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Melatonin—A pleiotropic, orchestrating regulator molecule

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Hardeland, Rüdiger, Cardinali, Daniel P., Srinivasan, Venkatramanujam, Spence, D. Warren, Brown, Gregory M., Pandi-Perumal, Seithikurippu R.·2011·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2010.12.004

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Abstract

Melatonin, the neurohormone of the pineal gland, is also produced by various other tissues and cells. It acts via G protein-coupled receptors expressed in various areas of the central nervous system and in peripheral tissues. Parallel signaling mechanisms lead to cell-specific control and recruitment of downstream factors, including various kinases, transcription factors and ion channels. Additional actions via nuclear receptors and other binding sites are likely. By virtue of high receptor density in the circadian pacemaker, melatonin is involved in the phasing of circadian rhythms and sleep promotion. Additionally, it exerts effects on peripheral oscillators, including phase coupling of parallel cellular clocks based on alternate use of core oscillator proteins. Direct central and peripheral actions concern the up- or downregulation of various proteins, among which inducible and neuronal NO synthases seem to be of particular importance for antagonizing inflammation and excitotoxicity. The methoxyindole is also synthesized in several peripheral tissues, so that the total content of tissue melatonin exceeds by far the amounts in the circulation. Emerging fields in melatonin research concern receptor polymorphism in relation to various diseases, the control of sleep, the metabolic syndrome, weight control, diabetes type 2 and insulin resistance, and mitochondrial effects. Control of electron flux, prevention of bottlenecks in the respiratory chain and electron leakage contribute to the avoidance of damage by free radicals and seem to be important in neuroprotection, inflammatory diseases and, presumably, aging. Newly discovered influences on sirtuins and downstream factors indicate that melatonin has a role in mitochondrial biogenesis.

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RETRACTED: Melatonin prevents oxidative stress and changes in antioxidant enzyme expression and activity in the liver of aging rats
Mauriz, J. L., Molpeceres, V., García‐Mediavilla, M. V., González, P., Lera, J. P. B., & González‐Gallego, J. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00409.x · Cited by 89
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RETRACTED: Changes in the expression of melatonin receptors induced by melatonin treatment in hepatocarcinoma HepG2 cells
Carbajo‐Pescador, S., Martín‐Renedo, J., Palomo, A. G., Tuñón, M. J., Mauriz, J. L., & González‐Gallego, J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00719.x · Cited by 46
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RETRACTED: Melatonin prevents lipopolysaccharide‐induced hyporeactivity in rat
Bianca, R. D. D. V., Marzocco, S., Paola, R. D., Autore, G., Pinto, A., Cuzzocrea, S., & Sorrentino, R. (2004) · Journal of Pineal Research · doi:10.1046/j.1600-079x.2003.00111.x · Cited by 31
Retracted
Phototransduction by retinal ganglion cells that set the circadian clock
Berson, D. M., Dunn, F. A., & Takao, M. (2002) · Science · doi:10.1126/science.1067262 · Cited by 3,629
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058
Hypothalamic regulation of sleep and circadian rhythms
Saper, C. B., Scammell, T. E., & Lu, J. (2005) · Nature · doi:10.1038/nature04284 · Cited by 2,804
The mammalian circadian timing system: organization and coordination of central and peripheral clocks
Dibner, C., Schibler, U., & Albrecht, U. (2010) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021909-135821 · Cited by 2,421
Pineal Melatonin: Cell Biology of Its Synthesis and of Its Physiological Interactions*
REITER, R. J. (1991) · Endocrine Reviews · doi:10.1210/edrv-12-2-151 · Cited by 2,192
Mitochondria, oxidative stress and cell death
Ott, M., Gogvadze, V. G., Orrenius, S., & Zhivotovsky, B. (2007) · APOPTOSIS · doi:10.1007/s10495-007-0756-2 · Cited by 2,020
ISOLATION OF MELATONIN, THE PINEAL GLAND FACTOR THAT LIGHTENS MELANOCYTES 1
Lerner, A. B., Case, J. D., TAKAHASHI, Y., Lee, T. H., & Mori, W. (1958) · Journal of the American Chemical Society · doi:10.1021/ja01543a060 · Cited by 1,759
Melatonin : a potent, endogenous hydroxyl radical scavenger
Tan, D. (1993) · Endocrine Journal · Cited by 1,659
One molecule, many derivatives: A never-ending interaction of melatonin with reactive oxygen and nitrogen species?
Tan, D., Manchester, L. C., Terron, M. P., Flores, L. J., & Reiter, R. J. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00407.x · Cited by 1,601
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control
Nakahata, Y., Kaluzova, M., Grimaldi, B., Sahar, S., Hirayama, J., Chen, D., Guarente, L. P., & Sassone-Corsi, P. (2008) · Cell · doi:10.1016/j.cell.2008.07.002 · Cited by 1,427
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis
Ahn, B.-H., Kim, H.-S., Song, S., Lee, I. H., Liu, J., Vassilopoulos, A., Deng, C.-X., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803790105 · Cited by 1,291
The Circadian Gene Period2 Plays an Important Role in Tumor Suppression and DNA Damage Response In Vivo
Fu, L., Pelicano, H., Liu, J., Huang, P., & Lee, C. C. (2002) · Cell · doi:10.1016/s0092-8674(02)00961-3 · Cited by 1,268
Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease
Wang, X., Su, B., Lee, H.-G., Li, X., Perry, G., Smith, M. A., & Zhu, X. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1357-09.2009 · Cited by 1,224
Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation
Lombard, D. B., Alt, F. W., Cheng, H.-L., Bunkenborg, J., Streeper, R. S., Mostoslavsky, R., Kim, J., Yancopoulos, G., Valenzuela, D., Murphy, A., et al. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01636-07 · Cited by 1,216
Circadian Control of the NAD + Salvage Pathway by CLOCK-SIRT1
Nakahata, Y., Sahar, S., Astarita, G., Kaluzova, M., & Sassone-Corsi, P. (2009) · Science · doi:10.1126/science.1170803 · Cited by 1,198
Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses
Reppert, S. M., Weaver, D. R., & Ebisawa, T. (1994) · Neuron · doi:10.1016/0896-6273(94)90055-8 · Cited by 1,096
The melatonin rhythm: both a clock and a calendar
Reiter, R. J. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923947 · Cited by 997
Sleep spindles: an overview
Gennaro, L. D., & Ferrara, M. (2003) · Sleep Medicine Reviews · doi:10.1053/smrv.2002.0252 · Cited by 957
Molecular characterization of a second melatonin receptor expressed in human retina and brain: the Mel1b melatonin receptor.
