Cited by 211Neuropeptides and Animal PhysiologyNeuroendocrine regulation and behaviorStress Responses and Cortisol

Behavioral effects of neuropeptides in rodent models of depression and anxiety

Rotzinger, Susan, Lovejoy, David A., Tan, Laura A.·2010·Peptides

Abstract

In recent years, studies have advocated neuropeptide systems as modulators for the behavioral states found in mood disorders such as depression and anxiety disorders. Neuropeptides have been tested in traditional animal models and screening procedures that have been validated by known antidepressants and anxiolytics. However, it has become clear that although these tests are very useful, neuropeptides have distinct behavioral effects and dose-dependent characteristics, and therefore, use of these tests with neuropeptides must be done with an understanding of their unique characteristics. This review will focus on the behavioral actions of neuropeptides and their synthetic analogs, particularly in studies utilizing various preclinical tests of depression and anxiety. Specifically, the following neuropeptide systems will be reviewed: corticotropin-releasing factor (CRF), urocortin (Ucn), teneurin C-terminal associated peptide (TCAP), neuropeptide Y (NPY), arginine vasopressin (AVP), oxytocin, the Tyr-MIF-1 family, cholecystokinin (CCK), galanin, and substance P. These neuropeptide systems each have a unique role in the regulation of stress-like behavior, and therefore provide intriguing therapeutic targets for mood disorder treatment.

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Crossref · 10.1016/j.peptides.2009.12.015

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  • Preclinical studies demonstrated that exogenous intravenous and intranasal oxytocin can influence fear related responses in rodents and monkeys respectively, reducing hiding behaviour during an open field test and attentional bias towards threatening facial expressions.

    “Preclinical studies demonstrated that exogenous intravenous and intranasal oxytocin can influence fear related responses in rodents and monkeys respectively, reducing hiding behaviour during an open field test and attentional bias towards threatening facial expressions (Parr et al., 2013;Rotzinger et al., 2010).”

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Authors
Rotzinger, S., Lovejoy, D. A., & Tan, L. A.
Affiliations
University of Toronto (CA)
Corresponding author
Tan, Laura A.
Venue
Peptides
Publisher
Elsevier BV
Published
2010-04
Volume
31
Issue
4
Pages
736-756
ISSN
0196-9781 (ISSN-L)
OpenAlex
W2087834131
Cited by
211
References
245
Citations by year
2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 10 · 2021: 6 · 2020: 6 · 2019: 8 · 2018: 9 · 2017: 14 · 2016: 10 · 2015: 12 · 2014: 21 · 2013: 24 · 2012: 27
FWCI
1.97
Type
journal article
Language
en
Open access
closed
Locations
  • Peptides (publishedVersion)
  • PubMed (publishedVersion)
Funders
Canadian Institutes of Health Research (FRN 72027622)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
neuropeptides, depression, anxiety, mood disorders, corticotropin-releasing factor, urocortin, neuropeptide Y, vasopressin, oxytocin, cholecystokinin, galanin, substance P, antidepressant screening, rodent models, therapeutic target
MeSH terms
Animals, Anxiety, Arginine Vasopressin, Behavior, Animal, Cholecystokinin, Corticotropin-Releasing Hormone, Depression, Disease Models, Animal, Humans, MSH Release-Inhibiting Hormone, Neuropeptide Y, Neuropeptides, Neuropsychological Tests, Oxytocin, Social Behavior, Galanin, Urocortins

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