Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.

Lübke, Joachim; Feldmeyer, Dirk

doi:10.1007/s00429-007-0144-2

Cited by 233Neural dynamics and brain functionNeuroscience and Neuropharmacology ResearchVisual perception and processing mechanisms

Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.

Lübke, Joachim, Feldmeyer, Dirk·2007·Brain Structure and Function

DOI 10.1007/s00429-007-0144-2

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Abstract

A basic feature of the neocortex is its organization in functional, vertically oriented columns, recurring modules of signal processing and a system of transcolumnar long-range horizontal connections. These columns, together with their network of neurons, present in all sensory cortices, are the cellular substrate for sensory perception in the brain. Cortical columns contain thousands of neurons and span all cortical layers. They receive input from other cortical areas and subcortical brain regions and in turn their neurons provide output to various areas of the brain. The modular concept presumes that the neuronal network in a cortical column performs basic signal transformations, which are then integrated with the activity in other networks and more extended brain areas. To understand how sensory signals from the periphery are transformed into electrical activity in the neocortex it is essential to elucidate the spatial-temporal dynamics of cortical signal processing and the underlying neuronal 'microcircuits'. In the last decade the 'barrel' field in the rodent somatosensory cortex, which processes sensory information arriving from the mysticial vibrissae, has become a quite attractive model system because here the columnar structure is clearly visible. In the neocortex and in particular the barrel cortex, numerous neuronal connections within or between cortical layers have been studied both at the functional and structural level. Besides similarities, clear differences with respect to both physiology and morphology of synaptic transmission and connectivity were found. It is therefore necessary to investigate each neuronal connection individually, in order to develop a realistic model of neuronal connectivity and organization of a cortical column. This review attempts to summarize recent advances in the study of individual microcircuits and their functional relevance within the framework of a cortical column, with emphasis on excitatory signal flow.

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L4 spiny neurons in the barrel cortex of the mouse are characterized by mainly vertically-oriented, predominantly intra-columnar, axons that target layer 2/3 pyramidal cells.
“For example, L4 spiny neurons in the barrel cortex of the mouse are characterized by mainly vertically-oriented, predominantly intra-columnar, axons that target layer 2/3 pyramidal cells [46].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [46]
Projections from layer 3 to layer 5 are confined to the same column.
“The projections from layer 3 to layer 5 are confined to the same column [46].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [46]
Layer 2/3 pyramidal cell axons have two distinct projection fields: one horizontal (long range axon collaterals) and one vertical.
“It is known that layer 2/3 pyramidal cell axons have two distinct projection fields: one horizontal (the long range axon collaterals), and one vertical [46].”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [46]

