Tests of unconditioned anxiety — Pitfalls and disappointments

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Neglected aspects of exploratory and investigatory behavior

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GABAA receptor subtypes as targets for neuropsychiatric drug development

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A functional analysis of danger and safety signals in anxiety disorders

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Modulation of Different States of Anxiety-Like Behavior by Chronic Stress.

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The rat exposure test: a model of mouse defensive behaviors

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Increased 5-HT2C receptor responsiveness occurs on rearing rats in social isolation

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Strain differences in activity and emotionality do not account for differences in learning and memory performance between C57BL/6 and DBA/2 mice

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Modulation of rhythmic brain activity by diazepam: GABA A receptor subtype and state specificity

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Contrasting phenotypes of C57BL/6JOlaHsd, 129S2/SvHsd and 129/SvEv mice in two exploration-based tests of anxiety-related behaviour

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Social deficits in BTBR T + tf/J mice are unchanged by cross‐fostering with C57BL/6J mothers

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Behavioral specificity of non-genomic glucocorticoid effects in rats: Effects on risk assessment in the elevated plus-maze and the open-field

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Ethopharmacological Analysis of 5-HT Ligands on the Rat Elevated Plus-Maze

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Three murine anxiety models: results from multiple inbred strain comparisons

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Escape, exploratory, and food-seeking responses of rats in a novel situation.

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Does neophobia necessarily imply fear or anxiety?

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Long-lasting consequences of a social conflict in rats: Behavior during the interaction predicts subsequent changes in daily rhythms of heart rate, temperature, and activity.

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Deletion of the α1 or β2 Subunit of GABAAReceptors Reduces Actions of Alcohol and Other Drugs

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Long-lasting, selective, anxiogenic effects of feline predator stress in mice

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Effects of acute fluoxetine, paroxetine and desipramine on rats tested on the elevated plus-maze

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Vulnerability to mild predator stress in serotonin transporter knockout mice

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General and social anxiety in the BTBR T+ tf/J mouse strain

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Influence of spatial and temporal manipulations on the anxiolytic efficacy of chlordiazepoxide in mice previously exposed to the elevated plus-maze

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Repeated exposure to stress across the childhood-adolescent period alters rats' anxiety-and depression-like behaviors in adulthood: The importance of stressor type and gender

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Evidence for expectancy as a mediator of avoidance and anxiety in a laboratory model of human avoidance learning

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Ethological comparison of the effects of diazepam and acute/chronic imipramine on the behaviour of mice in the elevated plus-maze

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Enhancement of anxiety-like responsiveness to the cannabinoid CB1 receptor agonist HU-210 following chronic stress

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The exploratory behavior of rats in an open environment optimizes security

Whishaw, I. Q., Gharbawie, O. A., Clark, B. J., & LEHMANN, H. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.037 · Cited by 118

Models of anxiety: Responses of rats to novelty in an open space and an enclosed space

Ennaceur, A., Michalikova, S., & Chazot, P. L. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.03.016 · Cited by 117

Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability

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Benzodiazepines have no effect on fear-potentiated startle in humans

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Patterns of emotional responses to affective situations: Relations among happiness, sadness, anger, fear, depression, and anxiety

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Effects of maternal separation, early handling, and standard facility rearing on orienting and impulsive behavior of adolescent rats

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Genuine antihyperalgesia by systemic diazepam revealed by experiments in GABAA receptor point-mutated mice

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Does escape behavior strengthen agoraphobic avoidance? A replication

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Both α2 and α3 GABAA receptor subtypes mediate the anxiolytic properties of benzodiazepine site ligands in the conditioned emotional response paradigm

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Brain neuropeptide Y and corticotropin-releasing hormone in mediating stress and anxiety

Thorsell, A. (2010) · Experimental Biology and Medicine · doi:10.1258/ebm.2010.009331 · Cited by 109

2,3,5-Trimethyl-3-thiazoline (TMT), a component of fox odor – Just repugnant or really fear-inducing?

Fendt, M., & Endres, T. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.05.010 · Cited by 108

Fluoxetine but not risperidone increases sociability in the BTBR mouse model of autism

Chadman, K. K. (2010) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2010.09.012 · Cited by 107

Modulation of mice anxiety in response to cat odor as a consequence of predators diet

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Pitfalls in the interpretation of genetic and pharmacological effects on anxiety-like behaviour in rodents

Bouwknecht, J. A., & Paylor, R. E. (2008) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32830c3658 · Cited by 105

Testing for anxiety

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Effects of GABAB receptor ligands in animal tests of depression and anxiety.

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Prior test experience compromises the anxiolytic efficacy of chlordiazepoxide in the mouse light/dark exploration test

Holmes, A., Iles, J. P., Mayell, S. J., & Rodgers, R. J. (2001) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00184-x · Cited by 102

Anxiety and cognition in histamine H3 receptor−/− mice

Rizk‐Jackson, A., Curley, J., Robertson, J., & Raber, J. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03251.x · Cited by 102

Changes in emotional behavior produced by long-term amygdala kindling in rats

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Behavioural and pharmacological characterisation of the canopy stretched attend posture test as a model of anxiety in mice and rats

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Relations between open-field, elevated plus-maze, and emergence tests as displayed by C57/BL6J and BALB/c mice

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Inhibitory avoidance, pain reactivity, and plus-maze behavior in Wistar rats with high versus low rearing activity

