The α1 subunit of the GABA(A) receptor modulates fear learning and plasticity in the lateral amygdala
Open accessAbstract
Synaptic plasticity in the amygdala is essential for emotional learning. Fear conditioning, for example, depends on changes in excitatory transmission that occur following NMDA receptor activation and AMPA receptor modification in this region. The role of these and other glutamatergic mechanisms have been studied extensively in this circuit while relatively little is known about the contribution of inhibitory transmission. The current experiments addressed this issue by examining the role of the GABA(A) receptor subunit alpha1 in fear learning and plasticity. We first confirmed previous findings that the alpha1 subunit is highly expressed in the lateral nucleus of the amygdala. Consistent with this observation, genetic deletion of this subunit selectively enhanced plasticity in the lateral amygdala and increased auditory fear conditioning. Mice with selective deletion of alpha1 in excitatory cells did not exhibit enhanced learning. Finally, infusion of a alpha1 receptor antagonist into the lateral amygdala selectively impaired auditory fear learning. Together, these results suggest that inhibitory transmission mediated by alpha1-containing GABA(A) receptors plays a critical role in amygdala plasticity and fear learning.
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The enhancement of fear conditioning by α1 knockout is mediated by α1GABAARs in GABAergic neurons, most likely PV+ interneurons, not excitatory neurons.
“Moreover, the enhancement of fear-conditioning is mediated by α1GABAARs not in excitatory neurons, but in GABAergic neurons [12] (most likely PV+ interneurons).”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [12]
Global knockout of α1GABAARs enhances auditory fear conditioning.
“and that the global knockout of α1 GABAARs enhances auditory fear conditioning (see Box 5) [12].”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [12]
α1GABAARs have been implicated in anxiety, fear and/or response to chronic stress.
“In addition, γ2GABAARs [11], α1GABAARs [10, 12], α3GABAARs [13] (but see [14-16] for contradictory findings), and more recently, α5GABAARs [16-18, 4] have been implicated in anxiety, fear and/or response to chronic stress.”
From An emerging circuit pharmacology of GABAA receptors (2018) · cites this paper as [12]
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- Authors
- Wiltgen, B.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Wiltgen, Brian
- ORCID
- Wiltgen, Brian
- Venue
- Frontiers in Behavioral Neuroscience
- Publisher
- Frontiers Media SA
- Published
- 2009
- Volume
- 3
- Pages
- 37-37
- ISSN
- 1662-5153 (ISSN-L)
- PMC
- PMC2769557
- OpenAlex
- W2126799774
- Cited by
- 47
- References
- 72
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 2 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 4 · 2018: 5 · 2017: 3 · 2015: 2 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 1.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Frontiers in Behavioral Neuroscience (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (AA10422)
- National Institute on Alcohol Abuse and Alcoholism (R37AA010422, R01AA010422)
- National Institute of Neurological Disorders and Stroke (R56NS051311, P01NS035985, R01NS051311)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABA-A receptor alpha1 subunit, lateral amygdala, fear conditioning, synaptic plasticity, synaptic inhibition, excitatory neurons, gene deletion, emotional learning
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