Melatonin—A pleiotropic, orchestrating regulator molecule

A three pulse phase response curve to three milligrams of melatonin in humans

Burgess, H. J., Revell, V. L., & Eastman, C. I. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.143180 · Cited by 176

The melatonin receptor in the human brain: cloning experiments and distribution studies

Mazzucchelli, C., Pannacci, M., Nonno, R., Lucini, V., FRASCHINI, F., & Stankov, B. M. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(96)00017-4 · Cited by 175

Mechanisms Contributing to the Phase-Dependent Regulation of Neurogenesis by the Novel Antidepressant, Agomelatine, in the Adult Rat Hippocampus

Soumier, A., Banasr, M., Lortet, S., Masmejean, F., Bernard, N., Goff, L. K., Gabriel, C., Millan, M. J., Mocaër, E., & Daszuta, A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.72 · Cited by 175

The orphan receptor family RZR/ROR, melatonin and 5‐lipoxygenase: An unexpected relationship

Carlberg, C., & Wiesenberg, I. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00157.x · Cited by 175

Thirty four years since the discovery of gastrointestinal melatonin.

Bubenik, G. A. (2008) · PubMed · Cited by 175

Testing the Circadian Gene Hypothesis in Prostate Cancer: A Population-Based Case-Control Study

Zhu, Y. L., Stevens, R. G., Hoffman, A. E., FitzGerald, L. M., Kwon, E. M., Ostrander, E. A., Davis, S., Zheng, T., & Stanford, J. L. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-0648 · Cited by 173

Circadian rhythms and treatment implications in depression

Monteleone, P., Martiadis, V., & Maj, M. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.07.028 · Cited by 171

Augmentation of indices of oxidative damage in life-long melatonin-deficient rats

Reiter, R. J., Tan, D., Kim, S. J., Manchester, L. C., Qi, W., García, J. J., Cabrera, J., El‐Sokkary, G. H., & Rouvier-Garay, V. (1999) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(99)00058-5 · Cited by 171

Melatonin receptors in pancreatic islets: good morning to a novel type 2 diabetes gene

Mulder, H., Nagorny, C. L. F., Lyssenko, V., & Groop, L. (2009) · Diabetologia · doi:10.1007/s00125-009-1359-y · Cited by 169

Cloning of a melatonin‐related receptor from human pituitary

Reppert, S. M., Weaver, D. R., Ebisawa, T., Mahle, C. D., & Kolakowski, L. F. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00437-1 · Cited by 169

Melatonin and the hair follicle

Fischer, T. W., Slominski, A. T., Tobin, D. J., & Paus, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00512.x · Cited by 169

A silent polymorphism in the PER1 gene associates with extreme diurnal preference in humans

Carpen, J. D., von Schantz, M., Smits, M. G., Skene, D. J., & Archer, S. N. (2006) · Journal of Human Genetics · doi:10.1007/s10038-006-0060-y · Cited by 168

Molecular Mechanisms of Melatonin Anticancer Effects

Hill, S. M., Frasch, T., Xiang, S., Yuan, L., Duplessis, T., & Mao, L. (2009) · Integrative Cancer Therapies · doi:10.1177/1534735409353332 · Cited by 168

Human Lymphocyte-Synthesized Melatonin Is Involved in the Regulation of the Interleukin-2/Interleukin-2 Receptor System

Carrillo‐Vico, A., Lardone, P. J., Fernández-Santos, J. M., Martín‐Lacave, I., Calvo, J. R., Karasek, M., & Guerrero, J. M. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-1429 · Cited by 168

Melatonin effect on plasma adiponectin, leptin, insulin, glucose, triglycerides and cholesterol in normal and high fat–fed rats

Ríos-Lugo, M. J., Cano, P., Jiménez‐Ortega, V., Fernández‐Mateos, P., Scacchi, P. A., Cardinali, D. P., & Esquifino, A. I. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00798.x · Cited by 168

Possible therapeutic value of melatonin in mild cognitive impairment: A retrospective study