Reppert, S. M., Godson, C., Mahle, C. D., Weaver, D. R., Slaugenhaupt, S. A., & Gusella, J. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.19.8734 · Cited by 882
Melatonin: Nature’s most versatile biological signal?
Pandi‐Perumal, S. R., Srinivasan, V., Maestroni, G. J. M., Cardinali, D. P., Poeggeler, B., & Hardeland, R. (2006) · The FEBS Journal · doi:10.1111/j.1742-4658.2006.05322.x · Cited by 875
Self-citation
Oxidative damage in the central nervous system: protection by melatonin
Reiter, R. J. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(98)00052-5 · Cited by 836
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
Wang, X., Su, B., Siedlak, S. L., Moreira, P. I., Fujioka, H., Wang, Y., Casadesus, G., & Zhu, X. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804871105 · Cited by 835
Functional MT1 and MT2 Melatonin Receptors in Mammals
Dubocovich, M. L., & Markowska, M. (2005) · Endocrine · doi:10.1385/endo:27:2:101 · Cited by 832
Effect of Bright Light and Melatonin on Cognitive and Noncognitive Function in Elderly Residents of Group Care Facilities: A Randomized Controlled Trial
Riemersma-van der Lek, R. F. (2008) · JAMA · doi:10.1001/jama.299.22.2642 · Cited by 803
Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide
Squadrito, G. L., & Pryor, W. A. (1998) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(98)00095-1 · Cited by 800
Physiological effects of melatonin: Role of melatonin receptors and signal transduction pathways
Pandi-Perumal, S. R., Trakht, I. N., SRINIVASAN, V., SPENCE, D., Maestroni, G. J. M., Zisapel, N., & Cardinali, D. P. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.04.001 · Cited by 799
Self-citation
Common variant in MTNR1B associated with increased risk of type 2 diabetes and impaired early insulin secretion
Lyssenko, V., Nagorny, C. L. F., Erdos, M. R., Wierup, N., Jonsson, A., Spégel, P., Bugliani, M., Saxena, R., Fex, M., Pulizzi, N., et al. (2009) · Nature Genetics · doi:10.1038/ng.288 · Cited by 742
A Length Polymorphism in the Circadian Clock Gene Per3 is Linked to Delayed Sleep Phase Syndrome and Extreme Diurnal Preference
Archer, S. N., Robilliard, D. L., Skene, D. J., Smits, M. G., Williams, A., Arendt, J., & von Schantz, M. (2003) · SLEEP · doi:10.1093/sleep/26.4.413 · Cited by 734
Molecular Dissection of Two Distinct Actions of Melatonin on the Suprachiasmatic Circadian Clock
Liu, C., Weaver, D. R., Jin, X., Shearman, L. P., Pieschl, R. L., Gribkoff, V. K., & Reppert, S. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80350-5 · Cited by 723
Superoxide flashes in single mitochondria
Wang, W., Fang, H., Groom, L., Cheng, A., Zhang, W., Liu, J., Wang, X., Li, K., Han, P., Zheng, M., et al. (2008) · Cell · doi:10.1016/j.cell.2008.06.017 · Cited by 715
Melatonin Shifts Human Orcadian Rhythms According to a Phase-Response Curve
Lewy, A. J., Ahmed, S., Jackson, J. M. L., & Sack, R. L. (1992) · Chronobiology International · doi:10.3109/07420529209064550 · Cited by 693
Antioxidative Protection by Melatonin: Multiplicity of Mechanisms from Radical Detoxification to Radical Avoidance
Hardeland, R. (2005) · Endocrine · doi:10.1385/endo:27:2:119 · Cited by 680
Self-citation
A Review of the Multiple Actions of Melatonin on the Immune System
Carrillo‐Vico, A., Guerrero, J. M., Lardone, P. J., & Reiter, R. J. (2005) · Endocrine · doi:10.1385/endo:27:2:189 · Cited by 677
REVIEW: Gastrointestinal Melatonin: Localization, Function, and Clinical Relevance
Bubenik, G. A. (2002) · Digestive Diseases and Sciences · doi:10.1023/a:1020107915919 · Cited by 655
Neurobiology of the Sleep-Wake Cycle: Sleep Architecture, Circadian Regulation, and Regulatory Feedback
Fuller, P. M., Gooley, J. J., & Saper, C. B. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406294627 · Cited by 636
International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors
Dubocovich, M. L., Delagrange, P., Krause, D. N., Sugden, D., Cardinali, D. P., & Olcese, J. (2010) · Pharmacological Reviews · doi:10.1124/pr.110.002832 · Cited by 636
Self-citation
Melatonin: A Coordinating Signal for Mammalian Reproduction?
Tamarkin, L., Baird, C. J., & Almeida, O. F. X. (1985) · Science · doi:10.1126/science.3881822 · Cited by 630
Melatonin as a chronobiotic
Arendt, J., & Skene, D. J. (2005) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.05.002 · Cited by 629
Melatonin as an antioxidant: biochemical mechanisms and pathophysiological implications in humans.
