Monounsaturated fatty acids prevent the aversive effects of obesity on locomotion, brain activity, and sleep behavior
Open accessAbstract
Fat and physical inactivity are the most evident factors in the pathogenesis of obesity, and fat quality seems to play a crucial role for measures of glucose homeostasis. However, the impact of dietary fat quality on brain function, behavior, and sleep is basically unknown. In this study, mice were fed a diet supplemented with either monounsaturated fatty acids (MUFAs) or saturated fatty acids (SFAs) and their impact on glucose homeostasis, locomotion, brain activity, and sleep behavior was evaluated. MUFAs and SFAs led to a significant increase in fat mass but only feeding of SFAs was accompanied by glucose intolerance in mice. Radiotelemetry revealed a significant decrease in cortical activity in SFA-mice whereas MUFAs even improved activity. SFAs decreased wakefulness and increased non-rapid eye movement sleep. An intracerebroventricular application of insulin promoted locomotor activity in MUFA-fed mice, whereas SFA-mice were resistant. In humans, SFA-enriched diet led to a decrease in hippocampal and cortical activity determined by functional magnetic resonance imaging techniques. Together, dietary intake of MUFAs promoted insulin action in the brain with its beneficial effects for cortical activity, locomotion, and sleep, whereas a comparable intake of SFAs acted as a negative modulator of brain activity in mice and humans.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Prolonged high-fat diet triggers neurobehavioral deficits associated with blunted mesolimbic dopamine function in rodents.
“To this end, rodent research has revealed that prolonged high-fat diet (HFD) elicits metabolic dysfunction and increases anxiety-and depressive-like behaviors [28][29][30][31][32][33][34][35][36], heightens stress and hypothalamic-pituitary-adrenal (HPA) responses [37,38], and triggers neurobehavioral deficits associated with blunted mesolimbic dopamine function [39][40][41].”
From The menace of obesity to depression and anxiety prevalence (2022) · cites this paper as [40]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Ropelle, E. R., Flores, M. B. S., Cintra, D. E., Rocha, G. Z., Pauli, J. R., Morari, J., de Souza, C. T., Moraes, J. C., Prada, P. O., Guadagnini, D., et al. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000465 · Cited by 326 · see citing works
RetractedThe oscillating brain: Complex and reliable
Zuo, X., Martino, A. D., Kelly, C. A. M., Shehzad, Z. E., Gee, D. G., Klein, D. F., Castellanos, F. X., Biswal, B. B., & Milham, M. P. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.09.037 · Cited by 1,460 · see citing works
Milanski, M., Degasperi, G., Coope, A., Morari, J., Denis, R., Cintra, D. E., Tsukumo, D. M. L., Anhe, G., Amaral, M. E., Takahashi, H. K., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2760-08.2009 · Cited by 1,125 · see citing works
Laufs, H., Krakow, K., Sterzer, P., Eger, E., Beyerle, A., Salek-Haddadi, A., & Kleinschmidt, A. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1831638100 · Cited by 1,028 · see citing works
Maedler, K., Oberholzer, J., Bucher, P., Spinas, G. A., & Donath, M. Y. (2003) · Diabetes · doi:10.2337/diabetes.52.3.726 · Cited by 552 · see citing works
Gillingham, L. G., Harris‐Janz, S., & Jones, P. J. H. (2011) · Lipids · doi:10.1007/s11745-010-3524-y · Cited by 550 · see citing works
Human hippocampal theta activity during virtual navigation
Ekstrom, A. D., Caplan, J. B., Ho, E. V., Shattuck, K., Fried, I., & Kahana, M. J. (2005) · Hippocampus · doi:10.1002/hipo.20109 · Cited by 411 · see citing works
Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study
Perseghin, G., Ghosh, S., Gerow, K., & Shulman, G. I. (1997) · Diabetes · doi:10.2337/diab.46.6.1001 · Cited by 367 · see citing works
Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
van Cauter, E., Holmbäck, U., Knutson, K., Leproult, R., Miller, A., Nedeltcheva, A., Pannain, S., Penev, P., Tasali, E., & Spiegel, K. (2007) · Hormone Research in Paediatrics · doi:10.1159/000097543 · Cited by 353 · see citing works
Desaturation and Elongation of Fatty Acids and Insulin Action
Vessby, B., Gustafsson, I. B., Tengblad, S., Boberg, M., & Andersson, A. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb04275.x · Cited by 324 · see citing works
Datta, S., & MacLean, R. R. (2007) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.02.004 · Cited by 296 · see citing works
Less body fat accumulation in rats fed a safflower oil diet than in rats fed a beef tallow diet
Shimomura, Y., Tamura, T., & Suzuki, M. (1990) · The Journal of Nutrition · doi:10.1093/jn/120.11.1291 · Cited by 287 · see citing works