Borta, A., & Schwarting, R. K. W. (2005) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.01.009 · Cited by 97

Evaluating the cognitive avoidance model of generalised anxiety disorder: Impact of worry on threat appraisal, perceived control and anxious arousal

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Benzodiazepine-induced anxiolysis and reduction of conditioned fear are mediated by distinct GABAA receptor subtypes in mice

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The Reinforcing Properties of Alcohol are Mediated by GABAA1 Receptors in the Ventral Pallidum

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Analysis of behavioral constraints and the neuroanatomy of fear to the predator odor trimethylthiazoline: A model for animal phobias

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Dopamine D3-Like Receptors Modulate Anxiety-Like Behavior and Regulate GABAergic Transmission in the Rat Lateral/Basolateral Amygdala

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Behavioral Effects of Acute and Chronic Fluoxetine in Wistar–Kyoto Rats

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A coherent pattern among social behavior, blood pressure, corticosterone and catecholamine measures in individual male rats

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Prediction and control: operational definitions for the experimental analysis of anxiety

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Impaired exploratory behaviour after DSP-4 treatment in rats: implications for the increased anxiety after noradrenergic denervation

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Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: Focus on pharmacology and preclinical translational models

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HZ166, a novel GABAA receptor subtype-selective benzodiazepine site ligand, is antihyperalgesic in mouse models of inflammatory and neuropathic pain

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Actions of sulpiride and tiapride in a simple model of anxiety in mice

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Sex-dependent effects of aversive stimulation on holeboard and elevated plus-maze behavior

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On the elevated plus-maze the anxiolytic-like effects of the 5-HT 1A agonist, 8-OH-DPAT, but not the anxiogenic-like effects of the 5-HT 1A partial agonist, buspirone, are blocked by the 5-HT 1A antagonist, WAY 100635

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The Gerbil Elevated Plus-Maze I Behavioral Characterization and Pharmacological Validation

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Stretched attend posture, a non-social form of ambivalence, is sensitive to a conflict-reducing drug action

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Behavioural comparisons of isolated, dominant and subordinate mice

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Do rats really express neophobia towards novel objects? Experimental evidence from exposure to novelty and to an object recognition task in an open space and an enclosed space

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Features of the Genetically Defined Anxiety in Mice

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The delayed effects of chronic unpredictable stress on anxiety measures

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Concordance and synchrony in measures of anxiety and panic reconsidered: A hierarchical model of anxiety and panic

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Anxiolytic activity of a novel potent serotonin 5-HT2C receptor antagonist FR260010: A comparison with diazepam and buspirone

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Temporal structure of the rat's behavior in elevated plus maze test

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Effect of 5-HT1A agonists on stress-induced deficit in open field locomotor activity of rats: Evidence that this model identifies anxiolytic-like activity

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Paradoxical Anxiogenic Response of Juvenile Mice to Fluoxetine

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Animal Models of Anxiety and Anxiolytic Drug Action

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The Effects of GABAergic Drugs on Grooming Behaviour in the Open Field

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‘Emotionality’ and adrenal cortical function: Effects of strain, tests, and the 24-hour corticosterone rhythm

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GABAAReceptors Containing α5 Subunits in the CA1 and CA3 Hippocampal Fields Regulate Ethanol-Motivated Behaviors: An Extended Ethanol Reward Circuitry

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Chronic psychosocial stress and antidepressant treatment in tree shrews: time-dependent behavioral and endocrine effects

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Cocaine effects on mouse incentive-learning and human addiction are linked to α2 subunit-containing GABA A receptors

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The GABAAReceptor α1Subtype in the Ventral Pallidum Regulates Alcohol-Seeking Behaviors

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The ventral hippocampus and the lateral septum work in tandem to regulate rats' open-arm exploration in the elevated plus-maze

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Susceptibility to subchronic unpredictable stress is related to individual reactivity to threat stimuli in mice

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Relationship between anxiety and serotonin in the ventral striatum

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Animal models of different anxiety states.

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Individual variability in the stress response of C57BL/6J male mice correlates with trait anxiety

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Influence of reactivity to novelty and anxiety on hypothalamic–pituitary–adrenal and prolactin responses to two different novel environments in adult male rats

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Anxiogenic-like effect of acute and chronic fluoxetine on rats tested on the elevated plus-maze

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Animal models: Trait or state measure? The test-retest reliability of the elevated plus-maze and behavioral despair

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Absence of intrinsic antagonist actions of benzodiazepine antagonists on an exploratory model of anxiety in the mouse

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Evaluation of the anxiolytic-like profile of the GABAB receptor positive modulator CGP7930 in rodents

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Differential basis of strain and rearing effects on open-field behavior in Fawn Hooded and Wistar rats

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Are GABAA Receptors Containing α5 Subunits Contributing to the Sedative Properties of Benzodiazepine Site Agonists?

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Chlordiazepoxide reduces the generalised anxiety, but not the direct responses, of rats exposed to cat odor

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Deletion of GABAA Receptor α1 Subunit-containing Receptors Alters Responses to Ethanol and Other Anesthetics

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Exaggerated responses to stress in the BTBR T+tf/J mouse: An unusual behavioral phenotype

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A Single Amino Acid Mutation in SNAP-25 Induces Anxiety-Related Behavior in Mouse

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Increases in plasma corticosterone and stretched-attend postures in rats naive and previously exposed to the elevated plus-maze are sensitive to the anxiolytic-like effects of midazolam

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