Bioactive natural products from marine cyanobacteria for drug discovery

Microtubules and actin filaments: dynamic targets for cancer chemotherapy

Jordan, M. A., & Wilson, L. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80095-1 · Cited by 613 · see citing works

Nonribosomal peptides: from genes to products

Schwarzer, D., Finking, R., & Marahiel, M. A. (2003) · Natural Product Reports · doi:10.1039/b111145k · Cited by 589 · see citing works

Commercial development of microalgal biotechnology: from the test tube to the marketplace

Olaizola, M. (2003) · Biomolecular Engineering · doi:10.1016/s1389-0344(03)00076-5 · Cited by 571 · see citing works

Patellamide A and C biosynthesis by a microcin-like pathway in <i>Prochloron didemni</i> , the cyanobacterial symbiont of <i>Lissoclinum patella</i>

Schmidt, E. W., Nelson, J. T., Rasko, D. A., Sudek, S., Eisen, J. A., Haygood, M. G., & Ravel, J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501424102 · Cited by 567 · see citing works

Nature's Inventory of Halogenation Catalysts: Oxidative Strategies Predominate

Vaillancourt, F. H., Yeh, E., Vosburg, D. A., et al. (2006) · Chemical Reviews · doi:10.1021/cr050313i · Cited by 558 · see citing works

Structure and Biosynthesis of the Jamaicamides, New Mixed Polyketide-Peptide Neurotoxins from the Marine Cyanobacterium Lyngbya majuscula

Edwards, D. J., Márquez, B. L., Nogle, L. M., McPhail, K. L., Goeger, D. E., Roberts, M. A., & Gerwick, W. H. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2004.03.030 · Cited by 506 · see citing works

Total Structure Determination of Apratoxin A, a Potent Novel Cytotoxin from the Marine Cyanobacterium <i>Lyngbya </i><i>m</i><i>ajuscula</i>

Luesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J., & Corbett, T. H. (2001) · Journal of the American Chemical Society · doi:10.1021/ja010453j · Cited by 373 · see citing works

SyrB2 in syringomycin E biosynthesis is a nonheme Fe II α-ketoglutarate- and O 2 -dependent halogenase

Vaillancourt, F. H., Yin, J., & Walsh, C. T. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504412102 · Cited by 348 · see citing works

Cryptic chlorination by a non-haem iron enzyme during cyclopropyl amino acid biosynthesis

Vaillancourt, F. H., Yeh, E., Vosburg, D. A., et al. (2005) · Nature · doi:10.1038/nature03797 · Cited by 328 · see citing works

β-Amino Acids: Versatile Peptidomimetics

Steer, D. L., Lew, R. A., Perlmutter, P., et al. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867024606759 · Cited by 281 · see citing works

Natural combinatorial peptide libraries in cyanobacterial symbionts of marine ascidians

Donia, M. S., Hathaway, B. J., Sudek, S., Haygood, M. G., Rosovitz, M. J., Ravel, J., & Schmidt, E. W. (2006) · Nature Chemical Biology · doi:10.1038/nchembio829 · Cited by 261 · see citing works

Halogenation of Unactivated Carbon Centers in Natural Product Biosynthesis: Trichlorination of Leucine during Barbamide Biosynthesis

Galonić, D. P., Vaillancourt, F. H., & Walsh, C. T. (2006) · Journal of the American Chemical Society · doi:10.1021/ja060151n · Cited by 194 · see citing works

Nitrogen-containing metabolites from marine cyanobacteria

Gerwick, W. H., Tan, L. T., & Sitachitta, N. (2001) · The Alkaloids. Chemistry and biology/The alkaloids. Chemistry and biology · doi:10.1016/s0099-9598(01)57003-0 · Cited by 186 · see citing works

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly

Marquez, B. L., Watts, K. S., Yokochi, A., Roberts, M. A., Verdier-Pinard, P., Jimenez, J. I., Hamel, E., Scheuer, P. J., & Gerwick, W. H. (2002) · Journal of Natural Products · doi:10.1021/np0106283 · Cited by 181 · see citing works

New apratoxins of marine cyanobacterial origin from guam and palau

Luesch, H. (2002) · Bioorganic & Medicinal Chemistry · doi:10.1016/s0968-0896(02)00014-7 · Cited by 165 · see citing works

