Lactobacillus fermentum NS9 restores the antibiotic induced physiological and psychological abnormalities in rats
Abstract
Gut microbiota play a vital role in maintaining the health of the host. Many factors affect gut microbiota; application of broad range antibiotics disturb microbiota, while probiotic application protects the microbiota. To investigate how probiotics alter the physiological and psychological changes induced by antibiotics, we tested the performance of ampicillin-treated rats in the presence or absence of Lactobacillus fermentum strain NS9, in elevated plus maze and Morris water maze. The results showed that NS9 normalised the composition of gut microbiota and alleviated the ampicillin-induced inflammation in the colon. The levels of the mineralocorticoid and N-methyl-D-aspartate receptors were also elevated in the hippocampus of the ampillicin+NS9 treated group. NS9 administration also reduced the anxiety-like behaviour and alleviated the ampicillin-induced impairment in memory retention. These findings suggest that NS9 is beneficial to the host, because it restores the physiological and psychological abnormalities induced by ampicillin. Our results highlight how gut contents regulate the brain, and shed light on the clinical applications of probiotics to treat the side effect of antibiotics and mental disorders.
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Expression of NMDAR and BDNF is significantly reduced in GF mice.
“In addition, expression of NMDAR and BDNF is significantly reduced in GF mice [572, 581, 582]”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [582]
Dysbiosis in weaned rats leads to impaired spatial memory and reduced NMDAR and BDNF levels in the brain.
“Dysbiosis in weaned rats leads to impaired spatial memory and reduced NMDAR and BDNF levels in the brain [582, 583].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [582]
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- Authors
- Wang, T., Hu, X., Liang, S., Li, W., Wu, X., Wang, L., & Jin, F.
- Affiliations
- Chinese Academy of Sciences (CN)
- Hangzhou Normal University (CN)
- Venue
- Beneficial Microbes
- Publisher
- Walter de Gruyter GmbH
- Published
- 2015-10-15
- Volume
- 6
- Issue
- 5
- Pages
- 707-718
- ISSN
- 1876-2883 (ISSN-L)
- 1876-2891
- OpenAlex
- W2099514643
- Cited by
- 233
- References
- 59
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 23 · 2023: 24 · 2022: 34 · 2021: 40 · 2020: 28 · 2019: 16 · 2018: 19 · 2017: 15 · 2016: 9 · 2015: 2
- FWCI
- 20.07
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Beneficial Microbes (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- probiotics, ampicillin, antibiotic-induced gut dysbiosis, gut-brain axis, anxiety-like behavior, memory impairment, hippocampus, mineralocorticoid receptor, NMDA receptor, colonic inflammation, antibiotic adverse effects
- MeSH terms
- Gastrointestinal Microbiome, Ampicillin, Animals, Anti-Bacterial Agents, Anxiety, Gastroenteritis, Hippocampus, Memory Disorders, Receptors, N-Methyl-D-Aspartate, Receptors, Mineralocorticoid, Probiotics, Rats, Limosilactobacillus fermentum
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