Reiter, R. J., Tan, D., Mayo, J. C., Sainz, R. M., León, J., & Czarnocki, Z. (2003) · Acta Biochimica Polonica · doi:10.18388/abp.2003_3637 · Cited by 623
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk
Bouatia-Naji, N., Bonnefond, A., Cavalcanti-Proença, C., Sparsø, T., Holmkvist, J., Marchand, M., Delplanque, J., Lobbens, S., Rocheleau, G., Durand, E., et al. (2009) · Nature Genetics · doi:10.1038/ng.277 · Cited by 611
Identification of the Melatonin-binding SiteMT 3 as the Quinone Reductase 2
Nosjean, O., Ferro, M., Cogé, F., Beauverger, P., Henlin, J., Lefoulon, F., Fauchère, J., Delagrange, P., Canet, E., & Boutin, J. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005141200 · Cited by 604
Oxidative stress caused by mitochondrial calcium overload
Peng, T., & Jou, M. (2010) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2010.05634.x · Cited by 569
Free-Running Activity Rhythms in the Rat: Entrainment by Melatonin
Redman, J., Armstrong, S., & Ng, K. T. (1983) · Science · doi:10.1126/science.6823571 · Cited by 551
Melatonin: a hormone, a tissue factor, an autocoid, a paracoid, and an antioxidant vitamin
Tan, D., Manchester, L. C., Hardeland, R., López‐Burillo, S., Mayo, J. C., Sainz, R. M., & Reiter, R. J. (2002) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.02111.x · Cited by 541
Self-citation
Melatonin mitigates mitochondrial malfunction
León, J., Acuña-Castroviejo, D., Escames, G., Tan, D. X., & Reiter, R. J. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00181.x · Cited by 518
Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome
Ebisawa, T., Uchiyama, M., Kajimura, N., Mishima, K., Kamei, Y., Katoh, M., Watanabe, T., Sekimoto, M., Shibui, K., Kim, K., et al. (2001) · EMBO Reports · doi:10.1093/embo-reports/kve070 · Cited by 517
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Guarente, L. (2008) · Cell · doi:10.1016/j.cell.2008.01.007 · Cited by 513
A proposed mechanism to explain the stimulatory effect of melatonin on antioxidative enzymes
Tomás‐Zapico, C., & Coto‐Montes, A. M. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00248.x · Cited by 512
SCN Outputs and the Hypothalamic Balance of Life
Kalsbeek, A., Palm, I. F., la Fleur, S., Scheer, F., Perreau‐Lenz, S., Ruiter, M., Kreier, F., Cailotto, C., & Buijs, R. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406293854 · Cited by 492
Subcellular localization of Nox4 and regulation in diabetes
Block, K. L., Gorin, Y. C., & Abboud, H. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906805106 · Cited by 484
Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines
Hardeland, R., Tan, D., & Reiter, R. J. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00701.x · Cited by 477
Self-citation
Melatonin and the ovary: physiological and pathophysiological implications
Tamura, H., Nakamura, Y., Korkmaz, A., Manchester, L. C., Tan, D., Sugino, N., & Reiter, R. J. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2008.05.016 · Cited by 477
Melatonin-Immune System Relationships
Guerrero, J. M., & Reiter, R. J. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394335 · Cited by 476
Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria
Brown, G. C., & Bal‐Price, A. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:325 · Cited by 467
Self-citation
Evidence of melatonin synthesis by human lymphocytes and its physiological significance: possible role as intracrine, autocrine, and/or paracrine substance
Carrillo‐Vico, A., Calvo, J. R., Abreu, P. M., Lardone, P. J., García‐Mauriño, S., Reiter, R. J., & Guerrero, J. M. (2004) · The FASEB Journal · doi:10.1096/fj.03-0694fje · Cited by 456
Mammalian melatonin receptors: molecular biology and signal transduction
von Gall, C., Stehle, J. H., & Weaver, D. R. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0581-4 · Cited by 455
Molecular pharmacology regulation and function of mammalian melatonin receptors
Dubocovich, M. L. (2003) · Frontiers in bioscience · doi:10.2741/1089 · Cited by 453
Spectral Responses of the Human Circadian System Depend on the Irradiance and Duration of Exposure to Light
Gooley, J. J., Rajaratnam, S. M. W., Brainard, G. C., Kronauer, R. E., Czeisler, C. A., & Lockley, S. W. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3000741 · Cited by 447
STRUCTURE OF MELATONIN1
Lerner, A. B., Case, J. D., & Heinzelman, R. V. (1959) · Journal of the American Chemical Society · doi:10.1021/ja01531a060 · Cited by 443
Pineal gland hormone melatonin binds and activates an orphan of the nuclear receptor superfamily.
Becker-André, M., Wiesenberg, I., Schaeren‐Wiemers, N., André, E., Missbach, M., Saurat, J. ‐., & Carlberg, C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)61934-4 · Cited by 434
Circadian clocks: regulators of endocrine and metabolic rhythms
Hastings, M., O’Neill, J. S., & Maywood, E. S. (2007) · Journal of Endocrinology · doi:10.1677/joe-07-0378 · Cited by 426
The significance of the metabolism of the neurohormone melatonin: Antioxidative protection and formation of bioactive substances
Hardeland, R., Reiter, R. J., Pöeggeler, B., & Tan, D. X. (1993) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80016-8 · Cited by 424
Self-citation
Dim light melatonin onset (DLMO): A tool for the analysis of circadian phase in human sleep and chronobiological disorders
Pandi-Perumal, S. R., Smits, M. G., Spence, W., Srinivasan, V., Cardinali, D. P., Lowe, A. D., & Kayumov, L. (2006) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2006.06.020 · Cited by 416
Self-citation
Effect of Melatonin on the Reproductive Systems of Male and Female Syrian Hamsters: A Diurnal Rhythm in Sensitivity to Melatonin12
Tamarkin, L., Westrom, W. K., HAMILL, A. I., & Goldman, B. D. (1976) · Endocrinology · doi:10.1210/endo-99-6-1534 · Cited by 404
Non‐vertebrate melatonin
Hardeland, R., & Pöeggeler, B. (2003) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2003.00040.x · Cited by 400
Self-citation
Hypothalamic melatonin receptor sites revealed by autoradiography
Vaněček, J., Pavlík, A., & Illnerová, H. (1987) · Brain Research · doi:10.1016/0006-8993(87)91625-8 · Cited by 399
Free Radical‐Mediated Molecular Damage
Reiter, R. J., Acuña-Castroviejo, D., Tan, D. X., & Burkhardt, S. (2001) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2001.tb03627.x · Cited by 398
Daily Melatonin Administration to Middle-Aged Male Rats Suppresses Body Weight, Intraabdominal Adiposity, and Plasma Leptin and Insulin Independent of Food Intake and Total Body Fat1
Wolden‐Hanson, T., Mitton, D. R., McCants, R. L., Yellon, S. M., Wilkinson, C. W., Matsumoto, A. M., & Rasmussen, D. D. (2000) · Endocrinology · doi:10.1210/endo.141.2.7311 · Cited by 390
Human Melatonin Suppression by Light is Intensity Dependent
Mclntyre, I. M., Norman, T. R., Burrows, G. D., & Armstrong, S. M. (1989) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1989.tb00412.x · Cited by 389