Furio, A. M., Brusco, L. I., & Cardinali, D. P. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00491.x · Cited by 167

The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system

Uz, T., Arslan, A. D., Kürtüncü, M., Imbesi, M., Akhisaroğlu, M., Dwivedi, Y., Pandey, G. N., & Manev, H. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.01.002 · Cited by 167

Nitrosation of melatonin by nitric oxide and peroxynitrite

Blanchard, B., Pompon, D., & Ducrocq, C. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.290308.x · Cited by 167

A New Concept for Melatonin Deficit On Pineal Calcification and Melatonin Excretion

Kunz, D. (1999) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00069-x · Cited by 166

Distribution of MT1 melatonin receptor immunoreactivity in the human hypothalamus and pituitary gland: Colocalization of MT1 with vasopressin, oxytocin, and corticotropin‐releasing hormone

Wu, Y., Zhou, J., Balesar, R. A., Unmehopa, U. A., Bao, A., Jockers, R., van Heerikhuize, J. J., & Swaab, D. F. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21152 · Cited by 165

Aging Decreases Electron Transport Complex III Activity in Heart Interfibrillar Mitochondria by Alteration of the Cytochrome c Binding Site

Lesnefsky, E. J., Gudz, T. I., Moghaddas, S., Migita, C. T., Ikeda-Saito, M., Turkaly, P. J., & Hoppel, C. L. (2001) · Journal of Molecular and Cellular Cardiology · doi:10.1006/jmcc.2000.1273 · Cited by 164

Melatonin‐induced neuroprotection after closed head injury is associated with increased brain antioxidants and attenuated late‐phase activation of NF‐κB and AP‐1

Beni, S. M., Kohen, R., Reiter, R. J., Tan, D. X., & Shohami, E. (2003) · The FASEB Journal · doi:10.1096/fj.03-0323fje · Cited by 164

The Immune-Pineal Axis: A Shuttle between Endocrine and Paracrine Melatonin Sources

Markus, R. P., Ferreira, Z. S., Fernandes, P. A. C. M., & Cecon, E. (2007) · NeuroImmunoModulation · doi:10.1159/000110635 · Cited by 163

Melatonin and Parkinson's Disease

Mayo, J. C., Sainz, R. M., Tan, D., Antolı́n, I., Rodrı́guez, C., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:169 · Cited by 162

Expansion of signal transduction by G proteins

Birnbaumer, L. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.12.002 · Cited by 162

Melatonin activates Th1 lymphocytes by increasing IL-12 production

García‐Mauriño, S., Pozo, D., Carrillo‐Vico, A., Calvo, J. R., & Guerrero, J. M. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00479-8 · Cited by 161

Melatonin and type 2 diabetes – a possible link?*

Peschke, E., Stumpf, I., Bazwinsky, I., Litvak, L., Dralle, H., & Mühlbauer, E. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00426.x · Cited by 161

Inhibition of neuronal nitric oxide synthase activity by N1‐acetyl‐5‐methoxykynuramine, a brain metabolite of melatonin

León, J., Escames, G., Rodríguez, M. I., López, L. C., Tapias, V., Entrena, A., Camacho, E., Carriòn, M. D., Gallo, M. Á., Espinosa, A., et al. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04029.x · Cited by 161

Early Morning Executive Functioning During Sleep Deprivation Is Compromised by a PERIOD3 Polymorphism

John A. Groeger, P., Viola, A., June C.Y. Lo, M., Malcolm von Schantz, P., Simon N. Archer, P., & Derk-Jan Dijk, P. (2008) · SLEEP · doi:10.5665/sleep/31.8.1159 · Cited by 161

The ExDression Pattern of the Orphan Nuclear Receptor RORβ in the Developing and Adult Rat Nervous System Suggests a Role in the Processing of Sensory Information and in Circadian Rhythm

Schaeren‐Wiemers, N., André, É., Kapfhammer, J. P., & Becker-André, M. (1997) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.1997.tb01698.x · Cited by 159