A functional genomics approach to the mode of action of apratoxin A

Luesch, H., Chanda, S. K., Raya, R. M., DeJesus, P., Orth, A. P., Walker, J. R., Belmonte, J. C. I., & Schultz, P. G. (2006) · Nature Chemical Biology · doi:10.1038/nchembio769 · Cited by 161 · see citing works

Distribution and Diversity of Natural Product Genes in Marine and Freshwater Cyanobacterial Cultures and Genomes

Ehrenreich, I. M., Waterbury, J. B., & Webb, E. A. (2005) · Applied and Environmental Microbiology · doi:10.1128/aem.71.11.7401-7413.2005 · Cited by 141 · see citing works

Isolation of Swinholide A and Related Glycosylated Derivatives from Two Field Collections of Marine Cyanobacteria

Andrianasolo, E. H., Gross, H., Goeger, D. E., Musafija-Girt, M., McPhail, K. L., Leal, R. M., Mooberry, S. L., & Gerwick, W. H. (2005) · Organic Letters · doi:10.1021/ol050188x · Cited by 139 · see citing works

The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares

Luesch, H., Harrigan, G. G., Goetz, G. H., & Horgen, F. D. (2002) · Current Medicinal Chemistry · doi:10.2174/0929867023369051 · Cited by 139 · see citing works

Aurilides B and C, Cancer Cell Toxins from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscula

Han, B., Gross, H., Goeger, D. E., Mooberry, S. L., & Gerwick, W. H. (2006) · Journal of Natural Products · doi:10.1021/np0503911 · Cited by 133 · see citing works

Structure of Trichamide, a Cyclic Peptide from the Bloom-Forming Cyanobacterium Trichodesmium erythraeum , Predicted from the Genome Sequence

Sudek, S., Haygood, M. G., Youssef, D. T. A., & Schmidt, E. W. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.00380-06 · Cited by 128 · see citing works

Identification of the cellular site of polychlorinated peptide biosynthesis in the marine sponge Dysidea (Lamellodysidea) herbacea and symbiotic cyanobacterium Oscillatoria spongeliae by CARD-FISH analysis

Flatt, P. M., Gautschi, J. T., THACKER, R. W., Musafija-Girt, M., Crews, P., & Gerwick, W. H. (2005) · Marine Biology · doi:10.1007/s00227-005-1614-9 · Cited by 116 · see citing works

Lobocyclamides A−C, Lipopeptides from a Cryptic Cyanobacterial Mat Containing Lyngbya confervoides

MacMillan, J. B., Ernst‐Russell, M. A., de Ropp, J. S., & Molinski, T. F. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo0261909 · Cited by 114 · see citing works

Total Synthesis of Apratoxin A

Chen, J., & Forsyth, C. J. (2003) · Journal of the American Chemical Society · doi:10.1021/ja036050w · Cited by 113 · see citing works

Pitipeptolides A and B, New Cyclodepsipeptides from the Marine Cyanobacterium Lyngbya majuscula

Luesch, H., Pangilinan, R., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2001) · Journal of Natural Products · doi:10.1021/np000456u · Cited by 108 · see citing works

Frontiers in Marine Biotechnology

Proksch, P., & Müller, W. E. G. (2006) · Cited by 106 · see citing works

Antillatoxin is a marine cyanobacterial toxin that potently activates voltage-gated sodium channels

Li, W. I., Berman, F. W., Okino, T., Yokokawa, F., Shioiri, T., Gerwick, W. H., & Murray, T. F. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121085898 · Cited by 106 · see citing works

Metabolic Coupling of Dehydration and Decarboxylation in the Curacin A Pathway: Functional Identification of a Mechanistically Diverse Enzyme Pair

Gu, L., Jia, J., Liu, H., et al. (2006) · Journal of the American Chemical Society · doi:10.1021/ja0626382 · Cited by 105 · see citing works

Molecular biology of peptide and polyketide biosynthesis in cyanobacteria

Dittmann, E., Neilan, B. A., & rner, T. B. X. F. (2001) · Applied Microbiology and Biotechnology · doi:10.1007/s002530100810 · Cited by 102 · see citing works

Total synthesis of the cyclodepsipeptide apratoxin A and its analogues and assessment of their biological activities

Ma, D., Zou, B., Cai, G., Hu, X., & Liu, J. O. (2006) · Chemistry – A European Journal · doi:10.1002/chem.200600599 · Cited by 99 · see citing works

Speciation and Biosynthetic Variation in Four Dictyoceratid Sponges and Their Cyanobacterial Symbiont, Oscillatoria spongeliae

Ridley, C. P., Bergquist, P. R., Harper, M. K., et al. (2005) · Chemistry & Biology · doi:10.1016/j.chembiol.2005.02.003 · Cited by 97 · see citing works

The Guineamides, Novel Cyclic Depsipeptides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscula

Tan, L. T., Sitachitta, N., & Gerwick, W. H. (2003) · Journal of Natural Products · doi:10.1021/np020492o · Cited by 94 · see citing works

Largamides A−H, Unusual Cyclic Peptides from the Marine Cyanobacterium Oscillatoria sp.