Melatonin and Human Rhythms
Arendt, J. (2006) · Chronobiology International · doi:10.1080/07420520500464361 · Cited by 383
Evidence for melatonin synthesis in mouse and human bone marrow cells
Conti, A., Conconi, S., Hertens, E., Skwarło‐Sońta, K., Markowska, M., & Maestroni, G. J. M. (2000) · Journal of Pineal Research · doi:10.1034/j.1600-079x.2000.280401.x · Cited by 381
Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
Paradies, G., Petrosillo, G., Paradies, V., Reiter, R. J., & Ruggiero, F. M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00759.x · Cited by 381
Melatonin as a Chronobiotic / Anticancer Agent: Cellular, Biochemical, and Molecular Mechanisms of Action and their Implications for Circadian-Based Cancer Therapy
Blask, D. E., Sauer, L. A., & Dauchy, R. T. (2002) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026023394407 · Cited by 381
Melatonin enhances IL-2, IL-6, and IFN-gamma production by human circulating CD4+ cells: a possible nuclear receptor-mediated mechanism involving T helper type 1 lymphocytes and monocytes
García‐Mauriño, S., González-Haba, M. G., Calvo, J. R., Rafii-El-Idrissi, M., Sánchez‐Margalet, V., Goberna, R., & Guerrero, J. M. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.2.574 · Cited by 380
Melatonin receptors in humans: biological role and clinical relevance
Ekmekçioğlu, C. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.01.002 · Cited by 377
The changing biological roles of melatonin during evolution: from an antioxidant to signals of darkness, sexual selection and fitness
Tan, D. X., Hardeland, R., Manchester, L. C., Paredes, S. D., Korkmaz, A., Sainz, R. M., Mayo, J. C., Fuentes‐Broto, L., & Reiter, R. J. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00118.x · Cited by 365
Self-citation
Mitochondrial biogenesis and healthy aging
López-Lluch, G., Irusta, P. M., Navas, P., & de Cabo, R. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.014 · Cited by 364
Melatonin receptors: role on sleep and circadian rhythm regulation
Dubocovich, M. L. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2007.10.007 · Cited by 364
Circadian Rhythms, Oxidative Stress, and Antioxidative Defense Mechanisms
Hardeland, R., Coto‐Montes, A. M., & Pöeggeler, B. (2003) · Chronobiology International · doi:10.1081/cbi-120025245 · Cited by 358
Self-citation
Minireview: Entrainment of the Suprachiasmatic Clockwork in Diurnal and Nocturnal Mammals
Challet, É. (2007) · Endocrinology · doi:10.1210/en.2007-0804 · Cited by 356
Significance and application of melatonin in the regulation of brown adipose tissue metabolism: relation to human obesity
Tan, D. ‐., Manchester, L. C., Fuentes‐Broto, L., Paredes, S. D., & Reiter, R. J. (2010) · Obesity Reviews · doi:10.1111/j.1467-789x.2010.00756.x · Cited by 353
Differential Association of Circadian Genes with Mood Disorders: CRY1 and NPAS2 are Associated with Unipolar Major Depression and CLOCK and VIP with Bipolar Disorder
Soria, V., Martínez‐Amorós, È., Escaramís, G., Valero, J., Pérez‐Egea, R., García, C. B., Gutiérrez‐Zotes, A., Puigdemont, D., Bayés, M., Crespo, J. M., et al. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.230 · Cited by 352
Melatonin signaling and cell protection function
Luchetti, F., Canonico, B., Betti, M., Arcangeletti, M., Pilolli, F., Piroddi, M., Canesi, L., Papa, S., & Galli, F. (2010) · The FASEB Journal · doi:10.1096/fj.10-154450 · Cited by 349
Phytomelatonin: a review
Paredes, S. D., Korkmaz, A., Manchester, L. C., Tan, D., & Reiter, R. J. (2008) · Journal of Experimental Botany · doi:10.1093/jxb/ern284 · Cited by 349
Redox signaling (cross-talk) from and to mitochondria involves mitochondrial pores and reactive oxygen species
Daiber, A. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.01.032 · Cited by 347
Light-at-night, circadian disruption and breast cancer: assessment of existing evidence
Stevens, R. G. (2009) · International Journal of Epidemiology · doi:10.1093/ije/dyp178 · Cited by 345
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
Johansson, C., Willeit, M., Smedh, C., Ekholm, J., Paunio, T., Kieseppä, T., Lichtermann, D., Praschak-Rieder, N., Neumeister, A., Nilsson, L.-G., et al. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300121 · Cited by 341
Cardiovascular diseases: protective effects of melatonin
Tengattini, S., Reiter, R. J., Tan, D., Terrón, M. P., Rodella, L. F., & Rezzani, R. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00518.x · Cited by 340
Night Shift Work and the Risk of Endometrial Cancer
Viswanathan, A. N., Hankinson, S. E., & Schernhammer, E. S. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2485 · Cited by 338
The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization
Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J., Couturier, C., Delagrange, P., & Jockers, R. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601193 · Cited by 335
Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease
Matsubara, E., Bryant‐Thomas, T., Pacheco Quinto, J., Henry, T. L., Poeggeler, B., Herbert, D., Cruz‐Sanchez, F., Chyan, Y., Smith, M. A., Perry, G., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01654.x · Cited by 332
Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages
Mayo, J. C., Sainz, R. M., Tan, D., Hardeland, R., León, J., Rodrı́guez, C., & Reiter, R. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.002 · Cited by 332
Self-citation
Monitoring of Ligand-independent Dimerization and Ligand-induced Conformational Changes of Melatonin Receptors in Living Cells by Bioluminescence Resonance Energy Transfer
Ayoub, M. A., Couturier, C., Lucas-Meunier, E., Angers, S., Fossier, P., Bouvier, M., & Jockers, R. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200729200 · Cited by 322
Retinoid X receptors: common heterodimerization partners with distinct functions
Lefèbvre, P., Benomar, Y., & Staels, B. (2010) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.06.009 · Cited by 320
Sleep disorders and melatonin rhythms in elderly people
Haimov, I., Laudon, M., Zisapel, N., Souroujon, M. C., Nof, D., Shlitner, A., Herer, P., Tzischinsky, O., & Lavie, P. (1994) · BMJ · doi:10.1136/bmj.309.6948.167 · Cited by 315
Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation
Karbownik‐Lewińska, M., & Reiter, R. J. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1111/j.1525-1373.2000.22502.x · Cited by 313
Direct inhibition of the mitochondrial permeability transition pore: a possible mechanism responsible for anti‐apoptotic effects of melatonin
Andrabi, S. A., Sayeed, I., Siemen, D., Wolf, G. L., & Horn, T. F. W. (2004) · The FASEB Journal · doi:10.1096/fj.03-1031fje · Cited by 311
Melatonin, endocrine pancreas and diabetes
Peschke, E. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00519.x · Cited by 309
Shift work: coping with the biological clock.
