Cited by 318Pain Mechanisms and TreatmentsStress Responses and CortisolPain Management and Treatment

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Stress-induced hyperalgesia

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Jennings, Elaine M., Okine, Bright N., Roche, Michelle, Finn, David P.·2014·Progress in Neurobiology

DOI 10.1016/j.pneurobio.2014.06.003

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Abstract

The importance of the modulation of pain by emotion is now widely recognised. In particular, stress and anxiety, depending on their nature, duration and intensity, can exert potent, but complex, modulatory influences typified by either a reduction or exacerbation of the pain state. Exposure to either acute or chronic stress can increase pain responding under experimental conditions and exacerbate clinical pain disorders. There is evidence that exposure to chronic or repeated stress can produce maladaptive neurobiological changes in pathways associated with pain processing, resulting in stress-induced hyperalgesia (SIH). Preclinical studies of SIH are essential for our understanding of the mechanisms underpinning stress-related pain syndromes and for the identification of neural pathways and substrates, and the development of novel therapeutic agents for their clinical management. In this review, we describe clinical and pre-clinical models used to study SIH and discuss the neural substrates, neurotransmitters and neuromodulatory systems involved in this phenomenon.

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Authors: Jennings, E. M., Okine, B. N., Roche, M., & Finn, D. P.
Affiliations: Ollscoil na Gaillimhe – University of Galway (IE)
Corresponding author: Finn, David P.
ORCID: Okine, Bright N.
Roche, Michelle
Finn, David P.
Venue: Progress in Neurobiology
Publisher: Elsevier BV
Published: 2014-10
Volume: 121
Pages: 1-18
ISSN: 0301-0082 (ISSN-L)
DOI: 10.1016/j.pneurobio.2014.06.003
OpenAlex: W2035912882
Cited by: 318
References: 218
Citations by year: 2026: 25 · 2025: 25 · 2024: 35 · 2023: 26 · 2022: 29 · 2021: 21 · 2020: 26 · 2019: 21 · 2018: 17 · 2017: 40 · 2016: 31 · 2015: 19 · 2014: 1
FWCI: 3.55
Type: journal article
Language: en
Open access: green
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Progress in Neurobiology (publishedVersion)
PubMed (publishedVersion)
ARAN (University of Galway Research Repository) (Ollscoil na Gaillimhe – University of Galway) (acceptedVersion, cc-by-nc-nd)
Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
University of Galway Research Repository (submittedVersion, cc-by)
Funders: Science Foundation Ireland (10/IN.1/B2976)
Topics: Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords: stress-induced hyperalgesia, chronic stress, anxiety, pain modulation, emotional pain, pain processing, neural correlates, neurotransmitters, neuromodulatory systems, preclinical models, clinical model
MeSH terms: Animals, Brain, Humans, Hyperalgesia, Pain, Spinal Cord, Stress, Psychological

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