Dietary Fat and Weight Gain Among Women in the Nurses’ Health Study
Field, A. E., Willett, W. C., Lissner, L., & Colditz, G. A. (2007) · Obesity · doi:10.1038/oby.2007.616 · Cited by 278 · see citing works
Kullmann, S., Heni, M., Veit, R., Ketterer, C., Schick, F., Häring, H., Fritsche, A., & Preissl, H. T. (2011) · Human Brain Mapping · doi:10.1002/hbm.21268 · Cited by 273 · see citing works
Self-citationWeigert, C., Brodbeck, K., Staiger, H., Kausch, C., Machicao, F., Häring, H. U., & Schleicher, E. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312692200 · Cited by 269 · see citing works
Standardized assessment of whole body adipose tissue topography by MRI
Machann, J., Thamer, C., Schnoedt, B., Haap, M., Haring, H., Claussen, C., Stumvoll, M., Fritsche, A., & Schick, F. (2005) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20292 · Cited by 266 · see citing works
Self-citationUpregulation of insulin receptor substrate-2 in pancreatic β cells prevents diabetes
Hennige, A. M., Burks, D. J., Özcan, U., Kulkarni, R., Ye, J., Park, S., Schubert, M., Fisher, T. L., Dow, M. A., Leshan, R. L., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18581 · Cited by 260 · see citing works
Self-citationKnutson, K. L., Van Cauter, E., Zee, P., Liu, K., & Lauderdale, D. S. (2011) · Diabetes Care · doi:10.2337/dc10-1962 · Cited by 230 · see citing works
Tschritter, O., Preissl, H., Hennige, A. M., Stumvoll, M., Porubska, K., Frost, R., Marx, H., Klösel, B., Lutzenberger, W., Birbaumer, N., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604404103 · Cited by 223 · see citing works
Self-citationAssociation of sleep duration with type 2 diabetes and impaired glucose tolerance
Chaput, J.-P., Després, J.-P., Bouchard, C., & Tremblay, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0786-x · Cited by 222 · see citing works
The frequency of rat's hippocampal theta rhythm is related to the speed of locomotion
Sławińska, U., & Kasicki, S. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00390-4 · Cited by 201 · see citing works
Eitel, K., Staiger, H., Rieger, J., Mischak, H., Brandhorst, H., Brendel, M. D., Bretzel, R. G., Häring, H., & Kellerer, M. (2003) · Diabetes · doi:10.2337/diabetes.52.4.991 · Cited by 142 · see citing works
Self-citation[Specific neurons for wakefulness in the posterior hypothalamus in the cat].
Vanni-Mercier, G., Sakai, K., & Jouvet, M. (1984) · PubMed · Cited by 135 · see citing works
The Composition of Dietary Fat Directly Influences Glucose-Stimulated Insulin Secretion in Rats
Dobbins, R. L., Szczepaniak, L. S., Myhill, J., Tamura, Y., Uchino, H., Giacca, A., & McGarry, J. (2002) · Diabetes · doi:10.2337/diabetes.51.6.1825 · Cited by 134 · see citing works
Different role of saturated and unsaturated fatty acids in β-cell apoptosis
Eitel, K., Staiger, H., Brendel, M. D., Brandhorst, D., Bretzel, R. G., Häring, H., & Kellerer, M. (2002) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02752-3 · Cited by 132 · see citing works
Self-citationDietary fats, fatty acids and insulin resistance: short review of a multifaceted connection.
Haag, M., & Dippenaar, N. (2005) · PubMed · Cited by 120 · see citing works
Variation in the FTO gene locus is associated with cerebrocortical insulin resistance in humans
Tschritter, O., Preissl, H. T., Yokoyama, Y., Machicao, F. E., Häring, H., & Fritsche, A. (2007) · Diabetologia · doi:10.1007/s00125-007-0839-1 · Cited by 114 · see citing works
Self-citationInteraction between specific fatty acids, GLP-1 and insulin secretion in humans
Beysen, C., Karpe, F., Fielding, B. A., Clark, A., Lévy, J., & Frayn, K. N. (2002) · Diabetologia · doi:10.1007/s00125-002-0964-9 · Cited by 104 · see citing works
Bergouignan, A., Momken, I., Schoeller, D. A., Simon, C., & Blanc, S. (2009) · Progress in Lipid Research · doi:10.1016/j.plipres.2009.02.004 · Cited by 97 · see citing works
Tissue selectivity of insulin detemir action in vivo
Hennige, A. M., Sartorius, T., Tschritter, O., Preissl, H. T., Fritsche, A., Ruth, P., & Häring, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0192-9 · Cited by 93 · see citing works
Self-citationHigh cerebral insulin sensitivity is associated with loss of body fat during lifestyle intervention
Tschritter, O., Preissl, H. T., Hennige, A. M., Sartorius, T., Štingl, K., Heni, M., Ketterer, C., Stefan, N., Machann, J., Schleicher, E., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2309-z · Cited by 63 · see citing works
Self-citationMetabolic Syndrome and Cognitive Function in Healthy Middle-Aged and Older Adults without Diabetes
