Effects of childhood trauma on HPA-axis reactivity in women free of lifetime psychopathology
Abstract
Exposure to childhood trauma may induce persistent changes in Hypothalamic-Pituitary-Adrenal (HPA)-axis functioning even in the absence of current psychopathology. Because previous studies did not systematically exclude subjects with lifetime psychiatric morbidity, prevalent psychopathology may have confounded the association. In this study we investigated whether women exposed to childhood trauma, but without a history of psychiatric disorders, show alterations in HPA-axis functioning. We included 10 women exposed to significant childhood trauma and 12 non-exposed women. All women were between 29 and 64 years old,mentally and physically healthy, and without current or lifetime psychopathology. HPA-axis functioning was assessed as 1) basal activity with salivary cortisol patterns over 8 time points on two consecutive sampling days and 2) plasma cortisol and adrenocorticotropic hormone (ACTH) reactivity over 7 time points after the combined dexamethasone/corticotropin-releasing hormone (dex/CRH) challenge test. Basal salivary cortisol output did not differ between trauma-exposed compared to non-exposed women. Significantly blunted plasma cortisol and ACTH responses in response to dex/CRH administration were found in the trauma exposed compared to the non-exposed women (F(1,20)=5.08, p=0.04 and F(1,20)=5.23, p=0.03 respectively). Adjusting for age, body mass index (BMI), oral contraceptive use, and menopausal status,somewhat weakened the associations for cortisol as well as ACT…
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The relationship between quality of early social environment and adult health appears partly mediated by development of individual differences in neural systems underlying behavioral and endocrine stress responses.
“The relationship between the quality of the early social environment and health in adulthood appears to be, in part, mediated by the development of individual differences in neural systems that underlie the expression of behavioral and endocrine responses to stress.26-30”
From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [29]
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“…associated with a two-to three-fold greater risk for depression [33] and a steeper CAR in both depressed and non-depressed samples [15,31,34] (though see Meinlschmidt & Heim [35] for evidence of an association between childhood adversity and a blunted CAR or Klaassens et al. [36] for null results).”
Brain Mineralocorticoid Receptors and Resilience to Stress.
Kanatsou, S., Joëls, M., & Krugers, H. (2019) · Vitamins and hormones · doi:10.1016/bs.vh.2018.11.001 · Cited by 7 · see citing works
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Barroca, N. C. B., Baes, C. W., Martins-Monteverde, C. M. S., Bosaipo, N. B., Umeoka, M. S. D. S., Tejada, J., Antunes-Rodrigues, J., de Castro, M., Juruena, M. F., Garcia-Cairasco, N., et al. (2020) · eNeuro · doi:10.1523/eneuro.0222-20.2020 · Cited by 4 · see citing works
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HPA axis dysfunction in women with premenstrual syndrome: A meta-analysis based on cortisol levels
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Traumatogenic Disturbances: PTSD, Complex PTSD and Trauma-Related Disorders
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The Epigenetics of Parental Effects
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Current awareness in human psychopharmacology
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Xia, S.-P. (2024) · Advances in Psychology · doi:10.12677/ap.2024.144190
Epigenetics of major depressive disorder
Braun, P., & Potash, J. (2021) · Epigenetics in Psychiatry · doi:10.1016/b978-0-12-823577-5.00002-7
Neuville, V., Terradas, M. M., Puentes-Neuman, G., Guillemette, R., & Grenier, C. (2020) · Revue québécoise de psychologie · doi:10.7202/1075467ar
EXAMINATION OF BASAL NEUROENDOCRINE LEVELS IN OIF/OEF/OND VETERANS
Hawn, S. E. (2015) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/6w94-6153
“…alterations following trauma irrespective of psychopathological diagnosis (De Kloet et al., 2007; Klaassens, Giltay, van Veen, Veen, & Zitman, 2010; Klaassens et al., 2009; Klaassens, van Veen, et al., 2010), whereas other studies have demonstrated changes in HPA functioning following trauma in…”
Result
- Authors
- Klaassens, E. R., van Noorden, M. S., Giltay, E. J., van Pelt, J., van Veen, T., & Zitman, F. G.
- Affiliations
- Leiden University Medical Center (NL)
- Corresponding author
- Klaassens, Ellen R.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 33
- Issue
- 5
- Pages
- 889-894
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2038427763
- Cited by
- 101
- References
- 0
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 7 · 2018: 10 · 2017: 8 · 2016: 7 · 2015: 9 · 2014: 9 · 2013: 9 · 2012: 8
- FWCI
- 2.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- childhood trauma, HPA axis reactivity, hypothalamic-pituitary-adrenal axis, cortisol, ACTH, salivary cortisol, women, menopause, oral contraceptive use
- MeSH terms
- Adult, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Middle Aged, Pituitary-Adrenal System, Psychopathology, Saliva, Biomarkers, Adult Survivors of Child Abuse
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