The cellular response in neuroinflammation: The role of leukocytes, microglia and astrocytes in neuronal death and survival
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Neuroinflammation is a complex integration of the responses of all cells present within the CNS, including the neurons, macroglia, microglia and the infiltrating leukocytes. The initiating insult, environmental factors, genetic background and age/past experiences all combine to modulate the integrated response of this complex neuroinflammatory circuit. Here, we explore how these factors interact to lead to either neuroprotective versus neurotoxic inflammatory responses. We specifically focus on microglia and astrocytic regulation of autoreactive T cell responses.
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Astrocytes, neurons and endothelial cells may also be involved in or affected by neuroinflammation.
“all of which may also be involved in, or be affected by neuroinflammation [28].”
From Pharmacological modulation of TSPO in microglia/macrophages and neurons in a chronic neurodegenerative model of prion disease (2023) · cites this paper as [28]
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- Authors
- Carson, M. J., Cameron Thrash, J., & Walter, B.
- Affiliations
- University of California, Riverside (US)
- Corresponding author
- Carson, Monica J.
- Venue
- Clinical Neuroscience Research
- Publisher
- Elsevier BV
- Published
- 2006-12
- Volume
- 6
- Issue
- 5
- Pages
- 237-245
- ISSN
- 1566-2772 (ISSN-L)
- PMC
- PMC2630233
- OpenAlex
- W1964913218
- Cited by
- 299
- References
- 66
- Citations by year
- 2026: 8 · 2025: 24 · 2024: 27 · 2023: 20 · 2022: 26 · 2021: 30 · 2020: 24 · 2019: 15 · 2018: 23 · 2017: 18 · 2016: 20 · 2015: 6 · 2014: 13 · 2013: 21 · 2012: 12
- FWCI
- 0.88
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Clinical Neuroscience Research (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Academy of Sciences of Ukraine
- National Institute of Neurological Disorders and Stroke (R01NS045735, R01NS039508)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Inflammasome and immune disorders
- Keywords
- neuroinflammation, microglia, astrocytes, leukocytes, neuronal cell death, neuronal survival, neuroprotection, neurotoxicity, autoreactive T cells, macroglia
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