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Morphological, Electrophysiological, and Synaptic Properties of Corticocallosal Pyramidal Cells in the Neonatal Rat Neocortex
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Cortical damping: analysis of thalamocortical response transformations in rodent barrel cortex
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Differential synaptic processing separates stationary from transient inputs to the auditory cortex
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Excitatory Connections Made by Presynaptic Cortico-Cortical Pyramidal Cells in Layer 6 of the Neocortex
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Optical probing of neuronal circuits with calcium indicators
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Modulation of synaptic transmission in neocortex by network activities
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Diversity in the Neuronal Machine: Order and Variability in Interneuronal Microcircuits
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Transmitter release modulation in nerve terminals of rat neocortical pyramidal cells by intracellular calcium buffers
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Intracortical Excitation of Spiny Neurons in Layer 4 of Cat Striate Cortex In Vitro
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Organization and significance of neurons that detect change of visual depth in the hawk moth Manduca sexta
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Somatosensory Thalamus of the Rat
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The Barrel Cortex of Rodents
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Synapses on axon collaterals of pyramidal cells are spaced at random intervals: a Golgi study in the mouse cerebral cortex
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Diversity in the Neuronal Machine
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“…neuron specificity (Beierlein et al. 2003; Koester and Johnston 2005; Kozloski et al. 2001; Markram et al. 1998; Reyes et al. 1998) as earlier described for interneurons in neocortex and hippocampus (reviewed by Freund and Buzsáki 1996; Somogyi et al. 1998; Markram et al. 2004; Soltesz 2006).”
BackgroundMethod
Developmental Synaptic Changes Increase the Range of Integrative Capabilities of an Identified Excitatory Neocortical Connection
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Dendroarchitecture of Relay Cells in Thalamic Barreloids: A Substrate for Cross-Whisker Modulation
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Short-Term Dynamics of Synaptic Transmission Within the Excitatory Neuronal Network of Rat Layer 4 Barrel Cortex
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Controlling Synaptic Input Patterns In Vitro by Dynamic Photo Stimulation
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Corticofugal axons from adjacent ‘barrel’ columns of rat somatosensory cortex: cortical and thalamic terminal patterns
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Circuitry of rat barrel cortex investigated by infrared-guided laser stimulation
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Reverse optical probing (ROPING) of neocortical circuits
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Neuroanatomy of autism
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The Functional Organization of the Barrel Cortex
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Synaptic mechanisms for plasticity in neocortex
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Long-Range Neuronal Circuits Underlying the Interaction between Sensory and Motor Cortex
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Seeking a unified framework for cerebellar function and dysfunction: from circuit operations to cognition
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Towards a mathematical theory of cortical micro-circuits
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Effects and Mechanisms of Wakefulness on Local Cortical Networks
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Regulation of spike timing in visual cortical circuits
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Synaptic Integration Gradients in Single Cortical Pyramidal Cell Dendrites
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Top-down laminar organization of the excitatory network in motor cortex
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Long‐range connectivity of mouse primary somatosensory barrel cortex
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Cell Type–Specific Three-Dimensional Structure of Thalamocortical Circuits in a Column of Rat Vibrissal Cortex
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Excitatory neuronal connectivity in the barrel cortex
Feldmeyer, D. (2012) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2012.00024 · Cited by 298 · see citing works
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Dimensions of a projection column and architecture of VPM and POm axons in rat vibrissal cortex
Wimmer, V. C., Bruno, R. M., de Kock, C. P. J., Kuner, T., & Sakmann, B. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq068 · Cited by 263 · see citing works
Synaptic Mechanisms Underlying Sparse Coding of Active Touch
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Anatomical Pathways Involved in Generating and Sensing Rhythmic Whisker Movements
