Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models
Open accessAbstract
Both astrocytes and microglia fulfil homeostatic and immune functions in the healthy CNS. Dysfunction of these cell types have been implicated in the pathomechanisms of several neurodegenerative diseases. Understanding the cellular autonomy and early pathological changes in these cell types may inform drug screening and therapy development. While animal models and post-mortem tissue have been invaluable in understanding disease processes, the advent of human in vitro models provides a unique insight into disease biology as a manipulable model system obtained directly from patients. Here, we discuss the different human in vitro models of astrocytes and microglia and outline the phenotypes that have been recapitulated in these systems.
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Astrocyte and microglia iPSC models partially recapitulate the transcriptomes of their in vivo counterparts and may capture authentic neurodegenerative disease phenotypes.
“Astrocyte and microglia iPSC models partially recapitulate the transcriptomes of their in vivo counterparts and may capture authentic neurodegenerative disease phenotypes [345,406,480,481,482,483,484].”
From Revisiting the Pathogenesis of X-Linked Adrenoleukodystrophy (2025) · cites this paper as [480]
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- Authors
- Franklin, H., Clarke, B. E., & Patani, R.
- Affiliations
- The Francis Crick Institute (GB)
- Corresponding author
- Patani, Rickie
- Venue
- Progress in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2021-05
- Volume
- 200
- Pages
- 101973
- ISSN
- 0301-0082 (ISSN-L)
- PMC
- PMC8052192
- OpenAlex
- W3112409504
- Cited by
- 66
- References
- 41
- Citations by year
- 2026: 10 · 2025: 16 · 2024: 12 · 2023: 10 · 2022: 11 · 2021: 7
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Progress in Neurobiology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- astrocytes, microglia, neurodegenerative diseases, human in vitro models, disease modeling, astrocyte dysfunction, microglial dysfunction, CNS homeostasis, drug screening, disease phenotypes
- MeSH terms
- Animals, Astrocytes, Humans, Microglia, Neurodegenerative Diseases
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