Lateralized readiness potentials and sensorimotor activity in adults with obsessive-compulsive disorder
Abstract
Obsessive-compulsive disorder (OCD) patients are known to have various functional abnormalities in prefrontal and motor areas. Given the presence of compulsions in many OCD patients, impaired response preparation processes could be a core feature of OCD. Yet, these processes remain understudied from a neurophysiological standpoint. Nineteen OCD patients were matched on age and sex to 19 healthy controls. Continuous EEG was recorded in all participants during a stimulus-response compatibility task. EEG from electrodes C3 and C4 was then averaged into stimulus- and response-locked LRPs. We compared both groups on various LRP measures, such as the LRP onset, the Gratton dip, and the maximum LRP peak. OCD patients showed significantly larger LRP peak than healthy controls, as well as larger Gratton dip. However, there was no group difference regarding LRP onset. Among OCD patients, it seems that motor regions are overactive during response preparation. Such overactivity was found for both incorrect responses that are aborted before execution and responses that are truly executed. These results suggest that regulation of sensorimotor activity should be addressed in the treatment of OCD.
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Novel behavioural interventions such as habit augmented ERP extend beyond traditional cognitive approaches and offer promise for moving toward a personalised treatment approach, based on measurable behavioural characteristics.
“Novel behavioural interventions such as habit augmented ERP extend beyond traditional cognitive approaches and offer promise for moving toward a personalised treatment approach, based on measurable behavioural characteristics [6,7,83,84]”
From Habit as a therapeutic component in psychological treatment for obsessive-compulsive disorder: A randomised controlled feasibility study. (2026) · cites this paper as [84]
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- Authors
- Morand-Beaulieu, S., Aardema, F., O'Connor, K. P., & Lavoie, M. E.
- Affiliations
- Institut universitaire en santé mentale de Montréal (CA)
- Corresponding author
- Lavoie, Marc E.
- Venue
- Progress in Neuro-Psychopharmacology and Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2021-01
- Volume
- 104
- Pages
- 110061
- ISSN
- 0278-5846 (ISSN-L)
- OpenAlex
- W3048086873
- Cited by
- 9
- References
- 45
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 4 · 2022: 1
- FWCI
- 0.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Progress in Neuro-Psychopharmacology and Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (415541, MOP84573, RCT244288)
- Université de Montréal
- Topics
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Free Will and Agency
- Keywords
- obsessive-compulsive disorder, lateralized readiness potential, sensorimotor activity, response preparation, compulsive behavior, prefrontal cortex, motor cortex
- MeSH terms
- Adult, Brain, Contingent Negative Variation, Electroencephalography, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder
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