Melatonin counteracts inducible mitochondrial nitric oxide synthase‐dependent mitochondrial dysfunction in skeletal muscle of septic mice

Escames, G., López, L. C., Tapias, V., Utrilla, P., Reiter, R., Hitos, A. B., León, J., Rodríguez, M. I., & Acuña-Castroviejo, D. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00281.x · Cited by 158

Circadian rhythm sleep disorders in the blind and their treatment with melatonin

Skene, D. J., & Arendt, J. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.013 · Cited by 157

Melatonin role in the mitochondrial function

Acuña-Castroviejo, D. (2006) · Frontiers in bioscience · doi:10.2741/2116 · Cited by 157

Role of phospholipids in respiratory cytochrome bc1 complex catalysis and supercomplex formation

Wenz, T., Hielscher, R., Hellwig, P., Schägger, H., Richers, S., & Hunte, C. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.02.012 · Cited by 154

Retinal Localization of the Hydroxyindole-O-methyl Transferase (HIOMT) in the Rat

Cardinali, D. P., & Rosner, J. M. (1971) · Endocrinology · doi:10.1210/endo-89-1-301 · Cited by 154

Serum melatonin and urinary 6-sulfatoxymelatonin in major depression

Crasson, M., Kjiri, S., Colin, A., Kjiri, K., L’Hermite‐Balériaux, M., Ansseau, M., & Legros, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00123-3 · Cited by 154

Melatonin and the Immune System in Aging

Cardinali, D. P., Esquifino, A. I., Srinivasan, V., & Pandi-Perumal, S. R. (2008) · NeuroImmunoModulation · doi:10.1159/000156470 · Cited by 152

Increased melatonin 1a‐receptor immunoreactivity in the hippocampus of Alzheimer's disease patients

Savaskan, E., Olivieri, G., Meier, F., Brydon, L., Jockers, R., Ravid, R., Wirz‐Justice, A., & Müller-Spahn, F. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2002.00841.x · Cited by 152

Homeostatic versus Circadian Effects of Melatonin on Core Body Temperature in Humans

Cagnacci, A., Kräuchi, K., Wirz-Justice, A., & Volpe, A. (1997) · Journal of Biological Rhythms · doi:10.1177/074873049701200604 · Cited by 151

Chronobiotics—drugs that shift rhythms

Dawson, D. E., & Armstrong, S. M. (1996) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(95)02020-9 · Cited by 150

A role of melatonin in neuroectodermal‐mesodermal interactions: the hair follicle synthesizes melatonin and expresses functional melatonin receptors

Kobayashi, H., Kromminga, A., Dunlop, T. W., Tychsen, B., Conrad, F., Suzuki, N., Memezawa, A., Bettermann, A., Aiba, S., Carlberg, C., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2293fje · Cited by 150

A length polymorphism in the circadian clock gene Per3 influences age at onset of bipolar disorder

Benedetti, F., Dallaspezia, S., Colombo, C., Pirovano, A., Marino, E., & Smeraldi, E. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.09.002 · Cited by 149

The Effect of Melatonin in Patients with Fibromyalgia: A Pilot Study

Citera, G., Arias, M. A., Maldonado-Cocco, J. A., La´zaro, M. A., Rosemffet, M. G., Brusco, L., Scheines, E. J., & Cardinalli, D. P. (2000) · Clinical Rheumatology · doi:10.1007/s100670050003 · Cited by 148

Attenuation of cardiac mitochondrial dysfunction by melatonin in septic mice

Escames, G., López, L. C., Ortiz, F., López, A., García, J. A. G., Ros, E., & Acuña-Castroviejo, D. (2007) · FEBS Journal · doi:10.1111/j.1742-4658.2007.05755.x · Cited by 147

Ubiquitous melatonin-presence and effects in unicells, plants and animals

Hardeland, R., & Fuhrberg, B. (1996) · Cited by 147

The chronobiotic properties of melatonin

Pévet, P., Bothorel, B., Slotten, H. A., & Saboureau, M. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0584-1 · Cited by 146

Epigenetic regulation: a new research area for melatonin?