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Microcircuits of excitatory and inhibitory neurons in layer 2/3 of mouse barrel cortex
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Spatial Organization of Neurons in the Frontal Pole Sets Humans Apart from Great Apes
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Anatomy and physiology of the thick-tufted layer 5 pyramidal neuron
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Linking macroscale graph analytical organization to microscale neuroarchitectonics in the macaque connectome
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Neuronal Basis for Object Location in the Vibrissa Scanning Sensorimotor System
Kleinfeld, D., & Deschênes, M. (2011) · Neuron · doi:10.1016/j.neuron.2011.10.009 · Cited by 153 · see citing works
Two calretinin-positive GABAergic cell types in layer 2/3 of the mouse neocortex provide different forms of inhibition
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Specificity of synaptic connectivity between layer 1 inhibitory interneurons and layer 2/3 pyramidal neurons in the rat neocortex
Wozny, C., & Williams, S. R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq257 · Cited by 129 · see citing works
Inhibitory Interneurons and their Circuit Motifs in the Many Layers of the Barrel Cortex
Feldmeyer, D., Qi, G., Emmenegger, V., & Staiger, J. F. (2017) · Neuroscience · doi:10.1016/j.neuroscience.2017.05.027 · Cited by 134 · see citing works
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Long-term channelrhodopsin-2 (ChR2) expression can induce abnormal axonal morphology and targeting in cerebral cortex
Miyashita, T., Shao, Y. R., Chung, J. E., Pourzia, O., & Feldman, D. E. (2013) · Frontiers in Neural Circuits · doi:10.3389/fncir.2013.00008 · Cited by 117 · see citing works
Beyond the cortical column: abundance and physiology of horizontal connections imply a strong role for inputs from the surround
Boucsein, C. (2011) · Frontiers in Neuroscience · doi:10.3389/fnins.2011.00032 · Cited by 117 · see citing works
The role of monoamine oxidase A in aggression: Current translational developments and future challenges
Godar, S. C., Fite, P. J., McFarlin, K. M., & Bortolato, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2016.01.001 · Cited by 113 · see citing works
Traumatic Brain Injury and Neuronal Functionality Changes in Sensory Cortex
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Efficient Recruitment of Layer 2/3 Interneurons by Layer 4 Input in Single Columns of Rat Somatosensory Cortex
Helmstaedter, M. N., Staiger, J. F., Sakmann, B. J., & Feldmeyer, D. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5701-07.2008 · Cited by 109 · see citing works
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Early transformations in odor representation
Cleland, T. A. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2009.12.004 · Cited by 106 · see citing works
A comparative quantitative analysis of cytoarchitecture and minicolumnar organization in Broca's area in humans and great apes
Schenker, N., Buxhoeveden, D., Blackmon, W., Amunts, K., Zilles, K., & Semendeferi, K. (2008) · The Journal of comparative neurology · doi:10.1002/cne.21792 · Cited by 100 · see citing works
In vivo two-photon voltage-sensitive dye imaging reveals top-down control of cortical layers 1 and 2 during wakefulness
Kühn, B., Denk, W. T., & Bruno, R. M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802462105 · Cited by 102 · see citing works
The NMDA receptor co-agonists, d-serine and glycine, regulate neuronal dendritic architecture in the somatosensory cortex
Balu, D. T., Basu, A. C., Corradi, J., Cacace, A. M., & Coyle, J. T. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.10.006 · Cited by 99 · see citing works
Cortical Inhibitory Cell Types Differentially Form Intralaminar and Interlaminar Subnetworks withExcitatory Neurons
Otsuka, T., & Kawaguchi, Y. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2219-09.2009 · Cited by 99 · see citing works
Determinants of regional and local diversity within the astroglial lineage of the normal central nervous system
Hewett, J. A. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06288.x · Cited by 94 · see citing works
Sequential Changes in AMPA Receptor Targeting in the Developing Neocortical Excitatory Circuit
Brill, J., & Huguenard, J. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3229-08.2008 · Cited by 89 · see citing works
Spatial ICA reveals functional activity hidden from traditional fMRI GLM-based analyses
Xu, J., Potenza, M. N., & Calhoun, V. D. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00154 · Cited by 90 · see citing works
Late Emergence of the Vibrissa Direction Selectivity Map in the Rat Barrel Cortex
Kremer, Y., Léger, J., Goodman, D. F. M., Brette, R., & Bourdieu, L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6541-10.2011 · Cited by 88 · see citing works
Firing-Pattern-Dependent Specificity of Cortical Excitatory Feed-Forward Subnetworks
Otsuka, T., & Kawaguchi, Y. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1921-08.2008 · Cited by 86 · see citing works
Pathophysiology of absence epilepsy: Insights from genetic models
Depaulis, A., & Charpier, S. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.02.035 · Cited by 86 · see citing works
Structure of a Single Whisker Representation in Layer 2 of Mouse Somatosensory Cortex
Clancy, K. B., Schnepel, P., Rao, A. T., & Feldman, D. E. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3887-14.2015 · Cited by 82 · see citing works
