Cited by 35Cholinesterase and Neurodegenerative DiseasesMedicinal Plants and NeuroprotectionAlzheimer's disease research and treatments

Ameliorative effect of deoxyvasicine on scopolamine-induced cognitive dysfunction by restoration of cholinergic function in mice

Deng, Gang, Wu, Chao, Rong, Xiaojuan, Li, Shuping, Ju, Zhengcai, Wang, Youxu, Ma, Chao, Ding, Wenzheng +4 more·2019·Phytomedicine

Abstract

Background Aerial parts of Peganum harmala Linn is used as a traditional medical herb for treatment of amnesia in Uighur medicine in China. Deoxyvasicine (DVAS) is one of the chief active ingredients in P. harmala, it possesses strong acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitory activities in vitro, but the therapeutic effect and mechanisms on amnesia in vivo are unclear.Purpose The objective of this study was to investigate the improvement effect of DVAS from P. harmala in learning and memory deficits of scopolamine-induced mice and elucidate the underlying mechanisms involved.Methods Mice were pretreated with DVAS (5, 15 and 45 mg/kg) and huperzine-A (0.2 mg/kg) by gavage for 7 days, and subsequently were daily intraperitoneally injected with scopolamine (1 mg/kg) to induce learning and memory deficits and behavioral performance was assessed by Morris water maze. To further evaluate the potential mechanisms of DVAS in improving learning and memory capabilities, pathological change, levels of various biochemical markers and protein expressions related to cholinergic system, oxidative stress, and neuroinflammation were examined.Results The results showed that DVAS could alleviate learning and memory deficits in scopolamine-treated mice. DVAS could regulate cholinergic function by inhibiting AChE and activating choline acetyltransferase (ChAT) activities and protein expressions. DVAS could induce brain-derived neurotrophic factor and protect hippocampal pyramidal cells against neuronal damage. DVAS also enhanced antioxidant defense via increasing the antioxidant enzyme level and activity of glutathione peroxidase, and anti-inflammatory function through suppressing tumor necrosis factor-α. Additionally, DVAS could regulate the neurotransmitters by elevating acetylcholine, 5-hydroxytryptamine, γ-aminobutyric acid and reducing 5-hydroxyindole-3-acetic acid and glutamic acid.Conclusion Results illustrated that DVAS may be a promising candidate compound against amnesia via restoration of cholinergic function, regulating neurotransmitters, attenuating neuroinflammation and oxidative stress.

Integrity signals

Registry

Crossref · 10.1016/j.phymed.2019.153007

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Extracts from Amygdalus spinosissima roots, Peganum harmala, Trianthema portulastrum, Centella asiatica, Citrus reticulata, and Cudrania tricuspidata reduced AChE activity and improved cognitive function in scopolamine-treated mice.

    “Extracts from Amygdalus spinosissima roots, Peganum harmala, Trianthema portulastrum, Centella asiatica, and other plants, including Citrus reticulata and Cudrania tricuspidata, have also shown promising results in reducing AChE activity and improving cognitive function in SCO-treated mice [30,31,32,33,34,35].”

Cites

Flagged first, then by citations

1 of the 77 references couldn’t be matched to a known paper.

Cited by

Sorted by citations

Authors
Deng, G., Wu, C., Rong, X., Li, S., Ju, Z., Wang, Y., Ma, C., Ding, W., Guan, H., Cheng, X., Liu, W., & Wang, C.
Affiliations
  • State Administration of Traditional Chinese Medicine of the People's Republic of China (CN)
  • Xinjiang Institute of Materia Medica (CN)
  • Chinese Academy of Sciences (CN)
Corresponding author
  • Liu, Wei
  • Wang, Changhong
Venue
Phytomedicine
Publisher
Elsevier BV
Published
2019-10
Volume
63
Pages
153007
ISSN
0944-7113 (ISSN-L)
OpenAlex
W2955383634
Cited by
34
References
77
Citations by year
2026: 3 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 3 · 2021: 3 · 2020: 6
FWCI
1.86
Type
journal article
Language
en
Open access
closed
Locations
  • Phytomedicine (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Xinjiang Uygur Autonomous Region Department of Education (U1130303, 2019D04018)
  • National Natural Science Foundation of China (81872933)
  • Ministry of Science and Technology of the People's Republic of China (2017ZX09301068-004)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
Peganum harmala, scopolamine-induced amnesia, learning and memory impairment, cholinergic activity, acetylcholinesterase inhibition, butyrylcholinesterase, choline acetyltransferase, brain-derived neurotrophic factor, hippocampal neuroprotection, oxidative stress, neuroinflammation, TNF-α, glutathione peroxidase, neurotransmitter modulation
MeSH terms
Acetylcholine, Alkaloids, Amnesia, Animals, Antioxidants, Cholinesterase Inhibitors, Hippocampus, Male, Memory, Memory Disorders, Mice, Inbred C57BL, Quinazolines, Scopolamine, Sesquiterpenes, Neurotransmitter Agents, Oxidative Stress, Brain-Derived Neurotrophic Factor, Peganum, Cognitive Dysfunction

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review