The importance of TCF4 gene in the etiology of recurrent depressive disorders
Abstract
Background A recurrent depressive disorder is one of the most commonly diagnosed disease entities among psychiatric disorders. The prevalence and morbidity of depression are constantly increasing. Numerous studies have demonstrated the role of genetic factors in the etiology of depressive disorders. Many studies are being conducted to identify genes that predispose to depression. The purpose of this study was to investigate the role of TCF4 gene in the etiology of recurrent depressive disorders and, in particular, to assess expression of the TCF4 gene at the mRNA and protein level in patients with recurrent depressive disorders versus healthy individuals.Material and methods The examined population consisted of 170 individuals suffering from depression and 90 healthy individuals. The expressions of the TCF4 gene at the mRNA and protein level were assessed.Results Decreased TCF4 expression at the mRNA and protein level was found in patients with depressive disorder versus healthy individuals. Expression of the studied gene was not affected by the patients' sex and age. The statistical analysis also showed no correlation between the expression of TCF4 at the mRNA and protein level and the number of episodes or the severity of symptoms. Among the clinical manifestations of depression, only the duration of the illness correlated with the expression of TCF4 at the mRNA level.Conclusions Expression of TCF4 at the mRNA and protein level may be significant in the pathomechanism of recurrent depressive disorder and it is not dependent on sex and age.
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The TCF4 coding region contained two independent depression-associated variants and has been reported in earlier depression studies.
“The TCF4 gene coding region (Supplementary Figure 12) is also noteworthy as it contained two independently-associated variants for depression and has been identified in previous studies of depression 5, 9, 29.”
From Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions (2019) · cites this paper as [29]
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- Authors
- Mossakowska-Wójcik, J., Orzechowska, A., Talarowska, M., Szemraj, J., & Gałecki, P.
- Affiliations
- Medical University of Lodz (PL)
- Corresponding author
- Mossakowska-Wójcik, Joanna
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2018-01
- Volume
- 80
- Issue
- Pt C
- Pages
- 304-308
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W2602351448
- Cited by
- 32
- References
- 51
- Citations by year
- 2026: 1 · 2025: 5 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 5 · 2020: 6 · 2019: 1 · 2018: 3 · 2017: 3
- FWCI
- 2.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical University of Lodz (503/5-062-02/503-51-004)
- Topics
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- recurrent depression, depression, gene expression, mRNA expression, protein expression, genetic susceptibility, disease duration
- MeSH terms
- Transcription Factor 4, Age Factors, Depressive Disorder, Humans, Recurrence, RNA, Messenger, Sex Factors, Case-Control Studies, Genetic Predisposition to Disease
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