role of Dietary Supplements in the Management of Brain Diseases

Bilal, M., Asif, S., Safdar, M. A., waqar, M., Aslam, R. M. N., Naveed, M., Arshad, J., & Nazakat, M. (2023) · doi:10.61748/cam.2023/018

Carthamus tinctorius seeds–Taraxacum coreanum combination attenuates scopolamine-induced memory deficit through regulation of inflammatory response and cholinergic function

He, M. T., Shin, Y. S., Kim, H. Y., & Cho, E. J. (2024) · Nutrition Research and Practice · doi:10.4162/nrp.2024.18.5.647

An Overview of Therapeutic Potential of Various Quinazoline Alkaloids and its Derivatives Containing Medicinal Plants

Ishaq, H. M., Rathinam, T., Natarajan, M., Lingam, N. K., Saji, J., & Rajendran, R. (2025) · Journal of Natural Remedies · doi:10.18311/jnr/2025/42031

Naturally occurring coumarins and derivatives may have potential for the treatment of Alzheimer's disease

Oresanya, I. O., Abacı, N., & Orhan, İ. E. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15366-2.00008-3

Activités antivirales et immunomodulatrices d’alcaloïdes contre l’infection par l’alphavirus arthritogénique O’nyong-nyong

Seteyen, A.-L. S. (2023) · doi:10.70675/a6eb1b46zd562z4ef1zb8dez266eecd56eea

Chinese herbal medicines in the treatment of noninfectious inflammatory diseases: Cholinergic mechanisms and therapeutic potential

Ming, S., Guo, P., Chen, F., Zhang, W., & Liu, X. (2026) · Journal of Chinese Integrative Medicine · doi:10.1016/j.joim.2026.08.003

Plant-derived phytochemicals as potential antibacterial agents for foodborne pathogen, Campylobacter jejuni targeting guaB-encoded IMPDH

Murugesan, R., Kalaimathi, K., Prathiviraj, R., Jain, S., Dass, K., Kaleeswaran, B., Ceasar, S. A., Prabhu, S., & Samiya, S. (2026) · Exploration of Foods and Foodomics · doi:10.37349/eff.2026.1010196

Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice

Li, S.-P., Wang, Y., Qi, S., Zhang, Y., Deng, G., Ding, W.-Z., Ma, C., Lin, Q., Guan, H., Liu, W., et al. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00346 · Cited by 133 · see citing works

Anti-amnesic effect of extract and alkaloid fraction from aerial parts of Peganum harmala on scopolamine-induced memory deficits in mice

Liu, W., Zhu, Y., Wang, Y., Qi, S., Wang, Y., Ma, C., Li, S., Jiang, B., Cheng, X. M., Wang, Z., et al. (2017) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2017.04.019 · Cited by 33 · see citing works

Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice

Kim, M., Lee, D. Y., Lee, J. H., Kim, H. W., Sung, S. H., Han, J., & Jeon, W. K. (2018) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-018-2212-y · Cited by 76 · see citing works

Aqueous extracts from asparagus stems prevent memory impairments in scopolamine-treated mice

Sui, Z., Qi, C., Huang, Y., Ma, S., Wang, X., Le, G., & Sun, J. (2017) · Food & Function · doi:10.1039/c7fo00028f · Cited by 31 · see citing works

Ameliorative effect of vanillic acid against scopolamine-induced learning and memory impairment in rat via attenuation of oxidative stress and dysfunctional synaptic plasticity

Choi, G.-Y., Lee, I.-S., Moon, E., Choi, H., Je, A. R., Park, J.-H., & Kweon, H. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117000 · Cited by 21 · see citing works