Korkmaz, A., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00509.x · Cited by 146

Melatonin mt1 and MT2 receptors stimulate c-Jun N-terminal kinase via pertussis toxin-sensitive and -insensitive G proteins

Chan, A. S. L., Lai, F. P. L., Lo, R. K. H., Voyno-Yasenetskaya, T., Stanbridge, E. J., & Wong, Y. H. (2002) · Cellular Signalling · doi:10.1016/s0898-6568(01)00240-6 · Cited by 146

G-allele of Intronic rs10830963 inMTNR1BConfers Increased Risk of Impaired Fasting Glycemia and Type 2 Diabetes Through an Impaired Glucose-Stimulated Insulin Release

Sparsø, T., Bonnefond, A., Galijatovic, E. A. A., Bouatia‐Naji, N., Holmkvist, J., Thørner, L. W., Grarup, N., Gjesing, A. P., Banasik, K., Cavalcanti-Proença, C., et al. (2009) · Diabetes · doi:10.2337/db08-1660 · Cited by 146

Role of melatonin in metabolic regulation

Korkmaz, A., Topal, T., Tan, D., & Reiter, R. J. (2009) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-009-9117-5 · Cited by 145

Mitochondrial regulation by melatonin And its metabolites

Acuña-Castroviejo, D., Escames, G., León, J., Carazo, Á., & Khaldy, H. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4615-0135-0_63 · Cited by 144

Characterization of a retinal melatonin receptor.

Dubocovich, M. L. (1985) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)23458-9 · Cited by 143

MT1 melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells

Yuan, L., Collins, A., Dai, J., Dubocovich, M. L., & Hill, S. M. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00029-1 · Cited by 142

Melatonin induces mitochondrial‐mediated apoptosis in human myeloid HL‐60 cells

Bejarano, I., Redondo, P. C., Espino, J., Rosado, J. A., Paredes, S. D., Barriga, C., Reiter, R. J., Pariente, J. A., & Rodríguez, A. B. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00675.x · Cited by 142

Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells

Jung-Hynes, B. D., Huang, W., Reiter, R. J., & Ahmad, N. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00767.x · Cited by 141

Melatonin induces apoptotic death in LNCaP cells via p38 and JNK pathways: therapeutic implications for prostate cancer

Joo, S. S., & Yoo, Y. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00682.x · Cited by 141

Lipopolysaccharide-induced hepatotoxicity is inhibited by the antioxidant melatonin

Sewerynek, E., Melchiorri, D., Reiter, R. J., Ortíz, G. G., & Lewiñski, A. (1995) · European Journal of Pharmacology Environmental Toxicology and Pharmacology · doi:10.1016/0926-6917(95)90052-7 · Cited by 140

Melatonin effect on daytime sleep in men: suppression of EEG low frequency activity and enhancement of spindle frequency activity

Dijk, D., Roth, C., Landolt, H., Werth, E., Aeppli, M., Achermann, P., & Borbély, A. A. (1995) · Neuroscience Letters · doi:10.1016/0304-3940(95)12118-n · Cited by 140

The roles of melatonin and light in the pathophysiology and treatment of circadian rhythm sleep disorders

Pandi-Perumal, S. R., Trakht, I., Spence, D. W., Srinivasan, V., Dagan, Y., & Cardinali, D. P. (2008) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0847 · Cited by 140

The Mel1a melatonin receptor gene is expressed in human suprachiasmatic nuclei

Weaver, D. R., & Reppert, S. M. (1996) · Neuroreport · doi:10.1097/00001756-199612200-00022 · Cited by 139

Epigenetic targets for melatonin: induction of histone H3 hyperacetylation and gene expression in C17.2 neural stem cells

Sharma, R., Ottenhof, T., Rzeczkowska, P. A., & Niles, L. P. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00587.x · Cited by 139

Expression of membrane and nuclear melatonin receptor mRNA and protein in the mouse immune system

