The promise and limitations of anti-inflammatory agents for the treatment of Major Depressive Disorder
Abstract
This review provides a critical perspective on recent meta-analyses suggesting that several anti-inflammatory modalities, including nonsteroidal anti-inflammatory drugs (NSAIDs), omega-3 fatty acids, and cytokine antagonist, possess generalizable antidepressant properties. By examining confounds and limitations in the available literature it is suggested that current data suggest that only a sub-group of individuals with major depressive disorder (MDD) have evidence of increased inflammatory biomarkers and it is in these individuals that anti-inflammatory agents show promise for reducing depressive symptoms. The treatment implications of this cautionary perspective are discussed.
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Targeting inflammatory pathways may benefit only a subset of depressed patients.
“and targeting inflammatory pathways may only benefit a subset of depressed patients (Raison, 2017).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Raison, 2017
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- Authors
- Raison, C. L.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Raison, Charles L.
- ORCID
- Raison, Charles L.
- Venue
- Current Topics in Behavioral Neurosciences
- Publisher
- Springer International Publishing
- Published
- 2016
- Volume
- 31
- Pages
- 287-302
- ISSN
- 1866-3370 (ISSN-L)
- 1866-3389
- OpenAlex
- W2417371332
- Cited by
- 36
- References
- 51
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 5
- FWCI
- 1.17
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Current topics in behavioral neurosciences (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- major depressive disorder, anti-inflammatory agents, nonsteroidal anti-inflammatory drugs, omega-3 fatty acids, cytokine antagonists, inflammatory markers, antidepressant effects, meta-analysis limitations
- MeSH terms
- Anti-Inflammatory Agents, Non-Steroidal, Depressive Disorder, Major, Major Depressive Disorder, Humans, Inflammation, Fatty Acids, Omega-3, Cytokines
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