Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs
Open accessAbstract
Traveling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss of appetite, reduced cognitive skills, and disruption of the sleep/wake cycle. In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity. Dysregulation of circadian rhythms and melatonin secretion represent the common underlying factor in jet lag and other circadian disorders. Recent studies have established the effectiveness of strategically timed administration of melatonin and appropriate timed exposure to environmental schedules including light in counteracting the dysregulation (chronobiologic actions). With the introduction of melatonergic agonists such as ramelteon and tasimelteon, which have both a stronger affinity for MT₁ and MT₂ melatonin receptors and a longer half-life, new therapeutic options now exist for treating the sleep disturbances associated with jet lag. The melatonin analogs are unique inasmuch as they can also enhance daytime alertness. The recently introduced melatonergic antidepressant agomelatine, which has established its supremacy over other antidepressants in having a significant chronobiologic activity, represents a good choice for treating depressive symptoms that are associated with jet lag.
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Generalizing depression by combining all types of depression results in a link between jet lag/social jet lag and depression.
“However, in common with shift work, generalizing depression (i.e., combining all types of depression) results in a link between jet lag/social jet lag and depression75–79.”
From Circadian rhythm disruption and mental health (2020) · cites this paper as [77]
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- Authors
- Srinivasan, V., Singh, J., Pandi-Perumal, S. R., Brown, G. M., Spence, D. W., & Cardinali, D. P.
- Affiliations
- Civil Aviation Authority of Singapore (SG)
- Centre for Addiction and Mental Health (CA)
- Pontificia Universidad Católica Argentina (AR)
- Corresponding author
- Cardinali, Daniel P.
- ORCID
- Venue
- Advances in Therapy
- Published
- 2010-09-06
- Volume
- 27
- Issue
- 11
- Pages
- 796-813
- ISSN
- 0741-238X (ISSN-L)
- 1865-8652
- OpenAlex
- W2025271862
- Cited by
- 129
- References
- 144
- Citations by year
- 2026: 2 · 2025: 18 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 9
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-sa
- www.springer.com/tdm (tdm)
- Locations
- Advances in Therapy (publishedVersion)
- PubMed (publishedVersion)
- Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Keywords
- jet lag, circadian rhythm sleep disorders, depression, melatonin, melatonin analogues, melatonin receptor agonists, ramelteon, tasimelteon, agomelatine, chronobiology, daytime alertness, sleep-wake cycle disruption
- MeSH terms
- Acetamides, Benzofurans, Central Nervous System Depressants, Cyclopropanes, Depressive Disorder, Humans, Indenes, Melatonin, Naphthalenes, Sleep Disorders, Circadian Rhythm, Jet Lag Syndrome
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