Postnatal development of synaptic transmission in local networks of L5A pyramidal neurons in rat somatosensory cortex
Frick, A., Feldmeyer, D., & Sakmann, B. J. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.141788 · Cited by 76 · see citing works
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Distinct roles of parvalbumin and somatostatin interneurons in gating the synchronization of spike times in the neocortex
Jang, H. J., Chung, H., Rowland, J. M., Richards, B. A., Kohl, M. M., & Kwag, J. (2020) · Science Advances · doi:10.1126/sciadv.aay5333 · Cited by 71 · see citing works
Impact of Altered Cholinergic Tones on the Neurovascular Coupling Response to Whisker Stimulation
Lecrux, C., Sandoe, C. H., Neupane, S., Kropf, P., Toussay, X., Tong, X., Lacalle‐Aurioles, M., Shmuel, A., & Hamel, É. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1784-16.2016 · Cited by 75 · see citing works
Cell Diversity and Connection Specificity between Callosal Projection Neurons in the Frontal Cortex
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Task-related concurrent but opposite modulations of overlapping functional networks as revealed by spatial ICA
Xu, J., Zhang, S., Calhoun, V. D., Monterosso, J. R., Li, C.-S. R., Worhunsky, P. D., Stevens, M. C. G., Pearlson, G. D., & Potenza, M. N. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.04.038 · Cited by 71 · see citing works
Towards a “canonical” agranular cortical microcircuit
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Analysis of Excitatory Microcircuitry in the Medial Entorhinal Cortex Reveals Cell-Type-Specific Differences
Beed, P. S., Bendels, M. H. K., Wiegand, H. F., Leibold, C., Johenning, F. W., & Schmitz, D. (2010) · Neuron · doi:10.1016/j.neuron.2010.12.009 · Cited by 69 · see citing works
Optogenetic-guided cortical plasticity after nerve injury
Li, N., Downey, J. E., Bar‐Shir, A., Gilad, A. A., Walczak, P., Kim, H., Joel, S. E., Pekar, J. J., Thakor, N. V., & Pelled, G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100815108 · Cited by 65 · see citing works
Spike-Timing-Dependent Potentiation of Sensory Surround in the Somatosensory Cortex Is Facilitated by Deprivation-Mediated Disinhibition
Gambino, F., & Holtmaat, A. J. D. G. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.020 · Cited by 63 · see citing works
Light Up the Brain: The Application of Optogenetics in Cell-Type Specific Dissection of Mouse Brain Circuits
Lee, C., Lavoie, A., Liu, J., Chen, S. X., & Liu, B. (2020) · Frontiers in Neural Circuits · doi:10.3389/fncir.2020.00018 · Cited by 67 · see citing works
Combination of High-density Microelectrode Array and Patch Clamp Recordings to Enable Studies of Multisynaptic Integration
Jäckel, D., Bakkum, D. J., Russell, T. L., Müller, J., Radivojević, M., Frey, U., Franke, F., & Hierlemann, A. R. (2017) · Scientific Reports · doi:10.1038/s41598-017-00981-4 · Cited by 62 · see citing works
Developmental alterations in the functional properties of excitatory neocortical synapses
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Spatiotemporal properties of sensory responses in vivo are strongly dependent on network context
Civillico, E. F., & Contreras, D. (2012) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2012.00025 · Cited by 56 · see citing works
A cortical sparse distributed coding model linking mini- and macrocolumn-scale functionality
Rinkus, G. J. (2010) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2010.00017 · Cited by 55 · see citing works
Local circuits targeting parvalbumin-containing interneurons in layer IV of rat barrel cortex
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Quantitative Architectural Analysis: A New Approach to Cortical Mapping
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Ultra high-resolution fMRI and electrophysiology of the rat primary somatosensory cortex
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Ultrastructural heterogeneity of layer 4 excitatory synaptic boutons in the adult human temporal lobe neocortex
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Authors: Lübke, J., & Feldmeyer, D.
Affiliations: Forschungszentrum Jülich (DE)
Corresponding author: Feldmeyer, Dirk
ORCID: Lübke, Joachim
Feldmeyer, Dirk
Venue: Brain Structure and Function
Publisher: Springer Science and Business Media LLC
Published: 2007-06-01
Volume: 212
Issue: 1
Pages: 3-17
ISSN: 1863-2653 (ISSN-L)
1863-2661
DOI: 10.1007/s00429-007-0144-2
OpenAlex: W1990931283
Cited by: 233
References: 129
Citations by year: 2026: 4 · 2025: 9 · 2024: 11 · 2023: 4 · 2022: 13 · 2021: 9 · 2020: 9 · 2019: 11 · 2018: 9 · 2017: 14 · 2016: 8 · 2015: 16 · 2014: 15 · 2013: 19 · 2012: 15
FWCI: 1.06
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Brain Structure and Function (publishedVersion)
PubMed (publishedVersion)
JuSER (Forschungszentrum Jülich) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Keywords: barrel cortex, cortical columns, neuronal connectivity, microcircuits, somatosensory cortex, synaptic transmission, horizontal connections, sensory signal processing
MeSH terms: Afferent Pathways, Animals, Humans, Nerve Net, Neural Pathways, Synaptic Transmission, Neurons, Afferent, Sensory Receptor Cells, Somatosensory Cortex, Pyramidal Cells, Ventral Thalamic Nuclei

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Excitatory signal flow and connectivity in a cortical column: focus on barrel cortex.

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