Gatto, N. M., Henderson, V. W., John, J. A. S., McCleary, C. A., Hodis, H. N., & Mack, W. J. (2008) · Aging Neuropsychology and Cognition · doi:10.1080/13825580802036936 · Cited by 62 · see citing works
The Insulin-Mediated Modulation of Visually Evoked Magnetic Fields Is Reduced in Obese Subjects
Guthoff, M., Stingl, K. T., Tschritter, O., Vidaković, M. R., Heni, M., Štingl, K., Hallschmid, M., Häring, H., Fritsche, A., Preissl, H. T., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019482 · Cited by 59 · see citing works
Self-citationTschritter, O., Preissl, H., Hennige, A. M., Sartorius, T., Grichisch, Y., Stefan, N., Guthoff, M., Düsing, S., Machann, J., Schleicher, E., et al. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-0469 · Cited by 42 · see citing works
Self-citationCrochet, S., & Sakai, K. (2003) · SLEEP · doi:10.1093/sleep/26.7.801 · Cited by 42 · see citing works
Hennige, A. M., Sartorius, T., Lutz, S. Z., Tschritter, O., Preissl, H., Hopp, S., Fritsche, A., Rammensee, H.-G., Ruth, P., & Häring, H.-U. (2009) · Diabetologia · doi:10.1007/s00125-009-1522-5 · Cited by 41 · see citing works
Self-citationInsulin Modulation of Magnetoencephalographic Resting State Dynamics in Lean and Obese Subjects
Stingl, K. T., Kullmann, S., Guthoff, M., Heni, M., Fritsche, A., & Preissl, H. T. (2010) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2010.00157 · Cited by 41 · see citing works
Self-citationTschritter, O., Haupt, A., Preissl, H. T., Ketterer, C., Hennige, A. M., Sartorius, T., Machicao, F. E., Fritsche, A., & Häring, H. (2011) · Journal of Obesity · doi:10.1155/2011/283153 · Cited by 33 · see citing works
Self-citationHennige, A. M., Lehmann, R., Weigert, C., Moeschel, K., Schaüble, M., Metzinger, E., Lammers, R., & Häring, H. (2005) · Diabetes · doi:10.2337/diabetes.54.2.361 · Cited by 32 · see citing works
Self-citationManco, M., BERTUZZI, A., Salinari, S., Scarfone, A., Calvani, M., Greco, A. V., & Mingrone, G. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041268 · Cited by 28 · see citing works
Insulin effects on beta and theta activity in the human brain are differentially affected by ageing
Tschritter, O., Hennige, A. M., Preissl, H. T., Grichisch, Y., Kirchhoff, K., Kantartzis, K., Machicao, F. E., Fritsche, A., & Häring, H. (2008) · Diabetologia · doi:10.1007/s00125-008-1187-5 · Cited by 27 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The menace of obesity to depression and anxiety prevalence
Fulton, S., Décarie-Spain, L., Fioramonti, X., Guiard, B., & Nakajima, S. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2021.10.005 · Cited by 441 · see citing works
Décarie-Spain, L., Sharma, S., Hryhorczuk, C., Issa-Garcia, V., Barker, P. A., Arbour, N., Alquier, T., & Fulton, S. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.018 · Cited by 107 · see citing works
Dornellas, A. P. S., Watanabe, R. L. H., Pimentel, G. D., Boldarine, V. T., Nascimento, C. M. O., Oyama, L. M., Ghebremeskel, K., Wang, Y., Bueno, A. A., & Ribeiro, E. B. (2015) · Prostaglandins, Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2015.10.003 · Cited by 18 · see citing works
- Authors
- Sartorius, T., Ketterer, C., Kullmann, S., Balzer, M., Rotermund, C., Binder, S., Hallschmid, M., Machann, J., Schick, F., Somoza, V., Preissl, H., Fritsche, A., Häring, H.-U., & Hennige, A. M.
- Affiliations
- University of Tübingen (DE)
- Leibniz-Institute for Food Systems Biology at the Technical University of Munich (DE)
- University of Lübeck (DE)
- University of Vienna (AT)
- University of Arkansas for Medical Sciences (US)
- Corresponding author
- Häring, Hans-Ulrich
- ORCID
- Venue
- Diabetes
- Publisher
- American Diabetes Association
- Published
- 2012-06-15
- Volume
- 61
- Issue
- 7
- Pages
- 1669-1679
- ISSN
- 0012-1797 (ISSN-L)
- 1939-327X
- PMC
- PMC3379681
- OpenAlex
- W2116908698
- Cited by
- 73
- References
- 41
- Citations by year
- 2026: 2 · 2025: 8 · 2024: 14 · 2023: 5 · 2022: 3 · 2021: 4 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 8 · 2014: 3 · 2013: 6 · 2012: 1
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Diabetes (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Keywords
- monounsaturated fatty acids, saturated fatty acids, dietary fat quality, obesity, glucose homeostasis, impaired glucose tolerance, locomotor activity, sleep behavior, wakefulness, NREM sleep, insulin resistance, hippocampal activity, fat mass
- MeSH terms
- Adult, Animals, Blood Glucose, Brain, Fatty Acids, Monounsaturated, Female, Humans, Hypoglycemic Agents, Insulin, Locomotion, Magnetic Resonance Imaging, Male, Mice, Inbred C57BL, Middle Aged, Obesity, Sleep, Sleep Stages, Dietary Supplements, Mice, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