Plaza, A., & Bewley, C. A. (2006) · The Journal of Organic Chemistry · doi:10.1021/jo061044e · Cited by 92 · see citing works

Structurally diverse new alkaloids from Palauan collections of the apratoxin-producing marine cyanobacterium Lyngbya sp.

Luesch, H., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)00895-5 · Cited by 89 · see citing works

The Wewakpeptins, Cyclic Depsipeptides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya semiplena

Han, B., Goeger, D. E., Maier, C. S., & Gerwick, W. H. (2005) · The Journal of Organic Chemistry · doi:10.1021/jo0478858 · Cited by 89 · see citing works

Malevamide D: Isolation and Structure Determination of an Isodolastatin H Analogue from the Marine CyanobacteriumSymplocahydnoides

Horgen, F. D., Kazmierski, E. B., Westenburg, H. E., Yoshida, W. Y., & Scheuer, P. J. (2002) · Journal of Natural Products · doi:10.1021/np010560r · Cited by 88 · see citing works

Synthesis and Biological Evaluation of Structurally Highly Modified Analogues of the Antimitotic Natural Product Curacin A

Wipf, P., Reeves, J. T., Balachandran, R., & Day, B. W. (2002) · Journal of Medicinal Chemistry · doi:10.1021/jm0105171 · Cited by 87 · see citing works

Isolation and structure of five lyngbyabellin derivatives from a Papua New Guinea collection of the marine cyanobacterium Lyngbya majuscula

Han, B., McPhail, K. L., Gross, H., Goeger, D. E., Mooberry, S. L., & Gerwick, W. H. (2005) · Tetrahedron · doi:10.1016/j.tet.2005.09.036 · Cited by 87 · see citing works

Isolation of Homodolastatin 16, a New Cyclic Depsipeptide from a Kenyan Collection of Lyngbya majuscula

Davies‐Coleman, M. T., Dzeha, T. M., Gray, C. A., Hess, S. Y., Pannell, L. K., Hendricks, D. T., & Arendse, C. E. (2003) · Journal of Natural Products · doi:10.1021/np030014t · Cited by 86 · see citing works

Total Synthesis of Apratoxin A

Doi, T., Numajiri, Y., Munakata, A., & Takahashi, T. (2006) · Organic Letters · doi:10.1021/ol052907d · Cited by 85 · see citing works

Symplostatin 3, a New Dolastatin 10 Analogue from the Marine Cyanobacterium Symploca sp. VP452

Luesch, H., Yoshida, W. Y., Moore, R. E., Paul, V. J., Mooberry, S. L., & Corbett, T. H. (2001) · Journal of Natural Products · doi:10.1021/np010317s · Cited by 84 · see citing works

Aurilide, a cytotoxic depsipeptide from the sea hare Dolabella auricularia: isolation, structure determination, synthesis, and biological activity

Suenaga, K., Mutou, T., Shibata, T., et al. (2004) · Tetrahedron · doi:10.1016/j.tet.2004.06.125 · Cited by 84 · see citing works

Belamide A, a new antimitotic tetrapeptide from a Panamanian marine cyanobacterium

Simmons, T. L., McPhail, K. L., Ortega‐Barría, E., Mooberry, S. L., & Gerwick, W. H. (2006) · Tetrahedron Letters · doi:10.1016/j.tetlet.2006.03.082 · Cited by 84 · see citing works

Somamides A and B, Two New Depsipeptide Analogues of Dolastatin 13 from a Fijian Cyanobacterial Assemblage of Lyngbya majuscula and Schizothrix Species

Nogle, L. M., Williamson, R. T., & Gerwick, W. H. (2001) · Journal of Natural Products · doi:10.1021/np000634j · Cited by 81 · see citing works

Isolation and Structure Determination of Obyanamide, a Novel Cytotoxic Cyclic Depsipeptide from the Marine Cyanobacterium Lyngbya confervoides

Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2001) · Journal of Natural Products · doi:10.1021/np0102253 · Cited by 81 · see citing works

Lyngbouilloside, a Novel Glycosidic Macrolide from the Marine Cyanobacterium Lyngbya bouillonii

Tan, L. T., Márquez, B. L., & Gerwick, W. H. (2002) · Journal of Natural Products · doi:10.1021/np010526c · Cited by 80 · see citing works

Kulokekahilide-2, a Cytotoxic Depsipeptide from a Cephalaspidean Mollusk Philinopsis speciosa

Nakao, Y., Yoshida, W. Y., Takada, Y., et al. (2004) · Journal of Natural Products · doi:10.1021/np049949f · Cited by 79 · see citing works

Isolation of Four New Cyclic Depsipeptides, Antanapeptins A−D, and Dolastatin 16 from a Madagascan Collection of Lyngbya majuscula

Nogle, L. M., & Gerwick, W. H. (2001) · Journal of Natural Products · doi:10.1021/np010348n · Cited by 79 · see citing works

Characterization of the Initial Enzymatic Steps of Barbamide Biosynthesis

Flatt, P. M., O'Connell, S. J., McPhail, K. L., Zeller, G., Willis, C. L., Sherman, D. H., & Gerwick, W. H. (2006) · Journal of Natural Products · doi:10.1021/np050523q · Cited by 77 · see citing works

The Isolation and Structure Elucidation of Tasiamide B, a 4-Amino-3-hydroxy-5-phenylpentanoic Acid Containing Peptide from the Marine Cyanobacterium Symploca sp.

Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2003) · Journal of Natural Products · doi:10.1021/np030114z · Cited by 74 · see citing works

Somocystinamide A, a Novel Cytotoxic Disulfide Dimer from a Fijian Marine Cyanobacterial Mixed Assemblage

Nogle, L. M., & Gerwick, W. H. (2002) · Organic Letters · doi:10.1021/ol017275j · Cited by 72 · see citing works

The Phosphopantetheinyl Transferase Superfamily: Phylogenetic Analysis and Functional Implications in Cyanobacteria

Copp, J. N., & Neilan, B. A. (2006) · Applied and Environmental Microbiology · doi:10.1128/aem.72.4.2298-2305.2006 · Cited by 71 · see citing works

SyrB2 in syringomycin E biosynthesis is a nonheme Fe^ α-ketoglutarate- and O_2-dependent enzyme

Vaillancourt, F. H. (2005) · Medical Entomology and Zoology · Cited by 71 · see citing works

The Structure of Palau'amide, a Potent Cytotoxin from a Species of the Marine Cyanobacterium Lyngbya

Williams, P. G., Yoshida, W. Y., Quon, M. K., Moore, R. E., & Paul, V. J. (2003) · Journal of Natural Products · doi:10.1021/np034001r · Cited by 70 · see citing works

Synthesis of the Apratoxin 2,4-Disubstituted Thiazoline via an Intramolecular Aza-Wittig Reaction

Chen, J., & Forsyth, C. J. (2003) · Organic Letters · doi:10.1021/ol0342148 · Cited by 70 · see citing works

Antillatoxin B, a Neurotoxic Lipopeptide from the Marine Cyanobacterium Lyngbya majuscula

Nogle, L. M., Okino, T., & Gerwick, W. H. (2001) · Journal of Natural Products · doi:10.1021/np010107f · Cited by 68 · see citing works

Phase I and Pharmacokinetic Study of Tasidotin Hydrochloride (ILX651), a Third-Generation Dolastatin-15 Analogue, Administered Weekly for 3 Weeks Every 28 Days in Patients with Advanced Solid Tumors

Mita, A. C., Hammond, L. A., Bonate, P. L., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-0179 · Cited by 67 · see citing works

Ulongapeptin, a Cytotoxic Cyclic Depsipeptide from a Palauan Marine Cyanobacterium Lyngbya sp.