Arendt, J. (2010) · Occupational Medicine · doi:10.1093/occmed/kqp162 · Cited by 308
Distinct Contributions of Rod, Cone, and Melanopsin Photoreceptors to Encoding Irradiance
Lall, G. S., Revell, V. L., Momiji, H., al Enezi, J., Altimus, C. M., Güler, A. D., Aguilar, C., Cameron, M. A., Allender, S., Hankins, M. W., et al. (2010) · Neuron · doi:10.1016/j.neuron.2010.04.037 · Cited by 306
The contribution of extrapineal sites of melatonin synthesis to circulating melatonin levels in higher vertebrates
Huether, G. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923948 · Cited by 306
Melatonin and cell death: differential actions on apoptosis in normal and cancer cells
Sainz, R. M., Mayo, J. C., Rodrı́guez, C., Tan, D. X., López‐Burillo, S., & Reiter, R. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-2319-1 · Cited by 306
Decreased Melatonin Levels in Postmortem Cerebrospinal Fluid in Relation to Aging, Alzheimer’s Disease, and Apolipoprotein E-ε4/4 Genotype1
Liu, R.-Y., Zhou, J.-N., van Heerikhuize, J., Hofman, M. A., & Swaab, D. F. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.1.5394 · Cited by 304
The site of production of superoxide radical in mitochondrial Complex I is not a bound ubisemiquinone but presumably iron–sulfur cluster N2
Genova, M. L., Ventura, B., Giuliano, G., Bovina, C., Formiggini, G., Castelli, G. P., & Lenaz, G. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02850-2 · Cited by 301
Abnormal mitochondrial dynamics and neurodegenerative diseases
Su, B., Wang, X., Zheng, L., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2009.09.013 · Cited by 301
Clinical Uses of Melatonin: Evaluation of Human Trials
Sanchez-Barcelo, E. J., Mediavilla, M. D., Tan, D. X., & Reiter, R. J. (2010) · Current Medicinal Chemistry · doi:10.2174/092986710791233689 · Cited by 301 · cited 1×
“Low levels of melatonin were also observed in women with fibromyalgia (Rohr and Herold, 2002; Acuña-Castroviejo et al., 2006; Reiter et al., 2007) and pain has been reported to be reduced by replacement therapy (Citera et al., 2000; Reiter et al., 2007; Sánchez-Barceló et al., 2010).”
Background
Association study of eight circadian genes with bipolar I disorder, schizoaffective disorder and schizophrenia
Mansour, H. A., Wood, J., Logue, T., Chowdari, K. V., Dayal, M., Kupfer, D. J., Monk, T. H., Devlin, B., & Nimgaonkar, V. L. (2006) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2005.00147.x · Cited by 293
Melatonin receptors, heterodimerization, signal transduction and binding sites: what's new?
Jockers, R., Maurice, P., Boutin, J. A., & Delagrange, P. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.184 · Cited by 293
Inhibition of NADPH Oxidase is Neuroprotective after Ischemia—Reperfusion
Chen, H., Song, Y. S., & Chan, P. H. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.47 · Cited by 291
Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice
Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010995 · Cited by 286 · cited 1×
“…functions of clock genes, in particular, Per1 and Per2, are uncovered (Yang et al., 2009a,b) and in which circadian disruption, by mutation, inadequate signaling or frequently repeated phase shifts, reveals an increased cancer risk (Fu et al., 2002; Hardeland et al., 2003a; Lee et al., 2010).”
Background
SIRT3 interacts with the daf-16 homolog FOXO3a in the Mitochondria, as well as increases FOXO3a Dependent Gene expression
Jacobs, K. M., Pennington, J. D., Bisht, K. S., Aykin‐Burns, N., Kim, H., Mishra, M. V., Sun, L., Nguyen, P., Ahn, B., Leclerc, J., et al. (2008) · International Journal of Biological Sciences · doi:10.7150/ijbs.4.291 · Cited by 285
Serotoninergic and melatoninergic systems are fully expressed in human skin
Slominski, A. T., Pisarchik, A. V., Semak, I. V., Sweatman, T. W., Wortsman, J., Szczesniewski, A., Slugocki, G., McNulty, J. A., Kauser, S., Tobin, D. J., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0952fje · Cited by 285
Disturbance and strategies for reactivation of the circadian rhythm system in aging and Alzheimer’s disease
Wu, Y., & Swaab, D. F. (2007) · Sleep Medicine · doi:10.1016/j.sleep.2006.11.010 · Cited by 284
Reduced oxidative damage in ALS by high‐dose enteral melatonin treatment
Weishaupt, J. H., Bartels, C., Pölking, E., Dietrich, J., Rohde, G., Pöeggeler, B., Mertens, N., Sperling, S., Bohn, M., Huether, G., et al. (2006) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2006.00377.x · Cited by 284
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Melatonin protects the mitochondria from oxidative damage reducing oxygen consumption, membrane potential, and superoxide anion production
López, A., García, J. A., Escames, G., Venegas, C., Ortiz, F., López, L. C., & Acuña-Castroviejo, D. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00647.x · Cited by 283
Melatonin Reduces Body Weight Gain in Sprague Dawley Rats with Diet-Induced Obesity
Prunet‐Marcassus, B., Desbazeille, M., Bros, A., Louche, K., Delagrange, P., Renard, P., Casteilla, L., & Pénicaud, L. (2003) · Endocrinology · doi:10.1210/en.2003-0693 · Cited by 281
Dual Signaling of Human Mel1a Melatonin Receptors via Gi2, Gi3, and Gq/11 Proteins
Brydon, L., Roka, F., Petit, L., de Coppet, P., Tissot, M., Barrett, P., Morgan, P. J., Nanoff, C., Strosberg, A. D., & Jockers, R. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.12.0390 · Cited by 281
Melatonin inhibits expression of the inducible NO synthase II in liver and lung and prevents endotoxemia in lipopolysaccharide‐induced multiple organ dysfunction syndrome in rats
Crespo, E., Macías, M. J., Pozo, D., Escames, G., Martı́n, M., Vives, F., Guerrero, J. M., & Acuña-Castroviejo, D. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.12.1537 · Cited by 280
Properties, Entrainment, and Physiological Functions of Mammalian Peripheral Oscillators
Stratmann, M., & Schibler, U. (2006) · Journal of Biological Rhythms · doi:10.1177/0748730406293889 · Cited by 277
Nox2-Derived Reactive Oxygen Species Mediate Neurovascular Dysregulation in the Aging Mouse Brain
