Cited by 36Tryptophan and brain disordersTreatment of Major DepressionStress Responses and Cortisol

The promise and limitations of anti-inflammatory agents for the treatment of Major Depressive Disorder

Raison, Charles L.·2016·Current Topics in Behavioral Neurosciences

Abstract

This review provides a critical perspective on recent meta-analyses suggesting that several anti-inflammatory modalities, including nonsteroidal anti-inflammatory drugs (NSAIDs), omega-3 fatty acids, and cytokine antagonist, possess generalizable antidepressant properties. By examining confounds and limitations in the available literature it is suggested that current data suggest that only a sub-group of individuals with major depressive disorder (MDD) have evidence of increased inflammatory biomarkers and it is in these individuals that anti-inflammatory agents show promise for reducing depressive symptoms. The treatment implications of this cautionary perspective are discussed.

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Crossref · 10.1007/7854_2016_26

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Authors
Raison, C. L.
Affiliations
University of Wisconsin–Madison (US)
Corresponding author
Raison, Charles L.
Venue
Current Topics in Behavioral Neurosciences
Published
2016
Volume
31
Pages
287-302
ISSN
  • 1866-3370 (ISSN-L)
  • 1866-3389
OpenAlex
W2417371332
Cited by
36
References
51
Citations by year
2026: 2 · 2025: 3 · 2024: 4 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 6 · 2018: 5 · 2017: 5
FWCI
1.17
Type
book chapter
Language
en
Open access
closed
Locations
  • Current topics in behavioral neurosciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
major depressive disorder, anti-inflammatory agents, nonsteroidal anti-inflammatory drugs, omega-3 fatty acids, cytokine antagonists, inflammatory markers, antidepressant effects, meta-analysis limitations
MeSH terms
Anti-Inflammatory Agents, Non-Steroidal, Depressive Disorder, Major, Major Depressive Disorder, Humans, Inflammation, Fatty Acids, Omega-3, Cytokines

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