Carrillo‐Vico, A., Garc�a-Perga�eda, A., Naji, L., Calvo, J. R., Romero, M., & Guerrero, J. M. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3207-4 · Cited by 139

Mitochondrial complex I dysfunction in rat heart with aging: critical role of reactive oxygen species and cardiolipin

Petrosillo, G., Matera, M. G., Moro, N., Ruggiero, F. M., & Paradies, G. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.09.031 · Cited by 138

Daily rhythm of serum melatonin in patients with dementia of the degenerate type

Uchida, K., Okamoto, N., Ohara, K., & Morita, Y. (1996) · Brain Research · doi:10.1016/0006-8993(96)00086-8 · Cited by 138

Melatonin Metabolism in the Central Nervous System

Hardeland, R. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246164 · Cited by 138

A defect in the activity of Δ6 and Δ5 desaturases may be a factor predisposing to the development of insulin resistance syndrome

Das, U. N. (2005) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2005.01.002 · Cited by 137

Melatonin, Aging, and Age-Related Diseases: Perspectives for Prevention, Intervention, and Therapy

Pöeggeler, B. (2005) · Endocrine · doi:10.1385/endo:27:2:201 · Cited by 137

Prospects of the Clinical Utilization of Melatonin

Bubenik, G. A., Blask, D. E., Brown, G. M., Maestroni, G. J. M., Pang, S. F., Reiter, R. J., Viswanathan, M., & Zisapel, N. (1998) · Neurosignals · doi:10.1159/000014545 · Cited by 136

Signal transduction pathways involved in melatonin‐induced neuroprotection after focal cerebral ischemia in mice

Kılıç, Ü., Kılıç, E., Reiter, R. J., Bassetti, C. L., & Hermann, D. M. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00178.x · Cited by 135

Melatonin Synthesis in the Gastrointestinal Tract and the Impact of Nutritional Factors on Circulating Melatonin

Huether, G. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56826.x · Cited by 135

Long‐term melatonin administration protects brain mitochondria from aging

Carretero, M., Escames, G., López, L. C., Venegas, C., Dayoub, J. C., García‐Corzo, L., & Acuña-Castroviejo, D. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00700.x · Cited by 135

Melatonin Metabolism in the Central Nervous System

Hardeland, R. (2010) · Current Neuropharmacology · doi:10.2174/157015910792246244 · Cited by 134

Polymorphism in the PER3 Promoter Associates with Diurnal Preference and Delayed Sleep Phase Disorder

Archer, S. N., Carpen, J. D., Gibson, M., Lim, G. H., Johnston, J. D., Skene, D. J., & von Schantz, M. (2010) · SLEEP · doi:10.1093/sleep/33.5.695 · Cited by 134

Gene Regulation by Melatonin

Carlberg, C. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05403.x · Cited by 134

Acknowledgement of Reviewers for Volume 16

Papp, M., Litwa, E., Gruca, P., & Mocaër, E. (2005) · Journal of Child Custody · doi:10.1080/15379418.2019.1703621 · Cited by 134

Daily rhythm of serum melatonin levels and effect of light exposure in patients with dementia of the Alzheimer’s type

Ohashi, Y., Okamoto, N., Uchida, K., Iyo, M., Mori, N., & Morita, Y. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00255-8 · Cited by 133

Removal of Melatonin Receptor Type 1 Induces Insulin Resistance in the Mouse

Contreras‐Alcantara, S., Baba, K., & Tosini, G. (2010) · Obesity · doi:10.1038/oby.2010.24 · Cited by 133

SIRT1 Is a Circadian Deacetylase for Core Clock Components

Belden, W. J., & Dunlap, J. (2008) · Cell · doi:10.1016/j.cell.2008.07.010 · Cited by 132

Bidirectional communication between sleep and circadian rhythms and its implications for depression: Lessons from agomelatine

Pandi-Perumal, S. R., Moscovitch, A., Srinivasan, V., Spence, D. W., Cardinali, D. P., & Brown, G. M. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.007 · Cited by 132

