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Ceramides in insulin resistance and lipotoxicity

SUMMERS, S·2006·Progress in Lipid Research

DOI 10.1016/j.plipres.2005.11.002

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Background
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“There is no doubt that lipotoxicity, as originally deﬁned, is evident in the pancreas, liver and possibly the heart (Garris 2005; Shimabukuro et al. 1998; Sparagna et al. 2000; Summers 2006; Wei et al. 2006).”
β-Hydroxybutyrate Elicits Favorable Mitochondrial Changes in Skeletal Muscle
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Destabilization of β Cell FIT2 by saturated fatty acids alter lipid droplet numbers and contribute to ER stress and diabetes
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Muscle adaptation to short-term fasting in healthy lean humans
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“…lipids (i.e., the production of reactive lipid intermediates), in addition to the pathological production of mitochondrial-derived ROS independently contribute to impairments in insulin signalling (Summers, 2006; Liu et al., 2007; Timmers et al., 2008; Anderson et al., 2009; Dubé et al., 2011).”
Background
The Role of Skeletal Muscle Estrogen Receptors in Metabolic Homeostasis and Insulin Sensitivity
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Authors: SUMMERS, S.
Venue: Progress in Lipid Research
Publisher: Elsevier BV
Published: 2006-01
Volume: 45
Issue: 1
Pages: 42-72
ISSN: 0163-7827 (ISSN-L)
DOI: 10.1016/j.plipres.2005.11.002
OpenAlex: W2025607561
Cited by: 848
References: 44
FWCI: 10.14
Type: journal article
Language: en
Open access: closed

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Ceramides in insulin resistance and lipotoxicity

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