Park, L., Anrather, J., Girouard, H., Zhou, P., & Iadecola, C. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600491 · Cited by 275
Melatonin rhythmicity: effect of age and Alzheimer's disease
Skene, D. J. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(02)00198-5 · Cited by 273
Peroxynitrite: an endogenous oxidizing and nitrating agent
Ducrocq, C., Blanchard, B., Pignatelli, B., & Ohshima, H. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050357 · Cited by 272
Melatonin secretion rhythm disorders in patients with senile dementia of Alzheimer’s type with disturbed sleep–waking
Mishima, K., Tozawa, T., Satoh, K., Matsumoto, Y., Hishikawa, Y., & Okawa, M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00510-6 · Cited by 269
On the primary functions of melatonin in evolution: Mediation of photoperiodic signals in a unicell, photooxidation, and scavenging of free radicals*
Hardeland, R., Balzer, I., Pöeggeler, B., Fuhrberg, B., Una, H., Behrmann, G., Wolf, R., Meyer, T. J., & Reiter, R. J. (1995) · Journal of Pineal Research · doi:10.1111/j.1600-079x.1995.tb00147.x · Cited by 268
Self-citation
Effect of tryptophan administration on circulating melatonin levels in chicks and rats: Evidence for stimulation of melatonin synthesis and release in the gastrointestinal tract
Huether, G., Pöeggeler, B., Reimer, A., & George, A. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90402-b · Cited by 267
Melatonin suppresses macrophage cyclooxygenase-2 and inducible nitric oxide synthase expression by inhibiting p52 acetylation and binding
Deng, W., Tang, S.-T., Tseng, H.-P., & Wu, K. K. (2006) · Blood · doi:10.1182/blood-2005-09-3691 · Cited by 267
Activation of MT2melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock
Hunt, A. E., Al‐Ghoul, W. M., Gillette, M. U., & Dubocovich, M. L. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.1.c110 · Cited by 266
Visualization of the antioxidative effects of melatonin at the mitochondrial level during oxidative stress‐induced apoptosis of rat brain astrocytes
Jou, M., Peng, T., Reiter, R. J., Jou, S., WU, H., & Wen, S. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00140.x · Cited by 265
The Nuclear Receptor for Melatonin Represses 5-Lipoxygenase Gene Expression in Human B Lymphocytes
Steinhilber, D., Brungs, M., Werz, O., Wiesenberg, I., Danielsson, C., Kahlen, J.-P., Nayeri, S., Schräder, M., & Carlberg, C. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7037 · Cited by 264
Protection against cognitive deficits and markers of neurodegeneration by long‐term oral administration of melatonin in a transgenic model of Alzheimer disease
Olcese, J., Cao, C., Mori, T., Mamcarz, M. B., Maxwell, A. K., Runfeldt, M. J., Wang, L., Zhang, C., Lin, X., Zhang, G., et al. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00692.x · Cited by 264
Melatonin Action and Signal Transduction in the Rat Suprachiasmatic Circadian Clock: Activation of Protein Kinase C at Dusk and Dawn
McArthur, A. J., Hunt, A. E., & Gillette, M. U. (1997) · Endocrinology · doi:10.1210/endo.138.2.4925 · Cited by 263
Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria
Martı́n, M., Macías, M. J., León, J., Escames, G., Khaldy, H., & Acuña-Castroviejo, D. (2002) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(01)00138-8 · Cited by 261
Melatonin protects against common deletion of mitochondrial DNA‐augmented mitochondrial oxidative stress and apoptosis
Jou, M., Peng, T.-I., Yu, P., Jou, S., Reiter, R. J., Chen, J., WU, H., Chen, C., & Hsu, L. (2007) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2007.00490.x · Cited by 260
PERIOD3, circadian phenotypes, and sleep homeostasis
Dijk, D., & Archer, S. N. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.07.002 · Cited by 254
Daily Melatonin Administration at Middle Age Suppresses Male Rate Visceral Fat, Plasma Leptin, and Plasma Insulin to Youthful Levels
Rasmussen, D. D., Boldt, B. M., Wilkinson, C. W., Yellon, S. M., & Matsumoto, A. M. (1999) · Endocrinology · doi:10.1210/endo.140.2.6674 · Cited by 250
Transcriptional activation of the nuclear receptor RZRα by the pineal gland hormone melatonin and identification of CGP 52608 as a synthetic ligand
Wiesenberg, I., Missbach, M., Kahlen, J.-P., Schräder, M., & Carlberg, C. (1995) · Nucleic Acids Research · doi:10.1093/nar/23.3.327 · Cited by 250
Circadian rhythm abnormalities of melatonin in Smith-Magenis syndrome
Potocki, L., Glaze, D., Tan, D.-X., Park, S.-S., Kashork, C. D., Shaffer, L. G., Reiter, R. J., & Lupski, J. R. (2000) · Journal of Medical Genetics · doi:10.1136/jmg.37.6.428 · Cited by 244
Both physiological and pharmacological levels of melatonin reduce DNA adduct formation induced by the carcinogen safrole
Tan, D., Reiter, R. J., Chen, L., Pöeggeler, B., Manchester, L. C., & Barlow‐Walden, L. (1994) · Carcinogenesis · doi:10.1093/carcin/15.2.215 · Cited by 243
An assessment of the antioxidant and the antiamyloidogenic properties of melatonin: implications for Alzheimer's disease
Pappolla, M. A., Chyan, Y., Pöeggeler, B., Frangione, B., Wilson, G. L., Ghiso, J. A., & Reiter, R. J. (2000) · Journal of Neural Transmission · doi:10.1007/s007020050018 · Cited by 241
Nature's knockout: the Mel1b receptor is not necessary for reproductive and circadian responses to melatonin in Siberian hamsters
Weaver, D. R., Liu, C., & Reppert, S. M. (1996) · Molecular Endocrinology · doi:10.1210/mend.10.11.8923472 · Cited by 241
Direct Action of Melatonin in Human Granulosa-Luteal Cells
Woo, M. M. M., Tai, C.-J., Kang, S. K., Nathwani, P. S., Pang, S. F., & Leung, P. C. K. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.86.10.4789 · Cited by 240
Targeted Disruption of the Mouse Mel1b Melatonin Receptor
Jin, X., von Gall, C., Pieschl, R. L., Gribkoff, V. K., Stehle, J. H., Reppert, S. M., & Weaver, D. R. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.1054-1060.2003 · Cited by 240
Antioxidant properties of the melatonin metabolite N1-acetyl-5-methoxykynuramine (AMK): scavenging of free radicals and prevention of protein destruction