Melatonin receptor subtype expression in human cerebellum

Al‐Ghoul, W. M., Herman, M. D., & Dubocovich, M. L. (1998) · Neuroreport · doi:10.1097/00001756-199812210-00011 · Cited by 132

Structure-Related Inhibition of Calmodulin-Dependent Neuronal Nitric-Oxide Synthase Activity by Melatonin and Synthetic Kynurenines

León, J., Macías, M. J., Escames, G., Camacho, E., Khaldy, H., Martı́n, M., Espinosa, A., Gallo, M. Á., & Acuña-Castroviejo, D. (2000) · Molecular Pharmacology · doi:10.1124/mol.58.5.967 · Cited by 132

Synchronization of mammalian circadian rhythms by melatonin.

Armstrong, S. M., Cassone, V. M., Chesworth, M. J., Redman, J., & Short, R. V. (1986) · PubMed · Cited by 132

Melatonin Reduces Oxidant Damage and Promotes Mitochondrial Respiration

Reiter, R. J., TAN, D. X., Manchester, L. C., & El-Sawi, M. R. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02096.x · Cited by 131

Role of the pineal gland and melatonin in seasonal reproductive function in mammals.

Arendt, J. (1986) · PubMed · Cited by 131

Serum Melatonin in Central Precocious Puberty Is Lower than in Age-Matched Prepubertal Children*

Waldhauser, F., Boepple, P. A., SCHEMPER, M., Mansfield, M. J., & Crowley, W. F. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-4-793 · Cited by 130

Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs

Srinivasan, V., Singh, J., Pandi-Perumal, S. R., Brown, G. M., Spence, D. W., & Cardinali, D. P. (2010) · Advances in Therapy · doi:10.1007/s12325-010-0065-y · Cited by 129

Time-dependent melatonin analgesia in mice: inhibition by opiate or benzodiazepine antagonism

Golombek, D. A., Escolar, E., Burin, L. J., Sanchez, M. G. D. B., & Cardinali, D. P. (1991) · European Journal of Pharmacology · doi:10.1016/0014-2999(91)90119-b · Cited by 129

Gpx4 protects mitochondrial ATP generation against oxidative damage

Liang, H., Remmen, H. V., Frohlich, V. C., Lechleiter, J. D., Richardson, A., & Ran, Q. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.045 · Cited by 128

Melatonin prevents endotoxin‐induced circulatory failure in rats

Wu, C., Chiao, C., Hsiao, G., Chen, A., & Yen, M. (2001) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2001.300303.x · Cited by 128

Melatonin administration prevents lipopolysaccharide‐induced oxidative damage in phenobarbital‐treated animals

Sewerynek, E., Abe, M., Reiter, R. J., Barlow‐Walden, L., Chen, L., McCabe, T. J. D., Roman, L. J., & Diaz‐Lopez, B. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240580406 · Cited by 128

Melatonin and its influence on immune system.

Szczepanik, M. (2007) · PubMed · Cited by 128

Effect of a high-fat diet on 24-h pattern of circulating levels of prolactin, luteinizing hormone, testosterone, corticosterone, thyroid-stimulating hormone and glucose, and pineal melatonin content, in rats

Cano, P., Jiménez‐Ortega, V., Jiménez, Á. L., Toso, C. F. R., Cardinali, D. P., & Esquifino, A. I. (2008) · Endocrine · doi:10.1007/s12020-008-9066-x · Cited by 127

Melatonin Treatment in Obese Patients with Childhood Craniopharyngioma and Increased Daytime Sleepiness

Müller, H. L., Handwerker, G., Gebhardt, U., Faldum, A., Emser, A., Kolb, R., & Sörensen, N. (2006) · Cancer Causes & Control · doi:10.1007/s10552-005-9012-7 · Cited by 127

Chronic melatonin treatment reduces the age‐dependent inflammatory process in senescence‐accelerated mice

Rodríguez, M. I., Escames, G., López, L. C., López, A., García, J. A. G., Ortiz, F., & Acuña-Castroviejo, D. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00416.x · Cited by 127

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