The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke
Open accessAbstract
Astrocytes are the most abundant cell type within the central nervous system. They play essential roles in maintaining normal brain function, as they are a critical structural and functional part of the tripartite synapses and the neurovascular unit, and communicate with neurons, oligodendrocytes and endothelial cells. After an ischemic stroke, astrocytes perform multiple functions both detrimental and beneficial, for neuronal survival during the acute phase. Aspects of the astrocytic inflammatory response to stroke may aggravate the ischemic lesion, but astrocytes also provide benefit for neuroprotection, by limiting lesion extension via anti-excitotoxicity effects and releasing neurotrophins. Similarly, during the late recovery phase after stroke, the glial scar may obstruct axonal regeneration and subsequently reduce the functional outcome; however, astrocytes also contribute to angiogenesis, neurogenesis, synaptogenesis, and axonal remodeling, and thereby promote neurological recovery. Thus, the pivotal involvement of astrocytes in normal brain function and responses to an ischemic lesion designates them as excellent therapeutic targets to improve functional outcome following stroke. In this review, we will focus on functions of astrocytes and astrocyte-mediated events during stroke and recovery. We will provide an overview of approaches on how to reduce the detrimental effects and amplify the beneficial effects of astrocytes on neuroprotection and on neurorestoration post stroke, which may lead to novel and clinically relevant therapies for stroke.
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Citations
Cites
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Cited by
Reactive astrocytes in neurodegenerative diseases
Li, K., Li, J., Zheng, J., & Qin, S. (2019) · Aging and disease · doi:10.14336/ad.2018.0720 · Cited by 398
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Depletion of microglia exacerbates postischemic inflammation and brain injury
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“Depending on the stage of brain pathology, astrocytes may acquire anti-inflammatory properties such as scar formation and restriction of inflammation by producing TGF-b.(28,29) Evidence suggests that inhibition of astrocyte activity or function correlates with decreased infarct size.”
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Capone, F., Salati, S., Vincenzi, F., Liberti, M., Aicardi, G., Apollonio, F., Varani, K., Cadossi, R., & Di Lazzaro, V. (2022) · Neuromodulation: Technology at the Neural Interface · doi:10.1111/ner.13489 · Cited by 28
Metadata
- Authors
- Liu, Z., & Chopp, M.
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 144
- Pages
- 103-120
- ISSN
- 0301-0082 (ISSN-L)
- OpenAlex
- W1911185606
- Cited by
- 590
- References
- 55
- FWCI
- 13.26
- Type
- journal article
- Language
- en
- Open access
- green
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