Ressmeyer, A., Mayo, J. C., Zelosko, V., Sainz, R. M., Tan, D., Pöeggeler, B., Antolı́n, I., Zsizsik, B. K., Reiter, R. J., & Hardeland, R. (2003) · Redox Report · doi:10.1179/135100003225002709 · Cited by 238
Self-citation
Antioxidative Effects of Melatonin in Protection Against Cellular Damage Caused by Ionizing Radiation
Karbownik‐Lewińska, M., & Reiter, R. J. (2000) · Proceedings of The Society for Experimental Biology and Medicine · doi:10.1046/j.1525-1373.2000.22502.x · Cited by 238
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer
Jung-Hynes, B. D., Reiter, R. J., & Ahmad, N. (2009) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2009.00729.x · Cited by 237
High physiological levels of melatonin in the bile of mammals
Tan, D., Manchester, L. C., Reiter, R. J., Qi, W., Hanes, M. A., & Farley, N. J. (1999) · Life Sciences · doi:10.1016/s0024-3205(99)00519-6 · Cited by 233
The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology
Genova, M. L., Pich, M. M., Bernacchia, A., Bianchi, C., Biondi, A., Bovina, C., Falasca, A. I., Formiggini, G., Castelli, G. P., & Lenaz, G. (2004) · Springer eBooks · doi:10.1007/978-3-662-41088-2_10 · Cited by 233
Suppression of Nocturnal Plasma Melatonin and 6-Sulphatoxymelatonin by Bright and Dim Light in Man
Bojkowski, C. J., Aldhous, M. E., English, J., Franey, C. S., Poulton, A. L., Skene, D. J., & Arendt, J. (1987) · Hormone and Metabolic Research · doi:10.1055/s-2007-1011846 · Cited by 233
Role of melatonin in neurodegenerative diseases
Srinivasan, V. J., Pandi-Perumal, S. R., Maestroni, G. J. M., Esquifino, A. I., Hardeland, R., & Cardinali, D. P. (2005) · Neurotoxicity Research · doi:10.1007/bf03033887 · Cited by 232
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The Antiapoptotic Activity of Melatonin in Neurodegenerative Diseases
Wang, X. (2009) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2009.00105.x · Cited by 232
Melatonin mediates two distinct responses in vascular smooth muscle
Doolen, S., Krause, D. N., Dubocovich, M. L., & Duckles, S. P. (1998) · European Journal of Pharmacology · doi:10.1016/s0014-2999(98)00064-8 · Cited by 229
Melatonin in Alzheimer's disease and other neurodegenerative disorders
Srinivasan, V. J., Pandi-Perumal, S. R., Cardinali, D. P., Pöeggeler, B., & Hardeland, R. (2006) · Behavioral and Brain Functions · doi:10.1186/1744-9081-2-15 · Cited by 229
Self-citation
Melatonin: Signaling mechanisms of a pleiotropic agent
Hardeland, R. (2009) · BioFactors · doi:10.1002/biof.23 · Cited by 227
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A relationship between heat loss and sleepiness: effects of postural change and melatonin administration
Kräuchi, K., Cajochen, C., & Wirz-Justice, A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.83.1.134 · Cited by 227
Neurotoxic Activation of Microglia Is Promoted by a Nox1-Dependent NADPH Oxidase
Chéret, C., Gervais, A., Lelli, A., Colin, C., Amar, L., Ravassard, P., Mallet, J., Cumano, A., Krause, K.-H., & Mallat, M. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3568-08.2008 · Cited by 225
Daily variation in the concentration of melatonin and 5-methoxytryptophol in the human pineal gland: effect of age and Alzheimer's disease
Skene, D. J., VIVIEN‐ROELS, B., Sparks, D. L., Hunsaker, J. C., Pévet, P., Ravid, D., & Swaab, D. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)90214-v · Cited by 224
Melatonin as a cytoskeletal modulator: implications for cell physiology and disease
Benítez‐King, G. (2005) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2005.00282.x · Cited by 224
Calmodulin mediates melatonin cytoskeletal effects
Benítez‐King, G., & Antón‐Tay, F. (1993) · Cellular and Molecular Life Sciences · doi:10.1007/bf01923944 · Cited by 222
Activation of human monocytes by the pineal hormone melatonin.
Morrey, K. M., McLachlan, J. A., Serkin, C. D., & Bakouche, O. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.6.2671 · Cited by 221
Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues
Fulco, M., & Sartorelli, V. (2008) · Cell Cycle · doi:10.4161/cc.7.23.7164 · Cited by 218
The modulatory role of melatonin on immune responsiveness.
Carrillo‐Vico, A., Reiter, R. J., Lardone, P. J., Herrera, J. L., Fernández-Montesinos, R., Guerrero, J. M., & Pozo, D. (2006) · PubMed · Cited by 217
Specific Binding of Melatonin in Bovine Brain*
Cardinali, D. P., Vacas, M. I., & BOYER, E. E. (1979) · Endocrinology · doi:10.1210/endo-105-2-437 · Cited by 217
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Disruption of retinoid‐related orphan receptor β changes circadian behavior, causes retinal degeneration and leads to vacillans phenotype in mice
André, É., Conquet, F., Steinmayr, M., Stratton, S. C., Porciatti, V., & Becker-André, M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.14.3867 · Cited by 214
The role of the thalamus in sleep, pineal melatonin production, and circadian rhythm sleep disorders
Jan, J. E., Reiter, R. J., Wasdell, M. B., & BAX, M. C. O. (2008) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2008.00628.x · Cited by 213
Reduced hippocampal MT2 melatonin receptor expression in Alzheimer's disease
Savaskan, E., Ayoub, M. A., Ravid, R., Angeloni, D., FRASCHINI, F., Meier, F., Eckert, A., Müller-Spahn, F., & Jockers, R. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00169.x · Cited by 213
Cardiolipin Switch in Mitochondria: Shutting off the Reduction of Cytochrome c and Turning on the Peroxidase Activity
Basova, L. V., Kurnikov, I. V., Wang, L., Ritov, V. B., Belikova, N. A., Vlasova, I. I., Pacheco, A. A., Winnica, D. E., Peterson, J., Bayir, H., et al. (2007) · Biochemistry · doi:10.1021/bi061854k · Cited by 212
Reactive oxygen and nitrogen species and cellular and organismal decline: amelioration with melatonin
Reiter, R. J., Tan, D., & Burkhardt, S. (2002) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(01)00384-0 · Cited by 212
Association of the Length Polymorphism in the Human Per3 Gene with the Delayed Sleep-Phase Syndrome: Does Latitude Have an Influence Upon It?
