Ceramides in insulin resistance and lipotoxicity

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Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase

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Inflammation, stress, and diabetes

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A central role for JNK in obesity and insulin resistance

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Adipose tissue, adipokines, and inflammation

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Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

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Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

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Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes

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Inflammation: the link between insulin resistance, obesity and diabetes

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Metabolic control through the PGC-1 family of transcription coactivators

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Mitochondrial dysfunction and type 2 diabetes

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Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase

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Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ

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IKK-β links inflammation to obesity-induced insulin resistance

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Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle

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Are oxidative stress-activated signaling pathways mediators of insulin resistance and β-cell dysfunction?

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Lipotoxic heart disease in obese rats: Implications for human obesity

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Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1 H NMR spectroscopy study

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Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

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Positive and negative regulation of insulin signaling through IRS-1 phosphorylation

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Interleukin-6 induces cellular insulin resistance in hepatocytes.

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Prevention of fat-induced insulin resistance by salicylate

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Inflammatory pathways and insulin action

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Suppressor of Cytokine Signaling-3 (SOCS-3), a Potential Mediator of Interleukin-6-dependent Insulin Resistance in Hepatocytes

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A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

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Role of apoptosis in failure of beta-cell mass compensation for insulin resistance and beta-cell defects in the male Zucker diabetic fatty rat

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Tumor necrosis factor impairs insulin action on peripheral glucose disposal and hepatic glucose output.

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PKC-θ knockout mice are protected from fat-induced insulin resistance

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Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

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JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes

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Regulation of Insulin Action by Ceramide

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Effects of Intravenous and Dietary Lipid Challenge on Intramyocellular Lipid Content and the Relation With Insulin Sensitivity in Humans

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Ganglioside GM3 Participates in the Pathological Conditions of Insulin Resistance

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Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

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Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells.

Hajduch, E., Alessi, D. R., Hemmings, B. A., & Hundal, H. S. (1998) · Diabetes · doi:10.2337/diabetes.47.7.1006 · Cited by 335

Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes

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Prolonged inhibition of muscle carnitine palmitoyltransferase-1 promotes intramyocellular lipid accumulation and insulin resistance in rats

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Increased Phosphorylation of Akt Substrate of 160 kDa (AS160) in Rat Skeletal Muscle in Response to Insulin or Contractile Activity

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Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

POWELL, D. J., TURBAN, S., GRAY, A., HAJDUCH, E., & HUNDAL, H. S. (2004) · Biochemical Journal · doi:10.1042/bj20040139 · Cited by 267

DAG accumulation from saturated fatty acids desensitizes insulin stimulation of glucose uptake in muscle cells

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Insulin Resistance in Type 2 Diabetes - Role of the Adipokines

Arner, P. (2005) · Current Molecular Medicine · doi:10.2174/1566524053766022 · Cited by 201

TNF -induced insulin resistance in adipocytes as a membrane microdomain disorder: involvement of ganglioside GM3

Kabayama, K. (2004) · Glycobiology · doi:10.1093/glycob/cwh135 · Cited by 155

Activation of the Drosophila MLK by Ceramide Reveals TNF-α and Ceramide as Agonists of Mammalian MLK3

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Effects of individual fatty acids on glucose uptake and glycogen synthesis in soleus muscle in vitro

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Inflammation and insulin resistance

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A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance

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Mechanisms linking obesity with cardiovascular disease

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Human gut microbes impact host serum metabolome and insulin sensitivity

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The Metabolic Syndrome

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