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Cited by 41Circadian rhythm and melatoninSleep and Wakefulness ResearchMemory and Neural Mechanisms

Effects of long-term continuous exposure to light on memory and anxiety in mice

Castro, J.P.M.V., Frussa-Filho, R., Fukushiro, D.F., Chinen, C.C., Abílio, V.C., Silva, R.H.·2005·Physiology & Behavior
DOI 10.1016/j.physbeh.2005.07.009
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Abstract

The studies on the relationship between the light/dark cycle and memory function mostly used protocols of acute disruption of the circadian rhythm. The aim of the present study is to verify the effects of long-term continuous exposure to light on memory, anxiety and motor parameters of mice tested in the plus-maze discriminative avoidance task. Mice were conditioned to choose between the two enclosed arms (one aversive and one non-aversive) while avoiding the open arms of a modified elevated plus-maze apparatus. Memory was evaluated by the time spent in the aversive enclosed arm, anxiety was evaluated by the time spent in the open arms and locomotor behavior was evaluated by number of entries in the arms of the maze. The results showed that long-term (35-42 days) continuous light exposure did not modify memory or anxiety parameters but increased locomotor activity. While the increase in locomotor behavior is in line with previous studies, the unexpected absence of alterations in memory and anxiety (reported to be influenced by the circadian rhythm) is discussed.

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  • The effects of light as a circadian disruptor are inconsistent across species and may depend on the developmental window during which circadian disruption occurs, as well as the type of light and its intensity.

    “However, the effects of light as a circadian disruptor are inconsistent across species104–108, and may depend on the developmental window during which circadian disruption occurs, as well as the type of light (i.e. halogen, compact fluorescent, or light emitting diode) and its intensity108,109.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [105]

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Authors
Castro, J. P. M. V., Frussa-Filho, R., Fukushiro, D. F., Chinen, C. C., Abílio, V. C., & Silva, R. H.
Affiliations
Universidade Federal de São Paulo (BR)
Corresponding author
Abílio, V.C.
ORCID
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2005-09
Volume
86
Issue
1-2
Pages
218-223
ISSN
0031-9384 (ISSN-L)
DOI
10.1016/j.physbeh.2005.07.009
OpenAlex
W1966246322
Cited by
41
References
43
Citations by year
2026: 3 · 2025: 3 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 2 · 2018: 5 · 2016: 3 · 2015: 3 · 2013: 5 · 2012: 1
FWCI
0.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
continuous light exposure, circadian rhythm, memory, anxiety, locomotor activity, elevated plus maze, discriminative avoidance, light-dark cycle, mice
MeSH terms
Analysis of Variance, Animals, Anxiety, Avoidance Learning, Behavior, Animal, Discrimination Learning, Light, Male, Memory, Mice, Inbred Strains, Phototherapy, Time Factors, Maze Learning, Mice

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