Cited by 129Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

Jet lag, circadian rhythm sleep disturbances, and depression: the role of melatonin and its analogs

Open access
Srinivasan, Venkatramanujam, Singh, Jarnail, Pandi-Perumal, Seithikurippu R., Brown, Gregory M., Spence, David Warren, Cardinali, Daniel P.·2010·Advances in Therapy

Abstract

Traveling through several time zones results in a constellation of symptoms known as jet lag. These include reduced alertness, daytime fatigue, loss of appetite, reduced cognitive skills, and disruption of the sleep/wake cycle. In susceptible air travel passengers, jet lag may exacerbate affective illness and result in psychiatric morbidity. Dysregulation of circadian rhythms and melatonin secretion represent the common underlying factor in jet lag and other circadian disorders. Recent studies have established the effectiveness of strategically timed administration of melatonin and appropriate timed exposure to environmental schedules including light in counteracting the dysregulation (chronobiologic actions). With the introduction of melatonergic agonists such as ramelteon and tasimelteon, which have both a stronger affinity for MT₁ and MT₂ melatonin receptors and a longer half-life, new therapeutic options now exist for treating the sleep disturbances associated with jet lag. The melatonin analogs are unique inasmuch as they can also enhance daytime alertness. The recently introduced melatonergic antidepressant agomelatine, which has established its supremacy over other antidepressants in having a significant chronobiologic activity, represents a good choice for treating depressive symptoms that are associated with jet lag.

Integrity signals

Registry

Crossref · 10.1007/s12325-010-0065-y

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144 of 144 references verified0 citation errors · 0 not checkable

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  • Generalizing depression by combining all types of depression results in a link between jet lag/social jet lag and depression.

    “However, in common with shift work, generalizing depression (i.e., combining all types of depression) results in a link between jet lag/social jet lag and depression75–79.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [77]

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Authors
Srinivasan, V., Singh, J., Pandi-Perumal, S. R., Brown, G. M., Spence, D. W., & Cardinali, D. P.
Affiliations
  • Civil Aviation Authority of Singapore (SG)
  • Centre for Addiction and Mental Health (CA)
  • Pontificia Universidad Católica Argentina (AR)
Corresponding author
Cardinali, Daniel P.
Venue
Advances in Therapy
Published
2010-09-06
Volume
27
Issue
11
Pages
796-813
ISSN
  • 0741-238X (ISSN-L)
  • 1865-8652
OpenAlex
W2025271862
Cited by
129
References
144
Citations by year
2026: 2 · 2025: 18 · 2024: 6 · 2023: 6 · 2022: 2 · 2021: 10 · 2020: 9 · 2019: 7 · 2018: 10 · 2017: 7 · 2016: 3 · 2015: 11 · 2014: 8 · 2013: 7 · 2012: 9
FWCI
0.97
Type
journal article
Language
en
Open access
Licence
Locations
  • Advances in Therapy (publishedVersion)
  • PubMed (publishedVersion)
  • Americanae (AECID Library) (submittedVersion, cc-by-nc-sa)
  • LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
jet lag, circadian rhythm sleep disorders, depression, melatonin, melatonin analogues, melatonin receptor agonists, ramelteon, tasimelteon, agomelatine, chronobiology, daytime alertness, sleep-wake cycle disruption
MeSH terms
Acetamides, Benzofurans, Central Nervous System Depressants, Cyclopropanes, Depressive Disorder, Humans, Indenes, Melatonin, Naphthalenes, Sleep Disorders, Circadian Rhythm, Jet Lag Syndrome

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