Williams, P. G., Yoshida, W. Y., Quon, M. K., Moore, R. E., & Paul, V. J. (2003) · Journal of Natural Products · doi:10.1021/np030050s · Cited by 66 · see citing works

Dolastatin 11, a Marine Depsipeptide, Arrests Cells at Cytokinesis and Induces Hyperpolymerization of Purified Actin

Bai, R., Verdier‐Pinard, P., Gangwar, S., Stessman, C. C., McClure, K. J., Sausville, E. A., Pettit, G. R., Bates, R. B., & Hamel, E. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.3.462 · Cited by 65 · see citing works

Genetic Evidence Supports Secondary Metabolic Diversity in Prochloron spp., the Cyanobacterial Symbiont of a Tropical Ascidian

Schmidt, E. W., Sudek, S., & Haygood, M. G. (2004) · Journal of Natural Products · doi:10.1021/np049948n · Cited by 65 · see citing works

Tasipeptins A and B: New Cytotoxic Depsipeptides from the Marine CyanobacteriumSymplocasp.

Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2003) · Journal of Natural Products · doi:10.1021/np020582t · Cited by 65 · see citing works

Ulongamides A−F, New β-Amino Acid-Containing Cyclodepsipeptides from Palauan Collections of the Marine Cyanobacterium Lyngbya sp.

Luesch, H., Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2002) · Journal of Natural Products · doi:10.1021/np0200461 · Cited by 65 · see citing works

Voltage-Gated Sodium Channel Toxins: Poisons, Probes, and Future Promise

Blumenthal, K. M., & Seibert, A. L. (2003) · Cell Biochemistry and Biophysics · doi:10.1385/cbb:38:2:215 · Cited by 65 · see citing works

Nonribosomal peptide synthetase genes occur in most cyanobacterial genera as evidenced by their distribution in axenic strains of the PCC

Christiansen, G., Dittmann, E., Ordorika, L. V., et al. (2001) · Archives of Microbiology · doi:10.1007/s002030100349 · Cited by 65 · see citing works

Semiplenamides A−G, Fatty Acid Amides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya semiplena

Han, B., McPhail, K. L., Ligresti, A., Marzo, V. D., & Gerwick, W. H. (2003) · Journal of Natural Products · doi:10.1021/np030242n · Cited by 61 · see citing works

Total synthesis of the marine cyanobacterial cyclodepsipeptide apratoxin A

Chen, J., & Forsyth, C. J. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402752101 · Cited by 59 · see citing works

Chemoenzymatic Synthesis of Cryptophycin/Arenastatin Natural Products

Beck, Z. Q., Aldrich, C. C., Magarvey, N. A., Georg, G. I., & Sherman, D. H. (2005) · Biochemistry · doi:10.1021/bi051140u · Cited by 58 · see citing works

Synthesis of an Oxazoline Analogue of Apratoxin A

Zou, B., Wei, J., Cai, G., & Ma, D. (2003) · Organic Letters · doi:10.1021/ol035332y · Cited by 57 · see citing works

Trungapeptins A−C, Cyclodepsipeptides from the Marine Cyanobacterium Lyngbya majuscula

Bunyajetpong, S., Yoshida, W. Y., Sitachitta, N., & Kaya, K. (2006) · Journal of Natural Products · doi:10.1021/np050485a · Cited by 57 · see citing works

Diverse Secondary Metabolites from a Puerto Rican Collection of Lyngbya majuscula

Nogle, L. M., & Gerwick, W. H. (2003) · Journal of Natural Products · doi:10.1021/np020332c · Cited by 56 · see citing works

Hectochlorin and Morpholine Derivatives from the Thai Sea Hare, Bursatella leachii

Suntornchashwej, S., Chaichit, N., Isobe, M., et al. (2005) · Journal of Natural Products · doi:10.1021/np0500124 · Cited by 55 · see citing works

Chemical Deterrence of a Cyanobacterial Metabolite against Generalized and Specialized Grazers

Cruz‐Rivera, E., & Paul, V. J. (2006) · Journal of Chemical Ecology · doi:10.1007/s10886-006-9212-y · Cited by 54 · see citing works

Morphological, Chemical, and Genetic Diversity of Tropical Marine Cyanobacteria Lyngbya spp. and Symploca spp. ( Oscillatoriales )

THACKER, R. W., & Paul, V. J. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.6.3305-3312.2004 · Cited by 54 · see citing works

Wewakazole, a Novel Cyclic Dodecapeptide from a Papua New Guinea Lyngbya majuscula

Nogle, L. M., Márquez, B. L., & Gerwick, W. H. (2002) · Organic Letters · doi:10.1021/ol026811k · Cited by 53 · see citing works

Kulokekahilide-1, a Cytotoxic Depsipeptide from the Cephalaspidean Mollusk Philinopsis speciosa

