Postnatal lesion evidence against a primary role for the corpus callosum in mouse sociability
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The BTBR T+tf/J (BTBR) strain is an inbred strain of mice that displays prominent social deficits and repetitive behaviors analogous to the defining symptoms of autism, along with complete congenital agenesis of the corpus callosum (CC). The BTBR strain is genetically distant from the widely used C57BL/6J (B6) strain, which exhibits high levels of sociability, a low level of repetitive behaviors, and an intact CC. Emerging evidence implicates compromised interhemispherical connectivity in some cases of autism. We investigated the hypothesis that the disconnection of CC fiber tracts contributes to behavioral traits in mice that are relevant to the behavioral symptoms of autism. Surgical lesion of the CC in B6 mice at postnatal day 7 had no effect on juvenile play and adult social approaches, and did not elevate repetitive self‐grooming. In addition, LP/J, the strain that is genetically closest to the BTBR strain but has an intact CC, displayed juvenile play deficits and repetitive self‐grooming similar to those seen in BTBR mice. These corroborative results offer evidence against the hypothesis that the CC disconnection is a primary cause of low sociability and a high level of repetitive behaviors in inbred mice. Our findings indicate that genes mediating other aspects of neurodevelopment, including those whose mutations underlie more subtle disruptions in white matter pathways and connectivity, are more likely to contribute to the aberrant behavioral phenotypes in the BTBR mouse model of autism.
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Experimentally induced postnatal lesions of the corpus callosum in B6 mice did not recapitulate the social deficits or repetitive self-grooming that characterize BTBR.
“Experimentally induced postnatal lesions of the corpus callosum in B6 mice, however, did not recapitulate the social deficits, or the repetitive self-grooming, that characterize BTBR (82).”
From Negative allosteric modulation of the mGluR5 receptor reduces repetitive behaviors and rescues social deficits in mouse models of autism (2012) · cites this paper as [82]
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Neuropsychological outcome of corpus callosotomy in children and adolescents.
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The Genetics of Autism Spectrum Disorders
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Callosotomy for intractable epilepsy: overall outcome.
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Regional Callosal Morphology in Autism and Macrocephaly
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Neonatal transection of the corpus callosum affects rotational side preference in adult Swiss mice
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Behavioural phenotyping assays for mouse models of autism
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Self-citationAutomated Three‐Chambered Social Approach Task for Mice
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Self-citationChd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
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Sociability and motor functions in Shank1 mutant mice
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Reduced scent marking and ultrasonic vocalizations in the BTBR T+tf/J mouse model of autism
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The BTBR T+tf/J mouse model for autism spectrum disorders–in search of biomarkers
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Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
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Low sociability in BTBR T+tf/J mice is independent of partner strain
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“Mice were scored for spontaneous self-grooming behaviors as described previously (Yang et al., 2007, 2009; McFarlane et al., 2008; Silverman et al., 2010).”
MethodModeling autism-relevant behavioral phenotypes in rats and mice: Do ‘autistic’ rodents exist?
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The autism diagnosis in translation: shared affect in children and mouse models of ASD
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Novel inter-hemispheric white matter connectivity in the BTBR mouse model of autism
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McClintic, A. M., King, B. H., Webb, S. J., & Mourad, P. D. (2014) · Autism Research · doi:10.1002/aur.1349 · Cited by 25 · see citing works
- Authors
- Yang, M., Clarke, A. M., & Crawley, J. N.
- Affiliations
- National Institutes of Health (US)
- Venue
- European Journal of Neuroscience
- Publisher
- Wiley
- Published
- 2009-04
- Volume
- 29
- Issue
- 8
- Pages
- 1663-1677
- ISSN
- 0953-816X (ISSN-L)
- 1460-9568
- PMC
- PMC2762200
- OpenAlex
- W2090460252
- Cited by
- 117
- References
- 99
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 6 · 2014: 11 · 2013: 11 · 2012: 20
- FWCI
- 7.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- European Journal of Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 MH999999)
- National Institute of Mental Health (Z01MH002179)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- corpus callosum, sociability, repetitive behavior, autism spectrum disorder, BTBR T+tf/J mice, agenesis of the corpus callosum, corpus callosum lesions, interhemispheric connectivity, self-grooming, white matter tracts, mouse models of autism
- MeSH terms
- Animals, Anxiety, Autistic Disorder, Behavior, Animal, Corpus Callosum, Female, Grooming, Humans, Male, Mice, Inbred Strains, Motor Activity, Neuropsychological Tests, Phenotype, Play and Playthings, Social Behavior, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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