The DOI matches its Crossref record; 338 of the 338 references it cites were found in a registry or an index.
Barrel cortex function
Open accessAbstract
Neocortex, the neuronal structure at the base of the remarkable cognitive skills of mammals, is a layered sheet of neuronal tissue composed of juxtaposed and interconnected columns. A cortical column is considered the basic module of cortical processing present in all cortical areas. It is believed to contain a characteristic microcircuit composed of a few thousand neurons. The high degree of cortical segmentation into vertical columns and horizontal layers is a boon for scientific investigation because it eases the systematic dissection and functional analysis of intrinsic as well as extrinsic connections of the column. In this review we will argue that in order to understand neocortical function one needs to combine a microscopic view, elucidating the workings of the local columnar microcircuits, with a macroscopic view, which keeps track of the linkage of distant cortical modules in different behavioral contexts. We will exemplify this strategy using the model system of vibrissal touch in mice and rats. On the macroscopic level vibrissal touch is an important sense for the subterranean rodents and has been honed by evolution to serve an array of distinct behaviors. Importantly, the vibrissae are moved actively to touch - requiring intricate sensorimotor interactions. Vibrissal touch, therefore, offers ample opportunities to relate different behavioral contexts to specific interactions of distant columns. On the microscopic level, the cortical modules in primary somatosensory cortex process touch inputs at highest magnification and discreteness - each whisker is represented by its own so-called barrel column. The cellular composition, intrinsic connectivity and functional aspects of the barrel column have been studied in great detail. Building on the versatility of genetic tools available in rodents, new, highly selective and flexible cellular and molecular tools to monitor and manipulate neuronal activity have been devised. Researchers have started to combine these with advanced and highly precise behavioral methods, on par with the precision known from monkey preparations. Therefore, the vibrissal touch model system is exquisitely positioned to combine the microscopic with the macroscopic view and promises to be instrumental in our understanding of neocortical function.
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“Most information about whisker contact with objects is relayed through lemniscal pathway (8, 15, 43) (Fig. 5A).”
From Neural correlates of perceptual decision-making in the primary somatosensory cortex (2026) · cites this paper as [15]
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Citations
Cites
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“Two-photon calcium imaging in L2/3 of barrel cortex in vivo (Helmchen and Denk, 2005; Wallace et al., 2008; Grewe and Helmchen, 2009) has provided additional insights into the spatiotemporal aspects of population reponses.”
BackgroundSelf-citationInterneurons of the neocortical inhibitory system
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MethodInfluentialNEURONAL CIRCUITS OF THE NEOCORTEX
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BackgroundA resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex
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Background
Research works printed but not linked: 4
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Cited by
Sorted by citations
Sleep spindles: mechanisms and functions
Fernandez, L. M. J., & Lüthi, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2018 · Cited by 716
Membrane potential correlates of sensory perception in mouse barrel cortex
Sachidhanandam, S., Sreenivasan, V., Kyriakatos, A., Kremer, Y., & Petersen, C. C. H. (2013) · Nature Neuroscience · doi:10.1038/nn.3532 · Cited by 384
Self-citationA Cellular Resolution Map of Barrel Cortex Activity during Tactile Behavior
Peron, S., Freeman, J., Iyer, V., Guo, C., & Svoboda, K. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.027 · Cited by 334
“Tactile information from individual whiskers is processed in single barrel columns in vS1 (Feldmeyer et al., 2013; Simons, 1978).”
Excitatory neuronal connectivity in the barrel cortex
Feldmeyer, D. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00024 · Cited by 298
Self-citationLuhmann, H. J., Sinning, A., Yang, J., Reyes‐Puerta, V., Stüttgen, M. C., Kirischuk, S., & Kilb, W. (2016) · Frontiers in Neural Circuits · doi:10.3389/fncir.2016.00040 · Cited by 288
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Metadata
- Authors
- Feldmeyer, D., Brecht, M., Helmchen, F., Petersen, C. C. H., Poulet, J. F. A., Staiger, J. F., Luhmann, H. J., & Schwarz, C.
- Affiliations
- Forschungszentrum Jülich (DE)
- Humboldt-Universität zu Berlin (DE)
- University of Zurich (CH)
- École Polytechnique Fédérale de Lausanne (CH)
- Max Delbrück Center (DE)
- University of Göttingen (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Corresponding author
- Schwarz, Cornelius
- ORCID
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 103
- Pages
- 3-27
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2119610099
- Cited by
- 354
- References
- 338
- Citations by year
- 2026: 15 · 2025: 22 · 2024: 14 · 2023: 15 · 2022: 18 · 2021: 31 · 2020: 31 · 2019: 35 · 2018: 26 · 2017: 37 · 2016: 32 · 2015: 32 · 2014: 29 · 2013: 16
- FWCI
- 1.98
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in Neurobiology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (acceptedVersion, other-oa)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- GRO (submittedVersion, cc-by-nc-nd)
- RWTH Publications (RWTH Aachen) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- Swiss National Science Foundation (SNSF)
- Deutsche Forschungsgemeinschaft (FOR 1341)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- barrel cortex, barrel columns, neocortex, whisker representation, primary somatosensory cortex, cortical microcircuits, sensorimotor integration, genetic instruments, rodent behavior, cortical connectivity
- MeSH terms
- Afferent Pathways, Animals, Somatosensory Cortex, Vibrissae, Neocortex, Mice, Rats, Touch Perception
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