Kimura, J., Takada, Y., Inayoshi, T., Nakao, Y., Goetz, G. H., Yoshida, W. Y., & Scheuer, P. J. (2002) · The Journal of Organic Chemistry · doi:10.1021/jo010176z · Cited by 52 · see citing works

A New Biologically Active Malyngamide from a New Zealand Collection of the Sea Hare Bursatella leachii

Appleton, D. R., Sewell, M. A., Berridge, M. V., et al. (2002) · Journal of Natural Products · doi:10.1021/np010511e · Cited by 50 · see citing works

Continuing Studies on the Cyanobacterium Lyngbya sp.: Isolation and Structure Determination of 15-Norlyngbyapeptin A and Lyngbyabellin D

Williams, P. G., Luesch, H., Yoshida, W. Y., et al. (2003) · Journal of Natural Products · doi:10.1021/np030011g · Cited by 50 · see citing works

Tasiamide, a Cytotoxic Peptide from the Marine CyanobacteriumSymplocasp.

Williams, P. G., Yoshida, W. Y., Moore, R. E., & Paul, V. J. (2002) · Journal of Natural Products · doi:10.1021/np020184q · Cited by 49 · see citing works

Solid Phase Library Synthesis of Cyclic Depsipeptides: Aurilide and Aurilide Analogues

Takahashi, T., Nagamiya, H., Doi, T., et al. (2003) · Journal of Combinatorial Chemistry · doi:10.1021/cc020091r · Cited by 49 · see citing works

Taveuniamides: new chlorinated toxins from a mixed assemblage of marine cyanobacteria

Williamson, R. T., Singh, I. P., & Gerwick, W. H. (2004) · Tetrahedron · doi:10.1016/j.tet.2004.02.076 · Cited by 47 · see citing works

Micromide and Guamamide: Cytotoxic Alkaloids from a Species of the Marine CyanobacteriumSymploca

Williams, P. G., Yoshida, W. Y., Moore, R. E., et al. (2003) · Journal of Natural Products · doi:10.1021/np030215x · Cited by 46 · see citing works

Dysideaprolines A−F and Barbaleucamides A−B, Novel Polychlorinated Compounds from aDysideaSpecies

Harrigan, G. G., Goetz, G. H., Luesch, H., et al. (2001) · Journal of Natural Products · doi:10.1021/np0101999 · Cited by 45 · see citing works

Total syntheses of lyngbyabellins A and B, potent cytotoxic lipopeptides from the marine cyanobacterium Lyngbya majuscula

Yokokawa, F., Sameshima, H., Katagiri, D., et al. (2002) · Tetrahedron · doi:10.1016/s0040-4020(02)01224-3 · Cited by 42 · see citing works

Total synthesis of somamide A, an Ahp (3-amino-6-hydroxy-2-piperidone)-containing cyclic depsipeptide

Yokokawa, F., & Shioiri, T. (2002) · Tetrahedron Letters · doi:10.1016/s0040-4039(02)02178-0 · Cited by 42 · see citing works

Antitumor activity of TZT-1027 (Soblidotin).

Watanabe, J., Minami, M., & Kobayashi, M. (2006) · PubMed · Cited by 42 · see citing works

Genetic potential for secondary metabolite production in stromatolite communities

Burns, B. P., Seifert, A., Goh, F. Q. Y., et al. (2004) · FEMS Microbiology Letters · doi:10.1016/j.femsle.2004.12.019 · Cited by 41 · see citing works

Isolation and Structure Determination of Lyngbyastatin 3, a Lyngbyastatin 1 Homologue from the Marine Cyanobacterium Lyngbya majuscula. Determination of the Configuration of the 4-Amino-2,2-dimethyl-3-oxopentanoic Acid Unit in Majusculamide C, Dolastatin 12, Lyngbyastatin 1, and Lyngbyastatin 3 from Cyanobacteria

Williams, P. G., Moore, R. E., & Paul, V. J. (2003) · Journal of Natural Products · doi:10.1021/np0302145 · Cited by 41 · see citing works

Total synthesis of lyngbyabellin A, a potent cytotoxic metabolite from the marine cyanobacterium Lyngbya majuscula

Yokokawa, F., Sameshima, H., & Shioiri, T. (2001) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)00678-5 · Cited by 38 · see citing works

Total Synthesis of Hectochlorin

Cetusic, J. R. P., Green, F. R., Graupner, P. R., et al. (2002) · Organic Letters · doi:10.1021/ol025604h · Cited by 36 · see citing works

Three New Malyngamides from a Papua New Guinea Collection of the Marine Cyanobacterium Lyngbya majuscula

McPhail, K. L., & Gerwick, W. H. (2002) · Journal of Natural Products · doi:10.1021/np0204186 · Cited by 34 · see citing works

NMR J-based analysis of nitrogen-containing moieties and application to dysithiazolamide, a new polychlorinated dipeptide from Dysidea sp.