Pereira, D. S., Tufik, S. B., Louzada, F. M., Benedito‐Silva, A. A., Lopez, A. R., Lemos, N. A. M., Korczak, A., Vania D´Almeida, P., & Pedrazzoli, M. (2005) · SLEEP · doi:10.1093/sleep/28.1.29 · Cited by 212
Binding of 3H-melatonin to calmodulin
Benítez‐King, G., Huerto‐Delgadillo, L., & Antón‐Tay, F. (1993) · Life Sciences · doi:10.1016/0024-3205(93)90670-x · Cited by 211
Melatonin Effects on Behavior: Possible Mediation by the Central GABAergic System
Golombek, D. A., Pévet, P., & Cardinali, D. P. (1996) · Neuroscience & Biobehavioral Reviews · doi:10.1016/0149-7634(95)00052-6 · Cited by 209
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Decreased MT1 melatonin receptor expression in the suprachiasmatic nucleus in aging and Alzheimer's disease
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Self-citation
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Self-citation
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Comparative pharmacological studies of melatonin receptors: mt1, mt2 and mt3/qr2. tissue distribution of mt3/qr2 11Abbreviations: MCA-NAT, methoxy-carbonylamino-N-acetyltrypta- mine, 2-[125I]-I-MCA-NAT, 2-[125I]-iodomethoxy-carbonylamino-N-acetyltryptamine; 2-IbMT, 2-iodo-N-butanoyl-5-methoxytryptamine; 4-P-PDOT, 4-phenyl-2-propionamido-tetraline; DH97, N-pentanoyl-2-benzyltryptamine; S20760, 5-methoxy-N-cyclopropanoyl-tryptamine; S24635, N-[2-(5-carbamoylbenzofuran-3-yl)ethyl]-acetamide; S25726, N-methyl-(3-{2-[(cyclopropylcarbonyl)-amino]ethyl}benzo[b]furan-5-yl)carbamate; S26553, N-methyl-{1-[2-(acetylamino)ethyl]-naphthalen-7-yl}carbamate.
Nosjean, O., Nicolas, J., Klupsch, F., Delagrange, P., Canet, E., & Boutin, J. A. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(01)00615-3 · Cited by 185
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Strong nuclear factor-?B-DNA binding parallels cyclooxygenase-2 gene transcription in aging and in sporadic alzheimer's disease superior temporal lobe neocortex
Lukiw, W. J., & Bazan, N. G. (1998) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19980901)53:5 · Cited by 182
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Pineal clock gene oscillation is disturbed in Alzheimer's disease, due to functional disconnection from the “master clock”
Wu, Y., Fischer, D. F., Kalsbeek, A., Garidou, M., van der Vliet, J., Heijningen, C. L. V., Liu, R., Zhou, J., & Swaab, D. F. (2006) · The FASEB Journal · doi:10.1096/fj.05-4446fje · Cited by 176

Research works printed but not linked: 4

Eds T. Partonen and S.R. Pandi-Perumal. Oxford University Press: Oxford.
Eds J.M. Monti, S.R. Pandi-Perumal, C.M. Sinton. Cambridge University Press: Cambridge UK.
Hardeland, R., Poeggeler, B., Balzer, I., and Behrmann, G., 1993b. A hypothesis on the evolutionary origins of photoperiodism based on circadian rhythmicity of melatonin in phylogenetically distant organisms. In: Chronobiology & Chronomedicine, pp. 113-120.
Turjanski, A.J., Estrin, D.A., Rosenstein, R.E., Mccormick, J.E., Martín, S.R., Pastore, A., Biokofsky, R.R., and Martoran, V., 2007. The interaction between melatonin and calmodulin: a NMR and molecular dynamics study. In: Melatonin -From Molecules to Therapy, pp. 47-68.

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Authors: Hardeland, R., Cardinali, D. P., Srinivasan, V., Spence, D. W., Brown, G. M., & Pandi-Perumal, S. R.
Affiliations: University of Göttingen (DE)
Pontificia Universidad Católica Argentina (AR)
Karpagam Academy of Higher Education (IN)
Centre for Addiction and Mental Health (CA)
Corresponding author: Hardeland, Rüdiger
ORCID: Hardeland, Rüdiger
Cardinali, Daniel P.
Spence, D. Warren
Brown, Gregory M.
Pandi-Perumal, Seithikurippu R.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2011-03
Volume: 93
Issue: 3
Pages: 350-384
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2010.12.004
OpenAlex: W2157611470
Cited by: 843
References: 733
Citations by year: 2026: 20 · 2025: 38 · 2024: 34 · 2023: 57 · 2022: 71 · 2021: 64 · 2020: 72 · 2019: 67 · 2018: 74 · 2017: 59 · 2016: 61 · 2015: 53 · 2014: 49 · 2013: 58 · 2012: 45
FWCI: 17.92
Type: journal article
Language: en
Open access: green
repositorio.uca.edu.ar
Licence: cc-by-nc-sa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, cc-by-nc-sa)
Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
GRO (submittedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › melanin and skin pigmentation
Physical Sciences › Environmental Science › Global and Planetary Change › Impact of Light on Environment and Health
Keywords: melatonin, pineal gland, G protein-coupled receptors, circadian rhythm, sleep regulation, peripheral oscillators, nitric oxide synthase, inflammation, excitotoxicity, metabolic syndrome, type 2 diabetes, insulin resistance, mitochondrial function, mitochondrial biogenesis, sirtuins, neuroprotection, aging
MeSH terms: Aging, Animals, Binding Sites, Circadian Rhythm, Energy Metabolism, Humans, Immune System, Melatonin, Mitochondria, Pineal Gland, Signal Transduction, Receptors, Melatonin

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Melatonin—A pleiotropic, orchestrating regulator molecule

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