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Cited by 279Stress Responses and CortisolChild Abuse and TraumaPersonality Disorders and Psychopathology

Hyperresponsiveness of hypothalamic-pituitary-adrenal axis to combined dexamethasone/corticotropin-releasing hormone challenge in female borderline personality disorder subjects with a history of sustained childhood abuse

Rinne, Thomas, de Kloet, E.Ronald, Wouters, Luuk, Goekoop, Jaap G, DeRijk, Roel H, van den Brink, Wim·2002·Biological Psychiatry
DOI 10.1016/s0006-3223(02)01395-1
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Abstract

Background High coincidence of childhood abuse, major depressive disorder (MDD), and posttraumatic stress disorder (PTSD) has been reported in patients with borderline personality disorder (BPD). Animals exposed to early trauma show increased stress-induced hypothalamic-pituitary-adrenal (HPA) axis activity due to an enhanced corticotropin-releasing hormone (CRH) drive and glucocorticoid feedback resistance. In humans, PTSD and MDD are associated with decreased and increased resistance to glucocorticoid feedback, respectively, which might reflect persistent changes in neuroendocrine sequelae following childhood abuse. Methods We investigated the relationship between childhood abuse and HPA axis function using a combined dexamethasone/CRH (DEX/CRH) test in 39 BPD patients with (n = 24) and without (n = 15) sustained childhood abuse and comorbid PTSD (n = 12) or MDD (n = 11) and 11 healthy control subjects. Results Chronically abused BPD patients had a significantly enhanced corticotropin (ACTH) and cortisol response to the DEX/CRH challenge compared with nonabused subjects. Comorbid PTSD significantly attenuated the ACTH response. Conclusions Hyperresponsiveness of the HPA axis in chronically abused BPD subjects might be due to the enhanced central drive to pituitary ACTH release. Sustained childhood abuse rather than BPD, MDD, or PTSD pathology accounts for this effect. Possibly due to an enhanced efficacy of HPA suppression by dexamethasone, PTSD attenuates the ACTH response…

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  • High CRF may arise from GR downregulation and impaired negative feedback inhibition, as childhood abuse and parental loss are associated with higher cortisol response to the DEX/CRH challenge test in adults with and without depression.

    “High CRF may arise due to GR downregulation and impaired negative feedback inhibition, as evidenced by the finding that childhood abuse58,62 and parental loss63 are associated with higher Cortisol response to the dcxamethasone (DEX)/corticotropin-releasing hormone (CRH) challenge test in adults with and without depression.”

    From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [62]

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Authors
Rinne, T., de Kloet, E. R., Wouters, L., Goekoop, J. G., DeRijk, R. H., & van den Brink, W.
Affiliations
  • Vrije Universiteit Amsterdam (NL)
  • Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author
Rinne, Thomas
ORCID
Wouters, Luuk
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2002-12
Volume
52
Issue
11
Pages
1102-1112
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/s0006-3223(02)01395-1
OpenAlex
W2068221498
Cited by
279
References
74
Citations by year
2026: 1 · 2025: 2 · 2024: 3 · 2023: 7 · 2022: 4 · 2021: 4 · 2020: 9 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 11 · 2015: 14 · 2014: 20 · 2013: 19 · 2012: 10
FWCI
5.72
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
Nationaal Fonds Geestelijke Volksgezondheid (4820)
Topics
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
Keywords
borderline personality disorder, childhood abuse, hypothalamic-pituitary-adrenal axis, ACTH response, cortisol, post-traumatic stress disorder, major depressive disorder, trauma exposure
MeSH terms
Adolescent, Adrenocorticotropic Hormone, Adult, Borderline Personality Disorder, Child Abuse, Corticotropin-Releasing Hormone, Dexamethasone, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Middle Aged, Pituitary-Adrenal System, Stress Disorders, Post-Traumatic, Case-Control Studies

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