Ardá, A., Rodrı́guez, J., Nieto, R. M., et al. (2005) · Tetrahedron · doi:10.1016/j.tet.2005.08.011 · Cited by 33 · see citing works

An efficient synthesis of semiplenamide C

Davies, I. R., Cheeseman, M. D., Niyadurupola, D. G., et al. (2005) · Tetrahedron Letters · doi:10.1016/j.tetlet.2005.06.027 · Cited by 31 · see citing works

New chlorinated peptides from the tropical marine sponge Dysidea sp.

Dargaville, B. L., Cameron, G. M., & Garson, M. J. (2001) · Tetrahedron · doi:10.1016/s0040-4020(01)00379-9 · Cited by 23 · see citing works

Phormidinines A and B, novel 2-alkylpyridine alkaloids from the cyanobacterium Phormidium sp.

Teruya, T., Kobayashi, K., Suenaga, K., et al. (2005) · Tetrahedron Letters · doi:10.1016/j.tetlet.2005.04.029 · Cited by 18 · see citing works

Dolastatin 11 conformations, analogues and pharmacophore

Ali, M. A., Bates, R. B., Crane, Z. D., et al. (2005) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2005.04.040 · Cited by 16 · see citing works

Polychlorinated Acetamides from the Cyanobacterium Microcoleus lyngbyaceus

Orsini, M. A., Pannell, L. K., & Erickson, K. L. (2001) · Journal of Natural Products · doi:10.1021/np000452p · Cited by 14 · see citing works

NMR J‐Based Analysis of Nitrogen‐Containing Moieties and Application to Dysithiazolamide (I), a New Polychlorinated Dipeptide from Dysidea sp.

Ardá, A., Rodrı́guez, J., Nieto, R. M., et al. (2006) · ChemInform · doi:10.1002/chin.200606193 · Cited by 2 · see citing works

Cultivation of filamentous cyanobacteria (blue-green algae) in agro-industrial wastes and wastewaters: a review

Markou, G., & Georgakakis, D. (2011) · Applied Energy · doi:10.1016/j.apenergy.2010.12.042 · Cited by 577 · see citing works

Marine Natural Products: A Source of Novel Anticancer Drugs

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., Moustafa, M. S., Abd El-Wahed, A., Al-Mousawi, S. M., Musharraf, S. G., et al. (2019) · Marine Drugs · doi:10.3390/md17090491 · Cited by 555 · see citing works

Marine natural products

Blunt, J. W., Copp, B. R., Hu, W.-P., Munro, M. H. G., Northcote, P. T., & Prinsep, M. R. (2009) · Natural Product Reports · doi:10.1039/b805113p · Cited by 520 · see citing works

Immense essence of excellence: Marine microbial bioactive compounds

Bhatnagar, I., & Kim, S.-K. (2010) · Marine Drugs · doi:10.3390/md8102673 · Cited by 384 · see citing works

A global assembly line for cyanobactins

Donia, M. S., Ravel, J., & Schmidt, E. W. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.84 · Cited by 279 · see citing works

Cyanobacterial Toxins as Allelochemicals with Potential Applications as Algaecides, Herbicides and Insecticides

Berry, J., Gantar, M., Perez, M., Berry, G., & Noriega, F. (2008) · Marine Drugs · doi:10.3390/md6020117 · Cited by 231 · see citing works

Coibamide A, a Potent Antiproliferative Cyclic Depsipeptide from the Panamanian Marine Cyanobacterium <i>Leptolyngbya</i> sp.

Medina, R. A., Goeger, D. E., Hills, P., Mooberry, S. L., Huang, N., Romero, L. I., Ortega-Barría, E., Gerwick, W. H., & McPhail, K. L. (2008) · Journal of the American Chemical Society · doi:10.1021/ja801383f · Cited by 231 · see citing works

Cyanobacteria: Review of Current Potentials and Applications.

