The DOI matches its Crossref record; 217 of the 218 references it cites were found in a registry or an index.
Stress-induced hyperalgesia
Open accessAbstract
The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding under experimental conditions and exacerbate clinical pain disorders. There is evidence that exposure to chronic or repeated stress can produce maladaptive neurobiological changes in pathways associated with pain processing, resulting in stress-induced hyperalgesia (SIH). Preclinical studies of SIH are essential for our understanding of the mechanisms underpinning stress-related pain syndromes and for the identification of neural pathways and substrates, and the development of novel therapeutic agents for their clinical management. In this review, we describe clinical and pre-clinical models used to study SIH and discuss the neural substrates, neurotransmitters and neuromodulatory systems involved in this phenomenon.
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“However, dysregulation of allostatic systems can manifest as either hypo- or hyper- responsiveness to stress later in life,(14–16) with consequent impairment in endogenous pain regulation.(17–19)”
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A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins
François, A., Low, S. A., Sypek, E. I., Christensen, A. J., Sotoudeh, C., Beier, K. T., Ramakrishnan, C., Ritola, K., Sharif‐Naeini, R., Deisseroth, K. A., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.01.008 · Cited by 368
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Metadata
- Authors
- Jennings, E. M., Okine, B. N., Roche, M., & Finn, D. P.
- Affiliations
- Ollscoil na Gaillimhe – University of Galway (IE)
- Corresponding author
- Finn, David P.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2014-10
- Volume
- 121
- Pages
- 1-18
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W2035912882
- Cited by
- 318
- References
- 218
- Citations by year
- 2026: 25 · 2025: 25 · 2024: 35 · 2023: 26 · 2022: 29 · 2021: 21 · 2020: 26 · 2019: 21 · 2018: 17 · 2017: 40 · 2016: 31 · 2015: 19 · 2014: 1
- FWCI
- 3.55
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Progress in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- University of Galway Research Repository (submittedVersion, cc-by)
- Funders
- Science Foundation Ireland (10/IN.1/B2976)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- stress-induced hyperalgesia, chronic stress, anxiety, pain modulation, emotional pain, pain processing, neural correlates, neurotransmitters, neuromodulatory systems, preclinical models, clinical model
- MeSH terms
- Animals, Brain, Humans, Hyperalgesia, Pain, Spinal Cord, Stress, Psychological
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