Deleterious effects of lard-enriched diet on tissues fatty acids composition and hypothalamic insulin actions
Abstract
Altered tissue fatty acid (FA) composition may affect mechanisms involved in the control of energy homeostasis, including central insulin actions. In rats fed either standard chow or a lard-enriched chow (high in saturated/low in polyunsaturated FA, HS-LP) for eight weeks, we examined the FA composition of blood, hypothalamus, liver, and retroperitoneal, epididymal and mesenteric adipose tissues. Insulin-induced hypophagia and hypothalamic signaling were evaluated after intracerebroventricular insulin injection. HS-LP feeding increased saturated FA content in adipose tissues and serum while it decreased polyunsaturated FA content of adipose tissues, serum, and liver. Hypothalamic C20:5n-3 and C20:3n-6 contents increased while monounsaturated FA content decreased. HS-LP rats showed hyperglycemia, impaired insulin-induced hypophagia and hypothalamic insulin signaling. The results showed that, upon HS-LP feeding, peripheral tissues underwent potentially deleterious alterations in their FA composition, whist the hypothalamus was relatively preserved. However, hypothalamic insulin signaling and hypophagia were drastically impaired. These findings suggest that impairment of hypothalamic insulin actions by HS-LP feeding was not related to tissue FA composition.
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Substitution of unsaturated fat for saturated fat in these protocols, or ablation of toll-like receptor signaling, reduces metabolic dysfunction and adiposity in rodents.
“Substitution of unsaturated fat for saturated fat in these protocols, or ablation of toll-like receptor signaling, reduces metabolic dysfunction and adiposity (137–143).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [142]
In rodents, high saturated fat content causes hyperinsulinemia, liver and muscle insulin resistance, and hypothalamic inflammation.
“which in rodents causes hyperinsulinemia, liver and muscle insulin resistance, and hypothalamic inflammation (137–143).”
From The carbohydrate-insulin model: A physiological perspective on the obesity pandemic (2021) · cites this paper as [142]
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The carbohydrate-insulin model: A physiological perspective on the obesity pandemic
Ludwig, D. S., Aronne, L. J., Astrup, A., de Cabo, R., Cantley, L. C., Friedman, M. I., Heymsfield, S. B., Johnson, J. D., King, J. C., Krauss, R. M., et al. (2021) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqab270 · Cited by 292 · see citing works
- Authors
- Dornellas, A. P. S., Watanabe, R. L. H., Pimentel, G. D., Boldarine, V. T., Nascimento, C. M. O., Oyama, L. M., Ghebremeskel, K., Wang, Y., Bueno, A. A., & Ribeiro, E. B.
- Affiliations
- Universidade Federal de São Paulo (BR)
- London Metropolitan University (GB)
- Imperial College London (GB)
- University of Worcester (GB)
- Corresponding author
- Ribeiro, E.B.
- ORCID
- Venue
- Prostaglandins, Leukotrienes and Essential Fatty Acids
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 102-103
- Pages
- 21-29
- ISSN
- 0952-3278 (ISSN-L)
- OpenAlex
- W2117623744
- Cited by
- 18
- References
- 75
- Citations by year
- 2022: 4 · 2021: 4 · 2020: 2 · 2019: 4 · 2018: 3 · 2016: 1
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Prostaglandins Leukotrienes and Essential Fatty Acids (publishedVersion)
- PubMed (publishedVersion)
- London Met Repository (London Metropolitan University) (acceptedVersion)
- Worcester Research and Publications (University of Worcester) (submittedVersion)
- Funders
- FAPESP
- CNPq
- National Council for Scientific and Technological Development
- Coordination for the Improvement of Higher Education Personnel
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- saturated fatty acids, polyunsaturated fatty acids, tissue fatty acid composition, energy homeostasis, adipose tissue, hyperglycemia, omega-3 fatty acids, omega-6 fatty acids, dietary fat
- MeSH terms
- Animals, Appetite Regulation, Dietary Fats, Fatty Acids, Hyperglycemia, Hypothalamus, Insulin Resistance, Liver, Male, Obesity, Organ Specificity, Organ Size, Random Allocation, Signal Transduction, Rats, Wistar, Intra-Abdominal Fat, Adiposity, Diet, High-Fat
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