Zahra, Z., Choo, D. H., Lee, H., & Parveen, A. (2020) · Environments · doi:10.3390/environments7020013 · Cited by 228 · see citing works

Microalgal-based feed: Promising alternative feedstocks for livestock and poultry production

Saadaoui, I., Rasheed, R., Aguilar, A., Cherif, M., Al Jabri, H., Sayadi, S., & Manning, S. R. (2021) · Journal of Animal Science and Biotechnology · doi:10.1186/s40104-021-00593-z · Cited by 223 · see citing works

Pharmaceutical applications of cyanobacteria—A review

Vijayakumar, S., & Menakha, M. (2015) · Journal of Acute Medicine · doi:10.1016/j.jacme.2015.02.004 · Cited by 205 · see citing works

Molassamide, a Depsipeptide Serine Protease Inhibitor from the Marine Cyanobacterium <i>Dichothrix utahensis</i>

Gunasekera, S. P., Miller, M. W., Kwan, J. C., Luesch, H., & Paul, V. J. (2010) · Journal of Natural Products · doi:10.1021/np900603f · Cited by 75 · see citing works

Assessment of <i>Anabaena</i> sp. Strain PCC 7120 as a Heterologous Expression Host for Cyanobacterial Natural Products: Production of Lyngbyatoxin A

Videau, P., Wells, K. N., Singh, A. J., Gerwick, W. H., & Philmus, B. (2016) · ACS Synthetic Biology · doi:10.1021/acssynbio.6b00038 · Cited by 66 · see citing works

Marine benthic cyanobacteria contain apoptosis-inducing activity synergizing with daunorubicin to kill leukemia cells, but not cardiomyocytes

Oftedal, L., Selheim, F., Wahlsten, M., Sivonen, K., Døskeland, S. O., & Herfindal, L. (2010) · Marine Drugs · doi:10.3390/md8102659 · Cited by 62 · see citing works

Cyanotherapeutics: An emerging field for future drug discovery

Tiwari, A. K., & Tiwari, B. S. (2020) · Applied Phycology · doi:10.1080/26388081.2020.1744480 · Cited by 49 · see citing works

Induction of apoptosis in cancer cell lines by the Red Sea brine pool bacterial extracts

Sagar, S., Esau, L., Holtermann, K., Hikmawan, T., Zhang, G., Stingl, U., Bajic, V. B., & Kaur, M. (2013) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-13-344 · Cited by 41 · see citing works

Protease Inhibitors from <i>Microcystis aeruginosa</i> Bloom Material Collected from the Dalton Reservoir, Israel

Adiv, S., & Carmeli, S. (2013) · Journal of Natural Products · doi:10.1021/np4006844 · Cited by 41 · see citing works

Microginins from a Microcystis sp. Bloom Material Collected from the Kishon Reservoir, Israel

Lodin-Friedman, A., & Carmeli, S. (2018) · Marine Drugs · doi:10.3390/md16030078 · Cited by 36 · see citing works

Biosynthesis of Yersiniabactin, a Complex Polyketide-Nonribosomal Peptide, Using Escherichia coli as a Heterologous Host

Pfeifer, B. A., Wang, C. C. C., Walsh, C. T., & Khosla, C. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.11.6698-6702.2003 · Cited by 126 · see citing works

Structure and Biosynthesis of Myxochromides S1–3 in Stigmatella aurantiaca: Evidence for an Iterative Bacterial Type I Polyketide Synthase and for Module Skipping in Nonribosomal Peptide Biosynthesis

Wenzel, S. C., Kunze, B., Höfle, G., Silakowski, B., Scharfe, M., Blöcker, H., & Müller, R. (2005) · ChemBioChem · doi:10.1002/cbic.200400282 · Cited by 124 · see citing works

Phylogenetic Study of Polyketide Synthases and Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Mycotoxins

Gallo, A., Ferrara, M., & Perrone, G. (2013) · Toxins · doi:10.3390/toxins5040717 · Cited by 95 · see citing works

Fungal Polyketide-Nonribosomal Peptide Synthetases and Their Associated Natural Products

Li, H., Booth, T., & Chooi, Y. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-409547-2.14677-3 · Cited by 11 · see citing works

Hybrid Peptide–Polyketide Natural Products: Biosynthesis and Prospects toward Engineering Novel Molecules

Du, L., Sánchez, C., & Shen, B. (2001) · Metabolic Engineering · doi:10.1006/mben.2000.0171 · Cited by 211 · see citing works